KR20120050442A - 플라스미노겐 및 플라스민의 변이체 - Google Patents
플라스미노겐 및 플라스민의 변이체 Download PDFInfo
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- KR20120050442A KR20120050442A KR1020127003121A KR20127003121A KR20120050442A KR 20120050442 A KR20120050442 A KR 20120050442A KR 1020127003121 A KR1020127003121 A KR 1020127003121A KR 20127003121 A KR20127003121 A KR 20127003121A KR 20120050442 A KR20120050442 A KR 20120050442A
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- plasmin
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- ser
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
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- Chemical & Material Sciences (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
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| US22451409P | 2009-07-10 | 2009-07-10 | |
| EP09165237.0 | 2009-07-10 | ||
| US61/224,514 | 2009-07-10 | ||
| EP09165237 | 2009-07-10 |
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| KR20120050442A true KR20120050442A (ko) | 2012-05-18 |
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| EP (1) | EP2451835A1 (enExample) |
| JP (1) | JP5819293B2 (enExample) |
| KR (1) | KR20120050442A (enExample) |
| CN (1) | CN102482338B (enExample) |
| AU (1) | AU2010270146B9 (enExample) |
| CA (1) | CA2767612A1 (enExample) |
| IL (1) | IL217113A0 (enExample) |
| MX (1) | MX2012000475A (enExample) |
| NZ (1) | NZ597452A (enExample) |
| RU (1) | RU2564131C2 (enExample) |
| WO (1) | WO2011004011A1 (enExample) |
| ZA (1) | ZA201200191B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170010798A (ko) * | 2014-05-28 | 2017-02-01 | 파피에르패브릭 어거스트 쾰러 에스이 | 감열성 기록물질 |
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| NZ597452A (en) | 2009-07-10 | 2013-10-25 | Thrombogenics Nv | Variants of plasminogen and plasmin |
| WO2011023805A1 (en) | 2009-08-28 | 2011-03-03 | Thrombogenics N.V. | Use of plasmin for the treatment of filtration failure after trabeculectomy |
| RU2604807C2 (ru) | 2011-01-05 | 2016-12-10 | ТромбоДженикс НВ | Варианты плазминогена и плазмина |
| CA2844644A1 (en) | 2011-08-12 | 2013-02-21 | Thrombogenics N.V. | Plasminogen and plasmin variants |
| PL2785739T3 (pl) * | 2011-12-01 | 2017-10-31 | Thrombogenics Nv | Poprawa wyniku trabekulektomii |
| JP6483083B2 (ja) * | 2013-03-14 | 2019-03-13 | ウェイン ステイト ユニバーシティー | 治療用化合物の眼への送達を増強する方法 |
| EP2821081A1 (en) | 2013-07-05 | 2015-01-07 | ResuSciTec GmbH | Protective solution for preventing or reducing reperfusion injury of the brain and the whole body |
| HUE068351T2 (hu) * | 2014-12-19 | 2024-12-28 | Kedrion Biopharma Inc | Plazminogént tartalmazó gyógyszerkészítmény és annak felhasználásai |
| RU2597782C1 (ru) * | 2015-08-25 | 2016-09-20 | Василий Николаевич Яковлев | Способ определения содержания продуктов протеолиза в плазме крови и диагностическая тест-система для его осуществления |
| TWI801331B (zh) * | 2015-11-03 | 2023-05-11 | 美商波麥堤克生物治療股份有限公司 | 纖維蛋白溶酶原缺乏症之纖維蛋白溶酶原替代療法 |
| JP6815413B2 (ja) * | 2015-12-18 | 2021-01-20 | タレンゲン インターナショナル リミテッドＴａｌｅｎｇｅｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ | 肝組織損傷及びその関連疾患を予防及び治療するための方法 |
| JP6876066B2 (ja) | 2015-12-18 | 2021-05-26 | タレンゲン インターナショナル リミテッドＴａｌｅｎｇｅｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｌｉｍｉｔｅｄ | 子宮膣部びらんを予防及び治療するための方法 |
| CN115845037A (zh) * | 2015-12-18 | 2023-03-28 | 泰伦基国际有限公司 | 一种用于预防或治疗急性及慢性血栓的方法 |
| CN106890320A (zh) * | 2015-12-18 | 2017-06-27 | 深圳瑞健生命科学研究院有限公司 | 一种用于预防或治疗急性及慢性血栓的方法 |
| CN108463236A (zh) | 2015-12-18 | 2018-08-28 | 泰伦基国际有限公司 | 一种预防或治疗放射性和化学性损伤的方法 |
| EP3391902B1 (en) | 2015-12-18 | 2023-10-18 | Talengen International Limited | Plasminogen for use in the treatment of diabetic angiocardiopathy |
| CA3047170A1 (en) * | 2016-12-15 | 2018-06-21 | Talengen International Limited | Method for preventing and treating drug-induced renal injury |
| CN108210905A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗皮肤纤维化的药物及其用途 |
| TW201822809A (zh) * | 2016-12-15 | 2018-07-01 | 深圳瑞健生命科學硏究院有限公司 | 一種預防和治療高脂血症的方法 |
| US11389515B2 (en) | 2016-12-15 | 2022-07-19 | Talengen International Limited | Method for mitigating heart disease |
| TWI763680B (zh) | 2016-12-15 | 2022-05-11 | 大陸商深圳瑞健生命科學硏究院有限公司 | 纖溶酶原在製備藥物中的用途 |
| CN108210898A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗脂肪异常沉积导致的组织损伤的药物及其用途 |
| CN108210917A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗肥胖症的方法和药物 |
| WO2018108161A1 (zh) * | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗肥胖症的方法和药物 |
| EP3556380A4 (en) * | 2016-12-15 | 2020-05-13 | Talengen International Limited | METHOD FOR PREVENTING AND TREATING FABRIC OF TISSUE AND ORGAN |
| ES3036897T3 (en) | 2017-06-19 | 2025-09-25 | Talengen Int Ltd | Plasminogen for use in treating parkinson's and alzheimer's disease |
| CN113795274A (zh) * | 2019-05-10 | 2021-12-14 | 泰伦基国际有限公司 | 一种治疗肌萎缩侧索硬化的方法和药物 |
| TW202143999A (zh) * | 2020-03-24 | 2021-12-01 | 大陸商深圳瑞健生命科學研究院有限公司 | 一種促進錯誤摺疊蛋白及其聚集物降解的方法和藥物 |
| US11964004B2 (en) * | 2021-03-31 | 2024-04-23 | Shenzhen Bay Laboratory | Short in vivo half-life and in vivo unstable recombinant microplasmin, pharmaceutical composition comprising thereof and method of treating thromboembolism related diseases including administration thereof |
| CN113755476B (zh) * | 2021-10-14 | 2023-04-11 | 北京农学院 | 蛆激酶制备方法及其用途 |
| CN119331857B (zh) * | 2024-12-19 | 2025-05-16 | 南通大学 | 一种新型重组蛋白Plasminogen-CTM及应用 |
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| NZ597452A (en) | 2009-07-10 | 2013-10-25 | Thrombogenics Nv | Variants of plasminogen and plasmin |
| RU2604807C2 (ru) | 2011-01-05 | 2016-12-10 | ТромбоДженикс НВ | Варианты плазминогена и плазмина |
| CA2844644A1 (en) | 2011-08-12 | 2013-02-21 | Thrombogenics N.V. | Plasminogen and plasmin variants |
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2010
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- 2010-07-09 US US13/383,086 patent/US9226953B2/en not_active Expired - Fee Related
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- 2010-07-09 EP EP10734727A patent/EP2451835A1/en not_active Withdrawn
- 2010-07-09 MX MX2012000475A patent/MX2012000475A/es unknown
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170010798A (ko) * | 2014-05-28 | 2017-02-01 | 파피에르패브릭 어거스트 쾰러 에스이 | 감열성 기록물질 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102482338A (zh) | 2012-05-30 |
| HK1167265A1 (zh) | 2012-11-23 |
| CA2767612A1 (en) | 2011-01-13 |
| JP2012532596A (ja) | 2012-12-20 |
| US20120114630A1 (en) | 2012-05-10 |
| US9226953B2 (en) | 2016-01-05 |
| IL217113A0 (en) | 2012-02-29 |
| CN102482338B (zh) | 2016-09-28 |
| AU2010270146B9 (en) | 2015-04-02 |
| RU2012103949A (ru) | 2013-08-20 |
| AU2010270146B2 (en) | 2015-02-05 |
| ZA201200191B (en) | 2012-09-26 |
| NZ597452A (en) | 2013-10-25 |
| EP2451835A1 (en) | 2012-05-16 |
| AU2010270146A1 (en) | 2012-02-02 |
| RU2564131C2 (ru) | 2015-09-27 |
| JP5819293B2 (ja) | 2015-11-24 |
| MX2012000475A (es) | 2012-03-26 |
| WO2011004011A1 (en) | 2011-01-13 |
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