KR20100124732A - 파르네실 피로포스페이트 합성효소의 억제제로서의 퀴놀린 - Google Patents
파르네실 피로포스페이트 합성효소의 억제제로서의 퀴놀린 Download PDFInfo
- Publication number
- KR20100124732A KR20100124732A KR1020107019046A KR20107019046A KR20100124732A KR 20100124732 A KR20100124732 A KR 20100124732A KR 1020107019046 A KR1020107019046 A KR 1020107019046A KR 20107019046 A KR20107019046 A KR 20107019046A KR 20100124732 A KR20100124732 A KR 20100124732A
- Authority
- KR
- South Korea
- Prior art keywords
- naphthalen
- quinolin
- formula
- amino
- phosphonic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 Cc1c2nc(*)ccc2cc(*)c1 Chemical compound Cc1c2nc(*)ccc2cc(*)c1 0.000 description 3
- VPEPHQBPBQRZII-UHFFFAOYSA-N CN(N)/N=C(/c(ccc1cc(-c2ccc[s]2)c2)nc1c2-c1cccc2ccccc12)\N Chemical compound CN(N)/N=C(/c(ccc1cc(-c2ccc[s]2)c2)nc1c2-c1cccc2ccccc12)\N VPEPHQBPBQRZII-UHFFFAOYSA-N 0.000 description 1
- SVYATFPZDCUKMZ-VAWYXSNFSA-N COC(Nc1cc(-c2cccc3ccccc23)c2nc(/C=C/P(O)(O)=O)ccc2c1)=O Chemical compound COC(Nc1cc(-c2cccc3ccccc23)c2nc(/C=C/P(O)(O)=O)ccc2c1)=O SVYATFPZDCUKMZ-VAWYXSNFSA-N 0.000 description 1
- IPDDLBRKILFKMY-UHFFFAOYSA-N Cc1c(cccc2-c(cccc3cc4)c3nc4C(O)=O)c2ccc1 Chemical compound Cc1c(cccc2-c(cccc3cc4)c3nc4C(O)=O)c2ccc1 IPDDLBRKILFKMY-UHFFFAOYSA-N 0.000 description 1
- RSHSGQQZDAKAOC-UHFFFAOYSA-N OC(c(ccc1cc(-c2ccc[nH]2)c2)nc1c2-c1c(cccc2)c2ccc1)=O Chemical compound OC(c(ccc1cc(-c2ccc[nH]2)c2)nc1c2-c1c(cccc2)c2ccc1)=O RSHSGQQZDAKAOC-UHFFFAOYSA-N 0.000 description 1
- TWKSFBHDPHIEOI-UHFFFAOYSA-N OP(CNc(ccc1cc(-c2c[nH]cc2)c2)nc1c2-c1c(cccc2)c2ccc1)(O)=O Chemical compound OP(CNc(ccc1cc(-c2c[nH]cc2)c2)nc1c2-c1c(cccc2)c2ccc1)(O)=O TWKSFBHDPHIEOI-UHFFFAOYSA-N 0.000 description 1
- TVZSJHZLCGEPMV-UHFFFAOYSA-N OP(c(ccc1cc(-c2c[nH]cc2)c2)nc1c2-c1cccc2ccccc12)(O)=O Chemical compound OP(c(ccc1cc(-c2c[nH]cc2)c2)nc1c2-c1cccc2ccccc12)(O)=O TVZSJHZLCGEPMV-UHFFFAOYSA-N 0.000 description 1
- BFHMEXQKIZPMEU-UHFFFAOYSA-N [O-][N+](c(cc1cc2)cc(-c3c(cccc4)c4ccc3)c1nc2P(O)(O)=O)=O Chemical compound [O-][N+](c(cc1cc2)cc(-c3c(cccc4)c4ccc3)c1nc2P(O)(O)=O)=O BFHMEXQKIZPMEU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/60—Quinoline or hydrogenated quinoline ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08152046 | 2008-02-28 | ||
| EP08152046.2 | 2008-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20100124732A true KR20100124732A (ko) | 2010-11-29 |
Family
ID=39636965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107019046A Withdrawn KR20100124732A (ko) | 2008-02-28 | 2009-02-26 | 파르네실 피로포스페이트 합성효소의 억제제로서의 퀴놀린 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20120094958A1 (enExample) |
| EP (1) | EP2250152A1 (enExample) |
| JP (1) | JP2011514893A (enExample) |
| KR (1) | KR20100124732A (enExample) |
| CN (1) | CN101959865A (enExample) |
| AU (1) | AU2009218468A1 (enExample) |
| BR (1) | BRPI0908396A2 (enExample) |
| CA (1) | CA2717011A1 (enExample) |
| EA (1) | EA201001362A1 (enExample) |
| MX (1) | MX2010009518A (enExample) |
| WO (1) | WO2009106586A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201171098A1 (ru) * | 2009-03-02 | 2012-04-30 | Сертрис Фармасьютикалз, Инк. | 8-замещенные хинолины и родственные аналоги в качестве модуляторов сиртуина |
| WO2013090929A1 (en) * | 2011-12-15 | 2013-06-20 | Gilead Sciences, Inc. | Amino quinoline derivatives inhibitors of hcv |
| CN104142378B (zh) * | 2014-07-29 | 2015-12-30 | 华南理工大学 | 薄层色谱法半定量测定氨基甲酸乙酯的方法 |
| EP3698797A1 (en) | 2017-10-16 | 2020-08-26 | Tsinghua University | Mevalonic acid pathway inhibitor and pharmaceutical composition thereof |
| CN111440161B (zh) * | 2020-05-15 | 2023-04-14 | 中国药科大学 | 一种具有par4拮抗活性的二环杂芳基类化合物及其应用 |
| CN112980809B (zh) * | 2021-03-17 | 2023-04-11 | 云南中烟工业有限责任公司 | 一种烟草法尼基焦磷酸合酶基因及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5254544A (en) * | 1992-09-25 | 1993-10-19 | E. R. Squibb & Sons, Inc. | Hydroxyphosphinyl phosphonate squalene synthetase inhibitors and method |
| US20020151459A1 (en) * | 2000-02-25 | 2002-10-17 | Merck & Co., Inc. | Methods for identifying compounds useful for inhibiting farnesyl diphosphate synthase |
-
2009
- 2009-02-26 WO PCT/EP2009/052314 patent/WO2009106586A1/en not_active Ceased
- 2009-02-26 EA EA201001362A patent/EA201001362A1/ru unknown
- 2009-02-26 CA CA2717011A patent/CA2717011A1/en not_active Abandoned
- 2009-02-26 EP EP09715302A patent/EP2250152A1/en not_active Withdrawn
- 2009-02-26 JP JP2010548111A patent/JP2011514893A/ja active Pending
- 2009-02-26 KR KR1020107019046A patent/KR20100124732A/ko not_active Withdrawn
- 2009-02-26 US US12/918,880 patent/US20120094958A1/en not_active Abandoned
- 2009-02-26 CN CN2009801064544A patent/CN101959865A/zh active Pending
- 2009-02-26 BR BRPI0908396-0A patent/BRPI0908396A2/pt not_active IP Right Cessation
- 2009-02-26 MX MX2010009518A patent/MX2010009518A/es not_active Application Discontinuation
- 2009-02-26 AU AU2009218468A patent/AU2009218468A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009218468A1 (en) | 2009-09-03 |
| BRPI0908396A2 (pt) | 2019-03-06 |
| US20120094958A1 (en) | 2012-04-19 |
| CN101959865A (zh) | 2011-01-26 |
| EA201001362A1 (ru) | 2011-04-29 |
| JP2011514893A (ja) | 2011-05-12 |
| MX2010009518A (es) | 2010-09-14 |
| WO2009106586A1 (en) | 2009-09-03 |
| EP2250152A1 (en) | 2010-11-17 |
| CA2717011A1 (en) | 2009-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20100827 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |