KR20110133912A - Composition for treating or preventing oral bacterial infection diseases comprising an extract of artemisia fukudo - Google Patents
Composition for treating or preventing oral bacterial infection diseases comprising an extract of artemisia fukudo Download PDFInfo
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- KR20110133912A KR20110133912A KR1020100053576A KR20100053576A KR20110133912A KR 20110133912 A KR20110133912 A KR 20110133912A KR 1020100053576 A KR1020100053576 A KR 1020100053576A KR 20100053576 A KR20100053576 A KR 20100053576A KR 20110133912 A KR20110133912 A KR 20110133912A
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Abstract
Description
본 발명은 구강질환 예방 또는 치료용 조성물에 관한 것으로서, 더욱 상세하게는 치아우식증의 예방 또는 치료용 조성물에 관한 것이다.The present invention relates to a composition for preventing or treating oral disease, and more particularly, to a composition for preventing or treating dental caries.
치과 의학상 충치, 치아우식증 및 치은염 등을 포함하는 다양한 구강질환은 여러 가지 원인에 의해 발병할 수 있다. 상기 원인은 전신적인 원인 및 국소적인 원인으로 나눌 수 있는데, 보다 중요한 원인은 국소적인 원인인 것으로 알려져 있다. 국소적인 원인으로 가장 중요한 것은 구강 내에 상주하는 세균 즉, 병원성 미생물이다.Various oral diseases, including dental caries, dental caries and gingivitis, can be caused by a variety of causes. The causes can be divided into systemic causes and local causes. More important causes are known to be local causes. The most important local cause is bacteria that reside in the oral cavity, ie pathogenic microorganisms.
한편, 자연계에는 수 만 종에 이르는 미생물들이 각종 생태계에 폭 넓게 서식하고 있으며, 이러한 미생물들은 여러 질병 및 오염의 원인이 되기도 한다. 예를 들어, 사람의 구강 내에는 현재까지 밝혀진 바에 의하면 약 300 여종의 미생물이 치아표면, 치근부의 치아와 잇몸사이, 혀의 표면 등에 상주하고 있는 것으로 알려져 있으며, 이러한 미생물의 존재는 적절한 구강위생 활동이 이루어지는 경우 정상적 현상이라 할 수 있다.On the other hand, in the natural world, tens of thousands of microorganisms inhabit widely in various ecosystems, and these microorganisms also cause various diseases and pollution. For example, about 300 species of microorganisms are known to reside in the oral cavity of the human tooth, between the teeth and gums of the root and the surface of the tongue. This can be said to be a normal phenomenon.
그러나, 적절한 구강위생 활동이 이루어지지 아니하는 경우, 상기한 미생물 중 병원성 미생물에 의해 충치, 구취, 치은염 또는 치주질환 등 각종 구강질환이 야기될 수 있으며, 심한 경우 치아를 상실할 수도 있다. 일 예로, 구강 내에 상주하는 병원성 미생물의 발효작용에 의해 치아에 부착된 음식찌꺼기의 당분이나 전분 등의 탄수화물이 분해 되어 생기는 젖산이 치아 경조직의 석회를 탈각시켜 충치가 발생할 수 있고, 혐기성 병원균체들이 대량 증식하는 경우 다양한 구강질환의 원인이 될 수 있다.However, when proper oral hygiene activity is not performed, various oral diseases such as caries, bad breath, gingivitis or periodontal disease may be caused by pathogenic microorganisms among the above-mentioned microorganisms, and severe teeth may be lost. For example, lactic acid, which is produced by the breakdown of carbohydrates such as sugar or starch of food residues attached to teeth by fermentation of pathogenic microorganisms resident in the oral cavity, may decay dental hard tissues and cause tooth decay. Large growth can cause various oral diseases.
보다 상세하게는, 구강 내에 상주하는 병원성 미생물은 치아표면에 부착하여 몇 시간만 지나면 치태라고 하는 세균군집을 형성하고 증식하게 되며, 처음에는 눈에 보이는 치은 상부의 치아 표면에 집중적으로 병원성 미생물이 부착하여 치태를 형성하지만, 점차 진행되면 치은하부에 있는 치아표면에도 치태가 형성되게 된다. 상기 치태가 치아표면에서 형성될 경우, 상기 병원성 미생물은 구강 내에 들어온 당분을 이용하여 산을 생산하고 이 산은 치아의 주성부인 무기질을 탈회시킴으로써 치아가 파괴되는 충치 즉, 치아우식증를 유발할 수 있다.More specifically, the pathogenic microorganisms residing in the oral cavity attach to the tooth surface, and after several hours, form a bacterial community called plaque and multiply, and initially, the pathogenic microorganisms adhere to the surface of the upper teeth. By forming plaque, but gradually progressing, plaque is also formed on the tooth surface in the subgingival area. When the plaque is formed on the tooth surface, the pathogenic microorganisms produce an acid using sugars in the oral cavity, and the acid may cause tooth decay, that is, dental caries, by demineralizing the mineral that is the main part of the tooth.
한편, 치은하부 치태에 있는 세균들 중 특히 혐기성 그람음성 미생물들은 독소, 단백질 분해효소 등을 분비하여 치주조직을 직접 파괴하거나 우리 몸의 면역세포들과 반응함으로써 다양한 면역물질의 생산을 유도하고 이들 물질이 치주조직의 염증과 파괴를 초래할 수 있다.On the other hand, among the bacteria in the subgingival plaque, especially anaerobic gram-negative microorganisms secrete toxins and proteolytic enzymes to directly destroy the periodontal tissue or react with the immune cells of the body to induce the production of various immune substances. This can lead to inflammation and destruction of the periodontal tissue.
치아나 치주조직은 한번 파괴되면 치료는 될 수 있지만, 원래의 조직상태로 복구되지는 않는다는 점에서 그 심각성이 있고, 따라서 이들 국소원인의 대표적 요인인 병원성 미생물이 구강 내에서 번식하는 과정을 근본적으로 차단하는 것이 구강질환을 예방 또는 신속히 치료하는 방법일 수 있다.Once destroyed, the tooth or periodontal tissue can be cured, but it does not recover to its original tissue state, which is serious. Therefore, the pathogenic microorganisms, which are representative of these local causes, propagate in the oral cavity. Blocking may be a way to prevent or swiftly treat oral disease.
상기와 같은 구강질환을 유발하는데 가장 중요한 역할을 하는 미생물로는 스트렙토코커스 뮤탄스(Steptococcus mutans), 포피로모나스 긴기발리스(Porphyromonas gingivalis) 또는 프레보텔라 인터메디아(Prevotella intermedia) 등이 있다.Microorganisms that play the most important role in causing oral diseases such as Streptococcus mutans ( Steptococcus) mutans ), Porphyromonas gingivalis ) or Prevotella intermedia .
따라서, 종래 상기 미생물들에 대한 살균 및 정균작용을 갖는 항생제를 포함한 다양한 종류의 항균제제가 충치, 치주질환 또는 치은염 등의 억제 및 치료제로써 개발되어 왔다. 그러나, 치아우식증, 치은염이나 치주염과 같은 일부 구강질환의 경우 이들을 치료 또는 예방하기 위하여 개발된 항생제 혹은 화학약품은 매우 제한적이므로(Leke N, Grenier D, Golgner M, Mayrand D, Effects of hydrogen peroxide on growth and selected properties of Porphyromonas gingivalis. FEMS Microbiol. Letters 174:347-353(1999)), 대부분의 경우 치주질환수술 등의 수술요법이나 기계적 요법에 의해 치료하고 있으며, 그 예방을 위한 방법은 제한적으로 제안되고 있다.Therefore, various kinds of antimicrobial agents including antibiotics having bactericidal and bacteriostatic effects on the microorganisms have been developed as inhibitors and treatments for tooth decay, periodontal disease or gingivitis. However, some oral diseases, such as dental caries, gingivitis or periodontitis, have very limited antibiotics or chemicals developed to treat or prevent them (Leke N, Grenier D, Golgner M, Mayrand D, Effects of hydrogen peroxide on growth). and selected properties of Porphyromonas gingivalis . FEMS Microbiol. Letters 174: 347-353 (1999)), and most of the cases are treated by surgical therapy or mechanical therapy such as periodontal disease surgery, and methods for the prevention thereof are limited.
또한, 항생제의 경우 설사, 구토 등을 포함한 신체 전반에 대한 전신적인 부작용을 일으킬 수 있고, 구강 내 내성균의 출현 및 균교대증을 유발할 수 있기 때문에 장기적인 사용이 곤란하여 단지 치료제만으로 이용될 수 있는 단점이 있다. 예를 들어, 현재 널리 사용되고 있는 항생제인 클로로헥시딘(cholrohexidin)은 고농도로 구강 내에 사용하거나 혹은 저농도로 오랫동안 사용할 경우, 혀나 치아에 착색을 일으키고, 구강점막이 벗겨지거나, 미각이상을 일으키는 등의 부작용이 발생할 수 있으며, 균교대증이 유발될 수 있는 부작용이 있고, 발암성이 있어 임산부의 경우 사용이 제한된다는 단점이 있고(FlL, Gjermo P. RG, Waerhaug J. (1971) Side effects of chlorhexidine mouthwashes. Scand. J. Dent. Res. 79(1): 119-125), 트리클로산(triclosan)의 경우, 세포독성이 높아 장기간 사용시 부작용의 우려가 높고 내성균주의 발현이라는 문제점이 있다.In addition, antibiotics can cause systemic side effects on the entire body, including diarrhea and vomiting, and can cause long-term use due to the appearance of resistant bacteria in the oral cavity and myoclosis, which can be used only as a therapeutic agent. There is this. For example, the currently widely used antibiotic chlorohexidine (cholrohexidin) can cause pigmentation of the tongue or teeth, peeling of the oral mucosa, or palpitations when used in high doses in the oral cavity or at low concentrations for a long time. Side effects may occur, and there are side effects that may cause myoclosis, and carcinogenicity may limit the use of pregnant women (FlL, Gjermo P. RG, Waerhaug J. (1971) Side effects of chlorhexidine mouthwashes.Scand. J. Dent. Res. 79 (1): 119-125), triclosan has a high cytotoxicity, so there is a high risk of side effects in long-term use and expression of resistant strains.
따라서, 수술요법이나 기계적 요법에 비하여 그 예방 또는 치료가 용이하고, 장기간 사용하여도 항생제와 같이 내성이나 안정성에 대한 문제가 대두되어지지 아니하며, 부작용도 문제되지 아니하는 천연물질 유래의 구강질환 예방 또는 치료 조성물을 개발하는 것이 시급한 실정이다. 특히, 3면이 바다이고, 서해안에 넓은 염전 지역을 확보하고 있고, 다양한 해양자원이 풍부한 우리나라의 지리적 환경을 고려하면 해양 동식물과 염색생물을 포함한 해양 천연물질로부터 구강질환을 예방 또는 치료할 수 있는 조성물을 개발하고자 하는 요구가 증가되고 있다.Therefore, it is easier to prevent or treat than surgical therapy or mechanical therapy, and even long-term use does not raise resistance or stability problems like antibiotics and prevent oral diseases derived from natural substances that do not cause side effects. It is urgent to develop therapeutic compositions. In particular, considering the geographical environment of Korea, which has three sides on the sea, secures wide salt areas on the west coast, and is rich in various marine resources, it is a composition that can prevent or treat oral diseases from marine natural materials including marine animals and plants and dyed organisms. There is an increasing demand to develop the system.
본 발명은 상기와 같은 종래기술의 문제점을 개선하기 위한 것으로, 해조류추출물을 유효성분으로 포함하는 구강질환 예방 또는 치료용 조성물을 제공하는 것을 목적으로 한다.The present invention is to improve the problems of the prior art as described above, and an object of the present invention is to provide a composition for preventing or treating oral diseases comprising the seaweed extract as an active ingredient.
또한, 본 발명은 해조류 추출물을 유효성분으로 포함하는 스트렙토코커스 뮤탄스(Streptococcus mutans)에 대한 항균 조성물을 제공하는 것을 목적으로 한다.In addition, an object of the present invention is to provide an antimicrobial composition against Streptococcus mutans comprising the seaweed extract as an active ingredient.
상기 목적을 달성하기 위하여, 본 발명은 큰비쑥 추출물을 유효성분으로 포함하는 구강질환 예방 또는 치료용 조성물을 제공한다. 구체적으로, 상기 구강질환은 치아우식증일 수 있다.In order to achieve the above object, the present invention provides a composition for the prevention or treatment of oral diseases, comprising the extract of the larvae as an active ingredient. Specifically, the oral disease may be dental caries.
또한, 상기 목적을 달성하기 위하여, 본 발명은 큰비쑥 추출물을 유효성분으로 포함하는 구강질환 예방 또는 개선용 식품 조성물을 제공한다. 본 발명의 식품 조성물의 예로는 식품, 식품첨가제, 음료 또는 음료첨가제를 들 수 있다.In addition, in order to achieve the above object, the present invention provides a food composition for preventing or improving oral disease, comprising the extract of the larvae as an active ingredient. Examples of the food composition of the present invention include food, food additives, beverages or beverage additives.
또한, 상기 목적을 달성하기 위하여, 본 발명은 큰비쑥 추출물을 유효성분으로 포함하는 구강질환 예방 또는 개선용 구강 위생 조성물을 제공한다.In addition, in order to achieve the above object, the present invention provides an oral hygiene composition for preventing or improving oral disease, comprising the extract of the larvae as an active ingredient.
또한, 상기 목적을 달성하기 위하여, 본 발명은 큰비쑥 추출물을 유효성분으로 포함하는 스트렙토코커스 뮤탄스(Streptococcus mutans)에 대한 항균 조성물을 제공한다.In addition, in order to achieve the above object, the present invention provides an antimicrobial composition against Streptococcus mutans ( Streptococcus mutans ) comprising the extract of the larvae as an active ingredient.
이하, 본 발명을 보다 상세하게 설명한다.Hereinafter, the present invention will be described in more detail.
본 발명은 큰비쑥 추출물을 유효성분으로 포함하는 구강질환 예방 또는 치료용 조성물에 관한 것이다.The present invention relates to a composition for the prevention or treatment of oral diseases, comprising the extract of the larvae as an active ingredient.
또한, 본 발명은 큰비쑥 추출물을 유효성분으로 포함하는 구강질환 예방 또는 개선용 식품 조성물에 관한 것이다.In addition, the present invention relates to a food composition for preventing or improving oral disease, comprising the extract of the larvae as an active ingredient.
상기 큰비쑥(Artemisia fukudo)은 쌍떡잎식물 초롱꽃목 국화과의 두해살이풀로, 바닷가에서 주로 자란다. 상기 큰비쑥은 갯벌의 상부나 만조 시에 바닷물이 들어오는 지역에서 무리지어 살며, 한국 · 중국 · 일본 등지에 분포한다. 상기 큰비쑥은 30 ㎝ 내지 50㎝ 정도까지 곧게 자라고, 밑에서부터 많은 가지를 치며, 잎은 꼭지가 길고 잎몸이 부챗살 모양으로 갈라져 있으며, 무리지어 나는 뿌리잎과, 어긋나며, 깃 모양으로 깊이 갈라지는 줄기잎이 있다. 봄철에 싹이 트고, 9월 경에 거꾸로 선 고깔 모양의 꽃이 피며, 열매는 밤색으로, 종자로 번식한다. 예로부터 민간의학에서 간염이나 콩팥염과 같은 염증 또는 신장 결석 또는 담당 결석 등의 결석 등에 효과가 있는 것으로 알려져 사용되어 왔다.The Artemisia fukudo is a biennial plant of the dicotyledon plant Campanula Asteraceae, mainly grown on the beach. The larvae live in clusters in areas where seawater enters at the top of tidal flats or at high tide, and is distributed in Korea, China, and Japan. The larva grows straight up to about 30 cm to 50 cm, has many branches from the bottom, the leaves have long stems, and the leaf body is divided into bouchat flesh, flocked root leaves, and stem leaves diverging deeply into feathers. have. Buds bloom in spring, coniferous flowers standing upside down in September, and fruits are brown and multiply as seeds. It has been known to be effective in folk medicine for inflammation such as hepatitis and kidney disease, or for stones such as kidney stones or stones in charge.
상기 큰비쑥 추출물은 통상의 식품 추출물을 제조하는 방법으로 제조될 수 있으며, 추출용매를 이용한 용매추출법으로 제조될 수 있다.The larvae extract may be prepared by a method of preparing a conventional food extract, it may be prepared by a solvent extraction method using an extraction solvent.
상기 추출용매는 물, 50% 내지 100%의 메탄올, 에탄올 등의 탄소수 1 내지 4의 알콜, 에틸아세테이트 등의 극성용매와 헥산 또는 디클로로메탄의 비극성용매와 같은 유기용매, 이들의 혼합용매일 수 있으며, 바람직하게는 50% 내지 100%의 메탄올, 에탄올 등의 탄소수 1 내지 4의 알콜, 더욱 바람직하게는 80% 내지 100% 에탄올일 수 있다. 상기 추출물, 바람직하게는 50% 내지 100%의 메탄올, 에탄올 등의 탄소수 1 내지 4의 알콜 추출물, 더욱 바람직하게는 에탄올 추출물은 큰비쑥 추출물 중에서, 구강질환을 유발하는데 병원성 미생물 특히, 충치라 불리우는 치아우식증의 원인이 되는 스트렙토코커스 뮤탄스(Streptococcus mutans)에 대한 항균활성이 우수한 것으로 확인되었다.The extraction solvent may be water, 50% to 100% methanol, alcohol having 1 to 4 carbon atoms such as ethanol, polar solvent such as ethyl acetate, organic solvent such as a non-polar solvent of hexane or dichloromethane, mixed solvent thereof, , Preferably 50% to 100% methanol, ethanol and the like, alcohol having 1 to 4 carbon atoms, more preferably 80% to 100% ethanol. The extract, preferably an alcohol extract having 1 to 4 carbon atoms, such as 50% to 100% methanol and ethanol, more preferably an ethanol extract, is a pathogenic microorganism that causes oral disease, especially tooth decay, which causes oral diseases in the extract of the larvae. It was confirmed that the antibacterial activity against Streptococcus mutans , which causes caries, was excellent.
본 발명의 큰비쑥 추출물은 통상의 식물 추출물의 제조방법에 따라 제조된 것일 수 있으며, 구체적으로는 냉침추출법, 온침추출법 또는 열 추출법 등일 수 있으며, 통상의 추출기기, 초음파분쇄 추출기 또는 분획기를 이용할 수 있다.The wormwood extract of the present invention may be prepared according to a conventional method of producing a plant extract, specifically, may be cold extraction, hot extraction or heat extraction, etc., can be used a conventional extraction device, ultrasonic grinding extractor or fractionator have.
또한, 상기 용매로 추출한 추출물은 이후, 헥산, 메틸렌클로라이드, 아세톤, 에틸아세테이트, 에틸에테르, 클로로포름, 물 및 이들의 혼합물로 이루어진 군으로부터 선택된 용매로 분획과정을 더욱 실시할 수 있다.In addition, the extract extracted with the solvent may be further subjected to the fractionation process with a solvent selected from the group consisting of hexane, methylene chloride, acetone, ethyl acetate, ethyl ether, chloroform, water and mixtures thereof.
상기 제조된 추출물 또는 상기 분획과정을 수행하여 수득한 분획물은 이후 여과하거나 농축 또는 건조과정을 수행하여 용매를 제거할 수 있으며, 여과, 농축 및 건조를 모두 수행할 수 있다. 구체적으로 상기 여과는 여과지를 이용하거나 감압여과기를 이용할 수 있으며, 상기 농축은 감압 농축기, 일예로 회전 증발기를 이용하여 감압 농축할 수 있으며, 상기 건조는 일예로 동결건조법으로 수행할 수 있다.The prepared extract or the fraction obtained by performing the fractionation process can be filtered or concentrated or dried to remove the solvent, it can be carried out both filtration, concentration and drying. Specifically, the filtration may be performed using a filter paper or a reduced pressure filter, the concentration may be concentrated under reduced pressure using a reduced pressure concentrator, for example, a rotary evaporator, and the drying may be performed by, for example, a lyophilization method.
본 발명의 일예로, 상기 큰비쑥 추출물은 큰비쑥을 세척하여 큰비쑥의 염분 및 불순물을 제거한 후, 실온, 구체적으로 15℃ 내지 25℃에서 건조하여 건조시료를 제조하고, 상기 건조시료에 에탄올을 가하여 하루 동안 상온에서 정치 추출하여 조추출액을 얻으며, 상기 조추출액을 감압 농축하여 추출물을 제조할 수 있다. 이 때, 상기 큰비쑥의 염분 및 불순물의 제거는 유수를 이용하여 씻어내서 수행할 수 있으며, 상기 건조시료는 상기 염분 및 불순물을 제거한 큰비쑥을 건조한 후에 분쇄하여 제조할 수 있다. 또한, 상기 수득한 큰비쑥 추출물은 사용 시까지 급속 냉동 냉장고(deep freezer)에 보관할 수 있다.In one embodiment of the present invention, the larvae extract is washed with larvae to remove the salt and impurities of the larvae, dried at room temperature, specifically 15 ℃ to 25 ℃ to prepare a dry sample, the ethanol to the dry sample By adding a fixed extract at room temperature for one day to obtain a crude extract, the crude extract can be prepared by concentration under reduced pressure. At this time, the removal of the salt and impurities of the larvae may be performed by washing off with running water, and the dried sample may be prepared by drying and then grinding the larvae from which the salts and impurities are removed. In addition, the obtained wormwood extract can be stored in a deep freezer until use.
또한, 상기 큰비쑥 추출물은 상기 수득된 추출액을 농축 및 동결건조를 통하여 수분을 완전히 제거시킨 것일 수 있으며, 상기 수분을 완전히 제거시킨 큰비쑥 추출물은 분말형태로 사용하거나 상기 분말을 증류수 또는 통상의 용매에 녹여 사용할 수 있다.In addition, the larvae extract may be one obtained by completely removing the moisture through the concentration and lyophilization of the obtained extract, the larvae extract is completely removed from the moisture is used in the form of powder or distilled water or a common solvent Can be used after melting.
상기 큰비쑥 추출물을 유효성분으로 포함하는 구강질환 예방 또는 치료용 조성물은 조성물 총 부피에 대하여 상기 큰비쑥 추출물을 0.001 중량% 내지 99.99 중량%, 바람직하게는 0.1 중량% 내지 99 중량%로 포함할 수 있으나, 상기 구강질환 예방 또는 치료용 조성물의 사용방법 및 사용목적에 따라 유효성분의 함량을 적절히 조절할 수 있다.The composition for preventing or treating oral diseases comprising the extract of the larvae as an active ingredient may comprise 0.001% by weight to 99.99% by weight, preferably 0.1% to 99% by weight, based on the total volume of the composition. However, according to the method of use and purpose of using the composition for preventing or treating oral diseases, the content of the active ingredient may be appropriately adjusted.
본 발명에 있어서, 구강질환이란 스트렙토코커스 뮤탄스(Steptococcus mutans), 포피로모나스 긴기발리스(Porphyromonas gingivalis), 프레보텔라 인터메디아(Prevotella intermedia), 액티노바실러스 액티노마이세템코미탄스(Actinobacillus actinomycetemcomitans) 또는 칸디다 알비칸스(Candida albicans)를 포함하는 칸디다 속(Candida spp .)의 병원성 미생물에 의해 발병되는 치아우식증, 치은염, 치주염, 구강내 점막궤양, 구취, 구강건조증 및 아구창으로 이루어진 군에서 선택된 어느 하나를 포함하는 구강 내 질환을 의미한다. 상기 구강질환은 바람직하게는 충치, 즉 치아우식증일 수 있다.In the present invention, the oral disease is Streptococcus mutans ( Steptococcus mutans ), Porphyromonas gingivalis ( Porphyromonas) gingivalis ), Prevotella Candida genus containing intermedia), liquid Martino Bacillus liquid Martino Mai setem Cormier Tansu (Actinobacillus actinomycetemcomitans) or Candida albicans (Candida albicans) (Candida spp . Oral disease including any one selected from the group consisting of dental caries, gingivitis, periodontitis, oral mucosal ulcers, bad breath, dry mouth and thrush caused by a pathogenic microorganism. The oral disease may preferably be tooth decay, that is, dental caries.
본 발명의 큰비쑥 추출물은 구강질환의 원인균, 바람직하게는 스트렙토코커스 뮤탄스(Steptococcus mutans)에 대한 항균 활성을 가지고 있으므로, 상기 구강질환의 원인균에 의한 구강질환, 바람직하게는 충치 즉, 치아우식증에 대한 예방 및 치료 효과를 갖는다.Since the extract of the present invention has an antimicrobial activity against causative bacteria of oral diseases, preferably Streptococcus mutans , oral diseases caused by causative bacteria of the oral diseases, preferably caries, that is, dental caries Have a prophylactic and therapeutic effect.
본 발명에 있어서, 치아우식증(dental caries 또는 tooth decay)은 충치라고도 하며, 치아의 머리 부분 표면을 덮고 있고, 치아 상아질을 보호하는 유백색의 반투명하고 단단한 물질인 치아 법랑질 또는 에나멜질이 손상되어 발생되는 질환을 의미한다. 상기 치아 우식증은 주로 치아 표면에 생성된 세균막인 플라그(plaque)에 의해 발생되는데, 구체적으로 음식물 섭취 후에 입 안에 있는 음식 찌거기, 구체적으로 설탕이나 전분 등이 플라그를 이루는 스트렙토코커스 뮤탄스(Steptococcus mutans) 등에 의해 분해되면서 발생하는 산이 치아면의 법랑질을 공격하여 손상되는 경우 주로 발생한다.In the present invention, dental caries (dental caries or tooth decay), also referred to as caries, which is caused by damage to the tooth enamel or enamel covering the surface of the head of the tooth, the milky translucent and hard material protecting the dental dentin Means disease. The dental caries is mainly caused by plaque, which is a bacterial membrane formed on the surface of the tooth, specifically, food residues in the mouth after ingestion of food, specifically Streptococcus mutans ( Steptococcus) forming a plaque with sugar or starch. It occurs mainly when acid generated by decomposition by mutans etc. attacks and damages enamel of tooth surface.
따라서, 상기 치아우식증을 치료하기 위하여는 원인균인 스트렙토코커스 뮤탄스에 대한 항균활성이 있는 물질을 처방할 수 있다.Therefore, in order to treat the dental caries can be prescribed a substance having an antimicrobial activity against the causative bacteria Streptococcus mutans.
본 발명에 있어서, 항균 조성물이란 항미생물제를 총칭하는 의미인 항생제와 같은 의미일 수 있고, 항균제, 살균제, 방부제, 보존제 또는 제균제와 같은 의미일 수 있으며, 바람직하게는 구강 질환의 원인이 되는 스트렙토코커스 뮤탄스(Steptococcus mutans), 포피로모나스 긴기발리스(Porphyromonas gingivalis), 스트렙토코커스 뮤탄스(Streptococcus mutans), 악티노바실러스 악티노마이세템코미탄스(Actinobacillus actinomycetemcomitans) 또는 칸디다 알비칸스(Candida albicans)를 포함하는 칸디다 속(Candida spp .) 미생물 등을 포함하는 병원성 미생물의 발육과 생활 기능을 저지 또는 억제할 수 있는 물질을 의미한다.In the present invention, the antimicrobial composition may mean the same as an antibiotic which is a generic term for an antimicrobial agent, and may have the same meaning as an antimicrobial agent, a fungicide, a preservative, a preservative or an antimicrobial agent. Caucasus mutans ( Steptococcus) mutans ), Porphyromonas gingivalis , Streptococcus mutans), Bacillus bad bad Martino Martino Mai setem Cormier Tansu (Actinobacillus actinomycetemcomitans) or Candida albicans (Candida albicans) Candida genus (Candida containing spp . Means a substance capable of inhibiting or inhibiting the development and life functions of pathogenic microorganisms, including microorganisms.
본 발명의 항균 조성물은, 조성물 총 중량에 대하여 상기 큰비쑥 추출물을 0.001 내지 99.99중량%, 바람직하게는 0.1 내지 99 중량%로 포함할 수 있으며, 상기 항균 조성물의 사용방법 및 사용목적에 따라 유효성분의 함량을 적절히 조절할 수 있다.The antimicrobial composition of the present invention may include 0.001 to 99.99% by weight, preferably 0.1 to 99% by weight, based on the total weight of the composition, the active ingredient according to the method of use and purpose of use of the antimicrobial composition. The content of can be adjusted appropriately.
본 발명의 구강질환 예방 또는 치료용 조성물 및 항균 조성물은 인간을 포함한 동물에 직접 적용될 수 있다. 상기 동물은 식물에 대응하는 생물군으로 주로 유기물을 영양분으로 섭취하며, 소화나 배설 및 호흡기관이 분화되어 있는 것을 말하고, 바람직하게는 척추동물, 더욱 바람직하게는 포유류일 수 있다. 구체적으로는 상기 포유류는 인간, 돼지, 소 또는 염소 등일 수 있다.The composition for preventing or treating oral diseases and the antimicrobial composition of the present invention can be directly applied to animals including humans. The animal is a biological group corresponding to a plant, and mainly eats organic matter as nutrients, and means that digestion, excretion, and respiratory organs are differentiated, and preferably, vertebrates, more preferably mammals. Specifically, the mammal may be human, pig, cow or goat.
상기 구강질환 예방 또는 치료용 조성물은 큰비쑥 추출물을 유효성분으로 단독으로 포함할 수 있고, 이외 제형, 사용방법 및 사용목적에 따라 추가성분 즉, 약제학적으로 허용되거나 영양학적으로 허용되는 담체, 부형제, 희석제 또는 부성분을 추가로 포함할 수 있다. 상기 큰비쑥 추출물은 상기 추출용매에 의해 수득된 추출물이거나 상기 분획용매에 의해 수득된 분획물일 수 있다.The composition for the prevention or treatment of oral disease may include the extract of the larvae as an active ingredient alone, and additional ingredients, pharmaceutically acceptable or nutritionally acceptable carriers, excipients, depending on the formulation, method of use and purpose of use. It may further comprise a diluent or a subcomponent. The larvae extract may be an extract obtained by the extraction solvent or a fraction obtained by the fractionation solvent.
보다 상세하게는, 상기 구강질환 예방 또는 치료용 조성물은 상기 유효성분 외에 추가로 영양제, 비타민, 전해질, 풍미제, 착색제, 중진제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산 음료에 사용되는 탄산화제 등을 추가로 함유할 수 있다. 또한, 상기 담체, 부형제 또는 희석제는 락토스, 덱스트로스, 수크로스, 솔비톨, 만니톨, 자이리톨, 에리스리톨, 말티톨, 전분, 아키시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로오스, 메틸 셀룰로오스, 미정질 셀루로오스, 폴리비닐 피롤리돈, 물, 메틸하이드록시벤조에이트, 프로필하이드록시벤조에이트, 탈크, 마그네슘 스테아레이트 및 광물유, 덱스트린, 칼슘카보네이드, 프로필렌글리콜, 리퀴드 파라핀, 생리식염수로 이루어진 군에서 선택된 1이상 일 수 있으나, 이에 한정되는 것은 아니며 통상의 담체, 부형제 또는 희석제 모두 사용가능하다. 상기 유효성분인 큰비쑥 추출물에는 상기 성분들이 독립적으로 또는 조합하여 추가될 수 있다.More specifically, the composition for preventing or treating oral disease is additionally a nutrient, vitamin, electrolyte, flavor, colorant, neutralizer, pectic acid and salts thereof, alginic acid and salts thereof, organic acid, protective colloid, in addition to the active ingredient. Thickeners, pH adjusters, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. In addition, the carrier, excipient or diluent may be lactose, dextrose, sucrose, sorbitol, mannitol, ziitol, erythritol, maltitol, starch, acycia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, microcrystalline In the group consisting of cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, dextrin, calcium carbonate, propylene glycol, liquid paraffin, saline It may be one or more selected, but is not limited to any conventional carrier, excipient or diluent can be used. To the extract, the active ingredient, the larvae may be added independently or in combination.
상기 구강질환 예방 또는 치료용 조성물은 조성물 총 중량에 대하여 상기 큰비쑥 추출물을 0.001 중량% 내지 99.9 중량%, 바람직하게는 0.1 중량% 내지 99 중량%, 더욱 바람직하게는 1중량% 내지 50 중량% 포함될 수 있다. 또한, 상기 추가성분의 함량은 바람직하게는 상기 큰비쑥 추출물 또는 분획물 100 중량부 당 0.1 내지 20 중량부 범위에서 추가할 수 있다.The composition for preventing or treating oral diseases includes 0.001% by weight to 99.9% by weight, preferably 0.1% by weight to 99% by weight, and more preferably 1% by weight to 50% by weight, based on the total weight of the composition. Can be. In addition, the content of the additional component is preferably added in the range of 0.1 to 20 parts by weight per 100 parts by weight of the moth extract.
또한 상기 구강질환 예방 또는 치료용 조성물은 약제화하는 경우, 통상의 충진제, 증량제, 결합제, 붕해제, 계면활성제, 항응집제, 윤활제, 습윤제, 향료, 유화제 또는 방부제 등을 더욱 포함할 수 있으며, 경구 또는 비경구 모두 사용 할 수 있다.In addition, the composition for preventing or treating oral disease may further include conventional fillers, extenders, binders, disintegrants, surfactants, anti-coagulants, lubricants, wetting agents, fragrances, emulsifiers or preservatives, orally. Or parenteral can be used.
구체적으로 경구투여를 위한 고형제제에는 정제, 환제, 산제, 과립제, 캡슐제 등이 포함되며, 이러한 고형제제는 상기 추출물에 적어도 하나 이상의 부형제 예를 들면, 전분, 칼슘카보네이트(calcium carbonate), 수크로스(sucrose) 또는 락토오스(lactose), 젤라틴 등을 섞어 조제된다. 또한, 단순한 부형제 이외에 마그네슘 스테아레이트, 탈크 같은 윤활제들도 사용된다. 경구를 위한 액상 제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데, 흔히 사용되는 단순희석제인 물, 리퀴드 파라핀 이외에 여러가지 부형제 예를 들면, 습윤제, 감미제, 방향제, 보존제 등이 포함될 수 있다.Specifically, solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and the solid preparations include at least one excipient such as starch, calcium carbonate, and sucrose in the extract. (sucrose), lactose (lactose), gelatin, etc. are mixed and prepared. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Liquid preparations for oral use include suspensions, solvents, emulsions, and syrups. In addition to commonly used simple diluents such as water and liquid paraffin, various excipients may include, for example, wetting agents, sweeteners, fragrances, and preservatives. .
비경구투여를 위한 형태로는 치약, 구강세정제, 국소 투여제(크림, 연고, 드레싱 용액, 분무제, 기타 도포제 등) 등을 들 수 있다. 상기 국소 투여제의 제형의 일예로는, 유효성분인 큰비쑥 추출물 또는 구강질환 예방 또는 치료용 조성물을 천연 섬유 또는 합성 섬유로 만든 거즈 등의 담체에 함침시킨 것일 수 있다.Forms for parenteral administration include toothpaste, mouthwashes, topical administrations (creams, ointments, dressing solutions, sprays, other coatings, and the like). As an example of the formulation of the topical agent, it may be impregnated with a carrier, such as gauze made of natural fiber or synthetic fiber, the extract of the larvae as an active ingredient or a composition for preventing or treating oral diseases.
상기 크림 또는 연고의 경우, 치아의 법랑질이 손상된 분위나 그 주위에 직접 도포하는데 적합할 수 있다. 상기 분무제의 경우, 유효성분으로 큰비쑥 추출물을 포함하는 것을 제외하고는 통상적인 분무제 제조방법으로 제조될 수 있고, 압축용기나 기타 분무용기에 충전포장하여 구강질환 부위에 수시로 분무도포하여 구강질환을 예방 또는 치료할 수 있다. 상기 드레싱 용액의 경우, 유효성분으로 큰비쑥 추출물을 포함하는 것을 제외하고는 통상적인 드레싱 용액의 제조방법으로 제조될 수 있고, 구강질환 부위에 드레싱이나 기타 세균 감염부위의 드레싱에 사용하여 구강감염질환을 예방 또는 치료할 수 있다.In the case of the cream or ointment, the enamel of the tooth may be suitable for direct application to or around the damaged area. In the case of the spraying agent, it can be prepared by a conventional spraying method, except that it contains the extract of the wormwood as an active ingredient, filled with a compression container or other spray container and sprayed on the oral disease site from time to time to oral disease Can be prevented or treated. In the case of the dressing solution, it can be prepared by a conventional method of manufacturing a dressing solution, except that it contains the extract of the wormwood as an active ingredient, oral infections used in dressings or other bacterial infections in the oral disease site Can be prevented or treated.
또한, 본 발명의 구강질환 예방 또는 치료용 조성물의 제형은 사용방법에 따라 바람직한 형태일 수 있으며, 특히 포유동물에 투여된 후 활성 성분의 신속, 지속 또는 지연된 방출을 제공할 수 있도록 당업계에 공지된 방법을 채택하여 제형화할 수 있다. 구체적인 제형의 예로는 경고제, 과립제, 로션제, 리니멘트제, 리모나데제, 산제, 시럽제, 안연고제, 액제, 에어로솔제, 엑스제(EXTRACTS), 엘릭실제, 연고제, 유동엑스제, 유제, 현탁제, 전제, 침제, 점안제, 정제, 좌제, 주사제, 주정제, 캅셀제, 크림제, 환제, 연질 또는 경질 젤라틴 캅셀 등이 있다.In addition, the formulation of the composition for preventing or treating oral disease of the present invention may be in a preferred form depending on the method of use, and is known in the art to provide rapid, sustained or delayed release of the active ingredient, especially after administration to a mammal. Formulated methods may be employed. Examples of specific formulations include warnings, granules, lotions, linings, limonades, powders, syrups, ointments, liquids, aerosols, EXTRACTS, elixirs, ointments, liquid extracts, emulsions, Suspensions, premises, acupuncture, eye drops, tablets, suppositories, injections, spirits, capsules, creams, pills, soft or hard gelatin capsules.
더 나아가 본 발명의 구강질환 예방 또는 치료용 조성물은 당해 기술 분야의 공지된 적절한 방법을 사용하여 또는 레밍턴의 문헌(Remington's Pharmaceutical Science(최근판), Mack Publishing Company, Easton PA)에 개시되어 있는 방법을 이용하여 바람직하게 제형화될 수 있다.Furthermore, the composition for preventing or treating oral diseases of the present invention may be prepared using methods known in the art or as disclosed in Remington's Pharmaceutical Science (Recent Edition, Mack Publishing Company, Easton PA). And preferably formulated.
본 발명에 따른 구강질환 예방 또는 치료용 조성물의 투여량은, 투여방법, 복용자의 연령, 성별 및 체중, 및 질환의 중증도 등을 고려하여 당업자에 의해 적절하게 선택될 수 있다. 일예로, 본 발명의 구강질환 예방 또는 치료용 조성물은 큰비쑥 추출물을 기준으로 할 때, 0.0001 mg/kg 내지 1000 mg/kg으로, 보다 효과적이기 위해서는 0.01 mg/kg 내지 100 mg/kg으로 투여할 수 있다. 투여는 하루에 한번 투여할 수도 있고, 수회 나누어 투여할 수도 있다. 상기 투여량은 어떠한 면으로든 본 발명의 범위를 한정하는 것은 아니다.The dosage of the composition for preventing or treating oral diseases according to the present invention may be appropriately selected by those skilled in the art in consideration of the method of administration, the age, sex and weight of the recipient, and the severity of the disease. For example, the composition for preventing or treating oral diseases of the present invention may be administered in an amount of 0.0001 mg / kg to 1000 mg / kg, and more preferably 0.01 mg / kg to 100 mg / kg, based on the extract of the larvae. Can be. Administration may be administered once a day or may be divided several times. The dosage does not limit the scope of the invention in any aspect.
또한, 본 발명의 구강질환 예방 또는 치료용 조성물은, 큰비쑥 추출물 이외에 공지의 구강질환 억제활성을 갖는 화합물 또는 식물 추출물을 더욱 포함할 수 있으며, 큰비쑥 추출물 100 중량부에 대하여 각각 5 중량부 내지 20 중량부로 포함될 수 있다.In addition, the composition for preventing or treating oral diseases of the present invention may further include a compound or plant extract having a known oral disease inhibitory activity in addition to the extract of the larvae, each from 5 parts by weight to 100 parts by weight of the larvae extract It may be included in 20 parts by weight.
본 발명은 또한 큰비쑥 추출물을 유효성분으로 포함하는 구강질환 예방 또는 개선용 식품 조성물을 제공한다. 본 발명의 식품 조성물의 예로는 식품, 식품첨가제, 음료 또는 음료첨가제를 들 수 있다.The present invention also provides a food composition for preventing or ameliorating oral disease, comprising the extract of the wormwood as an active ingredient. Examples of the food composition of the present invention include food, food additives, beverages or beverage additives.
상기 큰비쑥 추출물을 유효성분으로 포함하는 식품 조성물은 그 제조에 통상적으로 사용하는 적절한 담체, 부형제 및 희석제를 더욱 포함할 수 있다.The food composition comprising the extract of the larvae as an active ingredient may further comprise a suitable carrier, excipients and diluents commonly used in the preparation thereof.
본 명세서에서 식품이란 함은 영양소를 한 가지 또는 그 이상 함유하고 있는 천연물 또는 가공품을 의미하며, 바람직하게는 어느 정도의 가공 공정을 거쳐 직접 먹을 수 있는 상태가 된 것을 의미하며, 통상적인 의미로서, 식품, 식품 첨가제, 건강 기능성 식품 및 음료를 모두 포함하는 의도이며, 바람직하게는 껌 또는 캔디일 수 있다.In the present specification, the term "food" means a natural product or processed product containing one or more nutrients, and preferably means a state in which it can be directly eaten through some processing process. It is intended to include all foods, food additives, health functional foods and beverages, preferably gum or candy.
본 발명의 큰비쑥 추출물을 첨가할 수 있는 식품으로는 예를 들어, 각종 식품류, 음료, 껌, 캔디, 차, 비타민 복합제, 기능성 식품 등이 있다. 추가로, 본 발명에서 식품에는 특수영양식품(예, 조제유류, 영,유아식 등), 식육가공품, 어육제품, 두부류, 묵류, 면류(예, 라면류, 국수류 등), 건강보조식품, 조미식품(예, 간장, 된장, 고추장, 혼합장 등), 소스류, 과자류(예, 스넥류), 유가공품(예, 발효유, 치즈 등), 기타 가공식품, 김치, 절임식품(각종 김치류, 장아찌 등), 음료(예, 과실,채소류 음료, 두유류, 발효음료류, 아이스크림류 등), 천연조미료(예, 라면 스프 등), 비타민 복합제, 알코올 음료, 주류 및 그 밖의 건강보조식품류를 포함하나 이에 한정되지 않는다. 상기 식품, 음료 또는 식품첨가제는 통상의 제조방법으로 제조될 수 있다.Examples of the food to which the wormwood extract of the present invention can be added include various foods, beverages, gums, candy, tea, vitamin complexes, and functional foods. In addition, the food in the present invention includes special nutritional products (e.g., prepared oils, infants, baby food, etc.), processed meat products, fish products, tofu, jelly, noodles (e.g. ramen, noodles, etc.), health supplements, seasoned foods ( For example, soy sauce, miso, red pepper paste, mixed soy sauce), sauces, confectionery (e.g. snacks), dairy products (e.g. fermented milk, cheese, etc.), other processed foods, kimchi, pickles (various kimchi, pickles, etc.), beverages ( Examples include, but are not limited to, fruits, vegetable drinks, soy milk, fermented beverages, ice cream, etc., natural seasonings (eg, ramen soup, etc.), vitamin complexes, alcoholic beverages, alcoholic beverages, and other health supplements. The food, beverage or food additive may be prepared by a conventional production method.
본 발명에서 기능성 식품이란 식품에 물리적, 생화학적, 생물공학적 수법 등을 이용하여 해당 식품의 기능을 특정 목적에 작용, 발현하도록 부가가치를 부여한 식품군이나 식품 조성이 갖는 생체방어리듬조절, 질병방지와 회복 등에 관한 체조절기능을 생체에 대하여 충분히 발현하도록 설계하여 가공한 식품을 의미하며, 바람직하게는 본 발명의 기능성 식품은 구강질환, 구체적으로 치아 우식증의 예방 또는 개선에 관한 체조절기능을 생체에 대하여 충분히 발현할 수 있는 식품을 의미한다. 상기 기능성 식품에는 식품학적으로 허용 가능한 식품 보조 첨가제를 포함할 수 있으며, 기능성 식품의 제조에 통상적으로 사용되는 적절한 담체, 부형제 및 희석제를 더욱 포함할 수 있다.Functional food in the present invention is the control of biological defense rhythm, disease prevention and recovery of food groups or food compositions that have added value to the food by using physical, biochemical, biotechnological techniques, etc. Means the food processed and designed to fully express the gymnastic function related to the living body, preferably the functional food of the present invention to the living body disease, specifically the gymnastic function related to the prevention or improvement of dental caries It means the food which can fully express. The functional food may include food acceptable food additives, and may further include appropriate carriers, excipients and diluents commonly used in the manufacture of functional foods.
본 발명에서 음료란 갈증을 해소하거나 맛을 즐기기 위하여 마시는 것의 총칭을 의미하며 기능성 음료를 포함하는 의도이다. 상기 음료는 지시된 비율로 필수 성분으로서 상기 큰비쑥 추출물을 유효성분으로 포함하는 것 외에 다른 성분에는 특별한 제한이 없으며 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다. 상기의 천연 탄수화물의 예는 모노사카라이드, 예를 들어 포도당, 과당 등 디사카라이드, 예를 들어 말토스, 수크로스 등 및 폴리사카라이드, 예를 들어 덱스트린, 시클로덱스트린 등과 같은 통상적인 당, 및 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 상기한 것 이외의 향미제로서 천연 향미제(타우마틴, 스테비아 추출물(예를 들어 레바우디오시드 A, 글리시르히진 등) 및 합성 향미제(사카린, 아스파르탐 등)를 유리하게 사용할 수 있다. 상기 천연 탄수화물의 비율은 본 발명의 조성물 100㎖ 당 일반적으로 약 1 내지 20g, 바람직하게는 5 내지 12g이다. 그밖에 본 발명의 조성물은 천연 과일 주스, 과일 쥬스 음료, 야채 음료의 제조를 위한 과육을 추가로 함유할 수 있다.In the present invention, the drink is a generic term for drinking to quench thirst or to enjoy the taste and is intended to include a functional drink. The beverage is not particularly limited to the other ingredients other than including the larvae extract as an active ingredient in the indicated ratio as an active ingredient, and may contain various flavors or natural carbohydrates as additional ingredients, such as ordinary drinks. . Examples of such natural carbohydrates include monosaccharides such as glucose, fructose and other disaccharides such as maltose, sucrose and the like and polysaccharides such as dextrin, cyclodextrin and the like, and Sugar alcohols such as xylitol, sorbitol, and erythritol. As flavoring agents other than those mentioned above, natural flavoring agents (tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The ratio of the natural carbohydrate is generally about 1 to 20 g, preferably 5 to 12 g per 100 ml of the composition of the present invention, in addition to the composition of the present invention, the flesh for preparing natural fruit juice, fruit juice beverage, vegetable beverage It may further contain.
상기 외에 본 발명의 조성물은 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 중진제(치즈, 초콜릿 등), 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산 음료에 사용되는 탄산화제 등을 함유할 수 있다. 이러한 성분을 독립적으로 또는 조합하여 사용할 수 있다. 상기 첨가제는 본 발명의 큰비쑥 추출물 100 중량부 당 0 내지 20 중량부, 바람직하게는 0.00001 내지 15 중량부 일 수 있으나, 이에 한정되는 것은 아니다.In addition to the above, the composition of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, coloring and neutralizing agents (such as cheese and chocolate), pectic acid and salts thereof, alginic acid and its Salts, organic acids, protective colloidal thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonation agents used in carbonated beverages, and the like. These components can be used independently or in combination. The additive may be from 0 to 20 parts by weight, preferably 0.00001 to 15 parts by weight, per 100 parts by weight of the wormwood extract of the present invention, but is not limited thereto.
본 발명에서 기능성 음료란 음료에 물리적, 생화학적, 생물공학적 수법 등을 이용하여 해당 음료의 기능을 특정 목적에 작용, 발현하도록 부가가치를 부여한 음료 군이나 음료 조성이 갖는 생체방어리듬조절, 질병방지와 회복 등에 관한 체조절기능을 생체에 대하여 충분히 발현하도록 설계하여 가공한 음료를 의미한다.Functional beverage in the present invention is a biological defense rhythm control, disease prevention and the like having a beverage group or a beverage composition that has added value to the beverage by using physical, biochemical, biotechnological techniques, etc. to function and express the function of the beverage to a specific purpose Means a beverage that is designed and processed to fully express the gymnastics function related to recovery.
상기 기능성음료는 지시된 비율로 필수 성분으로서 본 발명의 큰비쑥 추출물을 함유하는 외에는 다른 성분에는 특별한 제한이 없으며 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다. 상기 천연 탄수화물의 예는 모노사카라이드, 예를 들어 포도당, 과당 등 디사카라이드, 예를 들어 말토스, 수크로스 등 및 폴리사카라이드, 예를 들어 덱스트린, 시클로덱스트린 등과 같은 통상적인 당, 및 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 상기한 것 이외의 향미제로서 천연 향미제(타우마틴, 스테비아 추출물(예를 들어 레바우디오시드 A, 글리시르히진 등) 및 합성 향미제(사카린, 아스파르탐 등)를 유리하게 사용할 수 있다. 상기 천연 탄수화물은 본 발명의 조성물 100 중량부 당 0 중량부 내지 20 중량부, 바람직하게는 1 중량부 내지 18 중량부, 더욱 바람직하게는 5 중량부 내지 12 중량부 포함될 수 있다.The functional beverage is not particularly limited to other ingredients except for containing the extract of the present invention, as the essential ingredient in the ratio indicated, and may contain various flavors or natural carbohydrates, etc. as additional ingredients, such as ordinary drinks. Examples of such natural carbohydrates include monosaccharides such as glucose, fructose and other disaccharides such as maltose, sucrose and the like and polysaccharides such as dextrin, cyclodextrin and the like, and xylitol Sugar alcohols such as sorbitol and erythritol. As flavoring agents other than those mentioned above, natural flavoring agents (tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.) and synthetic flavoring agents (saccharin, aspartame, etc.) can be advantageously used. The natural carbohydrate may be included in an amount of 0 to 20 parts by weight, preferably 1 to 18 parts by weight, more preferably 5 to 12 parts by weight, per 100 parts by weight of the composition of the present invention.
또한, 구강질환의 예방 또는 개선의 효과를 목적으로 하는 식품 조성물에 있어서, 상기 큰비쑥 추출물의 양은 전체 식품 중량의 0.00001 중량% 내지 50 중량%로 포함될 수 있으며, 음료 조성물의 경우 식품 전체의 부피 100 ml 를 기준으로 0.001 g 내지 50 g, 바람직하게는 0.01 g 내지 10 g의 비율로 포함될 수 있으나, 이에 한정되는 것은 아니다.In addition, in the food composition for the purpose of preventing or improving the effect of oral diseases, the amount of the extract may be included in 0.00001% to 50% by weight of the total food weight, in the case of the
본 발명은 또한 큰비쑥 추출물을 유효성분으로 포함하는 구강질환 예방 또는 개선용 구강 위생 조성물을 제공한다. 본 발명의 구강 위생 조성물의 예로는 치약류, 바람직하게는 치약, 양치용액, 구강세척제, 치약크림 또는 로렌지 등일 수 있다.The present invention also provides an oral hygiene composition for preventing or improving oral disease, comprising the extract of the larvae as an active ingredient. Examples of oral hygiene compositions of the present invention may be toothpaste, preferably toothpaste, toothpaste solution, mouthwash, toothpaste cream or lozenge.
본 발명의 구강 위생 조성물이 치약류인 경우, 유효성분으로 큰비쑥 추출물을 포함하는 외에, 연마제, 점결제, 보습제, 발포제, 감미료, 미백제 또는 향미제를 추가로 포함할 수 있다.When the oral hygiene composition of the present invention is a toothpaste, in addition to including the wormwood extract as an active ingredient, it may further include an abrasive, caking agent, moisturizer, foaming agent, sweetener, whitening agent or flavoring agent.
상기 연마제로는 수산화알루미늄, 무수규산, 규산알루미늄, 제2인산칼슘 2 수산화물 및 무수물, 제3인산칼슘, 탄산칼슘, 피로인산칼슘, 불용성 메타인산나트륨, 제3인산마그네슘, 탄산마그네슘, 황산칼슘, 폴리메타아크릴산메틸 등을 단독 또는 복합적으로 사용할 수 있다. 상기 연마제의 함량은 전체 조성물을 기준으로 통상 20 중량% 내지 90중량%일 수 있으나, 상기 함량에 의해 한정되는 것은 아니다.Examples of the abrasive include aluminum hydroxide, silicic anhydride, aluminum silicate, dicalcium phosphate dihydrate and anhydride, tricalcium phosphate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, magnesium triphosphate, magnesium carbonate, calcium sulfate, Polymethyl methacrylate etc. can be used individually or in combination. The amount of the abrasive may be usually 20% to 90% by weight based on the total composition, but is not limited by the content.
상기 구강 위생 조성물이 페이스트상 조성물일 경우에는 상기 점결제는 가라기닌, 각종 점증용 셀룰로오스 유도체, 잔탄검, 트라가칸트 검(tragacanth gum) 등의 검류, 폴리비닐 알콜, 폴리아크릴산 나트륨, 폴리아크릴산/말레인산 공중합체, 카르복시비닐 폴리머 등의 합성 고분자 유도체 등의 유기계 점결제와 실리카, 라포나이트 등의 무기계 점결제 등을 단독 또는 복합적으로 사용할 수 있다. 상기 점결제의 함량은 전체 조성물을 기준으로 통상 0.3 중량% 내지 5 중량%일 수 있으나, 상기 함량에 의해 한정되는 것은 아니다.When the oral hygiene composition is a paste composition, the caking agent may include garginine, various thickening cellulose derivatives, gums such as xanthan gum and tragacanth gum, polyvinyl alcohol, sodium polyacrylate, polyacrylic acid / Organic binders such as maleic acid copolymers and synthetic polymer derivatives such as carboxyvinyl polymers and inorganic binders such as silica and laponite may be used alone or in combination. The content of the binder may be usually 0.3% to 5% by weight based on the total composition, but is not limited by the content.
또한, 상기 구강 위생 조성물에는 그 제조시 보습제로 솔비톨, 글리세린, 에틸렌글리콜, 프로필렌글리콜, 폴리에테르 글리콜, 폴리프로필렌 글리콜 등을 추가로 포함할 수 있다.In addition, the oral care composition may further include sorbitol, glycerin, ethylene glycol, propylene glycol, polyether glycol, polypropylene glycol, and the like as a moisturizing agent in the manufacture.
또한, 상기 구강 위생 조성물에는 향료 또는 감미제 등을 추가로 포함할 수 있다. 상기 감미제는 수크로즈, 락토오즈, 말토오즈, 솔비톨, 크실리톨, 나트륨시클라메이트, 글리세린, 사카린나트륨, 스테비오사이드, 아스파탐 등일 수 있고, 상기 향료는 페퍼민트, 멘톨, 아네톨, 오이게놀, 리모넨, 시트로네놀, 알파터피네올, 살리실메틸, 시네올, 리나롤, 에틸리나롤, 바닐린, 티몰, 스피아민트유, 세지유, 로즈마리유, 계피유 등일 수 있으며, 상기 감미제 또는 향료는 단독으로 또는 복합적으로 사용될 수 있다.In addition, the oral care composition may further include a flavoring or sweetening agent. The sweetener may be sucrose, lactose, maltose, sorbitol, xylitol, sodium cyclamate, glycerin, sodium saccharin, stevioside, aspartame and the like, and the fragrance may be peppermint, menthol, anetol, eugenol, Limonene, citronenol, alpha terpineol, salicymethylmethyl, cineol, linarol, ethylinalol, vanillin, thymol, spearmint oil, sage oil, rosemary oil, cinnamon oil, and the like, wherein the sweetener or flavoring agent alone It may be used in combination or in combination.
또한, 본 발명의 구강 위생 조성물에는 발포성분으로 사용되는 계면활성제나 추가 효능성분이 단독으로 또는 복합적으로 포함될 수 있다. 상기 발포성분으로 사용되는 계면활성제는 음이온 계면활성제, 비이온 계면활성제 및 양이온 계면활성제로 이루어진 군에서 선택된 어느 하나일 수 있다.In addition, the oral care composition of the present invention may contain a surfactant or an additional potency ingredient used alone as a foaming component alone or in combination. The surfactant used as the foaming component may be any one selected from the group consisting of anionic surfactants, nonionic surfactants and cationic surfactants.
본 발명의 구강 위생 조성물이 치약인 경우에는, 유효성분으로 큰비쑥 추출물을 포함하는 것을 제외하고는 통상적인 치약 제조방법으로 제조될 수 있으며, 본 발명의 구강 위생 조성물이 양치용액인 경우에는 통상적인 용액제에 큰비쑥 추출물을 혼합하고 양치용액으로 제형화하여 제조될 수 있으며, 하루 2 내지 10회 구강을 세척함으로써 구강질환을 예방 또는 치료할 수 있다.When the oral hygiene composition of the present invention is a toothpaste, it can be prepared by a conventional toothpaste manufacturing method, except that the extract contains the wormwood as an active ingredient, when the oral hygiene composition of the present invention is a toothpaste solution It can be prepared by mixing the larvae extract in a solution and formulated as a fern solution, it can prevent or treat oral diseases by washing the mouth 2 to 10 times a day.
또한, 본 발명의 구강 위생 조성물이 치약크림인 경우에는, 물과 보습제를 포함하는 액체, 겔화제 또는 수불용성 광택제, 감미료, 향료 등을 추가로 포함할 수 있다.In addition, when the oral care composition of the present invention is a toothpaste cream, it may further include a liquid containing water and a moisturizer, a gelling or water-insoluble varnish, sweeteners, fragrances and the like.
또한, 본 발명의 구강 위생 조성물이 구강 세척제인 경우에는, 치약 담체, 보다 상세하게는 비독성 알콜을 추가로 포함할 수 있다.In addition, when the oral care composition of the present invention is a mouthwash, it may further include a toothpaste carrier, more specifically a non-toxic alcohol.
본 발명은 또한 큰비쑥 추출물을 유효성분으로 포함하는 스트렙토코커스 뮤탄스(Streptococcus mutans) 및 포피로모나스 긴기발리스(Porphyromonas gingivalis)로 이루어진 군에서 선택된 1 이상에 대한 항균 활성을 갖는 항균 조성물일 수 있다.The present invention also Streptococcus mutans ( Streptococcus) comprising the larvae extract as an active ingredient mutans ) and Porphyromonas gingivalis ) may be an antimicrobial composition having antimicrobial activity against one or more selected from the group consisting of.
본 발명의 항균 조성물은 큰비쑥 추출물 외에 당질, 단백질, 지질, 비타민류 및 미네랄류를 포함할 수 있다. 상기 당질, 단백질, 지질, 비타민류 또는 미네랄류는 그 사용 목적 및 용도에 따라 적의 선택될 수 있으며, 일예로 상기 당질은 벌꿀, 덱스트린, 수크로오스, 팔라티노스, 포도당, 과당, 물엿, 당알콜(sugar alcohol), 소르비톨, 크실리톨, 말티톨일 수 있고 상기 단백질은 카제인(casein), 유청 단백질(whey protein) 등의 우유 유래 단백질, 대두 단백질, 이들 단백질의 트립신, 펩신 등의 동물 유래 효소 및 뉴트라아제(neutrase), 알칼라아제(alkilase)에 의한 가수분해물일 수 있으며, 상기 지질은 제1가 포화지방산, 다가 불포화지방산을 포함하는 해바라기유, 채종유(rapeseed oil), 올리브유, 홍화유(safflower oil), 옥수수유, 대두유, 팜유(palm oil), 야자유 등의 각종 식물 유래 유지, 중쇄 지방산(middle-chain fatty acid), EPA, DHA, 대두유래 인지질, 우유 유래 인지질일 수 있고, 상기 미네랄류는 인산칼륨, 탄산칼륨, 염화칼륨, 염화나트륨, 유산칼슘, 글루콘산칼슘, 판토텐산칼슘, 카제인칼슘, 염화마그네슘, 황산제1철, 탄산수소나트륨일 수 있으나, 각각의 예에 의해 특별히 제한되는 것은 아니다.The antimicrobial composition of the present invention may include sugars, proteins, lipids, vitamins and minerals in addition to the wormwood extract. The sugars, proteins, lipids, vitamins or minerals may be appropriately selected according to the purpose and use thereof. For example, the sugars may be honey, dextrin, sucrose, palatinose, glucose, fructose, starch syrup, sugar alcohol. , Sorbitol, xylitol, maltitol, the protein may be milk-derived protein such as casein, whey protein, soy protein, trypsin of these proteins, animal derived enzymes such as pepsin and neutrase ), Hydrolyzate by alkilase, the lipid may be monohydric saturated fatty acid, sunflower oil containing polyunsaturated fatty acid, rapeseed oil, olive oil, safflower oil, corn oil , Oils such as soybean oil, palm oil, palm oil, and other plant-derived oils, middle-chain fatty acids, EPA, DHA, soybean-derived phospholipids, milk-derived phospholipids, Lal may be potassium phosphate, potassium carbonate, potassium chloride, sodium chloride, calcium lactate, calcium gluconate, calcium pantothenate, calcium casein, magnesium chloride, ferrous sulfate, sodium hydrogen carbonate, but is not particularly limited by the examples. .
상기 당질, 단백질, 지질, 비타민류 및 미네랄류 중 어느 것에 대해서도, 조성물의 항균성이 유지되는 한 상기 구체예에 한정되지 않고 다른 성분을 포함할 수 있으며, 각각의 함량은 항균성이 유지되는 한 제한되지 아니하고, 바람직하게는 전체 조성물 대비 0.1 내지 15 중량%, 바람직하게는 0.5 내지 10 중량%일 수 있다.For any of the above saccharides, proteins, lipids, vitamins and minerals, as long as the antimicrobial properties of the composition are maintained, not limited to the above embodiments and may include other ingredients, each content is not limited as long as the antimicrobial properties are maintained Preferably, it may be 0.1 to 15% by weight, preferably 0.5 to 10% by weight relative to the total composition.
본 발명의 상기 항균 조성물은 항균 활성이 요구되는 다양한 목적 및 용도로 사용될 수 있으며, 구체적으로는 병원성 미생물 감염에 의한 구강질환, 바람직하게는 스트렙토코커스 뮤탄스(Streptococcus mutans)의 원인균인 치아우식증의 치료, 예방 또는 개선의 목적으로 사용될 수 있다.The antimicrobial composition of the present invention can be used for various purposes and uses that require antimicrobial activity, and specifically, the treatment of dental caries, which is a causative agent of oral diseases, preferably Streptococcus mutans , caused by pathogenic microbial infections. It can be used for the purpose of prevention, or improvement.
본 발명의 큰비쑥 추출물은 구강질환의 원인균, 바람직하게는 스트렙토코커스 뮤탄스에 대한 항균 활성을 가지고 있으므로, 상기 구강질환의 원인균에 의한 구강질환, 구체적으로 충치 또는 치아우식증에 대한 예방 및 치료 효과를 갖는다.Since the extract of the present invention has antibacterial activity against the causative agent of oral disease, preferably Streptococcus mutans, the preventive and therapeutic effect against oral disease, specifically caries or dental caries caused by the causative agent of the oral disease, Have
본 발명은 또한, 상기 항균 조성물을 유효성분으로 포함하는 구강질환 예방 또는 치료용 조성물을 제공한다. 상기 구강질환은 바람직하게는 치아우식증일 수 있다.The present invention also provides a composition for preventing or treating oral diseases including the antimicrobial composition as an active ingredient. The oral disease may preferably be dental caries.
또한, 본 발명은 상기 항균 조성물을 유효성분으로 포함하는 구강질환 예방 또는 치료용 조성물을 제공한다. 상기 본 발명의 식품 조성물의 예로는 식품, 식품첨가제, 음료 또는 음료첨가제를 들 수 있으며, 바람직하게는 껌 또는 사탕일 수 있다.In addition, the present invention provides a composition for preventing or treating oral diseases, including the antimicrobial composition as an active ingredient. Examples of the food composition of the present invention include food, food additives, beverages or beverage additives, preferably gum or candy.
또한, 본 발명은 상기 항균 조성물을 유효성분으로 포함하는 치아우식증 예방 또는 개선용 구강 위생 조성물을 제공한다.The present invention also provides an oral hygiene composition for preventing or improving dental caries comprising the antimicrobial composition as an active ingredient.
본 발명의 큰비쑥 추출물은 충치 또는 치아우식증의 원인균인 스트렙토코커스 뮤탄스(Streptococcus mutans)에 대한 우수한 항균 활성을 갖고 있으므로, 구강질환에 대한 우수한 예방 또는 치료용 효과가 있을 뿐만 아니라, 기존의 항생물질과는 달리 예로부터 섭취하여 온 염생식물인 큰비쑥에서 추출된 추출물을 유효성분으로 포함하고 있으므로, 부작용 등이 문제되지 아니하고, 우리나라 서해안 특히, 전라남도에 풍부하나 그 이용이 제한적이어 대부분 폐기처리되는 염생식물인 큰비쑥을 이용하는 것이므로 경제적으로도 유리하여 산업적으로 그 효과가 매우 크다 할 것이다.Since the extract of the present invention has an excellent antimicrobial activity against Streptococcus mutans , which is the causative agent of tooth decay or dental caries, not only does it have an excellent prophylactic or therapeutic effect on oral diseases, but also existing antibiotics. Unlike the extract, which is extracted from the larvae, a salty plant that has been ingested since ancient times, as an active ingredient, side effects are not a problem, and it is abundant in the west coast of Korea, especially Jeollanam-do, but its use is limited. Because it is using the plant, the wormwood is economically advantageous, the effect will be very large industrially.
도 1는 본 발명의 일 실시예에 따른 큰비쑥의 에탄올 추출물의 사용량에 따른 치아우식증의 원인균인 스트렙토코커스 뮤탄스에 대한 항균 활성을 나타낸 그래프이다.1 is a graph showing the antimicrobial activity against Streptococcus mutans, the causative agent of dental caries, according to the amount of ethanol extract of larvae according to one embodiment of the present invention.
이하, 본 발명의 바람직한 실시예를 기재한다. 다만, 하기의 실시예는 본 발명의 바람직한 일 실시예일 뿐, 본 발명이 하기 실시예에 의해 한정되는 것은 아니다.
Hereinafter, preferred embodiments of the present invention are described. However, the following examples are only preferred embodiments of the present invention, and the present invention is not limited to the following examples.
실시예Example 1: One: 큰비쑥Wormwood 추출물의 제조 Preparation of Extract
시험에 사용한 큰비쑥은 2008년 5월 전라남도 신안구 증도 태평염전(대한민국)에서 채집하여 사용하였다.The wormwood used for the test was collected and used in May 2008 at Jeung-do Jeungdo Taepyeong Salt Farm (South Korea).
상기 채집한 큰비쑥은 부착생물을 제거한 후, 깨끗한 담수로 씻어 실온에서 완전히 건조시켜 큰비쑥 건조시료를 제조하였다.The collected larvae were removed from adherent organisms, washed with clean fresh water, and dried completely at room temperature to prepare a larvae dried sample.
추출용매인 에탄올 15 L에 상기 큰비쑥 건조시료 1.5 kg를 첨가하고 침지시켜, 24시간 동안 정치 추출하였다. 24시간이 경과한 후, 균질기(Homogenizer)를 이용하여 상기 큰비쑥 건조시료 및 추출액을 추가로 분쇄한 후, 여과지(Whatman No.2)를 이용하여 여과하여 추출여액을 수득하는 방법으로 조추출액을 제조하였다. 상기 제조된 조추출액을 cooling aspirator(TOKYO RIKAKIKAI, 일본)가 장착된 감압농축기(vaccum evaporator)를 사용하여, 37℃에서 감압 농축하여 추출액을 제조하였다.
1.5 kg of the dried barley dry sample was added to 15 L of ethanol as an extraction solvent, and the resultant was immersed and left still for 24 hours. After 24 hours, the extract was further pulverized using the Homogenizer, and then the crude extract was obtained by filtration using a filter paper (Whatman No. 2) to obtain an extract filtrate. Was prepared. The prepared crude extract was concentrated under reduced pressure at 37 ° C. using a vacuum evaporator equipped with a cooling aspirator (TOKYO RIKAKIKAI, Japan) to prepare an extract.
실시예Example 2: 2: 큰비쑥Wormwood 추출물의 충치원인균에 대한 항균활성 확인 Identification of Antimicrobial Activity against Causative Agents
상기 실시예 1에서 제조된 큰비쑥 추출물의 충치원인균 즉, 치아우식증의 원인균인 스트렙토코커스 뮤탄스(Streptococcus mutans)에 대한 항균활성을 측정하였다. 스트렙토코커스 뮤탄스는 American type culture collection(ATCC 25175, USA)에서 구매하여 사용하였다.The antimicrobial activity of the causative agent of carp wormwood extract prepared in Example 1, ie, Streptococcus mutans , the causative agent of dental caries, was measured. Streptococcus mutans was purchased from the American type culture collection (ATCC 25175, USA).
보다 구체적으로, 상기 실시예 1에서 제조된 추출물을 dimethylsulfoxide(DMSO, Sigma, USA) 10μL에 각각 0.05mg, 0.5mg 및 2.5mg 씩 첨가한 후, 미리 121℃에서 15min 간 멸균한 각각의 배지 980μL에 첨가하였다. 상기 시료가 첨가된 배지에 37℃에서 전배양 시킨 Streptococcus mutans ATCC 25175를 10μL씩 접종하였다. 상기 Streptococcus mutans ATCC 25175를 접종한 후, 37℃에서 24시간 동안 배양하고, UV/Vis spectrophotometer(Genesys 20, 4001/4, Thermo, USA)를 이용하여 620nm의 파장으로 흡광도를 측정하여 큰비쑥 에탄올 추출물의 농도별 항균활성도를 측정하였다. 상기 측정결과를 도 1에 나타내었다.More specifically, 0.05 mg, 0.5 mg and 2.5 mg of dimethylsulfoxide (DMSO, Sigma, USA) were added to 10 μL of dimethylsulfoxide (DMSO, Sigma, USA), respectively, and then 980 μL of each medium sterilized at 121 ° C. for 15 min. Added. Streptococcus pre-cultured at 37 ° C. in the medium to which the sample was added mutans ATCC 25175 was inoculated in 10 μL increments. Streptococcus mutans After inoculating ATCC 25175, incubated for 24 hours at 37 ℃, by measuring the absorbance at a wavelength of 620nm using a UV / Vis spectrophotometer (
상기 도 1에 나타낸 바와 같이, 큰비쑥 추출물은 충치 원인균 즉, 치아우식증의 원인균으로 알려진 스트렙토코커스 뮤탄스에 시료의 농도의존적으로 균생장을 억제하여, 항균활성이 있는 것으로 확인되었고, 특히 2.5 mg/mL의 함량으로 처리한 경우, 아무런 처리를 하지 않은 대조군에 비하여 약 60%의 균만이 확인되어, 현저하게 우수한 항균효과를 갖는 것으로 확인되었다.As shown in FIG. 1, the extract of the larvae inhibited the growth of bacteria in the Streptococcus mutans known as the causative agent of tooth decay, that is, dental caries, depending on the concentration of the sample, and was confirmed to have antibacterial activity, in particular 2.5 mg / When treated with a content of mL, only about 60% of the bacteria were identified as compared to the control without any treatment, it was confirmed to have a remarkably excellent antibacterial effect.
따라서, 상기 결과로부터 큰비쑥 추출물은 구강질환 특히, 치아우식증의 개선, 예방 또는 치료를 위한 다양한 용도로 사용될 수 있을 것으로 예상되었다.Therefore, it is expected from the above results that the wormwood extract can be used for various purposes for the improvement, prevention or treatment of oral diseases, in particular dental caries.
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