KR20110102485A - 항종양 약제와 조합하여 사용하기 위한 알킬포스포콜린의 약물 제품 - Google Patents
항종양 약제와 조합하여 사용하기 위한 알킬포스포콜린의 약물 제품 Download PDFInfo
- Publication number
- KR20110102485A KR20110102485A KR1020117017914A KR20117017914A KR20110102485A KR 20110102485 A KR20110102485 A KR 20110102485A KR 1020117017914 A KR1020117017914 A KR 1020117017914A KR 20117017914 A KR20117017914 A KR 20117017914A KR 20110102485 A KR20110102485 A KR 20110102485A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- alkylphosphocholine
- combination
- treatment
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39961502P | 2002-07-30 | 2002-07-30 | |
| US60/399,615 | 2002-07-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057001510A Division KR101066804B1 (ko) | 2002-07-30 | 2003-07-29 | 항종양 약제와 조합하여 사용하기 위한 알킬포스포콜린의 약물 제품 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127034433A Division KR20130016413A (ko) | 2002-07-30 | 2003-07-29 | 항종양 약제와 조합하여 사용하기 위한 알킬포스포콜린의 약물 제품 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20110102485A true KR20110102485A (ko) | 2011-09-16 |
Family
ID=31495746
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117017914A Ceased KR20110102485A (ko) | 2002-07-30 | 2003-07-29 | 항종양 약제와 조합하여 사용하기 위한 알킬포스포콜린의 약물 제품 |
| KR1020057001510A Expired - Lifetime KR101066804B1 (ko) | 2002-07-30 | 2003-07-29 | 항종양 약제와 조합하여 사용하기 위한 알킬포스포콜린의 약물 제품 |
| KR1020127034433A Ceased KR20130016413A (ko) | 2002-07-30 | 2003-07-29 | 항종양 약제와 조합하여 사용하기 위한 알킬포스포콜린의 약물 제품 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057001510A Expired - Lifetime KR101066804B1 (ko) | 2002-07-30 | 2003-07-29 | 항종양 약제와 조합하여 사용하기 위한 알킬포스포콜린의 약물 제품 |
| KR1020127034433A Ceased KR20130016413A (ko) | 2002-07-30 | 2003-07-29 | 항종양 약제와 조합하여 사용하기 위한 알킬포스포콜린의 약물 제품 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US8389497B2 (OSRAM) |
| EP (2) | EP1545553B1 (OSRAM) |
| JP (1) | JP2005535688A (OSRAM) |
| KR (3) | KR20110102485A (OSRAM) |
| CN (1) | CN1302780C (OSRAM) |
| AR (1) | AR040717A1 (OSRAM) |
| AT (1) | ATE516036T1 (OSRAM) |
| AU (2) | AU2003253350B2 (OSRAM) |
| BR (1) | BR0313048A (OSRAM) |
| CA (1) | CA2493023C (OSRAM) |
| CY (1) | CY1111902T1 (OSRAM) |
| DK (1) | DK1545553T3 (OSRAM) |
| ES (1) | ES2369535T3 (OSRAM) |
| HR (1) | HRP20050184B1 (OSRAM) |
| IL (1) | IL166329A (OSRAM) |
| MX (1) | MXPA05001203A (OSRAM) |
| NO (1) | NO335196B1 (OSRAM) |
| NZ (1) | NZ538428A (OSRAM) |
| PL (1) | PL375493A1 (OSRAM) |
| PT (1) | PT1545553E (OSRAM) |
| RU (1) | RU2005105693A (OSRAM) |
| SI (1) | SI1545553T1 (OSRAM) |
| TW (1) | TWI332007B (OSRAM) |
| UA (1) | UA82322C2 (OSRAM) |
| WO (1) | WO2004012744A1 (OSRAM) |
| ZA (1) | ZA200500453B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ538428A (en) | 2002-07-30 | 2006-09-29 | Zentaris Gmbh | Use of alkylphosphocholines in combination with antitumor medicaments |
| US8383605B2 (en) | 2002-07-30 | 2013-02-26 | Aeterna Zentaris Gmbh | Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals |
| DE10324911B4 (de) | 2003-05-30 | 2005-08-18 | Siemens Ag | Röntgenvorrichtung mit partiellem digitalem Detektor und Verfahren zum Betrieb einer solchen |
| WO2006081452A2 (en) * | 2005-01-28 | 2006-08-03 | Robert Birch | Co-administration of perifosine with chemotherapeutics |
| KR101378005B1 (ko) | 2005-12-19 | 2014-03-27 | 아에테르나 젠타리스 게엠베하 | 세포독성이 감소된 알킬 인지질 유도체 및 이의 용도 |
| US20070167408A1 (en) * | 2005-12-19 | 2007-07-19 | Zentaris Gmbh | Novel alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof |
| EP1800684A1 (en) * | 2005-12-20 | 2007-06-27 | Zentaris GmbH | Novel alkyl phospholipid derivatives and uses thereof |
| US8703179B2 (en) | 2006-05-11 | 2014-04-22 | Kimberly-Clark Worldwide, Inc. | Mucosal formulation |
| KR20100092424A (ko) * | 2007-07-30 | 2010-08-20 | 아디아 바이오사이언스즈 인크. | 다형체를 포함하는, ｍｅｋ의 억제제로서의 ｎ-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법 |
| AU2009324464B2 (en) * | 2008-12-11 | 2016-05-05 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| CA2794513A1 (en) | 2010-03-31 | 2011-10-06 | Aeterna Zentaris Gmbh | Perifosine and capecitabine as a combined treatment for cancer |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59205998D1 (de) * | 1991-07-04 | 1996-05-23 | Asta Medica Ag | Arzneimittel mit antineoplastischer Wirkung enthaltend als Wirkstoff Octadecyl-[2-(N-methylpiperidino)-ethyl]-phosphat und Verfahren zu dessen Herstellung |
| US5942639A (en) * | 1991-07-04 | 1999-08-24 | Asta Medica Aktiengesellschaft | Process for the preparation of alkylphosphocholines and the production thereof in pure form |
| US6172050B1 (en) * | 1992-07-11 | 2001-01-09 | Asta Medica Aktiengesellschaft | Phospholipid derivatives |
| JP3079993B2 (ja) * | 1996-03-27 | 2000-08-21 | 日本電気株式会社 | 真空マイクロデバイスおよびその製造方法 |
| DE19650778C2 (de) * | 1996-12-06 | 2001-01-04 | Asta Medica Ag | Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie |
| SK284839B6 (sk) | 1998-01-22 | 2005-12-01 | Zentaris Gmbh | Použitie miltefozínu na výrobu lieku a farmaceutická kombinácia na liečenie leishmanózy |
| EP1135193B1 (de) * | 1998-12-04 | 2002-10-30 | Max-Delbrück-Centrum Für Molekulare Medizin | Mittel zur tumortherapie auf liposomenbasis, die tamoxifen enthalten |
| JP2002532553A (ja) * | 1998-12-21 | 2002-10-02 | インケイサ．ソシエダ アノニマ | 有害な胃腸副作用を引き起こさない有力な抗炎症剤としてのエーテルリゾリン脂質の使用 |
| LT3351246T (lt) * | 2001-02-19 | 2019-07-10 | Novartis Pharma Ag | Rapamicino darinys, skirtas kieto naviko, susijusio su nereguliuojama angiogeneze, gydymui |
| DE60234577D1 (de) * | 2001-03-23 | 2010-01-14 | Shire Canada Inc | Pharmazeutische mischung zur behandlung von krebs, die dioxolan nukleosidanalogen enthält |
| WO2003005522A1 (es) | 2001-07-04 | 2003-01-16 | Acuna Arturo | Tapones para sellado de ductos para redes electricas, telefonicas y de fibra optica. |
| DK1461083T3 (da) * | 2002-01-02 | 2006-07-10 | Nerviano Medical Sciences Srl | Kombineret terapi mod tumorer omfattende substitueret acryloyl distamycinderivater og proteinkinase- (serin/threoninkinase) inhibitorer |
| NZ538428A (en) | 2002-07-30 | 2006-09-29 | Zentaris Gmbh | Use of alkylphosphocholines in combination with antitumor medicaments |
| WO2005000318A2 (en) * | 2003-06-23 | 2005-01-06 | Neopharm, Inc. | Method of inducing apoptosis and inhibiting cardiolipin synthesis |
| WO2006081452A2 (en) | 2005-01-28 | 2006-08-03 | Robert Birch | Co-administration of perifosine with chemotherapeutics |
| US20070167408A1 (en) * | 2005-12-19 | 2007-07-19 | Zentaris Gmbh | Novel alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof |
| CA2794513A1 (en) | 2010-03-31 | 2011-10-06 | Aeterna Zentaris Gmbh | Perifosine and capecitabine as a combined treatment for cancer |
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- 2003-07-29 KR KR1020117017914A patent/KR20110102485A/ko not_active Ceased
- 2003-07-29 DK DK03766336.6T patent/DK1545553T3/da active
- 2003-07-29 AT AT03766336T patent/ATE516036T1/de active
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- 2003-07-29 KR KR1020057001510A patent/KR101066804B1/ko not_active Expired - Lifetime
- 2003-07-29 EP EP10010451A patent/EP2301551A1/de not_active Withdrawn
- 2003-07-29 JP JP2004525354A patent/JP2005535688A/ja active Pending
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- 2003-07-29 KR KR1020127034433A patent/KR20130016413A/ko not_active Ceased
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2008
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2010
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