KR20120107512A - 태아 이수성의 비침해성 출생전 진단을 위한 방법과 조성물 - Google Patents

태아 이수성의 비침해성 출생전 진단을 위한 방법과 조성물 Download PDF

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KR20120107512A
KR20120107512A KR1020127020832A KR20127020832A KR20120107512A KR 20120107512 A KR20120107512 A KR 20120107512A KR 1020127020832 A KR1020127020832 A KR 1020127020832A KR 20127020832 A KR20127020832 A KR 20127020832A KR 20120107512 A KR20120107512 A KR 20120107512A
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seq
dna
base pair
sample
chromosome
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필리포스 씨 파트살리스
엘리자베트 에이 파파게오르기오우
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엔아이피디 제네틱스 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020127020832A 2010-01-26 2011-01-26 태아 이수성의 비침해성 출생전 진단을 위한 방법과 조성물 Withdrawn KR20120107512A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29833910P 2010-01-26 2010-01-26
US61/298,339 2010-01-26
US40542110P 2010-10-21 2010-10-21
US61/405,421 2010-10-21

Publications (1)

Publication Number Publication Date
KR20120107512A true KR20120107512A (ko) 2012-10-02

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KR1020127020832A Withdrawn KR20120107512A (ko) 2010-01-26 2011-01-26 태아 이수성의 비침해성 출생전 진단을 위한 방법과 조성물

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US (1) US9249462B2 (enExample)
EP (1) EP2529032B1 (enExample)
JP (1) JP2013517789A (enExample)
KR (1) KR20120107512A (enExample)
CN (1) CN102892899A (enExample)
AU (1) AU2011210255B2 (enExample)
BR (1) BR112012018458A2 (enExample)
CA (1) CA2786174A1 (enExample)
CY (1) CY1118864T1 (enExample)
DK (1) DK2529032T3 (enExample)
EA (1) EA023565B1 (enExample)
ES (1) ES2623156T3 (enExample)
NZ (1) NZ601079A (enExample)
PL (1) PL2529032T3 (enExample)
PT (1) PT2529032T (enExample)
SG (1) SG182322A1 (enExample)
WO (1) WO2011092592A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014158001A1 (ko) 2013-03-29 2014-10-02 (주)셀트리온 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물
WO2020106116A1 (ko) 2018-11-23 2020-05-28 (주)셀트리온 인플루엔자 바이러스 질환을 치료하기 위한 투여 요법

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CN101153336B (zh) 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
EP2516680B1 (en) 2009-12-22 2016-04-06 Sequenom, Inc. Processes and kits for identifying aneuploidy
US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2872648B1 (en) 2012-07-13 2019-09-04 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
FI4056712T3 (fi) * 2012-09-20 2024-08-29 Univ Hong Kong Chinese Kasvaimen metyloomin nonivasiivinen määrittäminen plasmasta
CN104838013A (zh) * 2012-09-26 2015-08-12 新加坡科技研究局 用于唐氏综合症产前诊断的生物标志物
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
EP3117011B1 (en) 2014-03-13 2020-05-06 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
RU2583830C2 (ru) * 2014-04-21 2016-05-10 Закрытое акционерное общество "Геноаналитика" Способ неинвазивной пренатальной диагностики анеуплоидий плода
EP2942401A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Detection of DNA that originates from a specific cell-type
EP2942400A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex detection of DNA that originates from a specific cell-type
EP3521454A1 (en) 2014-05-09 2019-08-07 LifeCodexx AG Detection of dna that originates from a specific cell-type and related methods
US20180187267A1 (en) * 2017-01-05 2018-07-05 Michael J. Powell Method for conducting early detection of colon cancer and/or of colon cancer precursor cells and for monitoring colon cancer recurrence
US10174383B2 (en) * 2014-08-13 2019-01-08 Vanadis Diagnostics Method of estimating the amount of a methylated locus in a sample
WO2016176846A1 (zh) * 2015-05-06 2016-11-10 安诺优达基因科技(北京)有限公司 检测染色体非整倍性的试剂盒、装置和方法
WO2016189388A1 (en) 2015-05-22 2016-12-01 Nipd Genetics Ltd Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing
DK3168309T3 (da) 2015-11-10 2020-06-22 Eurofins Lifecodexx Gmbh Detektion af føtale kromosomale aneuploidier under anvendelse af dna-regioner med forskellig metylering mellem fosteret og det gravide hunkøn
SG11201804651XA (en) * 2015-12-04 2018-07-30 Green Cross Genome Corp Method for determining copy-number variation in sample comprising mixture of nucleic acids
KR101817180B1 (ko) * 2016-01-20 2018-01-10 이원다이애그노믹스(주) 염색체 이상 판단 방법
US10781490B2 (en) 2016-05-30 2020-09-22 The Chinese University Of Hong Kong Detecting hematological disorders using cell-free DNA in blood
CN109112209B (zh) * 2017-06-25 2022-06-24 国家卫生计生委科学技术研究所 用于无创产前检测胎儿非整倍体染色体的参考品
US12027237B2 (en) 2018-03-13 2024-07-02 Grail, Llc Anomalous fragment detection and classification
US12234514B2 (en) 2018-12-21 2025-02-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free DNA samples
US20230151409A1 (en) * 2020-03-30 2023-05-18 Vilnius University Methods and compositions for noninvasive prenatal diagnosis through targeted covalent labeling of genomic sites
KR102332540B1 (ko) * 2020-07-02 2021-11-29 의료법인 성광의료재단 다운증후군 특이적인 후성학적 마커를 이용한 다운증후군 진단 방법
US20250079015A1 (en) * 2022-01-10 2025-03-06 Washington State University Dna methylation biomarkers for preterm birth
WO2024216205A1 (en) * 2023-04-14 2024-10-17 Adela, Inc. Methods and systems for cell-free nucleic acid processing
WO2025179073A1 (en) * 2024-02-21 2025-08-28 Adela, Inc. Methods and systems for tissue informed differentially methylated region analysis

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US6582908B2 (en) * 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
JP5013869B2 (ja) * 2003-09-22 2012-08-29 トリソゲン バイオテクノロジー リミテッド パートナーシップ 遺伝子座コピー数の変化を検出するのに有用な方法およびキット
US20050282213A1 (en) 2003-09-22 2005-12-22 Trisogen Biotechnology Limited Partnership Methods and kits useful for detecting an alteration in a locus copy number
GB0413688D0 (en) 2004-06-18 2004-07-21 Novartis Forschungsstiftung Analysis of methylated nucleic acid
AU2005308918B2 (en) 2004-11-29 2012-09-27 Sequenom, Inc. Means and methods for detecting methylated DNA
WO2007044780A2 (en) 2005-10-07 2007-04-19 Emory University Methods and systems for screening for and diagnosing dna methylation associated abnormalities and sex chromosome aneuploidies
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
EP3892736A1 (en) 2007-07-23 2021-10-13 The Chinese University of Hong Kong Determining a nucleic acid sequence imbalance
JP5322471B2 (ja) 2008-03-27 2013-10-23 シスメックス株式会社 メチル化ｄｎａの解析方法及びプライマーセット
US8476013B2 (en) * 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014158001A1 (ko) 2013-03-29 2014-10-02 (주)셀트리온 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물
US10703802B2 (en) 2013-03-29 2020-07-07 Celltrion, Inc. Composition comprising at least two influenza A virus-neutralizing-binding molecules
WO2020106116A1 (ko) 2018-11-23 2020-05-28 (주)셀트리온 인플루엔자 바이러스 질환을 치료하기 위한 투여 요법

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Publication number Publication date
WO2011092592A3 (en) 2011-11-03
BR112012018458A2 (pt) 2018-07-10
CN102892899A (zh) 2013-01-23
PL2529032T3 (pl) 2017-07-31
US9249462B2 (en) 2016-02-02
CA2786174A1 (en) 2011-08-04
NZ601079A (en) 2014-08-29
US20120282613A1 (en) 2012-11-08
PT2529032T (pt) 2017-05-04
SG182322A1 (en) 2012-08-30
ES2623156T3 (es) 2017-07-10
JP2013517789A (ja) 2013-05-20
WO2011092592A2 (en) 2011-08-04
EA201290716A1 (ru) 2013-06-28
AU2011210255A1 (en) 2012-07-26
EP2529032B1 (en) 2017-01-25
AU2011210255B2 (en) 2014-11-20
EA023565B1 (ru) 2016-06-30
CY1118864T1 (el) 2018-01-10
EP2529032A2 (en) 2012-12-05
DK2529032T3 (en) 2017-05-01

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Patent event date: 20120808

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