KR102246313B1 - Multi-layered film for fluid bag, method for preparing the same and fluid bag including the same - Google Patents

Abstract

Provided are a multilayer film for an IV bag in which at least one layer of the multilayer film is applied with a cyclic olefin polymer, a method for manufacturing the same, and an IV bag including the same. The multilayer film for the IV bag effectively blocks oxygen and moisture, has UV resistance, and in particular, secures transparency after high-temperature and high-pressure sterilization. Also, the multilayer film does not require the use of an outer pouch because there is no peeling of the film and reduction in barrier properties due to folding and a whitening phenomenon.

Description

Multi-layered film for infusion container and method for manufacturing the same, infusion container including the same {Multi-layered film for fluid bag, method for preparing the same and fluid bag including the same}

The present specification relates to a multilayer film that can be applied to an infusion container commonly referred to as an infusion bag, a method of manufacturing the same, and an infusion container including the same.

More specifically, it has resistance to UV, moisture, and gas such as oxygen flowing into the infusion container from the outside, does not require the use of a separate external pouch, and can be applied in various ways to single and multi-chamber infusion containers. It relates to a multilayer film for a container, a method of manufacturing the same, and an infusion container including the same.

In the case of a conventional PVC-based medical infusion bag, there is an environmental problem, so a non-PVC-based infusion bag is required.

Accordingly, the existing film for non-PVC-based infusion bag is required for properties such as barrier properties against oxygen or moisture, and has been mainly developed in a polyolefin-based multilayer structure.

However, in most cases, when high-temperature and high-pressure sterilization (121° C., about 30 minutes), heat resistance is lowered to cause whitening, and there is still a need for improvement due to interlayer delamination due to insufficient interlayer adhesion and poor appearance during molding.

In order to improve the above problem, an infusion bag made of a film composed of an inorganic oxide deposited film, nylon, or polyolefin is being studied. However, if folding occurs repeatedly before or after sterilization or during use, the barrier layer film is damaged and the gas barrier property is remarkable. There is a problem of falling.

In order to solve this problem, there is a case where the infusion bag is sealed using a separate outer pouch or a secondary pouch for high-temperature sterilization, which increases the manufacturing cost and increases transparency due to the use of a separate pouch outside the inner pouch. In addition to this deterioration, there are many problems, such as the inability to recycle due to the barrier component and aluminum used in the outer pouch.

Korean Registered Patent No. 1107963 Publication

In exemplary embodiments of the present invention, in one aspect, it effectively blocks oxygen and moisture penetrating into the sap bag from the outside, has UV resistance, and is particularly capable of securing transparency after high temperature and high pressure sterilization, and whitening and folding It is intended to provide a multilayer film for an infusion container and a method for manufacturing the same, and an infusion container including the same, without reducing the barrier property and peeling off the film.

In exemplary embodiments of the present invention, in another aspect, it is intended to provide a multilayer film for an external pouch-free infusion container that does not require the use of an external pouch, a method of manufacturing the same, and an infusion container including the same.

In exemplary embodiments of the present invention, in the multilayer film for an infusion container, a multilayer film for an infusion container is provided, in which at least one layer of the multilayer film contains a cyclic olefin polymer.

In exemplary embodiments of the present invention, in the method of manufacturing a multilayer film for an infusion container, a method for producing a multilayer film for an infusion container is provided to include a cyclic olefin polymer in at least one layer when the multilayer film is manufactured. do.

Exemplary embodiments of the present invention also provide an infusion container made of the multilayer film described above.

In the multilayer film of exemplary embodiments of the present invention, unlike the conventional multilayer film having problems such as moisture, oxygen, UV blocking, whitening after high pressure sterilization, peeling due to folding, etc., at least one layer of the multilayer film By applying a cyclic olefin polymer, it is possible to have high barrier properties against oxygen and moisture and UV resistance. In addition, the multilayer film according to exemplary embodiments of the present invention has no delamination due to whitening and folding due to high temperature and high pressure sterilization.

In particular, the multilayer film according to exemplary embodiments of the present invention may have sufficient high barrier properties, UV resistance, and Gamma-ray resistance without the use of an outer pouch or a secondary pouch according to the use of a cyclic olefin polymer.

The multilayer film of the exemplary embodiments of the present invention may be used not only as a medical infusion container for administering a drug, but also in other special medical containers, such as a peritoneal dialysis bag and a surgical decompression infusion bag.

1A to 1G are cross-sectional views of multilayer films according to exemplary embodiments of the present invention.
2 is a schematic diagram of a medical multi-chamber infusion bag to which a multilayer film is applied according to an exemplary embodiment of the present invention.
3 is a schematic diagram of a medical single-chamber infusion bag to which a multilayer film is applied according to another exemplary embodiment of the present invention.

In the present specification, the outer pouch or the secondary pouch means a pouch that is additionally used on the outside of a bag containing a sap.

In the present specification, the external pouch free means that the use of a separate external pouch is not required. That is, after high-temperature sterilization treatment, there is no problem of whitening, peeling due to folding, moisture, gas barrier properties, etc., so that a separate external pouch for moisture and gas barrier is not required.

In the present specification, the single chamber means that the chamber containing the infusion solution in the infusion bag is a single chamber.

In the present specification, the multi-chamber means that there are a plurality of chambers that contain the infusion solution of the infusion bag.

In the present specification, the cyclic olefin polymer-containing layer refers to a layer consisting of a cyclic olefin polymer alone or a layer including a cyclic olefin polymer in the layer composition.

In the present specification, COP is an abbreviation for cyclic olefin polymer.

In the present specification, COC is an abbreviation of cyclic olefin copolymer.

In the present specification, CBC is an abbreviation of cyclic block copolymer.

In the present specification, the melt index is a melt index measured according to ASTM: D1238 at 230°C /2.16kg.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.

Multilayer film for infusion container and its manufacturing method

In exemplary embodiments of the present invention, in the multilayer film for an infusion container, a cyclic olefin polymer is included in at least one layer of the multilayer film, providing a multilayer film for an infusion container.

In an exemplary embodiment, the multilayer film may be composed of a cyclic olefin polymer alone or may include a cyclic olefin polymer-containing layer including a cyclic olefin polymer.

1A to 1G are cross-sectional views of multilayer films according to exemplary embodiments of the present invention.

As shown in Figure 1a, in an exemplary embodiment, the multilayer film is a five-layer film, the outer layer 100, the first adhesive layer 200, the intermediate layer 300, the second adhesive layer 400 and the inner The layers 500 may be sequentially included. Here, the outer layer may be a cyclyl olefin-containing layer including a cyclic olefin polymer.

As shown in FIGS. 1B to 1G, in another exemplary embodiment, the multilayer film may be formed between the outer layer 100 and the first adhesive layer 200; Or between the inner layer 500 and the second adhesive layer 400; Alternatively, one or more insertion layers 110, 120, 510, and 520 may be further included between the outer layer 100 and the first adhesive layer 200 and between the inner layer 500 and the second adhesive layer 400.

Specifically, in a non-limiting example, the multilayer film is a six-layer film, and the outer layer 100, the first insertion layer 110, the first adhesive layer 200, the intermediate layer 300, and the second adhesive layer 400 And an inner layer 500 (see FIG. 1B). Or, in a non-limiting example, the multilayer film is a seven-layer film, and the outer layer 100, the first insert layer 110, the second insert layer 120, the first adhesive layer 200, and the intermediate layer 300 , It may include a second adhesive layer 400 and an inner layer 500 (see FIG. 1C).

In the above, the first insertion layer 110 may be a cyclic olefin polymer-containing layer composed of cyclic olefin polymer alone. In the case of a single layer consisting of a cyclic olefin polymer alone, the thickness range may be 50 μm to 120 μm. If the thickness is less than 50 μm, there may be problems in physical properties (tensile, elongation) and barrier performance, and if the thickness is more than 120 μm, it may be disadvantageous in terms of economy.

In another non-limiting example, the multilayer film is a six-layer film, and includes an outer layer 100, a first adhesive layer 200, an intermediate layer 300, a second adhesive layer 400, a third insert layer 510, and an inner layer. It may include a layer 500 (see FIG. 1D). Or, in a non-limiting example, the multilayer film is a seven-layer film, the outer layer 100, the first adhesive layer 200, the intermediate layer 300, the second adhesive layer 400, the fourth insertion layer 520, It may include a third insertion layer 510 and an inner layer 500 (see FIG. 1E).

In the above, the third insertion layer 510 may be a cyclic olefin polymer-containing layer composed of cyclic olefin polymer alone. Here, in the case of a single layer composed of a cyclic olefin polymer alone, the thickness range may be 50 μm to 120 μm. If the thickness is less than 50 μm, there may be problems in physical properties (tension, elongation) and barrier performance, and if the thickness is more than 120 μm, it may be disadvantageous in terms of economy.

In another non-limiting example, the multilayer film is a seven-layer film, and includes an outer layer 100, a first insertion layer 110, a first adhesive layer 200, an intermediate layer 300, and a second adhesive layer 400, It may include a third insertion layer 510 and an inner layer 500 (see FIG. 1F). Here, the first insertion layer 110 and the third insertion layer 510 may be a cyclic olefin polymer-containing layer composed of a cyclic olefin polymer alone.

In another non-limiting example, the multilayer film is a 9-layer film, and includes an outer layer 100, a first insert layer 110, a second insert layer 120, a first adhesive layer 200, and an intermediate layer 300. , It may include a second adhesive layer 400, a fourth insertion layer 520, a third insertion layer 510, and an inner layer 500 (see FIG. 1G). Here, the first insertion layer 110 and the third insertion layer 510 may be a cyclic olefin polymer-containing layer composed of a cyclic olefin polymer alone.

In an exemplary embodiment, in the case of including a cyclic olefin polymer as part of the layer composition in the multilayer film, the cyclic olefin polymer is 30 to 40 parts by weight, preferably 50 to 60 parts by weight based on 100 parts by weight of the total composition component of the layer. It may be included in parts, or 70 to 80 parts by weight.

Cyclic olefin polymers are made of ethylene and cyclic olefins, which are hardly toxic compared to other plastic materials, so they are not only advantageous for environmental problems, but also have high transparency and low light transmittance of 90% or more, which is the same level as PMMA or PC. It can exhibit excellent optical properties such as a level of refractive index (1.51~1.54) and birefringence (20~25nm). It also has excellent thermal properties, small deformation in extrusion, injection, and blow molding, and excellent moldability.

In an exemplary embodiment, the cyclic olefin polymer may have a melt index (melt index measured according to ASTM: D1238 at 230° C. /2.16kg) of 1 to 3 g/10 minutes. If the melt index is out of the range, appearance defects and interlayer adhesion may be unstable during molding.

In addition, the cyclic olefin polymer may have a density of 0.94 to 1.05 g/cm 3. If it is out of the density range, there may be a problem in molding due to insufficient compatibility during film production.

In an exemplary embodiment, as the cyclic olefin polymer, TOPAZ of Polyplastics of Japan, Zeonex of Zeon of Japan, Arton of JSR of Japan, Zelas of Mitsubishi of Japan, Vivion of USI of Taiwan, Apel of Mitsui of Japan, etc. may be used.

In a non-limiting example, the cyclic olefin polymer is particularly preferably a cyclic block copolymer. That is, the cyclic block copolymer (CBC) is superior to other cyclic olefin polymers and cyclic olefin copolymers in terms of processability and heat adhesion when blended with polypropylene. In addition, it has excellent transmittance (92%), excellent thermal stability, and good mechanical properties, and can secure excellent UV resistance and disinfection and stability against gamma, E-beam, and ETO.

Each layer is described in more detail below.

Since the outer layer 100 has to adhere the inner layer by heat transfer without surface defects during water blocking, UV resistance, and heat sealing, the content of the propylene component must be high. The layer 500 and the intermediate layer 300 must have a higher melting point and better heat resistance than the resin composition. In addition, the outer layer 100 must have a higher melting point than the sealing temperature of the inner layer 500 so that no change occurs.

In a non-limiting example, the melting point of the outer layer 100 may be 148 to 170°C.

In a non-limiting example, the outer layer is 50 to 99% by weight of at least one polypropylene polymer selected from the group consisting of propylene homopolymer and propylene-based alpha olefin copolymer, and styrene-ethylene-butylene-styrene copolymer 1 It may be composed of ∼50% by weight. When the polypropylene polymer is applied at less than 50%, the film's rigidity is lowered, so it is easy to deform due to heat when it is used. If the styrene-ethylene-butylene-styrene copolymer is more than 50%, it will be applied to the outer pouch when sterilized at 121℃ at high temperature. Sticking may occur.

In a non-limiting example, the outer layer 100 has a melt index (melt index measured according to ASTM: D1238 at 230°C /2.16kg) of 1 to protect the surface while increasing the adhesion of the inner surface during thermal bonding. It is preferably 7.0 g/10min. If the melt index is out of the range, appearance defects and molding stability may deteriorate during molding.

The intermediate layer 300 is the most important element of oxygen barrier property, and should not have whitening phenomenon during high temperature and high pressure sterilization.

To this end, the intermediate layer 300 may include ethylene vinyl alcohol (EVOH) or polyketone (POLY-KETONE). In this way, ethylene vinyl alcohol (EVOH) or polyketone (POLY-KETONE) can be used to effectively block gases such as oxygen, and in this respect, the intermediate layer 300 is 100% by weight of ethylene vinyl alcohol (EVOH) or polyketone. (POLY-KETONE) It is preferably composed of 100% by weight.

In a non-limiting example, the melting point of the intermediate layer 300 may be 160 to 190°C.

In a non-limiting example, the ethylene vinyl alcohol (EVOH) may be a retort grade capable of sterilizing for 30 minutes at a high temperature of 121°C.

In a non-limiting example, ethylene vinyl alcohol (EVOH) has a melt index (melt index measured according to ASTM: D1238 at 230° C./2.16 kg) of 3 to 9 g/10 min, and a density of 0.98 to 1.25 g/cm 3 I can.

In addition, the polyketone (POLY-KETONE) may also be a retort grade capable of sterilizing at a high temperature of 121° C. for 30 minutes.

The inner layer 500 is a portion where medicines come into contact with each other and when the infusion container is sealed, the inner layer 500 has a lower melting point than other layers of the multilayer film. That is, the inner layer secures heat sealing properties and chemical stability properties, and during heat bonding, the melting point of the inner layer is lower than that of the intermediate layer and the outer layer, so that the inner layer must be melted and sealed.

In a non-limiting example, the melting point of the inner layer 500 may be 130 to 145°C. If the melting point is less than 130°C, smooth sealing may be insufficient when manufacturing the infusion container.

In an exemplary embodiment, the inner layer 500 preferably has a melt index (melt index measured according to ASTM: D1238 at 230° C. /2.16 kg) of 2.0 to 9.0 g/10 minutes. If the melt index is out of the range, appearance defects and interlayer peeling may occur due to the difference in melt index during molding.

In an exemplary embodiment, the inner layer 500 may be composed of a matrix polymer and a face polymer.

Examples of the matrix polymer include propylene-based alpha olefin copolymers (e.g., Vassell's Pro-fax, Borealis' Daplov, ExxonMobil's PP3505GE1, etc.), polyethylene, polyethylene copolymers, polypropylene homopolymers, and polypropylene. Polymers having a high melting temperature range, such as propylene copolymers, can be used. Among these, polypropylene polymers, in particular polypropylene random copolymers and polypropene random terpolymers, are preferred.

Examples of the face polymer include styrene ethylene/butylene styrene block polymer (SEBS), styrene ethylene/butylene styrene triblock polymer (SEBS) having a styrene ethylene/butylene diblock (SEB) component, and styrene ethylene propylene block copolymer ( SEEPS), styrene ethylene (SIS)/ ethylene vinyl acetate copolymer (EVA), ethylene terpolymer, ethylene-propylene heteropolymer rubber (Ethylene-Propylene-Diene-Rubber-Mixture: EPDM), or ethylene α-olefin copolymer Such as, polyolefin elastomer (POE) having a low melting point and the like can be used.

In a non-limiting example, the inner layer is 50 to 80% by weight, preferably 60 to 80% by weight of at least one polypropylene polymer selected from the group consisting of a propylene-based alpha-olefin copolymer and a polypropylene random copolymer containing propylene as a main component. Wt%, and more preferably 65 to 75 wt%; 5-20 weight of one or more components selected from the group consisting of ethylene vinyl acetate copolymer (EVA), ethylene terpolymer, ethylene-propylene heteropolymer rubber (EPDM), polyolefin elastomer (POE), and olefin block copolymer (OBC) %, preferably 10 to 20% by weight, more preferably 13 to 17% by weight; And styrene-ethylene-butylene-styrene copolymer 10 to 30% by weight, preferably 10 to 20% by weight, more preferably 13 to 17% by weight; may be composed of. If it is out of the above composition range, the Easy-Peel between the films and sealing with the port and the tube are not sufficiently performed, and thus defects may occur during use after bag molding.

In a non-limiting example, the inner layer may include 50 to 80% by weight of at least one polypropylene polymer selected from the group consisting of a propylene-based alpha-olefin copolymer and a polypropylene random copolymer containing propylene as a main component; 1-20% by weight of one or more components selected from the group consisting of olefin block copolymer (OBC), ethylene vinyl acetate copolymer (EVA), ethylene terpolymer, ethylene-propylene heteropolymer rubber (EPDM), and polyolefin elastomer (POE) ; And 10 to 30% by weight of a styrene-ethylene-butylene-styrene copolymer.

In a non-limiting example, the inner layer may include 60 to 80% by weight of at least one polypropylene polymer selected from the group consisting of a propylene-based alpha-olefin copolymer and a polypropylene random copolymer containing propylene as a main component; 5 to 20% by weight of polyolefin elastomer; 1-20% by weight of olefin block copolymer (OBC); And 10 to 30% by weight or 15 to 30% by weight of a styrene-ethylene-butylene-styrene copolymer.

In a non-limiting example, the polyolefin elastomer may be an ethylene α-olefin copolymer.

The adhesive layer of the first adhesive layer 200 and the second adhesive layer 400 serves to tie the intermediate layer and the outer layer or the intermediate layer and the inner layer, and the most important factor is that there is no peeling due to folding after high-temperature sterilization. Therefore, you must use an adhesive that meets the conditions.

In a non-limiting example, the adhesive used for at least one of the first adhesive layer 200 and the second adhesive layer 400 has obtained medical certification of a retort grade capable of sterilization at a high temperature of 121°C for 30 minutes. It is preferably an adhesive.

These retort grades have no whitening and micro-cracking after retort, and no cracking or peeling due to film deformation and folding (Gelbo) by the adhesive layer.

More specifically, using a test equipment with Gelbo Test ASTM F392, twist the film at a temperature of 23 degrees/humidity 50% at 45 cycles per minute and test at least 20 cycles to 2700 cycles, and then cracking or peeling due to film deformation and folding (Gelbo). There may be no.

In a non-limiting example, the adhesive includes, but is not limited to, maleic anhydride, nadic acid anhydride, himic acid anhydride, tetrahydrophthalic anhydride, and the like as a polypropylene resin. It may also include polypropylene modified by grafting of ethylenically unsaturated carboxylic anhydride. Examples of commercially available adhesive resins may include DuPont's Bynel, Mitsui's Admer, and Mitsubishi's Zelas.

In this way, by using an adhesive capable of high temperature and high pressure sterilization, it is possible to prevent the film from peeling due to a decrease in adhesion after high temperature and high pressure sterilization, and to prevent whitening.

The melt index of the resin composition constituting the adhesive layer is preferably the same or similar to that of the intermediate layer, the outer layer and the inner layer, because the difference in the melt index during film molding may make the film appearance defective and molding impossible. In this aspect, in a non-limiting example, the resin composition of the adhesive layer has a melt index (melt index measured according to ASTM: D1238 at 230°C /2.16kg) of 3 to 7 g/10 minutes, and a density of 0.89 to 1.01 g/ It may be cm 3.

In an exemplary embodiment, the thickness of the outer layer 100 in the multilayer film is 50-120 μm, and the thickness including the intermediate layer 300, the first adhesive layer 200, and the second adhesive layer 400 is 50- It is 70 μm, and the thickness of the inner layer 500 may be 50-120 μm.

When the thickness of the outer layer 100 is less than 50 μm, heat resistance and moisture barrier properties may be deteriorated, and when it exceeds 120 μm, flexibility may decrease.

If the thickness including the intermediate layer 300, the first adhesive layer 200, and the second adhesive layer 400 is less than 50 μm, the adhesiveness and oxygen barrier properties are deteriorated, and when the thickness exceeds 70 μm, the oxygen barrier property is good, but the economy is poor. I can.

When the thickness of the inner layer 500 is less than 50 μm, heat sealability and impact resistance decrease, and when it exceeds 120 μm, flexibility tends to decrease.

In an exemplary embodiment, the oxygen permeability of the multilayer film is 0.09 cc/m ² ·day or less at 23° C. and 0% relative humidity, and the moisture permeability is 1 g/m ² ·day or less at 23° C. and 100% relative humidity. I can.

In an exemplary embodiment, since the infusion container composed of the multilayer film is to be sterilized at about 121° C. after filling the contents, the material to be deformed or eluted at this time should be less than or equal to the specified value. For example, the use of additives specified in 3.1.3 (Plastic additives) of the European Pharmacopoeia and to be added within the limits specified for the content.

In an exemplary embodiment, the multilayer film preferably has a flexural modulus of 5000 kg/cm 2 or less. In other words, in order to maintain a constant rate of supply of the infusion solution when using a multilayer film, the container must be able to collapse almost at a constant rate with the supply rate, and thus the flexibility must be good, so that it has the aforementioned flexural modulus in this respect.

In an exemplary embodiment, in addition to the above-described layers, a layer may be added to the multilayer film to impart special functionality, which may be selected in consideration of the necessity of imparting functionality and economy.

On the other hand, in the exemplary embodiments of the present invention, in the method of manufacturing a multilayer film for an infusion container, a method for producing a multilayer film for an infusion container to include a cyclic olefin polymer in at least one layer when the multilayer film is produced. Provides.

In an exemplary embodiment, a method of manufacturing a multilayer film may use a known method, for example, a casting method of forming with a cooling roll through a T-Die, and an inflation method of forming with water cooling through a circular die. Etc. can be used.

In a non-limiting example, it is preferable to apply the inflation method.In the case of the inflation method, the transparency and flexibility of the manufactured film are superior to that of the T-Die manufacturing method or the lamination method, and the two-ply Since it is folded and wound, there is no possibility of foreign substances in the inner layer, so it is hygienic and has advantages such as convenience of work.

Infusion container

Exemplary embodiments of the present invention also provide an infusion container made of the above-described multilayer film.

As described above, the infusion container does not require the use of an outer pouch or a secondary pouch, that is, an outer pouch free.

In an exemplary embodiment, the infusion container may be a single chamber or a multi-chamber container as a fluid container used for medical purposes.

2 is a schematic diagram of a medical multi-chamber infusion bag to which a multi-layer film is applied according to an exemplary embodiment of the present invention, and FIG. 3 is a schematic view of a medical single-chamber infusion bag to which a multi-layer film is applied according to another exemplary embodiment of the present invention. to be.

As shown in Fig. 2, the multi-chamber infusion bag has an inner hard seal portion 1 and an outer hard seal portion 2, 3, and an inner easy-fill seal portion 4 between the chambers. Each chamber is provided with a Ringer connection port 6.

Meanwhile, as shown in FIG. 3, the single-chamber infusion bag has only an external hard seal part 5 because it is a single chamber. The single chamber is provided with a ringer connection port 6.

Exemplary embodiments of the present invention will be described in more detail through the following examples. The embodiments disclosed in the present specification are illustrated for purposes of explanation only, and the embodiments of the present invention may be implemented in various forms and should not be construed as being limited to the embodiments described herein.

[Experiment 1]

Manufacturing method

In the Examples and Comparative Examples of each of the following experimental examples, multilayer films were prepared at 200 to 230°C using a top-down five-layer blown film machine. Specifically, it was manufactured through water cooling in a coextrusion top-down inflation film machine.

In the molding method, the raw material was melted by an extruder, air was blown through a die, and a film made in a cylindrical tube shape was passed through a roller.

The thickness of the outer layer/intermediate layer (including the adhesive layer)/inner layer of the prepared multilayer film was 120 μm/70 μm/110 μm.

1) PP: Melt index 5 g/10 min, density 0.90, softening point 150℃, manufactured by Lotte Chemical

2) CBC: Melt index 5.0 g/10 min, density 0.94, softening point 114℃, Bibion product 0510

3) COP: Melt Index 11g/10min, Density 1.01, Xeon Product 330R

4) COC: Melt Index 5g/10min, Density 1.02, Topaz Product 6015

5) TIE: Melt Index 3g/10min, Density 0.89, Softening Point 157℃, Mitsubishi MC721

6) EVOH: melt index 7 g/10 min, density 1.19, melting point 188℃ Nippon Gosei RB7205

7) PP: Melt index 5.5 g/10 min, density 0.90, softening point 123℃, manufactured by Lotte Chemical

8) SEBS: melt index 4 g/10 min, density 0.90, manufactured by Asahi

Physical property measurement

The physical properties of the multilayer films prepared in the Examples and Comparative Examples were measured, and the results are shown in Table 2 below.

The experimental results were measured at room temperature after heat sterilization at 121°C for 30 minutes or more.

The elongation was measured by the ASTM D-882 method.

Transparency is measured according to ASTM D-1003, which is measured using a haze meter after forming a 200 μm film.

Oxygen permeability measurement experiment (OTR TEST) was performed by measuring the oxygen permeability of laminated and laminated films according to ASTM D 3985, and each film was cut into a size of 7 cm in width and 7 cm in length using MOCON's OX-TRAN 2/21. Oxygen permeability was measured under the conditions of 23° C. and 0% relative humidity.

In the water permeability measurement experiment (WVTR TEST), the oxygen permeability of laminated and laminated films was measured according to ASTM F 372, and each film was cut into a size of 7 cm in width and 7 cm in length using MOCON's PERMATRAN_W 3/33 MA. Moisture permeability was measured under the conditions of ℃, 100% relative humidity.

As can be seen from Table 2, in the multilayer films of the embodiments of the present invention, it was confirmed that high-performance moisture barrier properties were found as can be seen in the use example of the cyclic olefin polymer single layer. It was found that the lower the content, the lower the moisture barrier property.

In addition, it was found that oxygen barrier properties and moisture barrier properties were superior to COC and COP, especially when using CBC.

In the case of the comparative examples in which the cyclic olefin polymer was not used, oxygen barrier properties and physical properties were secured, but it was found that water barrier properties were poor.

[Experiment 2]

Manufacturing method

To further confirm the difference between CBC, COP, and COC, it was carried out as shown in Table 3.

As described above, the multilayer films in Examples and Comparative Examples of each of the following experimental examples were prepared at 200 to 230°C using a top-down five-layer blown film machine. Specifically, it was manufactured through water cooling in a coextrusion top-down inflation film machine.

In the molding method, the raw material was melted by an extruder, air was blown through a die, and a film made in a cylindrical tube shape was passed through a roller.

The thickness of the outer layer/intermediate layer (including the adhesive layer)/inner layer of the prepared multilayer film was 120 μm/70 μm/110 μm.

1) CBC: Melt Index 5.0 g/10min, density 0.94, softening point 114℃, Bibion product 0515

2) COP: Melt Index 11g/10min, Density 1.01, Xeon Product 330R

3) COC: melt index 5 g/10 min, density 1.02, Topaz product 6015

4) TIE: Melt Index 3g/10min, Density 0.89, Softening Point 157℃, Mitsubishi MC721

5) EVOH: melt index 7 g/10 min, density 1.19, melting point 188°C, manufactured by Nippon Gosei RB7205

6) PP: Melt index 5.5 g/10 min, density 0.90, softening point 123℃, manufactured by Lotte Chemical

7) SEBS: Melt Index 4 g/10 min, density 0.90, manufactured by Asahi

Physical property measurement

The following physical properties were measured and shown in Table 4.

The elongation was measured by the ASTM D-882 method.

Transparency is measured according to ASTM D-1003, which is measured using a haze meter after forming a 200 μm film.

Oxygen permeability measurement experiment (OTR TEST) was performed by measuring the oxygen permeability of laminated and laminated films according to ASTM D 3985, and each film was cut into a size of 7 cm in width and 7 cm in length using MOCON's OX-TRAN 2/21. Oxygen permeability was measured under the conditions of 23° C. and 0% relative humidity.

In the water permeability measurement experiment (WVTR TEST), the oxygen permeability of laminated and laminated films was measured according to ASTM F 372, and each film was cut into a size of 7 cm in width and 7 cm in length using MOCON's PERMATRAN_W 3/33 MA. Moisture permeability was measured under the conditions of ℃, 100% relative humidity.

UV resistance was visually checked after leaving for 300 hours by the outdoor exposure test method.

Gamma-Ray resistance was irradiated with 50 kGy to visually check the color change.

As can be seen from Table 4, in the case of Example 1 using a cyclic convex copolymer (CBC), it was confirmed that there was no color change over time, so that there was UV resistance and gamma ray resistance. In the case of the comparative examples (using COP and COC), it was found that color change occurred over time and was vulnerable to UV resistance and gamma rays.

[Experiment 3]

Manufacturing method

In this experiment 3, the composition of the inner layer was made more diverse.

In the examples of each of the following experimental examples, the multilayer film was manufactured at 200 to 230°C using a top-down five-layer blown film machine. Specifically, it was manufactured through water cooling in a coextrusion top-down inflation film machine.

In the molding method, the raw material was melted by an extruder, air was blown through a die, and a film made in a cylindrical tube shape was passed through a roller.

The thickness of the outer layer/intermediate layer (including the adhesive layer)/inner layer of the prepared multilayer film was 120 μm/70 μm/110 μm.

1) PP: Melt index 5 g/10 min, density 0.90, softening point 150℃, manufactured by Lotte Chemical

2) CBC: Melt Index 5.0 g/10min, Density 0.94, Softening Point 114℃, Bibion Product 0515

3) TIE: Melt index 3 g/10 min, density 0.89, softening point 157℃, Mitsubishi MC721

4) EVOH: melt index 7 g/10 min, density 1.19, melting point 188°C Nippon Gosei RB7205

5) POLY-KETONE: Melt index 5 g/10 minutes, softening point 192℃, Hyosung product

6) PP: Melt index 5.5 g/10 min, density 0.90, softening point 123℃, manufactured by Lotte Chemical

7) SEBS: Melt Index 4 g/10 min, density 0.90, manufactured by Asahi

8) POE (Polyolefin Elastomer): Melt Index 6 g/10 min, Melting Point 160℃, Mitsui Product-PN9060

9) EVA: Melt index 0.9 g/10 min, density 0.93, VA content 8%, DuPont product

10) OBC (Olefin Block Copolymer): Melt Index 3.1 g/10min, Density 0.91, Melting Point 137℃, Dow Product-XUS 69109

Physical property measurement

The physical properties of the multilayer films prepared in the above examples were measured, and the results are shown in Table 6 below.

The experimental results were measured at room temperature after heat sterilization at 121°C for 30 minutes or more.

The elongation was measured by the ASTM D-882 method.

Transparency is measured according to ASTM D-1003, which is measured using a haze meter after forming a 200 μm film.

Oxygen permeability measurement experiment (OTR TEST) was performed by measuring the oxygen permeability of laminated and laminated films according to ASTM D 3985, and each film was cut into a size of 7 cm in width and 7 cm in length using MOCON's OX-TRAN 2/21. Oxygen permeability was measured under the conditions of 23° C. and 0% relative humidity.

In the water permeability measurement experiment (WVTR TEST), the oxygen permeability of laminated and laminated films was measured according to ASTM F 372, and each film was cut into a size of 7 cm in width and 7 cm in length using MOCON's PERMATRAN_W 3/33 MA. Moisture permeability was measured under the conditions of ℃, 100% relative humidity.

Efflorescence was visually confirmed after heat sterilization at 121°C for 30 minutes or more.

Peeling was carried out for 1 hour (2700 cycles) of the Gelbo Test, and then the interlayer peeling of the film was confirmed.

UV resistance was visually checked after leaving for 300 hours by the outdoor exposure test method.

Code description:

X: No whitening, peeling, or discoloration

As can be seen from Table 6, in the multilayer films of the embodiments of the present invention, excellent multilayer films without whitening, peeling, ductility, UV resistance, transparency, and delamination after sterilization, which are required physical properties, were obtained.

Although non-limiting and exemplary embodiments of the present invention have been described above, the technical spirit of the present invention is not limited to the accompanying drawings or the above description. It is apparent to those of ordinary skill in the art that various modifications can be made within the scope of the technical spirit of the present invention, and it will be said that such modifications belong to the claims of the present invention.

1: internal hard seal part 2, 3, 5: external hard seal part
4: Internal easy-fill seal part 6: Ringer connection port part
100: outer layer 200: first adhesive layer
300: intermediate layer 400: second adhesive layer
500: inner layer 110, 120, 510, 520: insertion layer

Claims (14)

In the multilayer film for an infusion container,
A multilayer film for an infusion container, characterized in that the cyclic block copolymer is included in the outer layer of the multilayer film.
The method of claim 1,
The multilayer film for an infusion container, characterized in that the outer layer of the multilayer film consists of a cyclic block copolymer alone.
delete delete The method of claim 1,
The multilayer film is a multilayer film for an infusion container, characterized in that it sequentially includes an outer layer, a first adhesive layer, an intermediate layer, a second adhesive layer, and an inner layer.
delete The method of claim 5,
Between the outer layer and the first adhesive layer; Or between the inner layer and the second adhesive layer; Or between the outer layer and the first adhesive layer and between the inner layer and the second adhesive layer; to further include at least one intercalation layer,
The multilayer film for an infusion container, characterized in that the insertion layer is a cyclic block copolymer-containing layer composed of a cyclic block copolymer alone.
delete The method of claim 5,
The thickness of the outer layer is 50-120㎛,
The total thickness of the intermediate layer, the first adhesive layer and the second adhesive layer is 50-70㎛,
A multilayer film for an infusion container, characterized in that the thickness of the inner layer is 50-120㎛.
The method of claim 9,
The oxygen permeability of the multilayer film is 0.09cc/m ² ·day or less at 23°C and 0% relative humidity,
A multilayer film for an infusion container, characterized in that the ^{moisture permeability is 1g/m 2} ·day or less at 23°C and 100% relative humidity.
In the method for producing a multilayer film for an infusion container according to any one of claims 1, 2, 5, 7, 9 and 10,
A method for producing a multilayer film for an infusion container comprising a; step of including a cyclic block copolymer in the outer layer of the multilayer film.
An infusion container comprising a multilayer film for an infusion container according to any one of claims 1, 2, 5, 7, 9, and 10.
The method of claim 12,
The infusion container, characterized in that the outer pouch-free (free).
The method of claim 12,
The infusion container is a single chamber or a multi-chamber infusion container, characterized in that the infusion container.

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