KR20120050442A - 플라스미노겐 및 플라스민의 변이체 - Google Patents
플라스미노겐 및 플라스민의 변이체 Download PDFInfo
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- KR20120050442A KR20120050442A KR1020127003121A KR20127003121A KR20120050442A KR 20120050442 A KR20120050442 A KR 20120050442A KR 1020127003121 A KR1020127003121 A KR 1020127003121A KR 20127003121 A KR20127003121 A KR 20127003121A KR 20120050442 A KR20120050442 A KR 20120050442A
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- plasmin
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- ser
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
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- Epidemiology (AREA)
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- Immunology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
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| EP09165237.0 | 2009-07-10 |
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| KR (1) | KR20120050442A (enExample) |
| CN (1) | CN102482338B (enExample) |
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| KR20170010798A (ko) * | 2014-05-28 | 2017-02-01 | 파피에르패브릭 어거스트 쾰러 에스이 | 감열성 기록물질 |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2451835A1 (en) | 2009-07-10 | 2012-05-16 | ThromboGenics N.V. | Variants of plasminogen and plasmin |
| WO2011023805A1 (en) | 2009-08-28 | 2011-03-03 | Thrombogenics N.V. | Use of plasmin for the treatment of filtration failure after trabeculectomy |
| ES2583082T3 (es) | 2011-01-05 | 2016-09-19 | Thrombogenics N.V. | Variantes de plasminógeno y plasmina |
| WO2013024074A1 (en) | 2011-08-12 | 2013-02-21 | Thrombogenics N.V. | Plasminogen and plasmin variants |
| ES2628321T3 (es) * | 2011-12-01 | 2017-08-02 | Thrombogenics N.V. | Mejora del resultado de una trabeculectomía |
| WO2014160281A2 (en) * | 2013-03-14 | 2014-10-02 | Wayne State University | Method of enhancing delivery of therapeutic compounds to the eye |
| EP2821081A1 (en) | 2013-07-05 | 2015-01-07 | ResuSciTec GmbH | Protective solution for preventing or reducing reperfusion injury of the brain and the whole body |
| EP3233111B1 (en) * | 2014-12-19 | 2024-08-07 | Kedrion Biopharma Inc. | Pharmaceutical composition comprising plasminogen and uses thereof |
| RU2597782C1 (ru) * | 2015-08-25 | 2016-09-20 | Василий Николаевич Яковлев | Способ определения содержания продуктов протеолиза в плазме крови и диагностическая тест-система для его осуществления |
| TWI801331B (zh) * | 2015-11-03 | 2023-05-11 | 美商波麥堤克生物治療股份有限公司 | 纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法 |
| TWI653982B (zh) * | 2015-12-18 | 2019-03-21 | 大陸商深圳瑞健生命科學研究院有限公司 | Method for preventing or treating acute and chronic thrombosis |
| CN106890320A (zh) * | 2015-12-18 | 2017-06-27 | 深圳瑞健生命科学研究院有限公司 | 一种用于预防或治疗急性及慢性血栓的方法 |
| EP3391901B1 (en) * | 2015-12-18 | 2023-07-05 | Talengen International Limited | Plasminogen for use in treating liver tissue damage |
| DK3391902T5 (da) | 2015-12-18 | 2024-09-23 | Talengen Int Ltd | Plasminogen til anvendelse i behandlingen af diabetisk angiokardiopati |
| CA3008495A1 (en) | 2015-12-18 | 2017-06-22 | Talengen International Limited | Method for preventing and treating cervical erosion |
| WO2017101873A1 (zh) | 2015-12-18 | 2017-06-22 | 深圳瑞健生命科学研究院有限公司 | 一种预防或治疗放射性和化学性损伤的方法 |
| EP3556385A4 (en) | 2016-12-15 | 2020-12-30 | Talengen International Limited | PROCESS FOR ALLEGING HEART DISEASE |
| CN110114080A (zh) | 2016-12-15 | 2019-08-09 | 泰伦基国际有限公司 | 一种预防和治疗皮肤纤维化的方法 |
| CN108210914A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗脂肪代谢紊乱及其相关病症的药物及其用途 |
| JP7171572B2 (ja) | 2016-12-15 | 2022-11-15 | タレンゲン インターナショナル リミテッド | 糖尿病を治療するための新しい方法 |
| CN108210917A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗肥胖症的方法和药物 |
| WO2018108161A1 (zh) * | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗肥胖症的方法和药物 |
| JP7182793B2 (ja) * | 2016-12-15 | 2022-12-05 | タレンゲン インターナショナル リミテッド | 病理学的腎組織損傷を予防及び治療するための方法 |
| CN110366425A (zh) * | 2016-12-15 | 2019-10-22 | 泰伦基国际有限公司 | 一种预防动脉粥样硬化及其并发症的方法 |
| CN108210910A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗系统性硬化症的药物及其用途 |
| TWI714862B (zh) | 2017-06-19 | 2021-01-01 | 大陸商深圳瑞健生命科學硏究院有限公司 | 一種調控glp-1/glp-1r的方法和藥物 |
| CN113795274A (zh) * | 2019-05-10 | 2021-12-14 | 泰伦基国际有限公司 | 一种治疗肌萎缩侧索硬化的方法和药物 |
| CA3176937A1 (en) * | 2020-03-24 | 2021-09-30 | Talengen International Limited | Method and drug for promoting degradation of misfolded protein and aggregate thereof |
| US11964004B2 (en) * | 2021-03-31 | 2024-04-23 | Shenzhen Bay Laboratory | Short in vivo half-life and in vivo unstable recombinant microplasmin, pharmaceutical composition comprising thereof and method of treating thromboembolism related diseases including administration thereof |
| CN113755476B (zh) * | 2021-10-14 | 2023-04-11 | 北京农学院 | 蛆激酶制备方法及其用途 |
| CN119331857B (zh) * | 2024-12-19 | 2025-05-16 | 南通大学 | 一种新型重组蛋白Plasminogen-CTM及应用 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3208908A (en) | 1961-11-16 | 1965-09-28 | Parke Davis & Co | Fibrinolysin-desoxyribonuclease for enzymatic debridement |
| US4122158A (en) | 1976-09-23 | 1978-10-24 | Alza Corporation | Topical therapeutic preparations |
| NZ191320A (en) | 1978-09-07 | 1982-09-14 | Beecham Group Ltd | In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions |
| IT1194135B (it) | 1981-01-05 | 1988-09-14 | Novo Industri As | Composizioni di plasmina stabilizzata e metodo per la loro preparazione |
| US4774087A (en) | 1987-08-14 | 1988-09-27 | Northwestern University | Micro-size fibrinolytic plasmin |
| FI915149A0 (fi) | 1989-05-01 | 1991-10-31 | Univ Notre Dame Du Lac | Foerfarande och material foer expression av humant plasminogen i ett eukaryotiskt cellsystem som saknar en laegesspecifik plasminogenaktivator. |
| US5087572A (en) | 1989-12-01 | 1992-02-11 | Genentech, Inc. | Dna encoding human plasminogen modified at the cleavage site |
| AT402367B (de) | 1990-10-11 | 1997-04-25 | Immuno Ag | Pharmazeutische zubereitung auf basis von lys-plasminogen |
| US5288489A (en) | 1991-08-28 | 1994-02-22 | Orion Therapeutic Systems, Inc. | Fibrinolysis and fibrinogenolysis treatment |
| IT1260468B (it) | 1992-01-29 | 1996-04-09 | Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole | |
| US5304118A (en) | 1992-12-16 | 1994-04-19 | Trese Michael T | Method for performing a vitrectomy on an eye |
| US5520912A (en) | 1993-07-02 | 1996-05-28 | Immuno Aktiengesellschaft | Prevention and treatment of ischemic events and reperfusion injury resulting therefrom using lys-plasminogen |
| DE4411143C2 (de) | 1994-03-30 | 1996-08-01 | Immuno Ag | Thrombosemittel |
| US5879923A (en) | 1995-06-26 | 1999-03-09 | Daiichi Pure Chemicals Co., Ltd. | Stable plasmin solution |
| JP4426650B2 (ja) * | 1996-05-03 | 2010-03-03 | アボット・ラボラトリーズ | 新規な抗血管形成ペプチド、それをコードするポリヌクレオチド、および血管形成を阻害する方法 |
| US5801146A (en) * | 1996-05-03 | 1998-09-01 | Abbott Laboratories | Compound and method for inhibiting angiogenesis |
| JP4577992B2 (ja) * | 1998-09-29 | 2010-11-10 | リューベン・リサーチ・アンド・デベロップメント・ベー・ゼット・ウェー | 虚血性卒中の処置用の組成物を調製するための、α２抗プラスミンをインビボで減少する化合物の使用 |
| US20040081643A1 (en) | 1999-03-09 | 2004-04-29 | Peyman Gholam A. | Process for inhibiting vascular proliferation in the eye |
| US6733750B1 (en) | 1999-03-09 | 2004-05-11 | Minu, L.L.C. | Process and composition for inducing posterior vitreous detachment |
| US6585972B2 (en) | 1999-03-09 | 2003-07-01 | Gholam A. Peyman | Process for crosslinking of collagen in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina |
| US6899877B2 (en) | 1999-03-09 | 2005-05-31 | Minu, L.L.C. | Process for generating plasmin in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina |
| DK1194528T3 (da) | 1999-07-14 | 2007-07-09 | D Collen Res Foundation Vzw | Monoklonalt antistof mod faktor VII, hvilket antistof selv ved forekomst i molært overskud kun delvist inaktiverer faktor VII, samt fremgangsmåde til produktion af et sådant antistof |
| US6440414B1 (en) | 1999-10-01 | 2002-08-27 | Amgen Inc. | Pharmaceutical compositions of fibrinolytic agent |
| US7544500B2 (en) | 1999-11-13 | 2009-06-09 | Talecris Biotherapeutics, Inc. | Process for the production of a reversibly inactive acidified plasmin composition |
| US6969515B2 (en) | 1999-11-13 | 2005-11-29 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| US6355243B1 (en) | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
| US6964764B2 (en) | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| JP2004508006A (ja) * | 2000-02-08 | 2004-03-18 | ノースウエスタン ユニバーシティ | アンギオスタチンを生成するための方法および組成物 |
| AU2002218890A1 (en) * | 2000-12-21 | 2002-07-01 | Thromb-X N.V. | A yeast expression vector and a method of making a recombinant protein by expression in a yeast cell |
| US20020139378A1 (en) | 2001-03-28 | 2002-10-03 | Trese Michael T. | Method for creating a separation of posterior cortical vitreous from the retina of the eye |
| US20040009212A1 (en) | 2002-01-30 | 2004-01-15 | Pharma Power Biotec Co. Ltd. | Mucoadhesive thermoresponsive medicament-carrier composition |
| US7776026B2 (en) | 2002-02-06 | 2010-08-17 | Nuvue Technologies, Inc. | Method for vitreous liquefaction |
| EP1472346A2 (de) * | 2002-02-06 | 2004-11-03 | N-Zyme BioTec GmbH | Verfahren zur herstellung von rekombinanten proteinen in mikroorganismen |
| US6787135B2 (en) | 2002-03-13 | 2004-09-07 | William Beaumont Hospital | Modification of vitreal matrix metalloproteinase activity |
| WO2004045558A2 (en) | 2002-11-18 | 2004-06-03 | President And Fellows Of Harvard College | Compositions and methods for treating thrombotic disorders |
| GB0228409D0 (en) | 2002-12-06 | 2003-01-08 | Thromb X Nv | Pharmacological vitreolysis |
| EP1706079B1 (en) | 2003-08-14 | 2013-02-20 | ThromboGenics N.V. | Antibodies against factor viii with modified glycosylation in the variable region |
| EP1713921A2 (en) * | 2004-02-11 | 2006-10-25 | Biolex, Inc. | Expression of plasminogen and microplasminogen in duckweed |
| CN1253560C (zh) | 2004-03-01 | 2006-04-26 | 宁夏大学 | 组织型纤溶酶原激活剂缺失/点突变体基因转染细胞株 |
| JP5026254B2 (ja) | 2004-04-22 | 2012-09-12 | グリフオルス・セラピユーテイクス・インコーポレーテツド | 組換え的に改変されたプラスミン |
| US20060257391A1 (en) | 2005-05-11 | 2006-11-16 | Bausch & Lomb Incorporated | Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions |
| WO2007047874A2 (en) | 2005-10-20 | 2007-04-26 | Talecris Biotherapeutics, Inc. | Recombinantly modified plasmin |
| US20070134231A1 (en) | 2005-12-13 | 2007-06-14 | Jani Dharmendra M | Method for prolonging activity of autodegradable enzymes and compositions thereof |
| US20070134230A1 (en) | 2005-12-13 | 2007-06-14 | Jani Dharmendra M | Method for prolonging activity of autodegradable enzymes |
| US20070196350A1 (en) | 2006-02-22 | 2007-08-23 | Bartels Stephen P | Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment |
| US20070212358A1 (en) | 2006-03-10 | 2007-09-13 | Bartels Stephen P | Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment |
| EP2056864B1 (en) | 2006-08-28 | 2013-12-11 | Omnio Healer AB | Candidates against infection |
| GB2455262A (en) | 2006-09-29 | 2009-06-10 | Proteomtech Inc | Methods for production of recombinant plasminogen and plasmin polypeptides |
| WO2009073471A1 (en) | 2007-11-29 | 2009-06-11 | Talecris Biotherapeutics, Inc. | Recombinantly modified plasmin |
| WO2009073457A1 (en) | 2007-11-30 | 2009-06-11 | Bausch & Lomb Incorporated | Methods and compositions for the rescue of a filtering bleb |
| EP2451835A1 (en) | 2009-07-10 | 2012-05-16 | ThromboGenics N.V. | Variants of plasminogen and plasmin |
| ES2583082T3 (es) | 2011-01-05 | 2016-09-19 | Thrombogenics N.V. | Variantes de plasminógeno y plasmina |
| WO2013024074A1 (en) | 2011-08-12 | 2013-02-21 | Thrombogenics N.V. | Plasminogen and plasmin variants |
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2010
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- 2010-07-09 NZ NZ597452A patent/NZ597452A/xx unknown
- 2010-07-09 AU AU2010270146A patent/AU2010270146B9/en not_active Ceased
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170010798A (ko) * | 2014-05-28 | 2017-02-01 | 파피에르패브릭 어거스트 쾰러 에스이 | 감열성 기록물질 |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2012103949A (ru) | 2013-08-20 |
| NZ597452A (en) | 2013-10-25 |
| US20120114630A1 (en) | 2012-05-10 |
| US9226953B2 (en) | 2016-01-05 |
| WO2011004011A1 (en) | 2011-01-13 |
| MX2012000475A (es) | 2012-03-26 |
| JP5819293B2 (ja) | 2015-11-24 |
| HK1167265A1 (zh) | 2012-11-23 |
| IL217113A0 (en) | 2012-02-29 |
| CN102482338A (zh) | 2012-05-30 |
| AU2010270146A1 (en) | 2012-02-02 |
| CN102482338B (zh) | 2016-09-28 |
| ZA201200191B (en) | 2012-09-26 |
| JP2012532596A (ja) | 2012-12-20 |
| AU2010270146B2 (en) | 2015-02-05 |
| EP2451835A1 (en) | 2012-05-16 |
| RU2564131C2 (ru) | 2015-09-27 |
| AU2010270146B9 (en) | 2015-04-02 |
| CA2767612A1 (en) | 2011-01-13 |
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