KR20110015524A - Compositions for the treatment of lice - Google Patents

Abstract

The present invention provides compositions comprising glycerin, petrolatum and VP-hexadecene copolymers suitable for use in the treatment of this infection. The invention also provides a method of administering the composition such that the eggs, nits and nits are eradicated from the host.

Description

COMPOSITIONS FOR THE TREATMENT OF LICE

The present invention relates to a composition for treating this infection.

The resulting human infection is a common social and health problem in many countries. There are three types of anatomical teeth that infect humans: head lice, body, and quadrilaterals.

Head lice are small, hard-shelled in vitro parasites that live on human scalp and eat only human blood. Females have a 4 week life span and lay 50-100 eggs during this period. The eggs are firmly attached to the hair shaft by chitin, which is secreted by the female. The eggs hatch after 6-9 days and the larvae emerge out of the shell or “nit”. After three stages of molting, the larvae become reproductive adults.

Head lice infections are common in children aged 4-11 years and more often in women than men. It is spread by direct contact with an infected person. The presence of head lice can be identified by the itching caused by an allergic reaction to its saliva. Or it can be seen by looking at this, egg or nits.

The goal when treating head lice infections is to completely eliminate eggs, larvae, teeth and nits, and the continued presence of the latter only provides confusion in later diagnosis. Treatment is easy to perform, economical, and side effects are minimized.

 General head lice care usually involves the use of neurotoxic insecticides with wet combing. Combing with a thin, fine plastic comb for the detection or removal of an adult tooth, or a metal comb for eggs or nits, appears to be a safe method of removal, but it is a great burden and effort for parents. Commonly used insecticides or these exterminators are generally pyrethroid-based (Full Marks®), malachion-based (eg Derbac-M®) or carbaryl-based (eg Carylderm®). Pyrethroids such as permethrin and phenotrine are synthetic axionic poisons that lead to neuronal hypersensitivity and death. Malachion is an organophosphorus neuropathic drug that irreversibly binds to cholinesterase. Carbaryl (1-naphthyl methylcarbamate) is also a cholinesterase inhibitor.

However, these recent chemical therapies have significant drawbacks, in which evidence that fails to resolve these infection pathologies is evident, associated with side effects such as scalp irritation, and severe toxicity when swallowed orally. Carbaryl is also a potential carcinogen. In addition, there is evidence of this population being resistant to many of these commonly used eradication agents and anxiety regarding the safety of neurotoxin-based therapies, especially when used to treat young individuals.

Although there is no scientific evidence to explain the effectiveness, alternative therapies including essential oils, herbal extracts or homeopathic tinctures are also available. Dimethicone-based products inhibit their excess secretion and kill them. The products are not traditional pesticides and have a good safety profile and are recommended for pregnant and lactating mothers. However, dimethicone is not considered effective in removing eggs from the host.

Therefore, there is a need for the development of new compositions that allow effective and safe treatment of head lice while avoiding the problem of increased resistance.

The present invention relates to a composition suitable for use in the treatment of this infection. The invention also aims at a therapy wherein elements such as eggs, eggs and nits are eradicated from the host.

According to the first aspect of the invention, the composition comprises glycerin, petrolatum and VP (vinyl pyrrolidine) -hexadecene copolymer.

According to a second aspect of the invention, such a composition is used, in particular, in therapies for the topical treatment of ectoparasitic infections.

According to a third aspect of the present invention, the treatment of an IVF infection comprises contacting an infected site of an individual with a composition of the present invention.

The present invention provides compositions useful for the topical treatment of ectoparasitic infections and in particular for the treatment of parasitic parasites.

The term "external parasite" as defined herein refers to a parasite that lives on the outer surface of a host. The term "ectoparasitic infection" refers to an infection of an in vitro parasite.

The term "this parasite" as used herein refers to this infection. Three genera that affect humans are Pediculosis humanus capitis (head lice), Pediculosis humanus corporis (body) and Pthirus pubis (pigtail).

The compositions of the present invention are intended for use in the treatment of mammalian ectoparasitic infections. According to a preferred embodiment, the ectoparasitic infection to be treated by the use of the composition is this parasitic. More preferably the parasitic is a human infection, more preferably a head lice infection.

The term "this eradication agent" as used herein refers to a pharmaceutical composition for the treatment of this parasitic disease.

As used herein, the terms “individual” and “host” are used interchangeably and include non-primates (eg, cattle, pigs, horses, cats, dogs, rats, and mice) and primates (eg, monkeys and humans). And preferably mammals, including humans.

The composition of the present invention is a liquid formulation comprising glycerin, petrolatum and vinylpyrrolidine (VP) / hexadecene copolymer.

The term "glycerine" as used herein is intended to include all terms used to describe propane-1,2,3-triol compounds wherein the formula is HOCH ₂ CH (OH) CH ₂ OH.

The term "petrolatum" as used herein refers to pharmaceutical grade or cosmetic grade petrolatum and includes all synonyms including petroleum jelly and paraffin jelly. Petrolatum is a colorless to yellowish white nonpolar hydrocarbon mixture obtained by fractional distillation of petroleum and is marketed under the trade name Vaseline ^® .

The term "VP / hexadecene copolymer" as used herein refers to a copolymer of vinylpyrrolidine and long chain α-olefins. VP / hexadecene copolymer wear resistance and moisture barrier-viscosity striking a pale yellow commonly added to cosmetics because of ability to form a liquid and is commercially available as V-216 ^® Antaron or Ganex ^® V-216.

According to a preferred embodiment said composition of the invention also comprises either or both of pectin and xanthan gum.

As used herein, the term 'pectin' refers to a heteropolysaccharide derived from the cell walls of higher ground plants commonly used as gelling agents, thickeners, and stabilizers in foods. Its characteristic structure is linear homogalacturonan with substitutions of (1-2) -linked L-rhamnose. The isolated pectin is a white to light brown powder and generally has a molecular weight of 60-130000 g / mol depending on the origin and extraction conditions.

The term 'xanthan gum' used here is Xanthomonas campestris refers to polysaccharides produced during the fermentation of glucose or sucrose by bacterium . Xanthan gum is industrially useful because a small amount (about 0.5-1%) can greatly increase the viscosity of the liquid.

Generally, the composition comprises 0.1-5% w / w glycerin, 0.1-5% w / w petrolatum, 0.1-5% w / w VP-hexadecene polymer, 0.05-2% w / w pectin and 0.05-2 % w / w xanthan gum.

In a more preferred embodiment, the composition comprises a surfactant, preferably an anionic surfactant. Suitable cosmetic-grade surfactants are known in the art and include sodium dodecasulfate (SDS), ammonium lauryl sulfate, sodium laureth sulfate, soaps and fatty acid salts.

 In a preferred embodiment, this scavenger of the invention is a fluid formulation, preferably an aqueous lotion.

The components of the formulation include water, cosmetic grade emollients such as cetearyl alcohol, emulsifiers such as stearth-21, antistatic agents such as behentrimonium chloride, wetting agents such as propylene glycol, sorbitol, and glyceryl stearate citrate, such as propylene glycol Preservatives such as humectants, parabens and phenoxyethanol and aromatic esters.

% w / w
Composition water 68.80 C12-15 Alkyl Benzoate 16.00 Myristyl alcohol 2.85 Cetearyl Alcohol 2.50 Behentrimonium chloride 1.80 glycerin 1.50 Glyceryl Stearate Citrate 1.35 Petrolatum 1.00 VP / hexadecene copolymer 1.00 steareth-21 1.00 pectin 0.60 Phenoxyethanol 0.50 Xanthan Gum 0.40 Propylene glycol 0.25 Benzyl alcohol 0.20 Methyl paraben 0.10 Ethylparaben 0.10 Propylparaben 0.05 100.00

According to another embodiment according to the invention, the present scavenger is applied in an amount sufficient to cover the entire dry hair area of the infected individual. The hair is then preferably wrapped in a plastic wrap or cling film. The composition induces suffocation and death by sticking to the hair to form a persistent, impermeable film that prevents teeth and eggs from gaining oxygen.

In a preferred embodiment, the composition remains in the hair for a sufficient time to suffocate and kill the teeth and eggs. In a preferred embodiment, the composition remains in the hair for 40 to 80 minutes, more preferably 60 minutes, and then rinsed off with water to remove. The presence of an anionic surfactant allows the solution to be easily removed. Dead teeth and eggs can be removed by combing the hair with a true comb (0.2-0.3 mm comb spacing).

To effectively and effectively remove all teeth and nits, the subject should be treated for up to three days, preferably twice a day. In a more preferred embodiment, the treatment is repeated after 15 days to reliably eradicate any teeth or eggs that can survive even after the first treatment. Since this eradication agent uses a physical mode of action rather than a biochemical mode of action, these individuals cannot develop resistance and therefore the effect of the treatment does not decrease over time.

The invention is illustrated by the following non-limiting examples:

Example

The following effects study was conducted in 13 patients with this parasitic disease. Eleven of them were female and two were male, all ages between 8 and 40 years old. In all subjects, teeth were found near the scalp and itching was reported.

Two versions of this scavenger composition of the present invention were prepared, one with creamy consistency and the other with fluid consistency. The creamy version of this scavenger was tested on five individuals and the fluid version was tested on eight individuals. The components of the composition are summarized in Table 1.

In each case, this remover was applied to the entire head of the dry hair and left for about 2 hours after covering with a kling film. The product was removed via a conventional shampoo and the hair combed with a comb. This procedure was repeated after one week and all subjects were checked for teeth after the first month of application. The results of this study are summarized in Table 2.

Object (birth / gender) Product viscosity Early observation Results after 1 week Results after 1 month Reference 1996 / F cream Many teeth removed when combing Some teeth remain 15 cm above the scalp. Stop itching All removed No problem report 1999 / F cream Reduce this one when combing Some teeth remain 15 cm above the scalp. Stop itching All removed Not good smell complaints of the product 1999 / F cream Many teeth removed when combing Some teeth remain 20 cm above the scalp. Stop itching All removed No problem report 1994 / M cream No reduction of teeth Some teeth remain off the scalp. All removed No problem report 1999 / F cream No reduction of teeth Some teeth remain off the scalp. All removed No problem report 1995 / F Fluid Reduce this one when combing Some teeth remain off the scalp. Stop itching All removed Product causes tickling when applied 1996 / F Fluid No reduction of teeth All removed All removed No problem report 1996 / F Fluid Reduce this one when combing Some teeth remain off the scalp. All removed No problem report 1968 / F Fluid No reduction of teeth Some teeth remain off the scalp. All removed No problem report 1966 / F Fluid Reduce these two when combing Some teeth remain off the scalp. All removed No problem report 1999 / F Fluid Reduce this one when combing Some teeth remain off the scalp. All removed No problem report 1999 / F Fluid Reduce these two when combing All removed All removed No problem report 1996 / M Fluid No reduction of teeth All removed All removed No problem report

The results show that removal of 8 individuals was observed immediately after the first application of the composition. After one week, only empty crusts and dry nits were observed, all of which were far from the scalp of the subject. One month after the first application, the check showed that no teeth or nits existed in all subjects. In general, the composition proved satisfactory to all without any hypersensitivity, itching, pain or burning sensation.

Claims (21)

A composition comprising glycerin, petrolatum and a VP / hexadecene copolymer. The composition of claim 1, further comprising pectin. The composition of claim 1 or 2, further comprising xanthan gum. The composition of claim 1, further comprising a surfactant. The composition of claim 4, wherein the surfactant is an anionic surfactant. The method of claim 1, wherein 0.1-5% w / w glycerin, 0.1-5% w / w petrolatum, 0.1-5% w / w VP / hexadecene copolymer, 0.05-2 A composition comprising% w / w pectin and 0.05-2% w / w xanthan gum. This eradication agent comprising a composition according to any one of claims 1 to 6. 8. The killing agent of claim 7, wherein the composition is a liquid formulation. The agent according to claim 8, wherein the agent is an aqueous lotion. The composition according to any one of claims 1 to 6, which is used for treatment. The composition of claim 10, wherein the treatment is topical treatment of an ectoparasitic infection in a mammal. The composition of claim 11, wherein the ectoparasitic infection is an infection in a human subject. The composition according to claim 12, wherein the ectoparasitic infection is this parasite. The composition of claim 13, wherein the parasitic is head lice. A method for treating an in vitro parasitic infection comprising contacting an infected site of an individual with a composition according to any one of claims 1 to 6. 16. The method of claim 15, wherein the ectoparasitic infection is this parasite. The method of claim 16, wherein the parasitic is head lice. The method of claim 17, wherein the hair is dry on contact. The method of claim 18, wherein the composition is in contact with the hair for a time sufficient to suffocate and kill the tooth. The method of claim 19, wherein the composition is in contact with the hair for 40 to 80 minutes per treatment. The method of claim 20, wherein the treatment is repeated twice a day for up to 3 days.