KR20100056877A - Preparation method of cosmetic water composition for promoting stratum corneum delamination containing beta hydroxy acid and triclosan - Google Patents

Abstract

PURPOSE: A method for manufacturing a face lotion containing beta-hydroxy acid and triclosan is provided to ensure peeling effect with stability. CONSTITUTION: A method for manufacturing a face lotion composition for promoting peeling comprises: a step of preparing ethanol mixture having beta hydroxyl acid, triclosan, surfactant, and ethanol, and purified water mixture; a step of adding 10-30 weight% of purified water mixture to ethanol mixture; and a step of adding 70-90 weight% of purified water mixture to dilute. The beta hydroxyl acid is salicylic acid or salicylic acid derivative. The triclosan is contained in 0.05-10.0 weight% based on total weight.

Description

Preparation method of cosmetic water composition for promoting stratum corneum delamination containing beta hydroxy acid and triclosan}

The present invention relates to a method for preparing a keratin exfoliation promoting composition containing beta hydroxy acid and triclosan, more specifically, it can contain a high content of beta hydroxy acid and triclosan, excellent exfoliation effect and stability over time It is related with the manufacturing method of this cosmetic product composition for promoting exfoliation exfoliation.

The stratum corneum is the outermost layer in direct contact with the outside, protecting the skin and the body from physical and chemical hazards. The stratum corneum consists of 50% protein called keratin, 20% fat, 23% water soluble substance and 7% moisture. As skin cells continue to form, existing skin cells gradually rise to the stratum corneum, and the cells that reach the stratum corneum are flat, dead cells called 'keratomas', where millions of dead keratinocytes fall off the skin each day The action of turning into cells (turn over) occurs. Peeling literally means peeling dead cell layers from the skin's epidermis, allowing new skin to regenerate. The original skin naturally forms a turnover cycle of spontaneous exfoliation and new skin coming up, but it does not remain natural as it ages or depending on the surrounding environment such as dryness, UV rays and stress. Therefore, the artificial method called peeling removes dead skin cells and restores the regeneration cycle of the blocked skin and raises fresh cells generated from the bottom to keep the skin clear and clean. Cosmetics for such peeling may include chemical peeling products and physical peeling products.

Chemical peeling products are products that use acidic ingredients and are the fastest way to see the effects. The principle of chemical peeling is to loosen the stratum corneum of the thick stratum corneum on the skin by the action of acid to soften excess keratin that did not fall off in time, helping to remove it through cleansing. Chemical peeling agents are most often used in dermatological dermabrasion procedures. When using chemical peeling products at home, it is important to look ahead at the type and amount of acid used and to choose the right product for your skin. In addition, artificially removes the dead skin cells, temporarily reducing the amount of keratin may be a weak skin protection against the external environment. Therefore, it is advisable to use sunscreen together during daytime after using peeling products.

Physical peeling products are gradually varying from 'scrubbing agent' which removes dead skin by friction with granules and 'Microdermabrasion' using microparticles and additional potent ingredients. Microdermabrasion products are products that exfoliate aging keratin by applying physical particles to the skin and then applying physical stimulation by hand movement. Dermatologists use a grinding machine instead of hand movements to apply physical stimuli, or use a strong pressure to spray fine particles directly onto the skin to exfoliate the skin thinly. Physical peeling products come in various shapes and sizes depending on the type of microparticles, but because they are physically stimulating products, it is essential to select products containing particles suitable for skin sensitivity.

Betahydroxy acid and triclosan are dissolved in organic solvents such as ethanol and ether, but are low in solubility in water and precipitate without dissolving in a crystalline state. In order to prepare a lotion including the same, a conventional lotion is prepared by dissolving a surfactant, beta hydroxy acid and triclosan in ethanol, and then adding the ethanol mixture to a purified water mixture. However, this is a manufacturing method that does not ensure the stability over time of the lotion containing beta-hydroxy acid and triclosan, there is a problem to contain only a very small amount because beta-hydroxy acid and triclosan is precipitated during long-term storage at low temperatures.

Accordingly, the present inventors have solved the above problems and studied to find a method for preparing a cosmetic composition for exfoliation having excellent stability over time, the ethanol mixture and purified water mixture 10 containing beta hydroxy acid, triclosan, surfactant and ethanol 10 After mixing ~ 30% by weight, the cosmetic composition prepared by diluting the remaining purified water mixture can contain a high content of beta hydroxy acid and triclosan, it is found that the exfoliation effect is high and the stability over time is excellent and the present invention Was completed.

Accordingly, it is an object of the present invention to provide a method for preparing a cosmetic composition for exfoliation having high skin exfoliation effect and excellent stability over time.

In order to achieve the above object, in the present invention

a) preparing an ethanol mixture and a purified water mixture comprising betahydroxy acid, triclosan, a surfactant and ethanol, respectively;

b) adding 10-30% by weight of the purified water mixture to the ethanol mixture or mixing 10-10% by weight of the ethanol mixture into the purified water mixture; And

c) adding 70 to 90% by weight of the remaining purified water mixture to b) and diluting the same.

The skin lotion composition for promoting keratin exfoliation according to the present invention is prepared by mixing 10-30% by weight of an ethanol mixture containing beta hydroxy acid, triclosan, a surfactant, and ethanol and purified water mixture, and then adding the remaining purified water mixture. It was excellent in stability over time of the lotion composition and can contain high content of beta hydroxy acid and triclosan, thereby improving the exfoliation effect.

The present invention comprises the steps of: a) preparing an ethanol mixture and purified water mixture each comprising beta hydroxy acid, triclosan, a surfactant and ethanol;

b) adding 10-30% by weight of the purified water mixture to the ethanol mixture or mixing 10-10% by weight of the ethanol mixture into the purified water mixture; And

c) adding 70 to 90% by weight of the remaining purified water mixture to b) and diluting the same.

Hereinafter, the method for producing a cosmetic lotion composition of the present invention will be described in detail step by step.

a) preparing an ethanol mixture and a purified water mixture comprising betahydroxy acid, triclosan, a surfactant and ethanol, respectively;

Beta hydroxy acid, an active ingredient of the present invention, is a kind of organic compound including a hydroxy functional group and a carboxylic acid functional group. Beta hydroxy acid removes the link between keratin in the stratum corneum by the action of acid, gently dissolves the keratin, and effectively removes the areas where the keratin is excessively accumulated in the acne area. Easy to exfoliate skin exfoliation effect.

Specific examples of beta hydroxy acids usable in the present invention include salicylic acid, derivatives of salicylic acid, and the like.

Beta-hydroxy acid of the present invention is preferably contained in 0.05 to 10.0% by weight, more preferably 0.1 to 5.0% by weight relative to the total weight of the lotion composition. This is because if the content is less than 0.05% by weight, the exfoliation effect of the skin is insignificant, and if it exceeds 10.0% by weight, skin irritation occurs.

Triclosan (2,4,4'-trichloro-2'-hydroxy diphenyl ether), which is an active ingredient of the present invention, is a kind of chlorinated aromatic compound including an ether functional group and a phenol functional group. It is effective in the treatment of acne by preventing skin from clogging due to excessive keratin exfoliation effect is excellent, and helps the growth of new skin cells through exfoliation.

The triclosan of the present invention is preferably contained in 0.05 to 10.0% by weight, more preferably 0.1 to 5.0% by weight relative to the total weight of the lotion composition. This is because if the content is less than 0.05% by weight, the exfoliation effect of the skin is insignificant, and if it exceeds 10.0% by weight, skin irritation occurs.

Surfactant of the present invention may be used as a component contained to assist solubilization of the active ingredients, such as nonionic and anionic surfactants, and if it does not cause any problems related to formulation stability and skin irritation, it is special for that kind Various choices can be made without limitation. Specific examples of surfactants that can be used in the present invention include Fiji 60 Hydrogenated Castor Oil, Octyldodeces-16, Polysorbate 20, Polysorbate 60 and Polysorbate 80 Bis-Pigage-18 Methyl ether Dimethyl Silanes and the like.

It is preferable that surfactant of this invention is contained at 0.05-20.0 weight% with respect to the total weight of a composition. This is because if the content is less than 0.05% by weight, the stability of the formulation with time deteriorates, and if it exceeds 20.0% by weight, skin irritation occurs.

The ethanol mixture and purified water mixture of the present invention may further include fragrances, moisturizers, softeners, and preservatives, which may be included in a general lotion, and do not cause any special problems in the quality and function of the skin product for promoting exfoliation after mixing. The type or content can be changed in the range.

b) adding 10-30% by weight of the purified water mixture to the ethanol mixture or mixing 10-10% by weight of the ethanol mixture into the purified water mixture;

10 to 30% by weight of the purified water mixture is added to the ethanol mixture prepared in step a) or 10 to 30% by weight of the purified water mixture is added and mixed at room temperature using an azi mixer or paddle mixer.

c) diluting 70-90% by weight of the remaining purified water mixture in b);

70 to 90% by weight of the remaining purified water mixture is added to the mixture prepared in step b) and mixed at room temperature using an azi mixer or paddle mixer to prepare a cosmetic composition of the present invention.

Hereinafter, the present invention will be described in more detail with reference to Examples and Test Examples. However, the scope of the present invention is not limited to the following examples and test examples.

EXAMPLE 1 AND COMPARATIVE EXAMPLES 1-3

To the lotion of Example 1 and Comparative Examples 1 to 3 according to the composition shown in Table 1. Example 1 is a lotion composition containing beta hydroxy acid and triclosan together, Comparative Examples 1 to 2 contain beta hydroxy acid or triclosan, respectively, and Comparative Example 3 is a lotion composition containing neither beta hydroxy acid and triclosan Was prepared. The beta hydroxy acid was used salicylic acid purchased from Uksung Corporation, and triclosan was purchased from Ciba.

Triethanolamine of the purified water mixture was used to adjust the pH, and Fij60 hydrogenated castor oil and polysorbate 20 of the ethanol mixture were used as surfactants to aid in solubilization of salicylic acid.

division ingredient Example 1
(weight%) Comparative Example 1
(weight%) Comparative Example 2
(weight%) Comparative Example 3
(weight%) Purified water
mixture 1. Purified water Balance Balance Balance Balance 2. Glycerin 2.5 2.5 2.5 2.5 3. Butylene Glycol 2.5 2.5 2.5 2.5 4. Triethanolamine 0.2 0.2 0.2 0.2 5. Disodium ID 0.02 0.02 0.02 0.02 ethanol
mixture 6. Ethanol 10 10 10 10 7. Salicylic Acid 0.5 - 0.5 - 8. Triclosan 0.03 0.03 - - 9. Fiji 60 Hydrogenated Castor Oil 0.4 0.4 0.4 0.4 10. Polysorbate 20 0.15 0.15 0.15 0.15 11. Incense Quantity Quantity Quantity Quantity 12. Preservative Quantity Quantity Quantity Quantity

<Production method of Example 1 and Comparative Examples 1 to 3>

1) Components 1 to 5 were mixed to completely dissolve to prepare a purified water mixture.

2) The ethanol mixture was prepared by mixing at 40 ° C. to completely dissolve components 6-12.

3) The 2) was slowly added to 15% by weight of the above 1) while stirring and solubilized by mixing for 20 minutes at room temperature at 100 rpm using an azi mixer.

4) Subsequently, 85% by weight of the remaining purified water mixture of 1) was slowly added to 3) and mixed with az mixer at 100 rpm for 20 minutes at room temperature to prepare a lotion.

EXAMPLE 2 AND COMPARATIVE EXAMPLES 4-5

Example 2 and Comparative Examples 4 to 5 were made of the same composition as in Example 1, but were prepared by different manufacturing processes. Comparative Examples 4 to 5 is a method of adding the ethanol mixture to the total amount of the purified water mixture according to the conventional lotion preparation method and only the input rate of each ethanol mixture was different.

<Production Method of Example 2>

1) Components 1 to 5 were mixed to completely dissolve to prepare a purified water mixture.

2) The ethanol mixture was prepared by mixing at 40 ° C. to completely dissolve components 6-12.

3) 15% by weight of 1) was slowly added to 2) while stirring and solubilized by mixing for 20 minutes at room temperature at 100 rpm using an azi mixer.

4) Subsequently, after further stirring for 5-7 minutes, 85% by weight of the remaining purified water mixture of 1) was slowly added to 3), and the lotion was prepared by mixing at 100 rpm for 20 minutes at 100 rpm using an azi mixer. .

<Production Method of Comparative Example 4>

1) Components 1 to 5 were mixed to completely dissolve to prepare a purified water mixture.

2) The ethanol mixture was prepared by mixing at 40 ° C. to completely dissolve components 6-12.

3) The lotion was prepared by rapidly adding 2 ) to 1 ) above and mixing for 40 minutes at room temperature at 100 rpm using an azi mixer.

 <Manufacturing Method of Comparative Example 5>

1) Components 1 to 5 were mixed to completely dissolve to prepare a purified water mixture.

2) The ethanol mixture was prepared by mixing at 40 ° C. to completely dissolve components 6-12.

3) 2 ) was slowly added to 1 ) and mixed with az mixer at 100 rpm for 40 minutes at room temperature to prepare a lotion.

Test Example 1 Skin Exfoliation Effect

In order to compare the exfoliation effect that appears when the above Example 1 and Comparative Examples 1 to 3 were applied to the skin, the experiment was carried out by the following method. Twenty healthy women in their twenties and thirties were rinsed thoroughly, and then waited for a period of time under constant temperature and humidity conditions (24 ° C, 40-50%). Before applying the sample, the color of the subject's upper arm was measured by chromatometer (CR-200, Minolta), and then the color of the area colored in brown by dihydroxy acetone (DHA) was measured. The difference was compared. Thereafter, while applying the sample twice a day, the degree of discoloration was measured by a chromameter every day to determine the time (turnover time) to return to the original skin color. The results are shown in Table 2 below.

division Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Turnover time (days) 13.3 ± 1.9 18.5 ± 1.7 16.9 ± 2.0 20.3 ± 2.2

From the results of Table 2, Example 1 containing beta hydroxy acid and triclosan of the present invention has a shorter keratin turnover time as compared with Comparative Examples 1 to 3. Therefore, it was confirmed that the skin exfoliation effect of the composition for exfoliating the skin of the present invention is excellent.

 Test Example 2 Stability with Time

In order to confirm the stability over time of the exfoliating lotion composition prepared according to the present invention, in Examples 1 and 2 and Comparative Examples 4 to 5 in a 100ml glass bottle observed for 5 months at 4 ℃ and -15 ℃ and immediately after preparation The stability over time at, 1, 2, 3, 4 and 5 months was evaluated. The results are shown in Tables 3 to 4 below. The stability over time is indicated by O when the composition is completely transparent, △ when turbidity is observed, X when the precipitate is observed.

4 ℃ Stability Immediately after manufacture 1 month later 2 months later 3 months later 4 months later 5 months later Example 1 O O O O O O Example 2 O O O O O O Comparative Example 4 O △ X X X X Comparative Example 5 O O △ △ △ △

Stability over time -15 ℃ Immediately after manufacture 1 month later 2 months later 3 months later 4 months later 5 months later Example 1 O O O O X X Example 2 O O O O X X Comparative Example 4 O O X X X X Comparative Example 5 O △ △ X X X

As can be seen from Tables 3 to 4, when the lotion prepared by the conventional method is stored at 4 ℃, Comparative Example 4 precipitated sooner after two months and Comparative Example 5 than Examples 1 to 2 of the present invention High suspension showed low stability with time of formulation. In addition, when stored at -15 ℃, Comparative Example 4 is precipitated from two months later, Comparative Example 4 is more susceptible to suspension from one month after, whereas Examples 1 to 2 are more stable because the precipitate is formed after four months. Could know. This means that the beta-hydroxy acid precipitates at low temperature and is not stabilized in the formulation when the lotion is prepared by the conventional method, but using the preparation method of the present invention was able to increase the solubility of the beta-hydroxy acid and improve the stability over time in the formulation. . Therefore, it was confirmed that the skin lotion promoting lotion prepared according to the present invention is more stable than the lotion prepared by the conventional manufacturing method.

Claims (6)

a) preparing an ethanol mixture and a purified water mixture comprising betahydroxy acid, triclosan, a surfactant and ethanol, respectively; b) adding 10-30% by weight of the purified water mixture to the ethanol mixture or mixing 10-10% by weight of the ethanol mixture into the purified water mixture; And c) adding 70 to 90% by weight of the remaining purified water mixture into the b) and diluting the remaining distilled water mixture. The method of claim 1, wherein the beta hydroxy acid is salicylic acid or salicylic acid derivative, characterized in that the method for producing a keratin exfoliation promoting cosmetic composition. The method of claim 1, wherein the beta hydroxy acid is contained in an amount of 0.05 to 10.0% by weight based on the total weight of the composition. The method of claim 1, wherein the triclosan is contained in an amount of 0.05 to 10.0% by weight based on the total weight of the composition. The method of claim 1, wherein the surfactant is contained in an amount of 0.05 to 20.0% by weight based on the total weight of the composition. A skin lotion composition for promoting exfoliation prepared according to any one of claims 1 to 5.