KR20120050493A - Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정 - Google Patents

Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정 Download PDF

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KR20120050493A
KR20120050493A KR1020127007529A KR20127007529A KR20120050493A KR 20120050493 A KR20120050493 A KR 20120050493A KR 1020127007529 A KR1020127007529 A KR 1020127007529A KR 20127007529 A KR20127007529 A KR 20127007529A KR 20120050493 A KR20120050493 A KR 20120050493A
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ras
raf
mutant
tumor
inhibitor
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Korean (ko)
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조지아 하치바실리오우
시바 말렉
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제넨테크, 인크.
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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • G—PHYSICS
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020127007529A 2009-08-24 2010-08-24 Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정 Ceased KR20120050493A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US23646609P 2009-08-24 2009-08-24
US61/236,466 2009-08-24
US30114910P 2010-02-03 2010-02-03
US61/301,149 2010-02-03

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KR20120050493A true KR20120050493A (ko) 2012-05-18

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KR1020127007529A Ceased KR20120050493A (ko) 2009-08-24 2010-08-24 Ｋｒａｓ 돌연변이 및 ｒｔｋ 발현 수준을 검출하는 것에 의한 ｂ-ｒａｆ 억제제 치료에 대한 세포의 감수성 결정

Country Status (15)

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US (2) US20120214828A1 (forum.php)
EP (1) EP2470898A4 (forum.php)
JP (1) JP2013502236A (forum.php)
KR (1) KR20120050493A (forum.php)
CN (1) CN102859355B (forum.php)
AU (1) AU2010289794B2 (forum.php)
BR (1) BR112012003926A2 (forum.php)
CA (1) CA2771369A1 (forum.php)
IL (2) IL218099A0 (forum.php)
IN (1) IN2012DN01403A (forum.php)
MX (1) MX338856B (forum.php)
MY (1) MY165154A (forum.php)
RU (2) RU2015104058A (forum.php)
SG (2) SG178866A1 (forum.php)
WO (1) WO2011028540A1 (forum.php)

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CN101945869B (zh) 2007-12-19 2014-06-18 癌症研究技术有限公司 吡啶并[2,3-b]吡嗪-8-取代化合物及其用途
PH12012501361A1 (en) 2009-12-31 2012-10-22 Centro Nac De Investigaciones Oncologicas Cnio Tricyclic compounds for use as kinase inhibitors
WO2011092469A1 (en) 2010-02-01 2011-08-04 Cancer Research Technology Limited 1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
US8709419B2 (en) 2010-08-17 2014-04-29 Hoffmann-La Roche, Inc. Combination therapy
US9295669B2 (en) 2010-12-14 2016-03-29 Hoffman La-Roche Inc. Combination therapy for proliferative disorders
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013043715A1 (en) * 2011-09-19 2013-03-28 Genentech, Inc. Combination treatments comprising c-met antagonists and b-raf antagonists
US9408885B2 (en) 2011-12-01 2016-08-09 Vib Vzw Combinations of therapeutic agents for treating melanoma
WO2013106683A1 (en) * 2012-01-11 2013-07-18 Duke University Methods of treating and preventing cancer by disrupting the binding of copper in the map kinase pathway
US9216170B2 (en) 2012-03-19 2015-12-22 Hoffmann-La Roche Inc. Combination therapy for proliferative disorders
MY176031A (en) * 2012-08-07 2020-07-22 Array Biopharma Inc Pharmaceutical combinations comprising a b-raf inhibitor, an egfr inhibitor and optionally a pi3k-alpha inhibitor
HUE044789T2 (hu) 2012-08-17 2019-11-28 Hoffmann La Roche Cobimetinib és vemurafenib beadását magukban foglaló kombinált terápiák melanóma kezelésére
KR20150070393A (ko) * 2012-10-25 2015-06-24 글락소스미스클라인 엘엘씨 조합물
EP2786764B1 (en) 2013-04-01 2017-03-08 Samsung Electronics Co., Ltd. Combination therapy using anti-c-met antibody and sorafenib
US9532987B2 (en) 2013-09-05 2017-01-03 Genentech, Inc. Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
ES2844229T3 (es) * 2014-05-13 2021-07-21 Univ Texas Mutaciones génicas y alteraciones en el número de copias de EGFR, KRAS y MET
EP3236966B1 (en) * 2014-12-23 2020-08-12 DOT Therapeutics-1, Inc. Combination of raf inhibitors and taxanes
WO2017066664A1 (en) * 2015-10-16 2017-04-20 Millennium Pharmaceuticals, Inc. Combination therapy including a raf inhibitor for the treatment of colorectal cancer
JP6917595B2 (ja) * 2016-04-28 2021-08-11 デンカ株式会社 上皮性細胞成長因子受容体阻害剤に対する癌細胞の耐性を判定する方法
WO2018146253A1 (en) 2017-02-10 2018-08-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
WO2019133810A1 (en) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
SG11202012653XA (en) 2018-06-19 2021-01-28 Biontech Us Inc Neoantigens and uses thereof
CN115916346A (zh) * 2020-04-27 2023-04-04 维瑞斯特姆股份有限公司 用于治疗异常细胞生长的方法
US11873296B2 (en) 2022-06-07 2024-01-16 Verastem, Inc. Solid forms of a dual RAF/MEK inhibitor

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AU2005250484B2 (en) * 2004-06-04 2011-08-11 Genentech, Inc. EGFR mutations
US7976852B2 (en) * 2005-04-26 2011-07-12 Eisai R&D Management Co., Ltd. Compositions and methods for cancer immunotherapy
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EP1917528B1 (en) * 2005-08-24 2011-08-17 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators
EP2118322A2 (en) * 2007-03-13 2009-11-18 Amgen Inc. K-ras and b-raf mutations and anti-egfr antibody therapy

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SG178866A1 (en) 2012-04-27
IL218099A0 (en) 2012-04-30
MX338856B (es) 2016-05-03
HK1175248A1 (zh) 2013-06-28
EP2470898A4 (en) 2013-03-13
BR112012003926A2 (pt) 2020-08-11
EP2470898A1 (en) 2012-07-04
CN102859355B (zh) 2015-10-07
AU2010289794B2 (en) 2014-10-02
IN2012DN01403A (forum.php) 2015-06-05
RU2553379C2 (ru) 2015-06-10
MX2012002292A (es) 2012-03-19
CN102859355A (zh) 2013-01-02
US20120214828A1 (en) 2012-08-23
AU2010289794A1 (en) 2012-04-05
SG10201402917XA (en) 2014-08-28
MY165154A (en) 2018-02-28
US20150164895A1 (en) 2015-06-18
RU2012111231A (ru) 2013-10-10
WO2011028540A1 (en) 2011-03-10
JP2013502236A (ja) 2013-01-24
CA2771369A1 (en) 2011-03-10
IL235398A0 (en) 2014-12-31
RU2015104058A (ru) 2015-06-10

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