KR20100111057A - Multilayer film for medical use and the use thereof - Google Patents

Abstract

PURPOSE: A multilayered film for medical treatment and the use of the same are provided to encapsulate a medical solution by preventing a blocking phenomenon which attaches film inner layers while a high temperature sterilization process. CONSTITUTION: A multilayered film for medical treatment(10) includes an outer layer(2), a middle layer(4), and an inner layer(6). The outer layer is based on one polypropylene polymer selected from a group including polypropylene, polypropylene copolymer, and the combination of the same. The middle layer is based on thermoplastic elastomer and one polypropylene polymer selected from a group including polypropylene, polypropylene copolymer, and the combination of the same. The inner layer is based on polyethylene and one polypropylene polymer selected from a group including polypropylene, polypropylene copolymer, and the combination of the same. The polypropylene copolymer is based on the copolymer of propylene and one co-monomer selected from a group including ethylene, alpha-olefin or the combination of the same.

Description

Multilayer Film For Medical Use And The Use

The present invention is transparent, heat resistance, sealing, as well as blocking does not occur between the film inner layer bonding during high-temperature sterilization, as a sap container, medical pouch, contrast agent container and blood container for packaging and administering medical solutions such as fluid or blood The present invention relates to a medical multilayer film applicable, and a use thereof.

The chemical liquid packaging bag is required to have flexibility such as crushability, transparency that can easily observe the state of use of the solution, heat resistance, heat sealability, drop impact resistance, etc., and drug stability that can withstand high temperature sterilization.

Until now, pouches for packaging medical solutions have been the most widely used polyvinyl chloride materials, and polyvinyl chloride has sufficient flexibility to provide excellent physical properties such as transparency, heat resistance, modulus and impact resistance during bag molding. However, a compound such as DEHP, a plasticizer added for this purpose, is harmful to the human body, and polyvinyl chloride is also reluctant to be used as a material harmful to the environment.

In general, in the case of medical containers for packaging the drug solution is heat sterilized for about 20 minutes or more under sterile conditions of about 121 ℃. Therefore, in particular, the film outer layer exposed to the heated water vapor during heat sterilization must have sufficient heat resistance to withstand high temperatures. In addition, the film is often broken and unusable when subjected to impact after being left in a low temperature condition in a container state. Therefore, there is an urgent need to develop a film having both heat resistance and impact resistance that can withstand heat sterilization at the same time, even at low temperatures, and which have high breakage resistance.

In particular, the medical sap bag of the general sap bag is formed by bonding the two layers of the film through the thermal bonding, for this purpose is produced by melting the raw material of the inner layer and sealing under conditions that heat and pressure is applied outside the outer layer.

Thereafter, if a sufficient amount of the chemical is present in the sap container during sterilization, it is not a big problem because there is no adhesion between the inner layers of the film. As a result, a blocking phenomenon occurs. In particular, some sap fillings are often significantly less than the actual bag can fill for further blending. Therefore, there is a need for an infusion container having anti-blocking property (ANTI-BLOCKING) to prevent such blocking.

The antiblocking resistance is distinguished from the heat resistance. In other words, heat resistance is a property necessary to maintain a container form without wrinkle deformation after sterilization treatment, it is a property that can be confirmed through the appearance change. Therefore, the composition design should be made to have an anti-blocking property in addition to the heat resistance when preparing a sap container with a small amount of the liquid solution compared to the contents.

In the case of a multilayer film composed of a multilayer of an inner layer, a middle layer, and an outer layer, it is possible to prepare an infusion container having appropriate physical properties through the compositional design of each layer. In particular, the antiblocking property is most affected by the inner layer composition.

The inner layer of the sap container is a place where the welding (WELDING) is made during the manufacturing of the container is made so that the thermal bonding of the inner layer is made well. Since the inner layer of the fluid container is very easy to block during the high temperature sterilization process because of the easy heat adhesion, it is possible to prevent the blocking phenomenon through controlling the physical properties of the inner layer.

The blocking phenomenon due to the adhesion of the film inner layers during high temperature sterilization occurs when the Tm of the inner layer is low so that the viscous behavior becomes strong at the sterilization temperature (during viscoelastic behavior of the polymer). In addition, even when the raw material having a high Tm has good affinity between the raw materials constituting the inner layer, the surface energy at the interface is small, and this occurs when the inner layers are bonded to each other.

Therefore, in order to prevent the blocking phenomenon, it is preferable to design the inner layer with a material having a high Tm so as to have appropriate thermal resistance during contact between the inner layer films at high temperature sterilization. In addition to the heat resistance, the inner layer composition should be designed to facilitate thermal bonding for bag molding.

In general, the outer layer of the multilayer film has heat resistance at the back forming temperature, so it should not stick to the equipment during molding or leak or pinhole due to the deformation of the film. Will be used.

Therefore, in order for the sap container to have proper anti-blocking property, a raw material having a high Tm in the inner layer is basically used, but a larger Tm difference between the inner layer and the outer layer is advantageous to enable thermal adhesion.

However, in terms of drug stability, materials that can be used for medical sap bags are very limited. In particular, since the inner layer is in direct contact with the chemical solution, the drug stability is more important, and since the polyolefin-based material, which has been widely verified in terms of drug stability, is mainly used, there is a limit to largely controlling the difference between the outer layer and the inner layer. Therefore, the main component in the inner layer of the polyolefin resin is based on polypropylene having excellent Tm, but in the case of raw materials such as elastomers, the lower Tm is likely to cause blocking, so it is not used for the inner layer. In addition, in the case of the middle layer, a certain amount of the elastic body is used for impact resistance of the container, but if used more than that may affect the blocking.

In order to solve the above problems, the present invention is to provide a medical multilayer film that the multilayer film does not occur transparency, heat resistance, sealing properties as well as blocking phenomenon that the film inner layers are bonded during high temperature sterilization.

Another object of the present invention is to provide a fluid container, a medical pouch, a contrast agent container and a blood container for packaging and administering a medical solution such as a sap or blood, including the medical multilayer film.

In order to achieve the above object,

An outer layer comprising one polypropylene polymer selected from the group consisting of polypropylene, polypropylene copolymers, and combinations thereof;

A middle layer comprising 50 to 70 wt% of a polypropylene polymer and 30 to 50 wt% of a thermoplastic elastomer selected from the group consisting of polypropylene, polypropylene copolymer, and combinations thereof; And

Inner layer comprising 95 to 99.9 weight percent of one polypropylene polymer selected from the group consisting of polypropylene, polypropylene copolymer, and combinations thereof, and 0.1 to 5 weight percent polyethylene

It provides a medical multilayer film comprising a.

In addition, the present invention provides a fluid container, characterized in that it comprises the medical multilayer film.

In addition, the present invention provides a medical pouch comprising the medical multilayer film.

In addition, the present invention provides a contrast agent container comprising the medical multilayer film.

In another aspect, the present invention provides a blood container comprising the medical multilayer film.

The multilayer film does not have transparency, heat resistance, sealing properties, or blocking phenomenon in which film inner layers adhere to each other during high temperature sterilization. Such a multilayer film can be applied as a fluid container, a medical pouch, a contrast agent container, and a blood container for packaging and administering a medical solution such as a sap or blood, and the manufactured container is useful for various medical industries due to its excellent cost competitiveness. do.

Hereinafter, the present invention will be described in more detail with reference to the drawings.

It is preferable to understand that the shape and the like of the elements in each drawing are exaggerated in order to emphasize a more clear description. In this case, elements denoted by the same reference numerals in the drawings mean the same elements. In addition, where a layer is described as being "on" another layer, the layer may exist in direct contact with the other layer, or a third layer may be interposed therebetween. In one example, the multilayer film may include any additional layer, such as an adhesive layer, a water vapor barrier layer, a gas barrier layer.

1 is a cross-sectional view showing a multilayer film according to an embodiment of the present invention.

Referring to FIG. 1, the medical multilayer film 10 according to the present invention is composed of an outer layer 2, a middle layer 4, and an inner layer 6.

The outer layer 2 protects the entire film and ensures proper physical properties to enable printing on its surface. That is, even if the inner layer is bonded, it should not affect the workability, so proper printability and heat resistance are required, and the composition design is made to ensure the container quality and to be suitable for the high speed process.

The material of this outer layer 2 includes one polypropylene polymer selected from the group consisting of polypropylene, polypropylene copolymer, and combinations thereof, and preferably, polypropylene is used.

As used herein, the term 'polypropylene' is made using only propylene monomers, and includes all polypropylenes having isotactic, syndiotactic, and atactic structures. Preferably, a melt index (based on ASTM D1238) of 7 to 9 g / 10 minutes, a density of 0.85 to 0.95 and a softening point of 145 to 165 캜 are used.

As used herein, the term 'polypropylene copolymer' means a copolymer containing propylene as a main component and comonomer contained in a specific ratio. Typically, polypropylene copolymers include propylene-ethylene copolymers containing propylene as a main component and ethylene contained as a comonomer; A propylene-ethylene-alpha olefin copolymer containing propylene as a main component and containing ethylene and at least one alpha olefin as a comonomer is possible. In this case, the alpha olefin is a hydrocarbon having 3 to 12 carbon atoms, for example, 1-butene, 1-pentene, 1-hexene, 4-methyl-1-pentene, 1-heptene, 1-octene, 1-nonene, 1-decene , 1-undecene and 1-dodecene, and combinations thereof are possible.

Such polypropylene copolymer may be in the form of a random copolymer, a block copolymer or a graft copolymer, and may be appropriately selected and used depending on the intended use. Moreover, also in the physical property, what has a range similar to the physical property of the said polypropylene is used.

The middle layer 4 is a layer containing a high amount of thermoplastic elastomer to secure flexibility and absorb shock, and particularly, it is advantageous to secure excellent drop impact resistance.

The material of the middle layer (4) includes a polypropylene polymer and a thermoplastic elastomer selected from the group consisting of polypropylene, polypropylene copolymer, and combinations thereof, and control the content of each composition for cost competitiveness do.

The polypropylene and polypropylene copolymers follow those mentioned in the outer layer 12. Preferably, the polypropylene copolymer is a random copolymer, and more preferably, the polypropylene copolymer has a melt index (based on ASTM D1238) of 6.5 to 8.5 g / 10 minutes and a density of 0.85 to 0.95. And a melting point of 120 to 140 占 폚 and a softening point of 105 to 125 占 폚 are used.

As used herein, 'thermoplastic elastomer' means a styrene-based elastomer, preferably a hydrogenated styrene-based elastomer.

Thermoplastic elastomers can have many advantages over the physical properties of the multilayer film 10 by having a wide flexibility range and good restoring force. As such, the middle layer 4 according to the present invention adjusts the modulus of the multilayer film 10 by the content of the thermoplastic elastomer. In addition, in order to ensure flexibility with a thickness of about 60 to 94% with respect to the entire multilayer film 10, the content of the thermoplastic elastomer is a saturated type having excellent heat resistance while maintaining an appropriate amount and 30 to 50% by weight. Limited to thermoplastic styrene elastomers.

The thermoplastic elastomers that can be used can be any saturated hydrogenated double bond of an unsaturated thermoplastic elastomer, typically hydrogenated SIBS (styrene-isoprene-butadiene block copolymer), hydrogenated SBS (styrene- Butadiene-styrene copolymer), SIS (styrene-isoprene-styrene copolymer), hydrogenated SEBS (styrene-ethylene-butadiene block copolymer), hydrogenated SEPS (styrene-ethylene-propylene block copolymer), hydrogenated SEEPS (styrene-ethylene -Ethylene-propylene block copolymer), hydrogenated SBC (styrene-butadiene block copolymer), hydrogenated SBPS (styrene-ethylene-propylene-styrene copolymer), and a combination thereof. Uses hydrogenated SEBS.

The thermoplastic elastomer has a specific gravity of 0.85 to 0.95, a melt index (based on ASTM D1238) of 1 to 3 g / 10 minutes, and a 100% modulus of 0.5 to 0.7.

Such polypropylene-based polymers and thermoplastic elastomers are used by adjusting their content in consideration of their role and function as the intermediate layer 4. Preferably from 50 to 70% by weight of polypropylene polymer and from 30 to 50% by weight of thermoplastic elastomer. If the content of the polypropylene polymer is excessive, there is a problem that the flexibility is lowered, on the contrary, if the content of the thermoplastic elastomer is excessive, it is impossible to secure proper thermal stability.

The inner layer 6 is a layer which exists in the surface which the chemical liquid directly contacts, and in particular, in the present invention, the composition of the inner layer 6 is specified to secure antiblocking properties.

When one type of raw material is used for the inner layer 6, a blocking phenomenon tends to occur because the compatibility between the raw materials is high and the surface energy on the film surface is lowered. This prevents the blocking phenomenon by adding a different raw material from the basic raw material of the inner layer (6). For example, in addition to the polyolefin-based polymer that is typically used as the material of the inner layer 6, an inorganic material may be added to prevent the blocking phenomenon. In this case, the anti-blocking property is due to the low compatibility between the polyolefin-based polymer and the inorganic material. It can be sufficiently secured but the problem that the chemical stability is greatly reduced.

Accordingly, in the present invention, the material of the inner layer 6 includes anti-polypropylene, polypropylene copolymer, and 95-99.9% by weight of one polypropylene polymer selected from the group consisting of a combination thereof and 0.1-5% by weight of polyethylene. Both blocking and chemical stability can be secured.

This content range is to ensure the physical properties for performing the function as the inner layer 6 as described above, outside this range it is not possible to sufficiently secure the effects of the above.

Particularly, polyethylene, which is one of the components of the inner layer 6, is a component that makes the multilayer film have antiblocking property. If the content is less than the above range, it is difficult to realize antiblocking property. It leads to degradation.

At this time, the polypropylene and the polypropylene copolymer used for the inner layer 6 follow the above description.

Preferably, the polypropylene copolymer is a random copolymer, more preferably 6.5 to 8.5 g / 10 minutes, density 0.85 to 0.95, melting point 120 to 140 with a melt index (based on ASTM D1238). The thing of 110 degreeC-130 degreeC and softening point is used.

The polyethylene can be any known polyethylene form, including low density polyethylene (LDPE), linear low density polyethylene (LLDPE), high density polyethylene (HDPE), ultra high density polyethylene (VLDPE) and copolymers with alphaolefins, preferably high density polyethylene. Use

More preferably, the polyethylene has a melt index (based on ASTM D1238) of 2 to 4 g / 10 minutes, a density of 0.8 to 1.0, and a melting point of 120 to 140 ° C. Most preferably, the polyethylene uses high density polyethylene.

The multilayer film 10 composed of the outer layer 2 / the middle layer 4 / the inner layer 6 as described above can be used in any or all layers of the multilayers of the present invention if desired. The additives are not limited in the present invention, and known additives used in the art may be used, and examples thereof include antioxidants, anti-sticking agents, processing aids, pigments, antistatic agents, and the like. At this time, the content of the additive is preferably kept in a minimum amount in order to minimize the extraction into the medical solution during the heat-sterilization.

Multi-layer film 10 according to the present invention is produced by adjusting the thickness of each layer to have a proper physical properties and can be applied to medical containers. Preferably, the outer layer is 3-20% of the total thickness, the middle layer is 60-94%, and the inner layer is 3-20%. Specifically, the thickness of the outer layer 2 is 5 to 60 µm, the thickness of the middle layer 4 is preferably 110 to 250 µm, and the thickness of the inner layer 6 is 5 to 60 µm. If the thickness of each layer is less than the above range, the effect to be obtained through the configuration of each layer may not be sufficiently secured. For example, in the case of the outer layer 12, the heat resistance is lowered if the thickness is less than the thickness. On the contrary, if the outer layer 12 is exceeded, the flexibility of the entire film is lowered and the heat sealability is lowered.

In addition, the multilayer film 10 according to the present invention basically performs adhesion at a temperature slightly lower than the melting point of the material used.

That is, melting | fusing point of the outer layer 2 is 145-165 degreeC, the intermediate | middle layer 4 is 140-155 degreeC, and the inner layer 6 has the range of 125-140 degreeC.

Medical multilayer film according to the present invention is not particularly limited in the present invention, it can be produced using a method known in the art.

Representatively, the multilayer film is capable of co-extrusion and lamination of the film and the film.

The co-extrusion method is a method of melting two or more different raw materials in different extruders to send the molten resin into a die, stacking them in multiple layers, and cooling the multilayered raw materials in various ways. The coextrusion method can form a resin extrudate of constant thickness with improved efficiency, and there is little deterioration of the resin during extrusion, and as a result, the layers maintain their respective properties to obtain a product having high transparency and flexibility. There is an advantage to that. The coextrusion method is divided into an inflation method using a circular die and a T-die method using a flat die. The inflation method is used in terms of managing cleanliness of the film, and the T-die method is used in securing thickness uniformity. useful.

The production of the multilayer film by coextrusion is carried out at 170 to 250 ° C, preferably at 200 to 230 ° C. In this case, it is preferable that the resin forming each resin has a small difference in melt flow rate (MFR) therebetween in order to make thickness and extrudability uniform.

The multilayer film thus prepared has suitable haze properties, heat adhesive strength, tensile strength, modulus and elongation as well as the physical properties as described above for use as a medical container. Preferably, the multilayer film has a thickness (ASTM D 882) of 180 to 250㎛, haze after sterilization (ASTM D 1003) is 15% or less, tensile strength (ASTM 882) is 250 kgf / cm 2 or more, Modulus (ASTM D 882) is 1600-2300 kgf / cm2, elongation (ASTM 882) is 900% or more. In addition, it has antiblocking property in which no blocking phenomenon occurs during high temperature sterilization.

The multilayer film according to the invention is applicable to monobag or multichamber bag medical containers for general infusion products.

Especially, in case of small amount of product (100mL or less) or sap product for the purpose of mixing, small amount of chemical solution is added (e.g. 500mL in 1000mL volume) compared to the contents, so the film sticks to each other during sterilization. This occurs, so antiblocking property is necessary. Accordingly, the multilayer film according to the present invention has excellent anti-blocking property and at the same time can maintain sealing property in the case of heat-adhesive part during container molding, and at the same time, cost competitiveness can be achieved due to the use of appropriate raw materials.

Medical multilayer film according to the present invention can be used as an inner bag (inner bag) of the double bag for the sap packaging, sap containers, medical pouches, contrast agent containers, or for packaging and administering medical solutions such as various sap or blood It can be applied as a blood container.

Hereinafter, preferred examples and experimental examples of the present invention are presented. However, the following examples are only preferable examples of the present invention, and the present invention is not limited to these examples.

Examples 1-3 and Comparative Examples 1-5

To prepare a multilayer film using the extrusion method in the composition of Table 1. At this time, in order to maintain the cleanliness of the film, all the work is carried out in a clean room, and the water-cooling was manufactured by cooling the co-extrusion top-down inflation film machine. In the molding method, a raw material was melted by an extruder, and a film made into a cylindrical tube shape by blowing air through a die was formed by passing through a roller. The thickness of the outer layer / middle layer / inner layer of the produced multilayer film was 20 micrometers / 160 micrometers / 20 micrometers.

Outer layer Middle layer Inner layer HOMO PP ¹⁾ PP ²⁾ SEBS ³⁾ PP ⁴⁾ PE ⁵⁾ SiO ₂ Example 1 100 wt% 70 wt% 30 wt% 99.7 wt% 0.3 wt% - Example 2 100 wt% 70 wt% 30 wt% 99.0 wt% 1.0 wt% - Example 3 100 wt% 70 wt% 30 wt% 97.0 wt% 3.0 wt% - Example 4 100 wt% 70 wt% 30 wt% 95.0 wt% 5.0 wt% - Comparative Example 1 100 wt% 70 wt% 30 wt% 100 wt% - - Comparative Example 2 100 wt% 70 wt% 30 wt% 90 wt% 10 wt% - Comparative Example 3 100 wt% 70 wt% 30 wt% 80 wt% 20 wt% - Comparative Example 4 100 wt% 70 wt% 30 wt% 99.8 wt% - 0.2 wt% Comparative Example 5 100 wt% 70 wt% 30 wt% 99.3 wt% - 0.7 wt%

1) HOMO PP: Melt Index 8 g / 10min, Density 0.90, Softening Point 150 ℃, Honam Petrochemical Products

2) Propylene-ethylene-butene terpolymer: melt index 7.0 g / 10 min, density 0.90, melting point 125 ° C, softening point 110 ° C, SK Chemicals

3) SEBS: specific gravity 0.90, melt index 2 g / 10 min, 100% modulus 0.6 MPa, KRATON

4) Propylene-ethylene-butene terpolymer: melt index 7.0 g / 10 min, density 0.90, melting point 130 ℃, softening point 115 ℃, Honam Petrochemical Products

5) PE: Melt index 3 g / 10min, density 0.95, melting point 135 ° C, Korea Emulsified Product

Experimental Example 1

The haze property, sealing property, bag workability, film workability, and antiblocking property of the multilayer films produced in the above Examples and Comparative Examples were measured.

Haze was measured according to ASTM D 1003.

The antiblocking property was checked after the three-side sealing of the film (100 X 120 mm), filled with 50 mL of distilled water, after sealing the remaining one side at 121 ° C., and 30 minutes of high temperature steam sterilization. The assessment was based on the following:

Good: No blocking or fine blocking

Moderate: Blocking exists but spreads due to chemical pressure

Insufficient: Blocking exists and does not open even when pressed.

Not available: Products are too bad blocking

The bag workability (sealing property) was good: 10 degreeC or more of the temperature range which can be back-molded, and normal: 5-10 degreeC of temperature range which can be back-molded, and insufficient: The temperature range which can be back-molded was confirmed on the basis of 5 degrees C or less.

Film processability is good: film molding and film winding good, poor: After the film molding and film molding, the winding was confirmed on the basis of difficulty.

Haze after sterilization (%) Anti blocking property Machinability Film processability Example 1 7.9 Good usually Good Example 2 6.6 Good usually Good Example 3 8.9 Good Good Good Example 4 11.7 Good Good Good Comparative Example 1 8.2 Inadequate Inadequate Good Comparative Example 2 13.4 Inadequate Good Good Comparative Example 3 13.4 Impossible Good Good Comparative Example 4 7.8 Good Inadequate Inadequate Comparative Example 5 8.6 Good Inadequate Inadequate

Referring to Table 2, the multilayer films of Examples 1 to 4 according to the present invention showed excellent results in all properties.

In comparison, in the anti-blocking property, the multilayer film of Comparative Example 1 was insufficient due to the compatibility between PPs, and the multilayer films of Comparative Examples 2 and 3 exhibited high viscosity of PE at low sterilization temperature (polymer viscoelastic behavior). Medium) The viscous behavior became stronger, indicating insufficient results.

In the back workability, the multilayer film of Comparative Example 1 had a high inner layer Tm and had insufficient sealing property, and the multilayer films of Comparative Examples 4 and 5 had insufficient sealing property due to the addition of SiO ₂ to the inner layer.

In addition, in the film processability, the multilayer films of Comparative Examples 4 and 5 exhibited difficulty in winding due to too high antiblocking property between films due to SiO ₂ addition.

The medical multilayer film according to the present invention can be used as an infusion container, medical pouch, contrast medium container, or blood container.

1 is a cross-sectional view showing a multilayer film according to an embodiment of the present invention.

Claims (11)

An outer layer comprising one polypropylene polymer selected from the group consisting of polypropylene, polypropylene copolymers, and combinations thereof; A middle layer comprising 50 to 70 wt% of a polypropylene polymer and 30 to 50 wt% of a thermoplastic elastomer selected from the group consisting of polypropylene, polypropylene copolymer, and combinations thereof; And Inner layer comprising 95 to 99.9 weight percent of one polypropylene polymer selected from the group consisting of polypropylene, polypropylene copolymer, and combinations thereof, and 0.1 to 5 weight percent polyethylene Medical multilayer film comprising a. The method of claim 1, The polypropylene copolymer is a medical multilayer film, characterized in that the copolymer (propylene) of propylene, propylene, propylene, one comonomer selected from the group consisting of a combination thereof. The method of claim 1, The polyethylene is a medical multilayer film, characterized in that the copolymer of ethylene and an alpha olefin. The method according to claim 2 or 3, The alphaolefin is 1-butene, 1-pentene, 1-hexene, 4-methyl-1-pentene, 1-heptene, 1-octene, 1-nonene, 1-decene, 1-undecene, 1-dodecene, And one kind selected from the group consisting of a combination thereof. The method of claim 1, The thermoplastic elastomer includes hydrogenated SIBS (styrene-isoprene-butadiene block copolymer), hydrogenated SBS (styrene-butadiene-styrene copolymer), hydrogenated SIS (styrene-isoprene-styrene copolymer), hydrogenated SEBS (styrene-ethylene-butadiene Block copolymer), hydrogenated SEPS (styrene-ethylene-propylene block copolymer), hydrogenated SEEPS (styrene-ethylene-ethylene-propylene block copolymer), hydrogenated SBC (styrene-butadiene block copolymer), hydrogenated SBPS (styrene-ethylene -Propylene-styrene copolymer), and a combination of any one selected from the group consisting of medical multilayer film. The method of claim 1, A medical multilayer film having a thickness of 3-20% of an outer layer, 60-94% of a middle layer, and 3-20% of an inner layer with respect to the total thickness of the multilayer film. The method of claim 1, The multilayer film has a melting point of 145 to 165 ° C of the outer layer, a melting point of 140 to 155 ° C of the middle layer, and a melting point of the inner layer of 125 to 140 ° C. An infusion container comprising the medical multilayer film of claim 1. Medical pouch comprising the medical multilayer film of claim 1 Contrast agent container comprising the medical multilayer film of claim 1 A blood container comprising the medical multilayer film of claim 1

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