KR20120132129A - Manufacturing method of wormwood ferment and patch device using wormwood ferment - Google Patents

Abstract

PURPOSE: A method for making a wormwood fermentation and a patch device using the wormwood fermentation are provided to penetrate active ingredients of the fermentation onto epidermis and to ensure anti-inflammatory, antibacterial, and antifungal functions. CONSTITUTION: A method for making a wormwood fermentation comprises: a step of drying wormwood under the shade at room temperature; a step of adding 2L of ethanol to 1.0 kg of the wormwood and shaking for 8 hours; a step of filtering the ethanol extract using a filter paper by reduced pressure; a step of concentrating the filtered liquid at 45-55 Deg. C. by compression to prepare soft extract; a step of mixing 200g of the soft extract and 200 ml of enzyme solution containing beta-glucosidase in a fermentation tank; and a step of fermenting and maturing the mixture at 45-55 Deg. C. for 48 hours. The method further comprises: a step of adding 12g of carbomer 940 to 500 ml of purified water and mixing with the fermentation; a step of adding 50g of labrasol, 100g of propylene glycol, and 30g of ethanol and shaking; and a step of adding triethanol amine and incubating the final mixture at 4 Deg. C. for 24 hours. [Reference numerals] (AA) Adhesive patch; (BB) Wormwood-fermented gel; (CC) Epidermis; (DD) Drug; (EE) Dermis; (FF) Blood vessel; (GG) Subcutaneous tissue/fascia; (HH) Deep fascia; (II) Muscle; (JJ) Vein; (KK) Artery

Description

Manufacturing method of mugwort fermented products and herbal patch device using mugwort fermented products {MANUFACTURING METHOD OF WORMWOOD FERMENT AND PATCH DEVICE USING WORMWOOD FERMENT}

The present invention relates to a method of manufacturing mugwort fermented products used in the moxibustion of oriental medicine or medical institutions, and a herbal patch device using mugwort fermented products. More specifically, mugwort fermented products are prepared in the center of an adhesive patch in the form of a hydrogel gel Mugwort fermentation gel is attached to the lattice disappointment so as not to be separated from the adhesive patch, and the bottom side is attached to the human epidermis so that the mugwort fermentation gel is in contact with the human epidermis, and the upper side is the adhesive patch and mugwort fermentation It relates to a method of producing mugwort fermented products and a herbal patch device using mugwort fermented products produced in the same form on both sides so that the gel is easily attached to other apparatus.

Mugwort fermented product gel is manufactured in hydrogel form so that the mugwort fermented product can penetrate the epidermis even after long time attachment to the human body. Form.

Mugwort (apple leaf) is a perennial herb of Asteraceae, called wormwood, moxa, sesame, and Sajaebal wormwood.

In Korea, dried herbs and young stems of Artemisia argyi Lev. Et Vant., Mugwort (A. princeps Pamp. Var. Orientlis Hara) or mountain mugwort (A. montana Pamp.) Are used. In Japan, A. montana Pamp. And A. princeps Pamp. (艾草) are used, and in China, only Yellow Sea Worm (A. argyi Lev. Et Vant.) Is used.

The stem extends sideways in the ground, and branches again to sprout and sprout in various places. The leaves sprouting from the roots are deeply divided in the form of circular feathers, and the split leaves have 5-6 pieces of keratin or irregular sawtooth.

The leaves attached to the stem are a little long oval, disappearing ingots and monotonous as they go up. Stems and leaves have a lot of hair, and under the leaves are white hairs.

In oriental medicine, the effect of mugwort is to warm the bleeding and the meridians, resulting in uterine bleeding caused by the weak and cold of the uterus and lower abdomen and bleeding during pregnancy, bleeding, nosebleeds, and bleeding. It is fragile, cold, cold and painful symptoms in the abdomen, menstrual irregularities, dysmenorrhea, good treat.

The general efficacy of wormwood has been reported to be strong sterilization, warming action to help blood circulation, cleanse the blood, replenish the insufficient blood, help blood circulation to drive the body to keep the body warm.

This is the reason why people who eat a lot of cold eat wormwood for a long time. The effect of wormwood is that some people see a better effect than deer antler. Rather, it is because it works together.

In particular, it is effective in preventing adult diseases such as gastrointestinal disease, chronic hepatitis, anemia, asthma, headache, neuralgia, rheumatism, arteriosclerosis, hypertension, and fatigue recovery. have.

For external use, hemostasis is effected. When the wound is bleeding, the fresh leaves of mugwort are rubbed and attached to the wound, and the skin is swelled immediately.It is also good for skin care. It is good for neuralgia, coldness, etc. and removes toxic, waste and blemishes from the skin and makes it smooth and moist.

In addition, eczema and itching of the skin may be used to treat skin diseases by washing the affected area with wormwood. Wormwood is used as a drug, the older the better dried, the better the essential oil of the active ingredient is soaked and its efficacy is enhanced.

Mugwort is used for medicinal and various foods. It is a versatile plant that is used for bathing, fragrance and moxa. It is a powerful antidote for public poisoning that breaks down toxins such as various medicines, fertilizers and pesticides and sends them out of the body.

The leaves are picked and dried, and the leaves are used for food poisoning, cold, uterine bleeding, and abdominal pain.

Mugwort is used as moxibustion or medicinal herb. It is common to be found anywhere in the country, but the sea breeze Eum-Gun (海風 陰乾) worm facing the sea breeze is regarded as a good mugwort.

Traditionally, the main ingredient of herbal moxibustion is wormwood, which is taken before Dano (lunar May oil), which is the period of receiving the most nourishment. Only innocent things like cotton are taken and roasted again to remove moisture completely. Currently, moxa moxibustion is known to have a warming effect by the heat of the mugwort penetrates the human epidermis, but burns the epidermis when burned, and also has the problem of avoiding moxa moxibustion due to smoke from the mugwort.

In addition, wormwood contains hulabonoids such as eupatilin and essential oils such as cineol (1,8-cineole), so hemostasis, cytoprotective, anti-inflammatory, antibacterial and antifungal Action. When the extract of the wormwood heated with water, not only the active ingredients are not sufficiently released, but most essential oil components are volatilized, and thus the efficacy does not appear properly.

The present invention has been made in order to solve the problems as described above, the object of the present invention is to provide a method for producing a mugwort fermented product so that the active ingredients of mugwort are sufficiently extracted by introducing a solvent extraction method and low temperature fermentation method.

In addition, the mugwort fermented product is produced in the form of hydrogel in the center of the adhesive patch so that the gel is not separated from the adhesive patch. It is manufactured to be in contact with the human epidermis, and mugwort fermented product gel is produced in hydrogel form so that the mugwort fermented product can penetrate the epidermis well even if it is attached to the human body for a long time. It is an object of the present invention to provide a herbal patch device using the mugwort fermentation so that the faster absorption.

In the method for preparing the mugwort fermented product according to the first embodiment of the present invention, 1.0 kg of dried wormwood is taken at room temperature, and 2 liters of ethanol are left to stand for 8 hours and then shaken for 8 hours, followed by filtering under reduced pressure using a filter paper while shaking the ethanol extract solution. Steps; Putting the filtrate into a vacuum condenser and concentrating under reduced pressure at a constant condition at 45 to 55 ° C. to obtain a soft extract state; Taking 200 g of the soft extract made in the above step, adding 200 ml of an enzyme solution containing 2,000 units of betaglucosidase into a fermenter, and fermenting and aging for 48 hours at 45-55 ° C. to produce a mugwort fermented product. do.

12 g of carbomer, a gelling agent, was added to 500 ml of purified water in the mugwort fermented product prepared in the above step, followed by swelling. 50 g of Labrasol, 100 g of propylene glycol, and 30 g of ethanol were mixed sequentially, followed by shaking to add triethanolamine. To form a hydrogel to pH 6.5 and then left for 4 hours at 4 ℃ characterized in that it further comprises the step of preparing a hydrogel of the mugwort fermentation.

The herbal patch device using the wormwood fermented product according to the second embodiment of the present invention includes an annular lower adhesive patch coated with adhesive on the upper and lower surfaces so as to adhere to the epidermis; Lattice disappointment covering the central hole of the bottom adhesive patch; An upper adhesive patch having the same shape as the patch when the lower adhesive is attached, and attached to the lattice disappointment; Mugwort fermentation gel is placed on the lattice disappointment exposed in the central hole of the upper adhesive patch.

According to the herbal patch device using the mugwort fermented product and the mugwort fermented product of the present invention, by extracting the mugwort fermented product by heating and extracting the active ingredients sufficiently to penetrate the epidermis, hemostatic action, cytoprotective action, anti-inflammatory action, Has the effect of showing antibacterial and antifungal action.

1 is a perspective view showing a mugwort fermented herbal patch device attached to the human epidermis.
Figure 2 is a view showing the manufacturing process of the herbal patch using the mugwort fermentation of the present invention.
Figure 3 is a side cross-sectional view showing a mugwort fermented herbal patch device of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. In the following description of the present invention, detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

[Example]

Method for preparing a mugwort fermented product according to the present invention, the step of taking a dry wormwood 1.0kg at room temperature and putting 2 l of ethanol and shaking while leaving for 8 hours, shaking under reduced pressure using a filter paper while shaking the ethanol extract solution;

Putting the filtrate into a vacuum condenser and concentrating under reduced pressure at a constant condition at 45 to 55 ° C. to obtain a soft extract state;

Taking 200 g of the soft lead extract prepared in the above step, adding 200 ml of an enzyme solution containing 2,000 units of betaglucosidase into a fermenter, and fermenting and aging for 48 hours at 45 to 55 ° C. to prepare a mugwort fermented product;

12 g of carbomer, a gelling agent, was added to 500 ml of purified water in the mugwort fermented product prepared in the above step, followed by swelling. 50 g of Labrasol, 100 g of propylene glycol, and 30 g of ethanol were mixed sequentially, followed by shaking to add triethanolamine. It was made to pH 6.5 to form a hydrogel and then left for 24 hours at 4 ℃ to produce a hydrogel of the mugwort fermentation (hereinafter referred to as "wormwood fermentate gel").

1 is a perspective view showing a mugwort fermented Chinese herbal patch device attached to the human epidermis, after attaching the adhesive patch and the mugwort fermentation gel on the epidermis, the mugwort fermentation gel is the epidermis It is manufactured in the form of hydrogel so that it penetrates well, and is also in the form of a patch so that the speed of penetration is absorbed more quickly by applying heat stimulation to the mugwort fermentation gel.

Figure 2 is a view showing the manufacturing process of the mugwort fermented herbal patch 1 to 4, Figure 3 is a side cross-sectional view showing a mugwort fermented herbal patch device of the present invention. As shown in FIG. 2 and FIG. 3, step 1 in FIG. 2 is a process of attaching an annular lower adhesive patch having an adhesive applied on the upper and lower surfaces to the epidermis so as to attach to the epidermis, and the second process is the lower The process of attaching the lattice disappointment covering the center hole of the adhesive patch, step 3 is a process of covering the upper adhesive patch of the same shape as the patch during the lower bonding on the lattice disappointment, step 4 is the upper adhesive The mugwort fermentation herbal patch device is manufactured by placing a mugwort fermentation gel on the lattice disappointment exposed to the central hole of the patch.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. And will be included in the described technical idea.

Claims (3)

Taking 1.0 kg of dried wormwood at room temperature and putting 2 l of ethanol and shaking for 8 hours, and then filtering under reduced pressure using a filter paper while shaking the ethanol extract solution;
Putting the filtrate into a vacuum condenser and concentrating under reduced pressure at a constant condition at 45 to 55 ° C. to obtain a soft extract state;
Taking 200 g of the soft extract made in the above step, adding 200 ml of an enzyme solution containing 2,000 units of betaglucosidase into a fermenter, and fermenting and aging for 48 hours at 45-55 ° C. to produce a mugwort fermented product. Mugwort fermented product manufacturing method. The method of claim 1,
12 g of carbomer, a gelling agent, was added to 500 ml of purified water in the mugwort fermented product prepared in the above step. By the pH 6.5 to form a hydrogel and then left for 24 hours at 4 ℃ manufacturing mugwort fermentation method further comprising the step of preparing a hydrogel of the mugwort fermentation. An annular lower adhesive patch having an adhesive applied to the upper and lower surfaces so as to adhere to the epidermis;
Lattice disappointment covering the central hole of the bottom adhesive patch;
An upper adhesive patch having the same shape as the patch when the lower adhesive is attached, and attached to the lattice disappointment;
Herbal patch device using the mugwort fermentation, characterized in that consisting of the mugwort fermentation gel placed on the lattice disappointment exposed to the central hole of the upper adhesive patch.

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