CN1302780C - 烷基胆碱磷酸在制备用抗肿瘤药之前和/或期间治疗肿瘤的药物中的应用 - Google Patents

烷基胆碱磷酸在制备用抗肿瘤药之前和/或期间治疗肿瘤的药物中的应用 Download PDF

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Publication number
CN1302780C
CN1302780C CNB038181010A CN03818101A CN1302780C CN 1302780 C CN1302780 C CN 1302780C CN B038181010 A CNB038181010 A CN B038181010A CN 03818101 A CN03818101 A CN 03818101A CN 1302780 C CN1302780 C CN 1302780C
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preparation
application
treatment
alkyl
benign
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Expired - Fee Related
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CNB038181010A
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English (en)
Chinese (zh)
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CN1671397A (zh
Inventor
J·恩格尔
E·京特
H·辛德曼恩
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Aeterna Zentaris GmbH
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Zentaris AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB038181010A 2002-07-30 2003-07-29 烷基胆碱磷酸在制备用抗肿瘤药之前和/或期间治疗肿瘤的药物中的应用 Expired - Fee Related CN1302780C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39961502P 2002-07-30 2002-07-30
US60/399,615 2002-07-30

Publications (2)

Publication Number Publication Date
CN1671397A CN1671397A (zh) 2005-09-21
CN1302780C true CN1302780C (zh) 2007-03-07

Family

ID=31495746

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038181010A Expired - Fee Related CN1302780C (zh) 2002-07-30 2003-07-29 烷基胆碱磷酸在制备用抗肿瘤药之前和/或期间治疗肿瘤的药物中的应用

Country Status (26)

Country Link
US (3) US8389497B2 (OSRAM)
EP (2) EP1545553B1 (OSRAM)
JP (1) JP2005535688A (OSRAM)
KR (3) KR20110102485A (OSRAM)
CN (1) CN1302780C (OSRAM)
AR (1) AR040717A1 (OSRAM)
AT (1) ATE516036T1 (OSRAM)
AU (2) AU2003253350B2 (OSRAM)
BR (1) BR0313048A (OSRAM)
CA (1) CA2493023C (OSRAM)
CY (1) CY1111902T1 (OSRAM)
DK (1) DK1545553T3 (OSRAM)
ES (1) ES2369535T3 (OSRAM)
HR (1) HRP20050184B1 (OSRAM)
IL (1) IL166329A (OSRAM)
MX (1) MXPA05001203A (OSRAM)
NO (1) NO335196B1 (OSRAM)
NZ (1) NZ538428A (OSRAM)
PL (1) PL375493A1 (OSRAM)
PT (1) PT1545553E (OSRAM)
RU (1) RU2005105693A (OSRAM)
SI (1) SI1545553T1 (OSRAM)
TW (1) TWI332007B (OSRAM)
UA (1) UA82322C2 (OSRAM)
WO (1) WO2004012744A1 (OSRAM)
ZA (1) ZA200500453B (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ538428A (en) 2002-07-30 2006-09-29 Zentaris Gmbh Use of alkylphosphocholines in combination with antitumor medicaments
US8383605B2 (en) 2002-07-30 2013-02-26 Aeterna Zentaris Gmbh Use of alkylphosphocholines in combination with antimetabolites for the treatment of benign and malignant oncoses in humans and mammals
DE10324911B4 (de) 2003-05-30 2005-08-18 Siemens Ag Röntgenvorrichtung mit partiellem digitalem Detektor und Verfahren zum Betrieb einer solchen
WO2006081452A2 (en) * 2005-01-28 2006-08-03 Robert Birch Co-administration of perifosine with chemotherapeutics
KR101378005B1 (ko) 2005-12-19 2014-03-27 아에테르나 젠타리스 게엠베하 세포독성이 감소된 알킬 인지질 유도체 및 이의 용도
US20070167408A1 (en) * 2005-12-19 2007-07-19 Zentaris Gmbh Novel alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof
EP1800684A1 (en) * 2005-12-20 2007-06-27 Zentaris GmbH Novel alkyl phospholipid derivatives and uses thereof
US8703179B2 (en) 2006-05-11 2014-04-22 Kimberly-Clark Worldwide, Inc. Mucosal formulation
KR20100092424A (ko) * 2007-07-30 2010-08-20 아디아 바이오사이언스즈 인크. 다형체를 포함하는, ｍｅｋ의 억제제로서의 ｎ-(아릴아미노) 술폰아미드의 유도체 및 조성물, 사용 방법 및 이의 제조 방법
AU2009324464B2 (en) * 2008-12-11 2016-05-05 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
CA2794513A1 (en) 2010-03-31 2011-10-06 Aeterna Zentaris Gmbh Perifosine and capecitabine as a combined treatment for cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59205998D1 (de) * 1991-07-04 1996-05-23 Asta Medica Ag Arzneimittel mit antineoplastischer Wirkung enthaltend als Wirkstoff Octadecyl-[2-(N-methylpiperidino)-ethyl]-phosphat und Verfahren zu dessen Herstellung
US5942639A (en) * 1991-07-04 1999-08-24 Asta Medica Aktiengesellschaft Process for the preparation of alkylphosphocholines and the production thereof in pure form
US6172050B1 (en) * 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives
JP3079993B2 (ja) * 1996-03-27 2000-08-21 日本電気株式会社 真空マイクロデバイスおよびその製造方法
DE19650778C2 (de) * 1996-12-06 2001-01-04 Asta Medica Ag Verwendung von Dopaminrezeptor-Antagonisten in der palliativen Tumortherapie
SK284839B6 (sk) 1998-01-22 2005-12-01 Zentaris Gmbh Použitie miltefozínu na výrobu lieku a farmaceutická kombinácia na liečenie leishmanózy
EP1135193B1 (de) * 1998-12-04 2002-10-30 Max-Delbrück-Centrum Für Molekulare Medizin Mittel zur tumortherapie auf liposomenbasis, die tamoxifen enthalten
JP2002532553A (ja) * 1998-12-21 2002-10-02 インケイサ．ソシエダ アノニマ 有害な胃腸副作用を引き起こさない有力な抗炎症剤としてのエーテルリゾリン脂質の使用
LT3351246T (lt) * 2001-02-19 2019-07-10 Novartis Pharma Ag Rapamicino darinys, skirtas kieto naviko, susijusio su nereguliuojama angiogeneze, gydymui
DE60234577D1 (de) * 2001-03-23 2010-01-14 Shire Canada Inc Pharmazeutische mischung zur behandlung von krebs, die dioxolan nukleosidanalogen enthält
WO2003005522A1 (es) 2001-07-04 2003-01-16 Acuna Arturo Tapones para sellado de ductos para redes electricas, telefonicas y de fibra optica.
DK1461083T3 (da) * 2002-01-02 2006-07-10 Nerviano Medical Sciences Srl Kombineret terapi mod tumorer omfattende substitueret acryloyl distamycinderivater og proteinkinase- (serin/threoninkinase) inhibitorer
NZ538428A (en) 2002-07-30 2006-09-29 Zentaris Gmbh Use of alkylphosphocholines in combination with antitumor medicaments
WO2005000318A2 (en) * 2003-06-23 2005-01-06 Neopharm, Inc. Method of inducing apoptosis and inhibiting cardiolipin synthesis
WO2006081452A2 (en) 2005-01-28 2006-08-03 Robert Birch Co-administration of perifosine with chemotherapeutics
US20070167408A1 (en) * 2005-12-19 2007-07-19 Zentaris Gmbh Novel alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof
CA2794513A1 (en) 2010-03-31 2011-10-06 Aeterna Zentaris Gmbh Perifosine and capecitabine as a combined treatment for cancer

Also Published As

Publication number Publication date
EP1545553B1 (de) 2011-07-13
CA2493023A1 (en) 2004-02-12
TW200404073A (en) 2004-03-16
US8389497B2 (en) 2013-03-05
AU2008203060B2 (en) 2011-04-21
ATE516036T1 (de) 2011-07-15
HK1080751A1 (en) 2006-05-04
BR0313048A (pt) 2005-06-14
KR20130016413A (ko) 2013-02-14
PL375493A1 (en) 2005-11-28
NO20051040L (no) 2005-02-25
RU2005105693A (ru) 2005-07-10
MXPA05001203A (es) 2005-06-08
CY1111902T1 (el) 2015-11-04
US8507710B2 (en) 2013-08-13
TWI332007B (en) 2010-10-21
KR20050026028A (ko) 2005-03-14
EP1545553A1 (de) 2005-06-29
IL166329A0 (en) 2006-01-15
UA82322C2 (uk) 2008-04-10
AR040717A1 (es) 2005-04-20
AU2008203060A1 (en) 2008-07-31
US20100190738A1 (en) 2010-07-29
US20040097470A1 (en) 2004-05-20
WO2004012744A1 (de) 2004-02-12
IL166329A (en) 2012-08-30
KR20110102485A (ko) 2011-09-16
KR101066804B1 (ko) 2011-09-22
CN1671397A (zh) 2005-09-21
AU2003253350B2 (en) 2008-06-26
SI1545553T1 (sl) 2011-09-30
DK1545553T3 (da) 2011-09-12
ES2369535T3 (es) 2011-12-01
HRP20050184A2 (en) 2005-04-30
PT1545553E (pt) 2011-09-12
NZ538428A (en) 2006-09-29
US8551977B2 (en) 2013-10-08
HRP20050184B1 (hr) 2014-04-11
EP2301551A1 (de) 2011-03-30
ZA200500453B (en) 2005-08-31
US20100189784A1 (en) 2010-07-29
AU2003253350A1 (en) 2004-02-23
NO335196B1 (no) 2014-10-20
CA2493023C (en) 2012-01-31
JP2005535688A (ja) 2005-11-24

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