KR20110012696A - Food composition for stress relaxation, fatigue recovery or athletic performance enhancement comprising extract of root of vitis - Google Patents

Abstract

PURPOSE: A food composition containing a grape root extract is provided to enable an eater to recover from fatigue, and to reduce the stress of the eater. CONSTITUTION: A food composition contains a grape root extract as an active ingredient. The grape root extract is obtained by extracting grape roots with a solvent selected from the group consisting of water, alcohol with 1~6 carbons, and a mixture of the water and the alcohol.

Description

Food Composition for Stress Relaxation, Fatigue Recovery or Athletic Performance Enhancement Comprising Extract of root of vitis}

The present invention relates to a fatigue recovery or stress relief composition containing grape root extract as an active ingredient, and more particularly to a food composition for enhancing exercise performance, fatigue recovery or stress relief containing grape root extract as an active ingredient. It is about.

In general, 'fatigue' is a 'state of deterioration in work', 'a state of confusion of constantness' or 'a state of restraint of the cerebral cortex', and a reduction of the ability to perform physical and mental activities. 'Can be defined.

When the signal of fatigue comes, the body needs time to take a break and recover. However, in a busy modern society, it is difficult to keep such a cycle of fatigue and recovery. Accumulation of fatigue due to overwork can lead to chronic fatigue and can lead to many diseases such as peptic ulcer, hypertension, and diabetes. Cancer, stroke, and heart disease are the three major causes of death in modern people, and overwork is the main cause of their deaths. Recently, the importance of exercise has been highlighted to enjoy the leisure of life due to the well-being craze, and to prevent and treat various adult diseases. This social interest is increasing the need for scientific food intake not only for athletes but also for the general public to improve athletic performance and to effectively recover from fatigue.

The expression of fatigue or stress builds up when the mind and body are not functioning well. In the case of 'fatigue', a state in which the force required for muscle contraction activity is not sufficiently exerted, that is, a state in which exercise performance is reduced (Gibson H, et al, Sports Med., 1985. 2 (2): 120 In contrast to physical fatigue, stress can be understood as an imbalance of physical rhythm resulting from mental overload. Therefore, fatigue in the broad sense is a concept that includes both fatigue and stress, and can be said to be a reduction in the ability to perform physical or mental activities. Specifically, fatigue is a state in which work efficiency decreases mainly due to physical fatigue, and stress is mental It refers to a state where confusion of homeostasis occurs due to fatigue (establishment of functional evaluation system related to fatigue recovery of KFDA's health functional food, research report).

In general, if the stimulus to the body is more than a certain degree to damage the body, the living body represents a general adaptative syndrome (specific general syndrome) in response to a certain threat regardless of the type of stimulus, The image is called stress (Selye, H .: The stress of life, Toronto, Longnans Green and Co., pp. 1-50, 1958). These stresses appear in a variety of symptoms, such as tension headaches, migraines, high blood pressure, indigestion, fatigue, pain, menopausal disorders, hair growth, and rough skin. In addition, chronic stress persists in various neurosis and gastric ulcers, and decreases the body's physiological and immune activities, reduces mental activity and affects emotions, causing abnormal behavior.

In particular, because stress is excessively occurring in modern society, stress is a very important social problem.

The causes of stress and changes in the body vary, but in general, the function of the pituitary-adrenal system (HPA), which is the sympathetic nervous system, is promoted to induce hormone secretion, resulting in hyperfunction of the adrenal gland and hypofunction of the spleen. It is known that all symptoms caused by stress appear. When stress is added, the spleen is significantly reduced in weight due to a decrease in immune function, adrenal cortex stimulates the adrenal function to increase its weight, decreases lipids, and promotes the release of cortisol. The amount of cortisol tends to increase with age and stress, which also contributes to obesity. In addition, when stress is added, the adrenal glands secrete hormones to increase cholesterol, blood sugar, and lactate dehydrogenase (LDH) in the blood.

No special drugs have been developed to prevent stress, and chemical synthetic drugs such as neurostabilizers, anti-anxiety agents and sleeping pills are mainly used to alleviate the symptoms of mental and physical diseases caused by stress. There is a problem that there are various side effects when taking long-term, and recently, a variety of attempts to develop functional foods for the purpose of stress relief using herbal ingredients.

A study on the composition for fatigue recovery using natural herbal medicines includes a functional beverage using extracts extracted from Cheongung, Licorice, brown root, earth, red wine, dermis, control, buttercup, and ginkgo leaf in Korea Patent Publication No. 2000-0066777. In Korean Patent Application Publication No. 10-2005-0108856, a fatigue recovery herbal drink containing citrine, mammun-dong, goji berry, and Schisandra chinensis was disclosed.

In Korean Patent Registration No. 0278203, the stress relief beverage prepared using chrysanthemum extract is presented, and in Korea Patent Registration No. 0289555 is presented the Stress Relief beverage prepared mainly as rose extract. In 10-2004-0006705, stress relief health supplements containing deep water, organic germanium and sauerkraut, dermis, malt, sanjoin and jujube are disclosed, and red ginseng and cheonma in Korean Patent Publication No. 10-2004-0018888. , Stress relief foods mainly made of raw juice and the like have been released. In addition, Korean Patent Application Publication No. 10-2005-0080455 discloses a Kamisagunjatang having an anti-stress effect by adding plum, roundle, brown root, and cinnamon extract to a conventional Sagunjatang.

Vitis amurensis Rupr. Is a deciduous vine plant of the family Vitaceae. Fruit is berry and ripens in September with black purple and contains 2-3 seeds. They are either raw or soaked in alcohol. It is distributed in Korea, Japan and Sakhalin.

Vitis Radix is a Chinese herb that uses the root of Vitaceae in the sun or uses it as it is. In Dongbogam, grape roots have been recorded to be effective for nausea and hiccups. Since ancient times, it has the effect of blowing and stool, which is caused by rheumatism. ), Urine bulge (小 便 不 利) has been used for the treatment. As a study on the grape root, Korean Patent Laid-Open Publication No. 10-2005-0086169 discloses a method of extracting heineanol A from the root of Vitis amurensis and its anticancer activity.

However, it is not known whether there is activity enhancement, fatigue recovery or stress suppressing activity against the grape root extract, and there is no development of food using it.

The inventors of the present invention, while studying a composition composed of natural ingredients effective for stress, found that the composition consisting of grape root extract has improved exercise performance, fatigue recovery and stress inhibitory activity and completed the present invention.

Therefore, an object of the present invention is to provide a fatigue recovery food composition comprising the grape root extract as an active ingredient.

It is also an object of the present invention to provide a stress relief food composition comprising the grape root extract as an active ingredient.

It is also an object of the present invention to provide a food composition for enhancing exercise performance ability as an active ingredient grape root extract.

In order to solve the above problems, the present invention provides a fatigue recovery food composition comprising the grape root extract as an active ingredient.

In addition, the present invention provides a stress relief food composition comprising the grape root extract as an active ingredient to achieve another object of the present invention.

In another aspect, the present invention provides a food composition for enhancing exercise performance ability to the grape root extract as an active ingredient.

Hereinafter, the present invention will be described in detail.

Vitis Radix of the present invention refers to the root of the plant belonging to the family Vitaceae (葡萄 科, Vitaceae) and preferably may be the root of Vitis amurensis (scatter). Grape root extract refers to the extract from the grape root. Grape root extract of the present invention can be prepared by a solvent extraction method known in the art. Examples of the extraction solvent include any one selected from alcohols having 1 to 6 carbon atoms such as water, ethanol and methanol, organic solvents such as acetone, ethyl acetate, n-nucleic acid, diethyl ether, acetone, and benzene, or a mixture thereof. Solvents may be used. Preferably, the extraction may be performed using water or an alcohol having 1 to 6 carbon atoms or a mixed solvent thereof. When the extract is prepared by the solvent extraction method, hot water extraction, ultrasonic extraction and reflux extraction may be used. Most preferably, the grape root extract of the present invention may be prepared by a hydrothermal extraction method using water as a solvent. Although the ratio of grape root and water at the time of hot water extraction is not specifically limited, Water can be added to grape root 3 to 20 times (by weight). Preferably, in order to increase the extraction efficiency, water may be added in an amount of 8 to 15 times (by weight) relative to the grape root. During extraction, the temperature is preferably performed at 80 ° C. to 120 ° C. under normal pressure, and the extraction time depends on the extraction temperature, but is extracted for 0.5 to 4 hours, preferably 1 to 3 hours. In addition, to increase the extraction efficiency can be used by grinding the grape root with a grinder.

In one embodiment of the present invention, the grape root extract of the present invention is pulverized grape root to the size of 20 to 40mesh and then drinking water is added 10 times to the grape root powder and extracted with hot water at 100 ℃ for 2 hours. The hot water extract was heated, and then left for 1 hour to recover the supernatant except 10% of the inferior inferior liquor, and freeze-dried to prepare grape root extract.

The present invention provides a food composition for enhancing exercise performance, fatigue recovery or stress relief using grape root extract as an active ingredient.

The exercise performance enhancement, fatigue recovery or stress relief effect of the grape root extract according to the present invention was confirmed through the animal experiments by the present inventors.

That is, in one embodiment of the present invention to swim between the mice administered daily and the control group not administered the composition to fatigue state for 10 days to determine whether the composition has exercise performance enhancement, fatigue recovery or stress inhibitory activity The total swim time was measured, and blood was collected and the chemical test was performed after the last swim. In addition, the body weight was measured once every two days to observe the weight change. In addition, the heat sensitivity test was performed before and after swimming on the 8th and 10th days of swimming to compare the difference in pain sensitivity. As a result, the mice treated with Root extract daily improved their performance in exercise, which significantly increased total swimming time and suppressed weight loss due to fatigue, and inhibited muscle damage caused by fatigue. It was confirmed that there was no (see Experimental Example 2).

In another embodiment of the present invention to determine whether the composition has a stress inhibitory activity, the mice administered the composition and the control group not administered the stress through the submerged restraint and measuring the degree of damage to the stomach, bleeding degree Measurement, biopsy of gastric lesions, body weight, adrenal gland, spleen weight, blood test, bone marrow cell type peroxidase activity, gastric mucosa lipid peroxidation, reduced glutathione level and superoxide dismute The degree of stress inhibition was compared by measuring activity of Izu, glutathione peroxidase, and catalase.

As a result, mice treated with grape root extract daily had significantly lower gastric damage and gastric bleeding, suppressed stress-induced blood sugar, atrophy of spleen, and hypertrophy of adrenal gland, and myeloid cell type peroxidation, indicating inflammation in gastric tissue. The activity of the enzyme and the degree of lipid peroxidation were significantly lowered, and the concentration of reduced glutathione and superoxide dismutase, glutathione peroxidase, and catalase were confirmed to increase (see Experimental Example 1).

The food composition according to the present invention may be prepared in the form of a composition by mixing with a known active ingredient known to be effective in enhancing exercise performance, fatigue recovery or stress relief, and is a functional food (nutritional supplement). And all forms, such as health food and food additives. Food compositions of this type can be prepared in various forms according to conventional methods known in the art. For example, the health food can be prepared in the form of tea, juice and drink containing grape root extract, it can be ingested by granulating, encapsulating or powdering the food composition containing the grape root extract as an active ingredient.

The food composition of the present invention includes a mineral-containing compound such as vitamin B, C, E or beta-carotene, Ca, Mg, Zn or phospholipid such as lecithin or a compound such as maltol, oligosaccharide, amino acid, etc. Among these, it is more preferable to use a mixture of two or three components among vitamins C, E, beta carotene, maltol, etc., because it can reinforce the bioactive effect.

In addition to the above ingredients, in order to enhance the taste as a known additive, natural flavors such as plum, lemon, pineapple or herb, or natural fruit juice, natural pigments such as chlorophyllin and flavonoids, and fructose, sweet sugar Can be mixed with honey, sugar alcohol, sugar and acidulants such as citric acid and sodium citrate.

The preferred content of the grape root extract in the food composition of the present invention may include about 0.01 to 10% by weight based on the total weight of the food. Preferably in the amount of 0.1mg / kg / day to 200mg / kg / day intake may exhibit the effect of exercise performance enhancement, fatigue recovery or stress relief.

The present invention provides a functional food in the form selected from the group consisting of tablets, granules, and liquids comprising the food composition.

Functional food refers to foods that are designed and processed to fully exhibit biological control functions such as biological defense, biological rhythm control, and disease prevention and recovery.

The functional food production is not particularly limited other than those included in the food composition of the present invention, it may further contain the necessary ingredients for each food as a conventional food acceptable food supplement.

Tablets are easy-to-take and accurate dosages of powdered or crystalline materials that are aggregated and pressed into rounded discs or cones. Functional food tablets of the present invention may include, but are not limited to, excipients such as lactose, starch, white sugar, mannitol, sorbitol, inorganic salts, magnesium aluminum silicate, starch paste, gelatin, tragacanth, methylcellulose, May contain binders such as sodium carboxymethylcellulose and / or polyvinylpyrrolidine, optionally disintegrating or boiling mixtures such as starch, agar, alginic acid or its sodium salt and / or absorbents, colorants, flavors, And sweeteners. The formulations may be prepared by conventional mixing, granulating or coating methods.

Granules refer to a round, granulated formulation, which can always take a certain proportion and are easy to take for mixed formulations. If necessary, colorants, fragrances, etc. may be added to the granules of the present invention, and may be coated with a suitable coating agent. In the granules of granules, it is preferable that 20% of the whole premises have a size of 355 um or more and 1400 um or less.

A liquid formulation refers to a liquid formulation, and stabilizers, copulating agents, preservatives, etc. may be added as necessary for the present invention. In addition, the functional beverage composition of the present invention may further include fruit extract for flavor improvement. Fruit extracts have the advantage of being able to use various active ingredients with fruit with flavor improvement. The fruit used in the fruit extract is not limited thereto, but may include at least one selected from pineapple, lemon, citrus fruit, orange, apple, pear, grapefruit, apricot, strawberry, peach, melon, guava, lemon, and plum. Can be. Other functional beverage compositions of the present invention may include known additives. As these known additives, nicotinic acid amide, vitamins A, B, C, D, E, folic acid, etc. may be used as vitamins, and L-glycine, L-lysine, DL-methionine, and L- as amino acids. Valine, biotin, L-cysteine, L-cystine, L-tryptophan, L-threonine, L-phenylalanine, etc. may be used, and as herbal preparations, wolfberry, ogapi, baekrye, earl, green, red ginseng, ginseng, ginseng, sulphurine Can be used, such as yellow, mixed flavors, apple flavors, yogurt flavors, drink flavors, etc. The sweeteners are white sugar, glucose, fructose, fructooligosaccharides, isomaltoligosaccharides, malto oligosaccharides , Chitosan oligosaccharide, chito oligosaccharide, soy oligosaccharide, xylo oligosaccharide, isosaccharide (high fructose), invert sugar, aspartame, stevioside, sorbitol, mannitol, etc. can be used, and citric acid, DL-apple acid, succinic acid, etc. Can be used as stabilizer Among the sorbates, polysorbate 20, polysorbate 40, polysorbate 80 and the like can be used, and as preservatives, benzoic acid and its derivatives, dehydroacetic acid and its salts, sorbic acid and its salts, etc. Can be.

As described above, the exercise performance enhancing, fatigue recovery or stress relief food composition comprising the grape root extract of the present invention as an active ingredient has been reported to improve the exercise performance, fatigue recovery or stress relief effect of the grape root, which has not been reported in the past. It is effective in enhancing exercise performance, recovering from fatigue and relieving stress. Therefore, the food composition comprising the grape root extract of the present invention as an active ingredient can be used for the production of functional foods for enhancing exercise performance, fatigue recovery or stress relief.

Hereinafter, the present invention will be described in detail by way of examples.

However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.

≪ Example 1 >

Grape root extract manufacturer

100 g of grape root was ground to a size of 20 to 40 mesh and put in 1000 ml of water and heated at 100 ° C. for 2 hours. After heating, the mixture was left for 1 hour to remove 10% of inferior liquor (impurities, heavy metals, etc.) and freeze-dried to prepare grape root extract.

Experimental Example 1

Stress Inhibitory Effect of Grape Root Extract

<1-1> causing stress

The experimental rats were divided into three groups, and the experimental group was administered the grape root extract prepared in Example 1 at 10 AM daily for 7 days at a dose of 40 mg / kg. The control group was administered saline instead of the extract, and no treatment was given to the normal group. Grape root extract and saline were administered orally using an oral syringe. Except for the normal group, fasting was performed for 24 hours until the 7th day after the 6th day. Thirty minutes after the last dose on Day 7, stress was induced for 3 hours using the Water Immersion Restraint (WIR) model (Brzozowski T, et al, J Physiol Pharmacol. 2007 Dec; 58 Suppl 6: 53-64). Immersion restraint was placed in a cage forcibly immobilized and placed in a cage filled with water at 23 ± 0.5 ℃ for about 4 hours.

<1-2> stomach damage measurement

In Experimental Example 1-1, the stomach of the stress-induced experimental rat was extracted, and the degree of gastric injury (Ulcer Index) was measured, and the results are shown in FIG. 1.

In order to measure the gastric index (Ulcer Index), the extracted stomach was unfolded and photographed with a digital camera. The area of the gastric lesion was measured using ImagePartner software (SARAMSOFT, Korea) to indicate the gastric lesion.

As a result, as shown in Figure 1 was administered when the grape root extract was confirmed that the degree of gastric damage is significantly lower than the control group.

<1-3> Measurement of gastric bleeding

In Experimental Example 1-1, the stomach of the stress-induced experimental rats was extracted, and the degree of gastric bleeding was observed. The results were quantified as shown in Table 1, and the results are shown in FIG.

Bleeding Index Symptom score No bleeding 0 Very small amount of bleeding along the gastric mucosa folds One Small amount of bleeding along the gastric mucosa folds 2 Large amounts of bleeding along the gastric mucosa folds 3 Very large amount of bleeding along the gastric mucosa folds 4 Small amounts of coagulated blood are partially in the gastric mucosa 5 Partially in the gastric mucosa of large amounts of coagulated blood 6 Covers the entire gastric mucosa of large amounts of coagulated blood 7 Very large amounts of coagulated blood cover the entire gastric mucosa 8

As a result, as shown in Figure 2 when the grape root extract was administered, it was confirmed that the degree of gastric bleeding is significantly lower than the control group

<1-4> Histological examination of gastric injury

In Experimental Example 1-1, the stomach of the stress-induced rat was extracted, the tissue of the gastric injury site was fixed to paraffin, sections were made, and H & E (hematoxylin-eosin) staining was performed. Inspected.

As a result, as shown in FIG. 3, it was confirmed that the mucosal tissue damage was significantly lower than that of the control group in which the grape root extract was severely damaged.

<1-5> measurement of weight

The weight of the experimental rats to which the grape root extract of Experimental Example 1-1 was administered for one week was measured.

As a result, as shown in FIG. 4, the grape root extract administration group, the control group and the normal group did not show a difference.

<1-6> Weight measurement of the adrenal glands and spleen

Adrenal and spleen tissues of the experimental rats to which the grape root extract of Experimental Example 1-1 was administered for one week were extracted, and their weights were measured.

As a result, when the grape root extract was administered as shown in Fig. 5 or 6, it was confirmed that the atrophy of the spleen was significantly reduced compared to the control group, hypertrophy of the adrenal gland is also significantly suppressed.

<1-7> Hemochemical test after stress

Blood was collected from the experimental rats of Experimental Example 1-1 immediately after stress due to submerged restraint, and thus glucose, LDH (Lactic Acid Dehydrogenase), CK (Creatine Kinase), TG (TriGlyceride), total cholesterol, and cortisol The amount was measured. Blood was collected from the heart through heart puncture after anesthesia using ether immediately after stress.

As a result, as shown in Figure 7 there was no significant difference between the group and the control group administered the grape root extract.

<1-8> Gastric mucosal myeloid cell type myeloperoxidase activity measurement

An active amount of Experimental Example 1-1 Bone marrow cell-type peroxidase in the above structure of the literature (Grisham et al Inflammation 1990 Dec; 14 (6):.. 669-80) that bone marrow cell-type peroxidase H ₂ on the basis of The degree of O ₂ conversion to HOCl was determined, and the value was measured at 620 nm using a UV absorbance spectrometer. Bone marrow cell type peroxidase is an enzyme that is abundant in neutrophils. When neutrophils are activated, they increase secretion and are used as quantitative indicators of the degree of inflammation in tissues.

As a result, as shown in Figure 8, by the administration of the grape root extract, compared with the control group, it was confirmed that the activity of myeloid cell type peroxidase showing the degree of inflammation is significantly lowered.

As a result of synthesizing all the results of Experimental Example 1, it was confirmed that the grape root extract has an excellent stress inhibitory effect and can be usefully used as a composition for suppressing stress.

Experimental Example 2

Test to stop the sensory reaction rate reduction by enhancing exercise performance, fatigue recovery and stress of grape root extract

<2-1> Total Swimming Time Measurement

The experimental mice (IRC-mouse) were divided into three groups, and the experimental group was administered with 1 g / kg of grape root extract prepared in Example 1 daily from 1 to 10 days. The control group was administered saline instead of the extract, and no treatment was given to the normal group. Grape root extract and saline were administered orally using an oral syringe. Flow rate control waterfall was used to measure swimming ability. The acrylic plastic pool (90 x 45 x 45) was filled with water 38 cm deep and evaluated for fatigue when it could not rise above the surface within 7 seconds. Adapted to the waterpool for 30 minutes before the day of dosing (day 0), and tested once a day from day 1 to day 10 and repeated measurements for the same mice. The total swimming time was used before the fatigue state as an index of swimming ability (Matsumoto K, et al, J Appl Physiol. 1996 Oct; 81 (4): 1843-9), and the measurement results are shown in FIG. 9.

As a result, as shown in Figure 9 it was confirmed that the total swimming time is significantly longer than the control group when the grape root extract was administered. As a result, it was confirmed that administration of the root extract of the present invention enhances exercise performance.

<2-2> Weight change after swimming fatigue

The weight of the mice of Experimental Example 2-1 was measured once every two days for ten days during the experiment to observe the weight change during the experimental period.

As a result, as shown in Figure 10 it was confirmed that the administration of the grape root extract inhibits the weight loss due to fatigue.

<2-3> Blood Chemistry after Swimming Fatigue

Blood of the mice of Experimental Example 2-1 was collected and the amount of glucose, Lactic Acid Dehydrogenase (LDH), Creatine Kinase (CK), TriGlyceride (TG), total cholesterol, and cortisol in the method of Experimental Example 1-6. Was measured. Blood was collected from the heart through heart puncture after anesthesia using ether immediately after stress.

As a result, as shown in Figure 11, in the CK compared with the control group compared with the control group was confirmed that the CK level is significantly lowered, it was confirmed that no other difference in other tests.

<2-4> Pain Sensitivity Measurement (Hot Plate Test)

The degree of stress was assessed by measuring heat sensitivity before and after swimming on day 8 and day 10 (Wilson SG, et al, Behav Brain Res. 2001 Nov 1; 125 (1-2): 65-73.). The experimental mice (IRC-mouse) were placed on a hot plate (50 ± 1 ℃) and the time until the avoidance of heat pain, such as licking or jumping palms, was measured.

As a result, as shown in FIG. 12, the heat sensitivity of the control group was significantly reduced due to stress after swimming, but when the grape root extract was administered, it was confirmed that the pain sensitivity due to heat was maintained before the swimming level.

As a result of combining the results of Experimental Example 2, the grape root extract improves the exercise performance reduced by fatigue, has an excellent anti-fatigue effect, and suppresses the slowing of pain sensitivity caused by the exercise-induced stress. It was confirmed that it can be usefully used as a composition for fatigue recovery and stress suppression.

<Manufacture example 1>

Preparation of Liquid Functional Food Containing Grape Root Extract

After dissolving 1 ~ 10 g of grape root extract prepared in Example 1 in 1L of Passion or Membrane Filtration, 0.001-5% by weight of nicotinic acid, 0.01-5% by weight of aspartic acid, 0.01-1.0% by weight of calcium citrate , Honey 0.01 ~ 3%, Dextrin 0.01 ~ 3%, Ginseng Extract 0.01 ~ 10%, Apple 0.01 ~ 5%, Apple Flavor 0.05 ~ 1%, Fructooligosaccharide 0.1 ~ 10%, Citric Acid 0.05 ~ 5 Add 0.01% to 3.0% by weight of polysorbate and 0.05 to 1% by weight of benzoic acid so that the food additives are in the range of 0.28% to 55% by weight in the total composition ratio and homogenize them in a homogenizer at 98 ℃. Sterilized for 30 seconds, and filled into a container at 86 ℃ sealed. The sealed container was heated to sterilize the filling in the container and then cooled at 30 ° C. to prepare a beverage containing the functional grape root extract.

As described above, the exercise performance enhancing, fatigue recovery or stress relief food composition comprising the grape root extract of the present invention as an active ingredient has been reported to improve the exercise performance, fatigue recovery or stress relief effect of the grape root, which has not been reported in the past. It is effective in enhancing exercise performance, recovering from fatigue or relieving stress. Therefore, the food composition comprising the grape root extract of the present invention as an active ingredient can be used in the production of functional foods for enhancing exercise performance, fatigue recovery or stress relief, and thus has high industrial applicability.

1 is a graph showing the effect of inhibiting the stress of grape root extract stress in the rat area of the experimental rat (control: rats administered saline; grape roots: rats administered grape root extract).

Figure 2 is a graph showing the effect of inhibiting the stress of grape root extract gastric bleeding in the experimental rats (control group: rats administered saline; grape roots: rats administered grape root extract; Y-axis value: score according to Table 1 ).

3 is a diagram showing the stress inhibitory effect of grape root extract through histological examination of the gastric injury site of the rat (normal group: stomach anatomy of rats not administered anything; normal tissue: stomach tissue of normal rats HE stained pictures; Control group: Saline-administrated rat stomach; Control tissue: Control rat stomach tissue HE-stained; Grape root: Grape root extract rats; : HE stained stomach tissue of rats treated with grape root extract).

Figure 4 is a graph measuring the body weight of rats in order to determine the weight change by administration of the grape root extract (normal group: rats do not administer anything; control group: rats administered saline; grape root: administration of the grape root extract One rat).

5 is a graph showing the change in the spleen weight of experimental rats to the effect of inhibiting the stress of grape root extract (regular group: rats not administered anything; control group: rats administered saline; grape root: administration of the grape root extract One rat).

6 is a graph showing the change in the adrenal weight of the rats for the stress inhibitory effect of the grape root extract (Normal group: rats not administered anything; control group: rats administered saline; grape root: administration of the grape root extract One rat).

Figure 7 is a graph showing the results of the stress-induced hemochemical test of rats administered with grape root extract (normal group: rats do not administer anything; control: rats administered saline; grape root: rats administered grape root extract) Glucose: Glucose; LDH: Lactic Acid Dehydrogenase; CK: Creatine Kinase; TG: TriGlyceride; T.Chol .: Total cholesterol; Cortisol: Cortisol).

8 is a graph showing the stress inhibitory effect of grape root extract by measuring the gastric mucosal myeloid cell type myeloperoxidase activity of rats (normal group: rats not administered; control group: rats administered saline; Muscle: rats receiving grape root extract; MPO: myeloperoxidase).

9 is a graph showing the exercise performance enhancing effect of the grape root extract by measuring the swimming ability of the experimental mouse (control: mice administered saline; grape root: mice administered grape root extract).

Figure 10 is a graph showing the fatigue recovery effect of the grape root extract by measuring the weight change during the swimming period of the experimental mice (normal group: mice that do not swim with nothing; control: mice administered saline; Mice receiving grape root extract).

11 is a graph showing the blood recovery effect of the experimental mice administered with the grape root extract through the blood chemistry test results (normal group: mice that do not swim and do not swim; control group: mice administered saline; Grape Root: Mice treated with Grape Root Extract; Glucose: Glucose; LDH: Lactic Acid Dehydrogenase; CK: Creatine Kinase; TG: TriGlyceride; T.Chol .: Total cholesterol; Cortisol: Cortisol.

12 is a graph showing the pain sensitivity recovery effect of the grape root extract by measuring the hot plate test (normal group: mice that do not swim without administration of nothing; control group: mice administered saline; grape root : Mice administered with grape root extract).

Claims (4)

Fatigue recovery food composition comprising grape root extract as an active ingredient. A stress relief food composition comprising grape root extract as an active ingredient. Exercise composition for enhancing exercise performance with grape root extract as an active ingredient. The food composition according to any one of claims 1 to 3, wherein the grape root extract is extracted with any one solvent selected from the group consisting of water, alcohols having 1 to 6 carbon atoms, and mixed solvents thereof.

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