CN102245215A - 用包含带电荷的季氨基的聚合物的核酸载体的修饰 - Google Patents

用包含带电荷的季氨基的聚合物的核酸载体的修饰 Download PDF

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Publication number
CN102245215A
CN102245215A CN2008801322927A CN200880132292A CN102245215A CN 102245215 A CN102245215 A CN 102245215A CN 2008801322927 A CN2008801322927 A CN 2008801322927A CN 200880132292 A CN200880132292 A CN 200880132292A CN 102245215 A CN102245215 A CN 102245215A
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nucleic acid
polymer
acid carrier
modified nucleic
carrier
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CN2008801322927A
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Chinese (zh)
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L·W·西摩
K·乌尔布里希
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Akamis Bio Ltd
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Psioxus Therapeutics Ltd
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A—HUMAN NECESSITIES
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
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    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
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    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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CN2008801322927A 2008-12-11 2008-12-11 用包含带电荷的季氨基的聚合物的核酸载体的修饰 Pending CN102245215A (zh)

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PCT/GB2008/004097 WO2010067041A1 (en) 2008-12-11 2008-12-11 Modification of nucleic acid vectors with polymers comprising charged quaternary amino groups

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CN102245215A true CN102245215A (zh) 2011-11-16

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CN2009801494608A Pending CN102245213A (zh) 2008-12-11 2009-12-11 用包含带电荷的季氨基的聚合物的核酸载体的修饰

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US (2) US20110243897A1 (enExample)
EP (2) EP2370108A1 (enExample)
JP (2) JP2012511319A (enExample)
KR (2) KR20110097938A (enExample)
CN (2) CN102245215A (enExample)
AU (2) AU2008365111B2 (enExample)
BR (2) BRPI0823363A2 (enExample)
CA (2) CA2744959A1 (enExample)
EA (2) EA201100915A1 (enExample)
WO (2) WO2010067041A1 (enExample)

Cited By (1)

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CN105153339A (zh) * 2015-10-13 2015-12-16 浙江大学 一种氧化响应去正电荷的阳离子聚合物、制备方法和应用

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GB0907989D0 (en) * 2009-05-08 2009-06-24 Hybrid Systems Ltd Multivalent adjuvant display
WO2012051459A1 (en) * 2010-10-14 2012-04-19 Nitto Denko Corporation Nucleic acid delivery compounds
WO2012113413A1 (en) * 2011-02-21 2012-08-30 Curevac Gmbh Vaccine composition comprising complexed immunostimulatory nucleic acids and antigens packaged with disulfide-linked polyethyleneglycol/peptide conjugates
ES2526154T3 (es) * 2012-01-27 2015-01-07 Deutsches Krebsforschungszentrum Parvovirus modificado útil para silenciamiento génico
US9758606B2 (en) 2012-07-31 2017-09-12 The Trustees Of Columbia University In The City Of New York Cyclopropenium polymers and methods for making the same
ES2684552T3 (es) 2012-09-03 2018-10-03 Inserm - Institut National De La Santé Et De La Recherche Médicale Anticuerpos dirigidos contra ICOS para tratar la enfermedad de injerto contra hospedador
EP2931903B1 (en) * 2012-12-14 2021-07-28 The Regents of the University of California Viral vector nanocapsule for targeting gene therapy and its preparation
EP3007711B1 (en) 2013-06-14 2020-10-21 Psioxus Therapeutics Limited A dosing regime and formulations for type b adenoviruses
ES2747762T3 (es) 2013-08-21 2020-03-11 Curevac Ag Vacuna contra el virus respiratorio sincitial (RSV)
GB201510197D0 (en) 2014-06-12 2015-07-29 Psioxus Therapeutics Ltd Method of treating ovarian cancer
BR112019020853A2 (pt) 2017-04-04 2020-05-12 Avidea Technologies, Inc. Vacinas à base de peptídeo, métodos de fabricação e usos das mesmas para induzir uma resposta imune
GB201708203D0 (en) * 2017-05-22 2017-07-05 Sagetis Biotech Sl Chemical compounds

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AU7634694A (en) * 1993-08-20 1995-03-21 University Of Medicine And Dentistry Of New Jersey Bridged polycationic polymer-oligonucleotide conjugates and methods for preparing same
GB9623051D0 (en) * 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems
WO1998044143A1 (en) 1997-04-03 1998-10-08 Genzyme Corporation Polymer-modified viruses
GB9913359D0 (en) 1999-06-09 1999-08-11 Cancer Res Campaign Tech Polymer modified biological elements
CZ294996B6 (cs) * 2003-07-16 2005-04-13 Ústav Makromolekulární Chemie Av Čr Reaktivní polymery a kopolymery na bázi N-(2-hydroxypropyl)methakrylamidu, způsob jejich přípravy a jejich použití pro syntézu polymerních léčiv, pro modifikaci biologicky aktivních proteinů a přípravu systémů pro dopravu genů
WO2006085664A1 (ja) * 2005-02-10 2006-08-17 The University Of Tokyo ポリカチオン荷電性ポリマー及び核酸のキャリヤーとしての使用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105153339A (zh) * 2015-10-13 2015-12-16 浙江大学 一种氧化响应去正电荷的阳离子聚合物、制备方法和应用

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EA201100914A1 (ru) 2012-01-30
US20110243939A1 (en) 2011-10-06
KR20110097938A (ko) 2011-08-31
AU2009326176A1 (en) 2011-06-30
WO2010067081A2 (en) 2010-06-17
CN102245213A (zh) 2011-11-16
EP2373347A2 (en) 2011-10-12
WO2010067041A1 (en) 2010-06-17
CA2744938A1 (en) 2010-06-17
AU2008365111B2 (en) 2013-08-22
JP2012511320A (ja) 2012-05-24
US20110243897A1 (en) 2011-10-06
BRPI0823363A2 (pt) 2015-06-16
AU2008365111A1 (en) 2011-06-30
EP2370108A1 (en) 2011-10-05
WO2010067081A3 (en) 2010-11-04
EA201100915A1 (ru) 2012-01-30
KR20110099034A (ko) 2011-09-05
CA2744959A1 (en) 2010-06-17
BRPI0922957A2 (pt) 2019-09-24
JP2012511319A (ja) 2012-05-24

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Application publication date: 20111116