KR20120099147A - 각막 내피 장애 치료제(ｙ-39983) - Google Patents
각막 내피 장애 치료제(ｙ-39983) Download PDFInfo
- Publication number
- KR20120099147A KR20120099147A KR1020127019919A KR20127019919A KR20120099147A KR 20120099147 A KR20120099147 A KR 20120099147A KR 1020127019919 A KR1020127019919 A KR 1020127019919A KR 20127019919 A KR20127019919 A KR 20127019919A KR 20120099147 A KR20120099147 A KR 20120099147A
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- Prior art keywords
- corneal endothelial
- compound
- endothelial cells
- corneal
- cells
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K9/0012—Galenical forms characterised by the site of application
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/999—Small molecules not provided for elsewhere
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
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- Genetics & Genomics (AREA)
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- General Engineering & Computer Science (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
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| JPJP-P-2009-299180 | 2009-12-29 | ||
| JP2009299180 | 2009-12-29 | ||
| WOPCT/JP2010/071424 | 2010-11-24 | ||
| PCT/JP2010/071424 WO2011080984A1 (en) | 2009-12-29 | 2010-11-24 | Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction |
Publications (1)
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| KR20120099147A true KR20120099147A (ko) | 2012-09-06 |
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| KR1020127019919A Abandoned KR20120099147A (ko) | 2009-12-29 | 2010-12-28 | 각막 내피 장애 치료제(ｙ-39983) |
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| US (1) | US20120288482A1 (enExample) |
| EP (1) | EP2519237A1 (enExample) |
| JP (2) | JP5750444B2 (enExample) |
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| RU (1) | RU2563141C2 (enExample) |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2788472T (lt) * | 2011-12-06 | 2019-04-10 | Astellas Institute For Regenerative Medicine | Kryptingos diferenciacijos būdas, skirtas ragenos endotelio ląstelių gamybai |
| MX2016006915A (es) | 2013-11-27 | 2017-01-23 | Kyoto Prefectural Public Univ Corp | Aplicacion de laminina a cultivo de celulas endoteliales de la cornea. |
| US10959997B2 (en) | 2013-12-27 | 2021-03-30 | Kyoto Prefectural Public University Corporation | Combined agent for cell therapy of corneal endothelial cell |
| JP6598381B2 (ja) * | 2014-09-24 | 2019-10-30 | 興和株式会社 | 角膜厚調節剤 |
| EP3213762B1 (en) * | 2014-10-31 | 2023-11-29 | Kyoto Prefectural Public University Corporation | Novel treatment of cornea using laminin |
| JP6770435B2 (ja) | 2014-10-31 | 2020-10-14 | 京都府公立大学法人 | ラミニンによる網膜および神経の新規治療 |
| ES2947826T3 (es) * | 2016-02-15 | 2023-08-21 | Kyoto Prefectural Public Univ Corp | Célula endotelial corneal funcional humana y aplicación de la misma |
Family Cites Families (13)
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| EP1195372A1 (en) | 1994-04-18 | 2002-04-10 | Mitsubishi Pharma Corporation | N-heterocyclic substituted benzamide derivatives with antihypertensive activity |
| KR100865262B1 (ko) | 2001-04-11 | 2008-10-24 | 센주 세이야꾸 가부시키가이샤 | 시각 기능 장애 개선제 |
| JP2004024852A (ja) | 2002-04-30 | 2004-01-29 | Amniotec:Kk | 角膜内皮様シート、及びその作製方法 |
| US7087237B2 (en) * | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| CA2529613C (en) * | 2004-06-03 | 2013-10-01 | Senju Pharmaceutical Co., Ltd. | Agent for repairing corneal sensitivity containing amide compound |
| WO2006057270A1 (ja) * | 2004-11-26 | 2006-06-01 | Asahi Kasei Pharma Corporation | 含窒素３環化合物 |
| JP4766653B2 (ja) * | 2005-01-28 | 2011-09-07 | 株式会社林原生物化学研究所 | 眼科用医薬組成物 |
| JPWO2006095844A1 (ja) * | 2005-03-10 | 2008-08-21 | 田辺三菱製薬株式会社 | 医薬製剤 |
| WO2007083685A1 (ja) * | 2006-01-19 | 2007-07-26 | Senju Pharmaceutical Co., Ltd. | 生体内で細胞増殖可能な角膜内皮製剤 |
| RU2476219C2 (ru) * | 2006-07-31 | 2013-02-27 | Сэндзю Фармасьютикал Ко., Лтд. | Жидкая композиция на водной основе, содержащая амидное соединение |
| JP5657252B2 (ja) | 2007-08-29 | 2015-01-21 | 千寿製薬株式会社 | 角膜内皮細胞接着促進剤 |
| JP5251632B2 (ja) | 2008-05-13 | 2013-07-31 | 新日鐵住金株式会社 | 耐遅れ破壊特性に優れた高強度鋼材、高強度ボルト及びその製造方法 |
| JP2010071424A (ja) | 2008-09-19 | 2010-04-02 | Toyota Motor Corp | 変速機の制御装置 |
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2010
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- 2010-12-28 CA CA2785851A patent/CA2785851A1/en not_active Abandoned
- 2010-12-28 CN CN2010800649229A patent/CN102770136A/zh active Pending
- 2010-12-28 EP EP10805660A patent/EP2519237A1/en not_active Withdrawn
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- 2010-12-28 KR KR1020127019919A patent/KR20120099147A/ko not_active Abandoned
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- 2010-12-28 RU RU2012132443/15A patent/RU2563141C2/ru not_active IP Right Cessation
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- 2010-12-28 US US13/519,682 patent/US20120288482A1/en not_active Abandoned
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2015
- 2015-05-18 JP JP2015100969A patent/JP2015155460A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013515676A (ja) | 2013-05-09 |
| CA2785851A1 (en) | 2011-07-07 |
| WO2011080984A1 (en) | 2011-07-07 |
| CN102770136A (zh) | 2012-11-07 |
| JP2015155460A (ja) | 2015-08-27 |
| BR112012016128A2 (pt) | 2016-05-31 |
| EP2519237A1 (en) | 2012-11-07 |
| WO2011081221A1 (en) | 2011-07-07 |
| JP5750444B2 (ja) | 2015-07-22 |
| RU2563141C2 (ru) | 2015-09-20 |
| RU2012132443A (ru) | 2014-02-10 |
| BR112012016128A8 (pt) | 2017-12-05 |
| MX2012007671A (es) | 2012-08-23 |
| US20120288482A1 (en) | 2012-11-15 |
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