KR20110140143A - 혈관형성을 조절하는 α5β1 인테그린에 대한 키메라성 및 인간화 항체 - Google Patents

혈관형성을 조절하는 α5β1 인테그린에 대한 키메라성 및 인간화 항체 Download PDF

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KR20110140143A
KR20110140143A KR1020117029575A KR20117029575A KR20110140143A KR 20110140143 A KR20110140143 A KR 20110140143A KR 1020117029575 A KR1020117029575 A KR 1020117029575A KR 20117029575 A KR20117029575 A KR 20117029575A KR 20110140143 A KR20110140143 A KR 20110140143A
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antibody
thr
leu
gly
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Korean (ko)
Inventor
바니타 라마크리시난
데이비드 파워스
데일 이 존슨
우르줄라 예프리
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애보트 바이오테라퓨틱스 코포레이션
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Publication of KR20110140143A publication Critical patent/KR20110140143A/ko
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
    • C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
    • C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020117029575A 2002-11-26 2003-11-26 혈관형성을 조절하는 α5β1 인테그린에 대한 키메라성 및 인간화 항체 Abandoned KR20110140143A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42974302P 2002-11-26 2002-11-26
US60/429,743 2002-11-26

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020057009577A Division KR20050089151A (ko) 2002-11-26 2003-11-26 혈관형성을 조절하는 α5β1 인테그린에 대한 키메라성 및인간화 항체

Publications (1)

Publication Number Publication Date
KR20110140143A true KR20110140143A (ko) 2011-12-30

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Application Number Title Priority Date Filing Date
KR1020117029575A Abandoned KR20110140143A (ko) 2002-11-26 2003-11-26 혈관형성을 조절하는 α5β1 인테그린에 대한 키메라성 및 인간화 항체
KR1020057009577A Abandoned KR20050089151A (ko) 2002-11-26 2003-11-26 혈관형성을 조절하는 α5β1 인테그린에 대한 키메라성 및인간화 항체

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KR1020057009577A Abandoned KR20050089151A (ko) 2002-11-26 2003-11-26 혈관형성을 조절하는 α5β1 인테그린에 대한 키메라성 및인간화 항체

Country Status (14)

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EP (2) EP1575516B1 (enExample)
JP (2) JP4741242B2 (enExample)
KR (2) KR20110140143A (enExample)
CN (1) CN100369930C (enExample)
AU (1) AU2003298783B2 (enExample)
BR (1) BR0316670A (enExample)
CA (1) CA2507099C (enExample)
ES (1) ES2387985T3 (enExample)
MX (1) MXPA05005558A (enExample)
NO (1) NO20053101L (enExample)
NZ (1) NZ540562A (enExample)
RU (1) RU2346701C2 (enExample)
WO (1) WO2004056308A2 (enExample)
ZA (1) ZA200505114B (enExample)

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Publication number Publication date
WO2004056308A2 (en) 2004-07-08
JP2011120593A (ja) 2011-06-23
EP2351583A1 (en) 2011-08-03
ES2387985T3 (es) 2012-10-05
CN100369930C (zh) 2008-02-20
MXPA05005558A (es) 2005-07-26
EP1575516A4 (en) 2007-09-26
ZA200505114B (en) 2007-03-28
NZ540562A (en) 2008-04-30
JP2006516098A (ja) 2006-06-22
RU2346701C2 (ru) 2009-02-20
RU2005120019A (ru) 2006-01-20
WO2004056308A3 (en) 2005-09-01
AU2003298783A1 (en) 2004-07-14
AU2003298783B2 (en) 2010-11-04
CA2507099C (en) 2013-09-24
NO20053101D0 (no) 2005-06-24
BR0316670A (pt) 2005-10-11
NO20053101L (no) 2005-08-26
EP1575516B1 (en) 2012-05-30
CN1753911A (zh) 2006-03-29
EP1575516A2 (en) 2005-09-21
JP4741242B2 (ja) 2011-08-03
KR20050089151A (ko) 2005-09-07
CA2507099A1 (en) 2004-07-08

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