KR20120008034A - 우르소데옥시콜산의 증가된 투여량으로 비알콜성 지방간염을 치료하는 방법 - Google Patents
우르소데옥시콜산의 증가된 투여량으로 비알콜성 지방간염을 치료하는 방법 Download PDFInfo
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- KR20120008034A KR20120008034A KR1020117024296A KR20117024296A KR20120008034A KR 20120008034 A KR20120008034 A KR 20120008034A KR 1020117024296 A KR1020117024296 A KR 1020117024296A KR 20117024296 A KR20117024296 A KR 20117024296A KR 20120008034 A KR20120008034 A KR 20120008034A
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101401628B1 (ko) * | 2012-12-24 | 2014-06-02 | 삼성제약공업주식회사 | 간기능 개선용 정제 및 그 제조 방법 |
| WO2019098572A3 (ko) * | 2017-11-15 | 2019-07-11 | 주식회사 대웅제약 | 간염 바이러스에 의해 유발된 간 섬유화의 개선을 위한 약학 조성물 |
| WO2021020923A1 (ko) * | 2019-07-30 | 2021-02-04 | 주식회사 고바이오랩 | 간 손상 예방, 개선, 또는 치료용 조성물 및 간 손상 예방, 개선, 또는 치료방법 |
| KR20210014609A (ko) * | 2019-07-30 | 2021-02-09 | 주식회사 고바이오랩 | 비알코올성 지방간 질환의 예측 또는 진단용 키트, 및 진단방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011140441A2 (en) | 2010-05-06 | 2011-11-10 | Children's Hospital Medical Center | Methods and systems for converting precursor cells into intestinal tissues through directed differentiation |
| US9814733B2 (en) * | 2012-12-31 | 2017-11-14 | A,arin Pharmaceuticals Ireland Limited | Compositions comprising EPA and obeticholic acid and methods of use thereof |
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Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6297229B1 (en) * | 1994-11-14 | 2001-10-02 | Mayo Foundation For Medical Education And Research | Use of ursodeoxycholic acid to treat nonalcoholic steatohepatitis |
-
2010
- 2010-03-16 AU AU2010224587A patent/AU2010224587A1/en not_active Abandoned
- 2010-03-16 RU RU2011139643/15A patent/RU2011139643A/ru not_active Application Discontinuation
- 2010-03-16 CA CA2755708A patent/CA2755708A1/en not_active Abandoned
- 2010-03-16 WO PCT/IB2010/000551 patent/WO2010106420A1/en not_active Ceased
- 2010-03-16 CN CN2010800119928A patent/CN102361642A/zh active Pending
- 2010-03-16 MX MX2011009757A patent/MX2011009757A/es not_active Application Discontinuation
- 2010-03-16 EP EP10714958A patent/EP2408457A1/en not_active Ceased
- 2010-03-16 KR KR1020117024296A patent/KR20120008034A/ko not_active Withdrawn
- 2010-03-16 JP JP2012500328A patent/JP2012520866A/ja active Pending
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2011
- 2011-08-24 US US13/217,042 patent/US20120071451A1/en not_active Abandoned
- 2011-09-18 IL IL215195A patent/IL215195A0/en unknown
- 2011-10-17 ZA ZA2011/07578A patent/ZA201107578B/en unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101401628B1 (ko) * | 2012-12-24 | 2014-06-02 | 삼성제약공업주식회사 | 간기능 개선용 정제 및 그 제조 방법 |
| WO2019098572A3 (ko) * | 2017-11-15 | 2019-07-11 | 주식회사 대웅제약 | 간염 바이러스에 의해 유발된 간 섬유화의 개선을 위한 약학 조성물 |
| WO2021020923A1 (ko) * | 2019-07-30 | 2021-02-04 | 주식회사 고바이오랩 | 간 손상 예방, 개선, 또는 치료용 조성물 및 간 손상 예방, 개선, 또는 치료방법 |
| KR20210014609A (ko) * | 2019-07-30 | 2021-02-09 | 주식회사 고바이오랩 | 비알코올성 지방간 질환의 예측 또는 진단용 키트, 및 진단방법 |
| KR20210014605A (ko) * | 2019-07-30 | 2021-02-09 | 주식회사 고바이오랩 | 간 손상 예방, 개선, 또는 치료용 조성물 |
| US12274718B2 (en) | 2019-07-30 | 2025-04-15 | Kobiolabs, Inc. | Composition and method for preventing, alleviating, or treating liver injury |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102361642A (zh) | 2012-02-22 |
| IL215195A0 (en) | 2011-12-29 |
| WO2010106420A1 (en) | 2010-09-23 |
| JP2012520866A (ja) | 2012-09-10 |
| CA2755708A1 (en) | 2010-09-23 |
| RU2011139643A (ru) | 2013-04-27 |
| MX2011009757A (es) | 2012-02-28 |
| EP2408457A1 (en) | 2012-01-25 |
| US20120071451A1 (en) | 2012-03-22 |
| ZA201107578B (en) | 2013-06-26 |
| AU2010224587A1 (en) | 2011-09-22 |
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