KR20110097938A - 하전된 4차 아미노기를 포함하는 중합체를 사용한 핵산 벡터의 개질 - Google Patents

하전된 4차 아미노기를 포함하는 중합체를 사용한 핵산 벡터의 개질 Download PDF

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KR20110097938A
KR20110097938A KR1020117015840A KR20117015840A KR20110097938A KR 20110097938 A KR20110097938 A KR 20110097938A KR 1020117015840 A KR1020117015840 A KR 1020117015840A KR 20117015840 A KR20117015840 A KR 20117015840A KR 20110097938 A KR20110097938 A KR 20110097938A
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nucleic acid
polymer
acid vector
modified
group
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Korean (ko)
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레오나르드 윌리엄 세이무어
카렐 울브리히
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싸이오서스 테라퓨틱스 엘티디.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
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    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2810/10—Vectors comprising a non-peptidic targeting moiety

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KR1020117015840A 2008-12-11 2008-12-11 하전된 4차 아미노기를 포함하는 중합체를 사용한 핵산 벡터의 개질 Withdrawn KR20110097938A (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2008/004097 WO2010067041A1 (en) 2008-12-11 2008-12-11 Modification of nucleic acid vectors with polymers comprising charged quaternary amino groups

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KR20110097938A true KR20110097938A (ko) 2011-08-31

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KR1020117015840A Withdrawn KR20110097938A (ko) 2008-12-11 2008-12-11 하전된 4차 아미노기를 포함하는 중합체를 사용한 핵산 벡터의 개질
KR1020117015838A Withdrawn KR20110099034A (ko) 2008-12-11 2009-12-11 하전된 4차 아미노기를 포함하는 중합체를 사용한 핵산 벡터의 개질

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KR1020117015838A Withdrawn KR20110099034A (ko) 2008-12-11 2009-12-11 하전된 4차 아미노기를 포함하는 중합체를 사용한 핵산 벡터의 개질

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US (2) US20110243897A1 (enExample)
EP (2) EP2370108A1 (enExample)
JP (2) JP2012511319A (enExample)
KR (2) KR20110097938A (enExample)
CN (2) CN102245215A (enExample)
AU (2) AU2008365111B2 (enExample)
BR (2) BRPI0823363A2 (enExample)
CA (2) CA2744959A1 (enExample)
EA (2) EA201100915A1 (enExample)
WO (2) WO2010067041A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0907989D0 (en) * 2009-05-08 2009-06-24 Hybrid Systems Ltd Multivalent adjuvant display
WO2012051459A1 (en) * 2010-10-14 2012-04-19 Nitto Denko Corporation Nucleic acid delivery compounds
WO2012113413A1 (en) * 2011-02-21 2012-08-30 Curevac Gmbh Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates
ES2526154T3 (es) * 2012-01-27 2015-01-07 Deutsches Krebsforschungszentrum Parvovirus modificado útil para silenciamiento génico
US9758606B2 (en) 2012-07-31 2017-09-12 The Trustees Of Columbia University In The City Of New York Cyclopropenium polymers and methods for making the same
ES2684552T3 (es) 2012-09-03 2018-10-03 Inserm - Institut National De La Santé Et De La Recherche Médicale Anticuerpos dirigidos contra ICOS para tratar la enfermedad de injerto contra hospedador
EP2931903B1 (en) * 2012-12-14 2021-07-28 The Regents of the University of California Viral vector nanocapsule for targeting gene therapy and its preparation
EP3007711B1 (en) 2013-06-14 2020-10-21 Psioxus Therapeutics Limited A dosing regime and formulations for type b adenoviruses
ES2747762T3 (es) 2013-08-21 2020-03-11 Curevac Ag Vacuna contra el virus respiratorio sincitial (RSV)
GB201510197D0 (en) 2014-06-12 2015-07-29 Psioxus Therapeutics Ltd Method of treating ovarian cancer
CN105153339B (zh) * 2015-10-13 2017-10-24 浙江大学 一种氧化响应去正电荷的阳离子聚合物、制备方法和应用
BR112019020853A2 (pt) 2017-04-04 2020-05-12 Avidea Technologies, Inc. Vacinas à base de peptídeo, métodos de fabricação e usos das mesmas para induzir uma resposta imune
GB201708203D0 (en) * 2017-05-22 2017-07-05 Sagetis Biotech Sl Chemical compounds

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AU7634694A (en) * 1993-08-20 1995-03-21 University Of Medicine And Dentistry Of New Jersey Bridged polycationic polymer-oligonucleotide conjugates and methods for preparing same
GB9623051D0 (en) * 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems
WO1998044143A1 (en) 1997-04-03 1998-10-08 Genzyme Corporation Polymer-modified viruses
GB9913359D0 (en) 1999-06-09 1999-08-11 Cancer Res Campaign Tech Polymer modified biological elements
CZ294996B6 (cs) * 2003-07-16 2005-04-13 Ústav Makromolekulární Chemie Av Čr Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů
WO2006085664A1 (ja) * 2005-02-10 2006-08-17 The University Of Tokyo ポリカチオン荷電性ポリマー及び核酸のキャリヤーとしての使用

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EA201100914A1 (ru) 2012-01-30
US20110243939A1 (en) 2011-10-06
AU2009326176A1 (en) 2011-06-30
WO2010067081A2 (en) 2010-06-17
CN102245213A (zh) 2011-11-16
EP2373347A2 (en) 2011-10-12
WO2010067041A1 (en) 2010-06-17
CN102245215A (zh) 2011-11-16
CA2744938A1 (en) 2010-06-17
AU2008365111B2 (en) 2013-08-22
JP2012511320A (ja) 2012-05-24
US20110243897A1 (en) 2011-10-06
BRPI0823363A2 (pt) 2015-06-16
AU2008365111A1 (en) 2011-06-30
EP2370108A1 (en) 2011-10-05
WO2010067081A3 (en) 2010-11-04
EA201100915A1 (ru) 2012-01-30
KR20110099034A (ko) 2011-09-05
CA2744959A1 (en) 2010-06-17
BRPI0922957A2 (pt) 2019-09-24
JP2012511319A (ja) 2012-05-24

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