KR102147642B1 - Cosmetic composition for acne improvement - Google Patents

Abstract

The present invention relates to a pH-sensitive cosmetic composition for improving acne and a method of manufacturing the same. In the present invention, salicylic acid and tea tree oil are supported on the core, and a pH-sensitive material is supported on at least one or more of the plurality of through-holes, thereby including a pH-sensitive complex that discharges salicylic acid to the outside only in a specific pH range, Provides a cosmetic composition having a stable formulation and excellent acne improvement effect, low irritation to the skin, and a method of manufacturing the same.

Description

Cosmetic composition for improving acne {COSMETIC COMPOSITION FOR ACNE IMPROVEMENT}

The present invention relates to a pH-sensitive cosmetic composition for improving acne and a method of manufacturing the same.

Acne is an inflammatory skin disease that occurs in hair follicles and sebaceous glands, and is caused by excessive secretion of sebum, keratinization of hair follicles, and proliferation of acne bacteria. In particular, the growth of Propionabacterium acnes, an acne bacteria present in the hair follicle, may be promoted by excessive secretion of sebum and keratinization of the hair follicle.

At this time, Propionabacterium acnes eats triglycerides and releases fatty acids or free fatty acids. These fatty acids or free fatty acids irritate the skin or promote acne formation, causing inflammatory reactions as well as weakly acidic. Had a problem of alkalizing healthy skin. In addition, skin in a weakly acidic state of pH 4.0 to 6.0 can maintain a healthy state by maintaining homeostasis and antibacterial action on its own, but alkalized skin above pH 7.0 has difficulty in maintaining homeostasis and antibacterial action, so the function of the skin itself is difficult. There was a problem of deterioration.

Accordingly, various compositions for improving acne using antibiotics, drugs, etc. that sterilize acne bacteria and reduce inflammation while restoring alkalized skin to weakly acidic healthy skin have been developed.

Among them, salicylic acid is mainly used as a substance for improving or treating acne because of its excellent effect on improving acne. For example, Korean Patent Application Publication No. 10-2013-0055182 discloses a composition and a kit that can improve acne, including sulfur, calamine, and salicylic acid.

On the other hand, salicylic acid is a kind of strong acid and is effective in improving acne, but it is irritating to the skin and has a problem of unstable formulation of the cosmetic composition. However, in the prior art including the above patent, salicylic acid only discloses that it is effective in improving acne, and there is a problem that the skin irritation and formulation stability of the cosmetic composition using salicylic acid are not considered.

Accordingly, there is a need for development of a cosmetic composition that contains salicylic acid, which is effective for improving acne, is not only mild to skin, but also has a stable formulation.

Republic of Korea Patent Publication No. 10-2013-0055182

The first object of the present invention is to include hollow porous silica, salicylic acid, tea tree oil, and a pH sensitive material, wherein the hollow porous silica includes a core made of an empty space, and the core and the outer It is formed in the structure of a shell in which a plurality of through-holes are formed connecting the core, salicylic acid and tea tree oil are supported in the core, and a pH-sensitive material is supported in at least one or more of the plurality of through-holes. It is to provide a pH-sensitive complex capable of discharging salicylic acid to the outside.

A second object of the present invention includes the steps of impregnating a hollow porous silica with salicylic acid and tea tree oil, and impregnating a pH sensitive material in the hollow porous silica impregnated with the salicylic acid and tea tree oil, wherein the hollow type Porous silica is formed in a structure of a core made of an empty space and a shell in which a plurality of through holes connecting the core and the outside are formed, and salicylic acid and tea tree oil are supported in the core, and at least one of the plurality of through holes It is intended to provide a method for producing a pH-sensitive complex capable of discharging salicylic acid to the outside only in a specific pH range as a pH-sensitive material is supported.

A third object of the present invention is to provide a cosmetic composition having a stable formulation, which is not only excellent in acne improvement effect, but also has a stable formulation, as it includes a pH-sensitive complex that discharges salicylic acid supported on the core to the outside only in a specific pH range. To provide.

The object of the present invention is not limited to the technical problem as described above, and another technical problem may be derived from the following description.

In order to achieve the first object, the present invention includes a hollow porous silica, salicylic acid, tea tree oil, and a pH sensitive material, wherein the hollow porous silica is a core made of an empty space. And a shell structure in which a plurality of through holes connecting the core and the outside are formed, and salicylic acid and tea tree oil are supported in the core, and a pH-sensitive material is supported in at least one of the plurality of through holes. It relates to a pH sensitive complex.

The pH-sensitive composite contains 0.01 to 50.0% by weight of hollow porous silica, 0.01 to 40.0% by weight of salicylic acid, 0.01 to 40.0% by weight of tea tree oil, and 0.01 to 30.0% by weight of a pH-sensitive material based on the total weight of the pH-sensitive composite. I can.

The salicylic acid and tea tree oil may be included in a weight ratio of 1: 0.5 to 2.

The pH-sensitive material may be Meadowfoam delta-lactone.

In order to achieve the second object, the present invention provides a method for preparing a pH-sensitive composite comprising hollow porous silica, salicylic acid, tea tree oil, and a pH-sensitive material, Impregnating the silica with salicylic acid and tea tree oil; And impregnating a pH-sensitive material into the hollow porous silica impregnated with salicylic acid and tea tree oil, wherein the hollow porous silica includes a core formed of an empty space and a plurality of through holes connecting the core and the outside. It is formed in a shell structure, salicylic acid and tea tree oil are supported in the core, and a pH-sensitive material is supported in at least one or more of the plurality of through-holes, providing a method of manufacturing a pH-sensitive composite.

In order to achieve the third object, the present invention includes hollow porous silica, salicylic acid, tea tree oil and a pH-sensitive material, wherein the hollow porous silica is a core made of an empty space. And a shell structure in which a plurality of through-holes connecting the core and the outside are formed, and salicylic acid and tea tree oil are supported in the core, and a pH-sensitive material is supported in at least one of the plurality of through-holes. It provides a pH-sensitive cosmetic composition for improving acne, including a sensitive complex.

The pH-sensitive complex may be included in an amount of 0.01 to 30.0% by weight based on the total weight of the cosmetic composition.

The cosmetic composition may inhibit the activity of acne causative bacteria.

The cosmetic composition is selected from the group consisting of softening lotion, nutritional lotion, astringent lotion, skin, lotion, essence, cream, massage cream, pack, makeup base, BB cream, foundation, powder, cleansing foam, cleansing cream and cleansing water. It may be any one formulation.

The cosmetic composition is purified water, anti-wrinkle agent, anti-aging agent, antioxidant, elasticity improving agent, whitening agent, moisturizing agent, sunscreen, anti-inflammatory agent, atopic dermatitis improving agent, acne improving agent, sebum secretion inhibitor, trouble preventing agent, fatty substance, organic solvent, solubilizing agent, Thickening agent, gelling agent, emollient, suspending agent, stabilizer, blowing agent, fragrance, surfactant, emulsifier, filler, sequestering agent, chelating agent, preservative, vitamin, wetting agent, oil, dye, pigment, fragrance, hydrophilic or It may further include an additive comprising at least one selected from the group consisting of lipophilic active agents and lipid vesicles.

The pH-sensitive composite of the present invention is a hollow porous silica, salicylic acid, tea tree oil and pH-sensitive shell structure in which a core formed of an empty space and a plurality of through holes connecting the core and the outside are formed. Including a material, but salicylic acid and tea tree oil are supported in the core, and a pH-sensitive material is supported in at least one of the plurality of through holes. Can be discharged as.

In addition, a sufficient amount of salicylic acid and tea tree oil may be supported on the core of the hollow porous silica, and a sufficient amount of a pH-sensitive material may be supported in a plurality of through holes of the shell.

In addition, salicylic acid and tea tree oil are supported on the core of the hollow porous silica, but as the salicylic acid and tea tree oil are supported in a weight ratio of 1: 0.5 to 2, salicylic acid can be continuously released in a specific pH range, The pH-sensitive complex can remain more stable.

According to the method for preparing a pH-sensitive composite of the present invention, the step of impregnating salicylic acid and tea tree oil into a hollow porous silica having a shell structure having a core formed of an empty space and a plurality of through holes connecting the core and the outside, and the salicylic acid And impregnating the hollow porous silica impregnated with tea tree oil with a pH-sensitive material, wherein salicylic acid and tea tree oil are supported on the core of the hollow porous silica, and at least one of the plurality of through holes At least one of the pH-sensitive substances may be supported to prepare a pH-sensitive complex capable of discharging the salicylic acid of the core to the outside only in a specific pH range.

In addition, a sufficient amount of salicylic acid and tea tree oil may be supported on the core of the hollow porous silica, and a sufficient amount of a pH-sensitive material may be supported in a plurality of through holes of the shell.

As the pH-sensitive cosmetic composition of the present invention contains a pH-sensitive complex capable of discharging the salicylic acid of the core in a specific pH range, not only has excellent acne improvement effect, but also is mild to skin, and has a stable formulation. Is to provide.

In particular, Medoform delta-lactone, a pH-sensitive substance, dissolves in the oil phase in acid and in the aqueous phase in basic, thus blocking the shell through holes in a solid state in weakly acidic healthy skin, and in basic acne or inflammatory skin. It is dissolved in water and can be released from the through hole to the outside. In addition, salicylic acid and tea tree oil supported on the core of the hollow porous silica are released to the outside along the through hole of the shell, thereby improving acne or inflammatory skin.

In addition, in weakly acidic healthy skin, as salicylic acid is maintained in the core of the hollow porous silica, skin irritation can be reduced, and stable formulations and various formulations can be implemented.

In addition, since the pH-sensitive complex contains salicylic acid and tea tree oil in a weight ratio of 1: 0.5 to 2, salicylic acid can be continuously released in a specific pH range, so that the persistence of the acne improvement effect can be improved. In addition, the pH-sensitive complex contains salicylic acid and tea tree oil in a weight ratio of 1: 0.5 to 2, and it is possible to implement a more stable pH-sensitive complex, whereby the formulation stability of the cosmetic composition can be further improved. have.

1 is a view showing a hollow porous silica according to an embodiment of the present invention.
2 is a view showing a cross section of a pH-sensitive composite according to an embodiment of the present invention.
3 is a graph showing the amount of salicylic acid released according to the pH change of the pH-sensitive complex according to Example 3.
4 is a graph showing the release amount of salicylic acid over time of the pH-sensitive complexes according to Examples 1 to 4 exposed to an alkaline environment.
5 is a graph showing the results of evaluating the stability of the pH-sensitive complexes according to Examples 1 to 4.
6 is a diagram showing the effect of killing P.acnes bacteria of the pH-sensitive composite according to Example 3.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those of ordinary skill in the art can easily implement the present invention. However, the present invention may be implemented in various different forms and is not limited to the embodiments described herein. In the drawings, parts not related to the description are omitted in order to clearly describe the present invention.

The terms or words used in the specification and claims of the present invention are not limitedly interpreted in a conventional or dictionary meaning, and the inventor can appropriately define the concept of the term in order to describe his own invention in the best way. Based on the principle, it should be interpreted as a meaning and concept consistent with the technical idea of the present invention.

In the entire specification of the present invention, when a certain part "includes" a certain component, it means that other components may be further included rather than excluding other components unless otherwise stated. .

In the entire specification of the present invention, "A and/or B" means A or B, or A and B.

Throughout the specification of the present invention, "pH-sensitive cosmetic composition for improving acne" may be briefly referred to as "cosmetic composition".

In the entire specification of the present invention, "oil phase" may mean a known oil phase, oil, etc., but is not limited thereto.

In the entire specification of the present invention, "aqueous phase" may mean a known water phase, water, etc., but is not limited thereto.

In the entire specification of the present invention, "acne bacteria" may mean bacteria that cause acne, but are not limited thereto.

Hereinafter, the present invention has been described in detail, but the present invention is not limited thereto.

In the present invention, a pH-sensitive complex is provided.

In an embodiment of the present invention, a hollow porous silica, salicylic acid, tea tree oil, and a pH sensitive material are included, wherein the hollow porous silica includes a core 100 made of an empty space and the It is formed in a structure of a shell 200 in which a plurality of through holes 210 connecting the core 100 and the outside are formed, and salicylic acid and tea tree oil are supported in the core 100, and the plurality of through holes 210 ), as the pH-sensitive material is supported on at least one or more of), the salicylic acid of the core 100 is discharged to the outside in a specific pH range, providing a pH-sensitive complex. Preferably, the pH-sensitive complex of this embodiment may be applied to a pH-sensitive cosmetic composition for improving acne.

1 is a view showing a hollow porous silica according to an embodiment of the present invention. In addition, Figure 2 is a diagram showing a cross-section of the pH-sensitive composite according to an embodiment of the present invention. In FIG. 2, salicylic acid and tea tree oil are supported on the core 100 of the pH-sensitive composite, which corresponds to a point region, and at least one of the plurality of through-holes 210 of the shell 200 contains a pH-sensitive material. It is supported, which corresponds to the shaded area.

The hollow porous silica is formed in a structure of a core 100 formed of an empty space and a shell 200 having a plurality of through holes 210 connecting the core 100 to the outside. As shown in FIG. 1, the hollow porous silica of this embodiment may be spherical, but is not limited thereto. The hollow porous silica of the present embodiment may have a particle diameter of 7 to 10 micrometers, and a particle diameter of the core 100 may be 5 to 8 micrometers, but is not limited thereto.

Referring to FIG. 2, salicylic acid and tea tree oil are supported on the core 100 of the hollow porous silica according to the present embodiment, and a pH-sensitive material is supported on at least one of the plurality of through holes 210. Accordingly, the salicylic acid is not exposed to the outside, and may be exposed to the outside by deformation of the pH-sensitive material in a specific pH range. In particular, when the pH-sensitive complex of the present embodiment is applied to acne skin, the salicylic acid of the core 100 is discharged to the outside while the pH-sensitive material of the shell 200 is dissolved, thereby improving acne skin.

The pH-sensitive composite of this example contains 0.01 to 50.0% by weight of hollow porous silica, preferably 10.0 to 45.0% by weight, more preferably 15.0 to 40.0% by weight, most preferably 20.0 to 35.0% by weight, based on the total weight of the pH-sensitive composite. Can be included as.

If the pH-sensitive composite of this embodiment contains less than 0.01% by weight of hollow porous silica based on the total weight of the pH-sensitive composite, salicylic acid, tea tree oil, and a pH-sensitive material are used in the core 100 or the through hole 210 It may not be able to contain enough. Accordingly, the effect of improving acne of the cosmetic composition of this embodiment may be significantly reduced. On the other hand, when the pH-sensitive composite of this embodiment contains more than 50.0% by weight of hollow porous silica based on the total weight of the pH-sensitive composite, the core 100 or the through hole 210 is not sufficiently filled, which is not economical. In addition, there may be a problem in that salicylic acid and tea tree oil of the core 100 are easily discharged to the outside.

Salicylic acid is an aromatic oxycarboxylic acid, a colorless solid, has direct activity as an anti-inflammatory and antibacterial agent, regenerates the skin, promotes peeling, and prevents clogging of pores. In particular, it is possible to inhibit the propagation or activity of acne bacteria by preventing not only anti-inflammatory and antibacterial activities, but also excess sebum and clogging of pores that promote the growth of acne bacteria.

In addition, salicylic acid lowers the pH of the alkalized acne skin so that the skin can be maintained in a weakly acidic state, thereby improving homeostasis and antibacterial activity of the skin itself.

The pH-sensitive composite of this embodiment contains salicylic acid in an amount of 0.01 to 40.0% by weight, preferably 10.0 to 37.0% by weight, more preferably 15.0 to 33.0% by weight, and most preferably 20.0 to 30.0% by weight, based on the total weight of the pH-sensitive complex. I can.

If the pH-sensitive complex of the present embodiment contains less than 0.01% by weight of salicylic acid based on the total weight of the pH-sensitive complex, the anti-inflammatory activity, skin regeneration, and pore clogging of the cosmetic composition to which the pH-sensitive complex is applied are not sufficient. As a result, the acne improvement effect may be insignificant. On the other hand, when the pH-sensitive composite of the present embodiment contains more than 40.0% by weight of salicylic acid based on the total weight of the pH-sensitive composite, some salicylic acid is not supported on the core 100 of the hollow porous silica, or the shell 200 It is supported in the through hole 210 and can be discharged to the outside regardless of the pH change. Accordingly, the cosmetic composition to which the pH-sensitive complex of the present embodiment is applied may irritate the skin and may have a problem of deteriorating formulation stability.

Tea tree oil is an essential oil extracted from leaves and twigs of tea tree. It is an antibacterial oil that sterilizes and disinfects bacteria, viruses, and fungi, and plays a role in increasing immunity. That is, the tea tree oil of the present embodiment may inhibit the activity of acne bacteria by sterilizing or antibacterializing acne bacteria.

The pH-sensitive composite of this example contains tea tree oil in an amount of 0.01 to 40.0% by weight, preferably 10.0 to 37.0% by weight, more preferably 15.0 to 33.0% by weight, most preferably 20.0 to 30.0, based on the total weight of the pH-sensitive complex. It may be included in weight percent.

If the pH-sensitive composite of the present embodiment contains less than 0.01% by weight of tea tree oil based on the total weight of the pH-sensitive composite, sterilization and disinfection, antibacterial properties, etc. may be deteriorated, and the effect of improving acne may be insignificant. On the other hand, when the pH-sensitive composite of the present embodiment contains more than 40.0% by weight of tea tree oil based on the total weight of the pH-sensitive composite, some tea tree oil may not be supported on the core 100 of the hollow porous silica or the shell It may be supported in the through hole 210 of (200). Accordingly, the cosmetic composition of this embodiment may irritate the skin while being discharged to the outside irrespective of the pH change, and formulation stability may be deteriorated.

The pH-sensitive composite of the present embodiment includes 0.01 to 40.0% by weight of salicylic acid and 0.01 to 40.0% by weight of tea tree oil, respectively, based on the total weight of the pH-sensitive complex, wherein the salicylic acid and tea tree oil are 1: 0.5 to 2 in a weight ratio. Can include.

Preferably, the salicylic acid and tea tree oil may be included in a weight ratio of 1:1 to 1.5.

More preferably, in this embodiment, the salicylic acid and tea tree oil may be included in a weight ratio of 1:1.5.

In particular, the pH-sensitive composite of the present embodiment contains 0.01 to 40.0% by weight of salicylic acid and 0.01 to 40.0% by weight of tea tree oil, respectively, based on the total weight, but the salicylic acid and tea tree oil in a weight ratio of 1: 0.5 to 1.5 At this time, the persistence of the acne improvement effect can be improved by continuously releasing salicylic acid in a specific pH range. In addition, salicylic acid and tea tree oil may be supported in a stable state on the core 100 of the hollow porous silica, so that the pH-sensitive composite may maintain a stable state. Accordingly, the cosmetic composition including the pH-sensitive complex may have excellent formulation stability.

The pH-sensitive material is a material whose state changes according to a change in pH, and the pH-sensitive material of this embodiment is soluble in oil in acidic conditions and in basic conditions according to pH change. It may be soluble in aqueous.

Preferably, the pH-sensitive material of the present embodiment may be dissolved in an oily condition in an acidic condition of less than pH 4.0 and in an aqueous solution in an acidic condition of pH 7.0 or higher according to a change in pH.

In this embodiment, the pH-sensitive material is supported in at least one or more of the plurality of through-holes 210, so that in weakly acidic healthy skin, the pH-sensitive material is not dissolved in water and the through-hole of the shell 200 ( 210). On the other hand, in basic acne or inflammatory skin, the pH-sensitive substance is dissolved in water and discharged from the through hole 210 of the shell 200, so that salicylic acid and tea tree oil of the core 100 can be discharged to the outside. . That is, by supporting a pH-sensitive material that is soluble in oil in an acidic condition and soluble in aqueous in a basic condition in the through hole 210 of the shell 200, salicylic acid can be selectively discharged to the outside according to the pH of the skin.

Accordingly, since salicylic acid does not come into contact with the skin in healthy weakly acidic skin, and salicylic acid is in contact with the skin only in basic skin such as acne, it is possible not only to reduce skin irritation but also to maintain a stable formulation. In addition, conventionally, it has been difficult to implement various formulations by salicylic acid, but when the pH-sensitive complex according to the present embodiment is applied, it may be utilized in various formulations while including salicylic acid.

Preferably, the pH-sensitive material of this embodiment may be Meadowfoam delta-lactone.

Medoform delta-lactone is derived from Medoform, a plant, and is an amphoteric compound having isomers that change the solubility in the oil phase and the aqueous phase according to pH change. The medoform delta-lactone has the properties of an intermediate under neutral conditions, but changes to a structure of 5-hydroxy fatty acids under basic conditions, has the property of an aqueous phase, and can be dissolved in the aqueous phase. On the other hand, in acidic conditions, it changes to a lactone structure, has oily properties, and can be dissolved in an oily phase.

That is, in the basic condition of acne skin, the medoform delta-lactone is dissolved in the aqueous phase and discharged from the through hole 210, so that the salicylic acid and tea tree oil of the core 100 are discharged to the outside together, thereby improving acne skin. .

The pH-sensitive composite of the present example contains 0.01 to 30.0% by weight, preferably 5.0 to 25.0% by weight, more preferably 10.0 to 23.0% by weight, most preferably 15.0 to 20.0, based on the total weight of the pH-sensitive composite. It may be included in weight percent.

If the pH-sensitive composite of the present embodiment contains less than 0.01% by weight of the pH-sensitive material based on the total weight of the pH-sensitive composite, the through hole 210 is not sufficiently filled, so that the salicylic acid of the core 100 is difficult to be protected. In addition, there may be a problem that salicylic acid is exposed to the outside regardless of the pH change. Accordingly, skin irritation, formulation stability, and acne improvement effects of the cosmetic composition including the pH-sensitive complex of the present embodiment may be reduced.

On the other hand, when the pH-sensitive composite of the present embodiment contains in excess of 30.0% by weight of a pH-sensitive material based on the total weight of the pH-sensitive composite, the pH-sensitive material is excessively concentrated on the surface of the hollow porous silica, and thus from the core 100 There may be a problem that makes it difficult to release salicylic acid.

The present invention provides a method for preparing a pH-sensitive composite.

In an embodiment of the present invention, a step of impregnating a hollow porous silica with salicylic acid and tea tree oil, and impregnating a pH-sensitive material into the hollow porous silica impregnated with the salicylic acid and tea tree oil, wherein the hollow type The porous silica is formed in a structure of a core 100 made of an empty space and a shell 200 in which a plurality of through holes 210 connecting the core 100 and the outside are formed, and the core 100 includes salicylic acid and Ti. Preparation of a pH-sensitive composite capable of discharging the salicylic acid of the core 100 to the outside in a specific pH region as tree oil is supported and a pH-sensitive material is supported in at least one or more of the plurality of through holes 210 Provides a way. Preferably, the pH-sensitive complex of this embodiment may be applied to a pH-sensitive cosmetic composition for improving acne.

(1) impregnating salicylic acid and tea tree oil in hollow porous silica

In the step of impregnating the hollow porous silica with salicylic acid and tea tree oil, salicylic acid and tea tree oil may be impregnated in the core 100 of the hollow porous silica.

In more detail, in the step of impregnating salicylic acid and tea tree oil in (1) hollow porous silica of the present embodiment, salicylic acid is dissolved by heating (about 40° C.) in tea tree oil to prepare a mixture, and hollow porous silica in a closed Henschel mixer. After the silica is added, the mixed solution is sprayed with a spray sprayer through an inlet while stirring, so that the mixed solution is impregnated or adsorbed to the core 100 in the hollow porous silica.

Accordingly, it may be formed in a form in which salicylic acid and tea tree oil are supported on the core 100 of the hollow porous silica. In this case, separate drying, heating, cooling, ultrasonication, stirring, vibration treatment, etc. may be performed, but is not limited thereto.

Accordingly, as shown in FIG. 2, salicylic acid and tea tree oil may be supported on the core 100.

(2) impregnating a pH-sensitive material into hollow porous silica impregnated with salicylic acid and tea tree oil

In the step of impregnating a pH-sensitive material into the hollow porous silica impregnated with salicylic acid and tea tree oil of the present embodiment, a pH-sensitive material is added to the hollow porous silica on which salicylic acid and tea tree oil are supported on the core 100 according to the above. Can be impregnated. Preferably, a pH-sensitive material may be impregnated into at least one of a plurality of through-holes 210 of hollow porous silica in which salicylic acid and tea tree oil are supported on the core 100.

In more detail, in the step of impregnating a pH-sensitive material in the hollow porous silica impregnated with salicylic acid and tea tree oil of the present embodiment (2), a solid meadow delta-lactone was heated (about 40° C.) to liquefy, salicylic acid and The liquefied meadow delta-lactone is sprayed with a spray sprayer through the inlet while stirring the closed Henschel mixer containing the hollow porous silica loaded with tea tree oil, and the meadow delta-lactone is formed in the shell 200 of the hollow porous silica. It can be impregnated or adsorbed.

Meanwhile, according to the above process, the meadow delta-lactone may be impregnated or adsorbed into the shell 200 of the hollow porous silica. In addition, salicylic acid and tea tree oil may be supported and impregnated or adsorbed on the empty core 100, but may be impregnated or adsorbed while wrapping salicylic acid or tea tree oil so that they are not exposed to the outside. In this case, separate drying, heating, cooling, ultrasonication, stirring, vibration treatment, etc. may be performed, but is not limited thereto.

As a result, as shown in FIG. 2, a pH-sensitive material is supported on at least one or more of the plurality of through-holes 210 of the shell 200 of the hollow porous silica of the present embodiment, thereby preparing a pH-sensitive composite. I can.

The method for preparing the pH-sensitive composite of the present embodiment includes all the contents of the pH-sensitive composite.

The present invention provides a pH-sensitive cosmetic composition for improving acne.

In an embodiment of the present invention, a hollow porous silica, salicylic acid, tea tree oil, and a pH sensitive material are included, wherein the hollow porous silica includes a core 100 made of an empty space and the It is formed in a structure of a shell 200 in which a plurality of through holes 210 connecting the core 100 and the outside are formed, and salicylic acid and tea tree oil are supported in the core 100, and the plurality of through holes 210 A pH-sensitive cosmetic composition for improving acne, including a pH-sensitive complex on which at least one of) a pH-sensitive material is supported, is provided.

Preferably, the cosmetic composition of this embodiment can improve acne by inhibiting the activity of acne causative bacteria.

In this embodiment, the pH-sensitive complex may be included in an amount of 0.01 to 30.0% by weight based on the total weight of the cosmetic composition. When the pH-sensitive complex is included in an amount of less than 0.01% by weight based on the total weight of the cosmetic composition of this embodiment, the effect of improving acne may be insignificant. On the other hand, when the pH-sensitive complex is included in excess of 30.0% by weight with respect to the total weight of the cosmetic composition of the present embodiment, it is not economical, skin irritation increases, and formulation stability may be deteriorated.

The cosmetic composition of this embodiment is from the group consisting of softening lotion, nutrient lotion, astringent lotion, skin, lotion, essence, cream, massage cream, pack, makeup base, BB cream, foundation, powder, cleansing foam, cleansing cream and cleansing water. It may be any one formulation selected, but is not limited thereto.

The cosmetic composition of the present embodiment may contain a cosmetically acceptable carrier or additive in addition to salicylic acid, tea tree oil, pH-sensitive material, and hollow porous silica. For example, the cosmetic composition may be purified water, anti-wrinkle agent, anti-aging agent, antioxidant, elasticity improving agent, whitening agent, moisturizing agent, sunscreen, anti-inflammatory agent, atopic dermatitis improving agent, acne improving agent, sebum secretion inhibitor, trouble preventing agent, fatty substance, organic Solvents, solubilizers, thickeners, gelling agents, softening agents, suspending agents, stabilizers, blowing agents, fragrances, surfactants, emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, wetting agents, oils, dyes, pigments, It may further include an additive including at least one selected from the group consisting of fragrances, hydrophilic or lipophilic active agents, and lipid vesicles, but is not limited thereto.

The pH-sensitive cosmetic composition for improving acne of this embodiment includes all the contents of the pH-sensitive complex.

The present invention provides a method for preparing a pH-sensitive cosmetic composition for improving acne.

In an embodiment of the present invention, a hollow porous silica, salicylic acid, tea tree oil, and a pH sensitive material are included, wherein the hollow porous silica includes a core 100 made of an empty space and the It is formed in a structure of a shell 200 in which a plurality of through holes 210 connecting the core 100 and the outside are formed, and salicylic acid and tea tree oil are supported in the core 100, and the plurality of through holes 210 ) To prepare a pH-sensitive composite in which a pH-sensitive material is supported on at least one or more of), and then mix it with an additive, to prepare a cosmetic composition.

For example, the additives are purified water, anti-wrinkle agents, anti-aging agents, antioxidants, elasticity improvers, whitening agents, moisturizers, sunscreens, anti-inflammatory agents, atopic dermatitis improvers, acne improvers, sebum secretion inhibitors, trouble preventing agents, fatty substances, organic solvents , Solubilizing agent, thickening agent, gelling agent, softening agent, suspending agent, stabilizer, foaming agent, fragrance, surfactant, emulsifier, filler, sequestering agent, chelating agent, preservative, vitamin, wetting agent, oil, dye, pigment, fragrance , Hydrophilic or lipophilic active agents, and may include one or more selected from the group consisting of lipid vesicles, but are not limited thereto.

According to the present embodiment, stirring, heating, cooling, ultrasonication, vibration treatment, etc. may be performed in the process of mixing the pH-sensitive composite and the additive, but is not limited thereto.

Hereinafter, through Examples, Comparative Examples, and Experimental Examples, a pH-sensitive cosmetic composition for improving acne of the present invention and a method of manufacturing the same will be described in detail. Since these examples are for illustrative purposes only, the scope of the present invention is not to be construed as being limited by these examples.

[Example]

Examples 1 to 4

First, as shown in FIG. 1, a hollow porous silica having a shell structure in which a core formed of an empty space and a plurality of through holes connecting the core and the outside were formed was prepared. Separately, after mixing salicylic acid and tea tree oil, a mixed solution heated at about 40°C was prepared. Thereafter, the hollow porous silica was added to the closed Henschel mixer and while stirring, the mixture was sprayed with a spray sprayer to impregnate the core of the hollow porous silica with a mixture of salicylic acid and tea tree oil.

Then, the hollow porous silica in which the mixture of salicylic acid and tea tree oil is supported on the core is injected into a closed Henschel mixer and stirred, while the liquid medoform delta-lactone heated at about 40°C is sprayed with a spray sprayer, and the hollow type Medoform delta-lactone was impregnated in the pores including the through holes of the porous silica.

By cooling and drying it to room temperature, a pH-sensitive composite was prepared. At this time, silica, salicylic acid, tea tree oil, and medoform delta-lactone were mixed in the composition [unit: wt%] shown in Table 1.

In Table 1, the salicylic acid and tea tree oil of Examples 1 to 4 were mixed so that the total content of the two components was 50% by weight, and the mixing ratio of salicylic acid and tea tree oil in Table 2 [unit: weight ratio] Changed to and marked.

[Comparative Example]

Comparative Examples 1 to 8

Prepared in the same manner as in the above example, silica, salicylic acid, tea tree oil, and medoform delta-lactone were mixed in the composition [unit: wt%] shown in Table 3.

[Manufacture example]

A cream-type cosmetic composition comprising the pH-sensitive complex of Examples or Comparative Examples prepared according to the above was prepared according to a known method.

At this time, the cosmetic composition was prepared in the composition shown in Table 4 [unit: wt%].

[Experimental Example 1]

Experimental Example 1: Salicylic acid release according to pH change

(1) Evaluation of release of salicylic acid according to pH change

The amount of salicylic acid released according to the pH change of the pH-sensitive complexes according to Examples 1 to 4 and Comparative Examples 1 to 8 was analyzed using HPLC (liquid chromatography), and when salicylic acid was released, it was marked as ○, and salicylic acid was released. If not, it is marked with X.

At this time, check whether salicylic acid is released using HPLC, as described below, [Standard and test method for functional cosmetics : It was carried out according to the internal standard method of liquid chromatography method of general test method].

First, add 50% acetonitrile containing 1% phosphoric acid to about 2.0 g of the sample, and sufficiently disperse the sample by ultrasonic shaking, and then add 1 mL of the internal standard solution and 50% acetonitrile containing 1% phosphoric acid to make 50 mL. Use it as the sample solution. The sample refers to a pH-sensitive complex according to Examples 1 to 4 or Comparative Examples 1 to 8.

Separately from the sample solution, 50 mg of salicylic acid standard was dissolved in 50% acetonitrile containing 1% phosphoric acid to make 25 mL. Take 0.63 mL, 1.25 mL, 2.5 mL, 5.0 mL, and 10.0 mL of the standard stock solution, add 1.0 mL of the internal standard solution, and add 50% acetonitrile containing 1% phosphoric acid to make 100 mL, and use it as each standard solution.

The internal standard solution is prepared by mixing about 100 mg of acetaminophen and 50% acetonitrile containing 1% phosphoric acid and then dissolving it. If necessary, the sample collection amount or the dilution factor can be adjusted within the calibration curve of the standard solution.

-Detector (wavelength): Ultraviolet absorption spectrophotometer (220 nm)

-Column: Shiseido, Capcellpak C18 UG 120 (5 μm, 4.6 × 250 mm)

-Mobile phase flow rate: 1.0 mL/min, injection volume 20 μL

Looking at Table 5, it can be seen that in the case of Examples 1 to 4, salicylic acid is specifically released only in an alkaline region of pH 7 or higher.

In addition, in the case of Comparative Example 1 in which a very small amount of hollow porous silica is used, it is difficult to sufficiently support salicylic acid, tea tree oil, and medoform delta-lactone in the hollow porous silica, so that the evaluation of whether salicylic acid is released according to pH change itself is not performed. It was difficult. On the other hand, in the case of Comparative Example 2 in which the hollow porous silica was used in a very excessive amount, release of salicylic acid was observed in all regions between pH 4.5 and 9.0. It is believed that as the hollow porous silica is used in excess, the salicylic acid of the core is not sufficiently protected by the medoform delta-lactone, and thus it is released to the outside regardless of the pH change.

In addition, even in the case of Comparative Example 3 in which a very small amount of salicylic acid was used, it was difficult to evaluate whether salicylic acid was released according to a pH change. On the other hand, in the case of Comparative Example 4 in which salicylic acid was used in a very excessive amount, release of salicylic acid was observed in all regions between pH 4.5 and 9.0. It is believed that as salicylic acid is used in excess, the salicylic acid of the core is not sufficiently protected by the medoform delta-lactone, and thus, it is released to the outside regardless of the pH change.

In addition, in the case of Comparative Example 5 in which a small amount of tea tree oil is used, it can be seen that salicylic acid is specifically released only in an alkaline region of pH 7 or higher. On the other hand, in the case of Comparative Example 6 in which an excessive amount of tea tree oil was used, release of salicylic acid was observed in all regions between pH 4.5 and 9.0. This is because the mixture of tea tree oil and salicylic acid is not sufficiently supported in the hollow porous silica due to excessive use of tea tree oil, so that the material of the core is not protected by the medoform delta-lactone, regardless of the pH change. It appears to have been released to the outside.

In addition, in the case of Comparative Example 7 in which a small amount of medoform delta-lactone was used, the salicylic acid supported in the hollow porous silica was not protected by the medoform delta-lactone, so it can be seen that it is released to the outside regardless of the pH change. . On the other hand, in the case of Comparative Example 8 in which an excessive amount of medoform delta-lactone was used, salicylic acid was released to the outside by forming a film on the outside of the hollow porous silica as well as through holes in the shell of the medoform delta-lactone. It seems to interfere with becoming.

That is, according to the above results, a pH-sensitive complex that contains all of the hollow porous silica, salicylic acid, tea tree oil, and pH-sensitive substances, but can specifically release salicylic acid only in a specific pH region when they are included in a specific amount. It can be seen that the formation of is possible.

(2) Evaluation of salicylic acid release according to pH change

After analyzing the amount of salicylic acid released according to the pH change of the pH-sensitive complex according to Example 3 using HPLC (liquid chromatography), the results are shown in FIG. 3.

3, it can be seen that the pH-sensitive complex according to Example 3 does not release salicylic acid under acidic conditions and specifically releases salicylic acid only under pH 7 or higher conditions.

Experimental Example 2: Evaluation of the amount of salicylic acid released over time in an alkaline environment

After the pH-sensitive complexes of Examples 1 to 4 were exposed to an alkaline environment, the amount of salicylic acid released to the outside was measured by time, and the results are shown in FIG. 4.

The amount of salicylic acid released was obtained by mixing potassium hydroxide with purified water to prepare an aqueous solution under alkaline conditions (pH 7.5), and then adding a pH-sensitive complex, stirring with a magnetic stirrer, and aliquoting a certain amount for each time period. In the same manner, it was analyzed by HPLC. At this time, in the evaluation of the amount of salicylic acid released in Examples 1 to 4, an aqueous solution and a pH-sensitive complex in the same amount of alkaline conditions were used.

Referring to FIG. 4, it can be seen that salicylic acid is released in all of Examples 1 to 4 after the pH-sensitive complex is exposed to an alkaline environment of pH 7.5 or higher.

In more detail, in the case of Examples 1 to 3 in which salicylic acid and tea tree oil are mixed in a weight ratio of 1: 0.5 to 1.5, it can be seen that the amount of salicylic acid released increases as time passes, which is an effect of improving acne by salicylic acid. Means that can be maintained for a long time.

In particular, in the case of Example 3 in which salicylic acid and tea tree oil were mixed in a weight ratio of 1: 1.5, compared to Examples 1 and 2, it was confirmed that a high concentration of salicylic acid was continuously released for a long time, and the best acne improvement effect It can be seen that the persistence of the acne improvement effect is the most excellent while having

On the other hand, in the case of Example 4 in which salicylic acid and tea tree oil were mixed in a weight ratio of 1: 2, the concentration of salicylic acid was rapidly released and then the concentration was sharply lowered. It can be seen that it is low.

Experimental Example 3: Evaluation of the stability of the pH-sensitive complex

Using Lumisizer (L.U.M. GmbH, Berlin, Germany), an accelerated stability test of the pH-sensitive complexes according to Examples 1 to 4 was carried out. The acceleration stability test follows the stability evaluation method specified in the ISO guideline (ISO/TR13097).

In more detail, it was carried out by measuring the transmittance (865 nm wavelength) at intervals of about 60 seconds for 12 hours while accelerating the pH-sensitive composite from 40° C. to 4,000 rpm.

Thereafter, the instability index based on the transmittance measured according to the above is shown in FIG. 5. At this time, the instability index is represented by 0 to 1. The closer the instability index is to 1, the more unstable the pH-sensitive complex is. If the pH-sensitive complex is unstable, the internal lipophilic component (tea tree oil) ) Is emitted to the outside and the transmittance is lowered.

5, in the case of Examples 1 to 3, the instability index is low, but in the case of Example 4, it can be seen that the instability index is significantly increased close to 1. That is, it can be seen that in Examples 1 to 3 than in Example 4, a stable pH-sensitive complex can be implemented.

Experimental Example 4: Acne improvement effect

(1) Evaluation of killing effect of p.acne strain

The pH-sensitive complex of Example 1 was exposed to an alkaline environment of pH 7.5 for about 6 hours so that salicylic acid was released, and then p.acne (Propionibacterium acnes) was cultured in an anaerobic condition in a medium of 0.5%, 1.0%, 2.0% After injecting at the concentration of, each degree of death (size of the growth inhibitory ring) was evaluated, and the results are shown in Table 6.

At this time, the p.acne (Propionibacterium acnes) was cultured on a plate under anaerobic conditions, and then inoculated into a broth medium under anaerobic conditions, and cultured.

In addition, the degree of killing of p.acne strains according to Examples 2 to 4 and Comparative Examples 1 to 8 was always evaluated in the same manner as in Example 1, and the results are shown in Table 6 [unit: cm].

Referring to Table 6, it can be seen that the killing effect of the p.acne strain is significantly superior to that of Comparative Examples 1 to 8 in the case of Examples according to this Example. In particular, among Examples 1 to 4, it can be seen that the killing effect of the p.acne strain of Example 3 containing salicylic acid and tea tree oil in a weight ratio of 1: 1.5 is the most excellent.

In addition, in Comparative Examples 1, 3, and 8, in which salicylic acid was not easily released in Experimental Example 1, the killing effect of the p.acne strain was hardly found.

In addition, a diagram of the experimental results of Example 3 is shown in FIG. 6. As shown in FIG. 6, it can be seen that the killing effect of the p.acne strain can be implemented when the present embodiment is followed.

(2) Verification of acne improvement effect through panel test

The cosmetic composition containing the pH-sensitive complex according to Example 3 was evenly applied to the face twice a day (5 mL) for about 6 weeks, and then the 2nd, 3rd, 4th and 6th weeks of The Investigator's assessment grade was evaluated and the results are shown in Table 7.

In addition, as a control group, the acne severity ratings of the 2nd, 3rd, 4th and 6th weeks of subjects who did not apply the cosmetic composition containing the pH-sensitive complex according to Example 3 were evaluated, and the results are shown in Table 8.

At this time, the experimental group to which the cosmetic composition containing the pH-sensitive complex according to Example 3 was applied and the control group to which it was not applied were all subject to a group of subjects consisting of 5 males and 5 females aged 20 years or older to less than 50 years old. Experimented with.

The acne severity rating was measured through a face meter (JANUS equipment), and the acne severity rating was evaluated according to the following conditions.

-Grade O: No lesion

-Grade 1: Almost no lesions (nodules: none, papules/pustules: 1 or less, comedones: few)

-Grade 2: Mild (nodule: none, papule/concentration: 5 or less, comedones: slightly)

-Grade 3: Severity (nodule: less than 1, papules/pustules: more than 6, comedones: many)

-Grade 4: Severe (nodules: less than 5, papules/pustules: many, comedones: many)

Looking at Tables 7 and 8, in the case of the control group, no improvement in the severity of acne was observed, but when the cosmetic composition containing the pH-sensitive complex of Example 1 was applied, about 8 out of 10 people improved the severity of acne. I can confirm.

That is, it can be seen that according to the present embodiment, the acne improvement effect is excellent.

In addition, the degree of improvement in the severity of acne in Examples 1, 2 and 4 and Comparative Examples 1 to 8 was evaluated in the same manner as in Example 3. Each of the test subjects was composed of 10 subjects under the same conditions, and Table 9 shows the number of persons whose acne severity grade improved by 1 or more.

Referring to Table 9, it can be seen that in the case of the example according to the present example, the acne improvement effect is significantly superior to that of the comparative example. In particular, it can be seen that the acne improvement effect of Example 3 is the most excellent.

In addition, in the case of Comparative Examples 1, 3 and 8 in which the release of salicylic acid was not easy in Experimental Example 1, there was little effect of improving acne.

As described above, the description of the present invention is for illustrative purposes only, and those of ordinary skill in the art to which the present invention pertains can easily transform into other specific forms without changing the technical spirit or essential features of the present invention. You can understand. Therefore, the embodiments described above are illustrative in all respects and should be understood as non-limiting. For example, each component described as a single type may be implemented in a distributed manner, and similarly, components described as being distributed may also be implemented in a combined form.

The scope of the present invention is indicated by the claims to be described later rather than the detailed description, and all changes or modified forms derived from the meaning and scope of the claims and their equivalent concepts should be interpreted as being included in the scope of the present invention. do.

100: core
200: shell
210: through hole

Claims (9)

Including hollow porous silica, salicylic acid, tea tree oil, and a pH sensitive material,
The hollow porous silica is formed in a structure of a core formed of an empty space and a shell having a plurality of through holes connecting the core and the outside,
Salicylic acid and tea tree oil are supported on the core,
At least one or more of the plurality of through-holes are supported with a pH-sensitive material,
The salicylic acid and tea tree oil are characterized in that contained in a weight ratio of 1: 0.5 ~ 2, pH-sensitive complex.
The method of claim 1,
The pH-sensitive complex is
It characterized in that it comprises 0.01 to 50.0% by weight of hollow porous silica, 0.01 to 40.0% by weight of salicylic acid, 0.01 to 40.0% by weight of tea tree oil, and 0.01 to 30.0% by weight of a pH-sensitive material based on the total weight of the pH-sensitive composite, pH sensitive complex.
delete In the method for producing a pH-sensitive composite comprising hollow porous silica, salicylic acid, tea tree oil, and a pH-sensitive material,
Impregnating the hollow porous silica with salicylic acid and tea tree oil; And
Including the step of impregnating a pH-sensitive material into the hollow porous silica impregnated with salicylic acid and tea tree oil,
The hollow porous silica is formed in a structure of a core formed of an empty space and a shell having a plurality of through holes connecting the core and the outside,
Salicylic acid and tea tree oil are supported on the core,
At least one or more of the plurality of through-holes are supported with a pH-sensitive material,
The salicylic acid and tea tree oil are 1: 0.5 to 2, characterized in that contained in a weight ratio of, pH-sensitive composite manufacturing method.
A pH-sensitive cosmetic composition for improving acne, comprising the pH-sensitive complex of claim 1.
The method of claim 5,
A pH-sensitive cosmetic composition for improving acne, characterized in that the pH-sensitive complex is contained in an amount of 0.01 to 30.0% by weight based on the total weight of the cosmetic composition.
The method of claim 5,
The cosmetic composition is
A pH-sensitive cosmetic composition for improving acne, characterized in that it inhibits the activity of acne causative bacteria.
The method of claim 5,
The cosmetic composition is
Any one formulation selected from the group consisting of softening lotion, nutrient lotion, astringent lotion, skin, lotion, essence, cream, massage cream, pack, makeup base, BB cream, foundation, powder, cleansing foam, cleansing cream and cleansing water Characterized in that, a pH-sensitive cosmetic composition for improving acne.
The method of claim 5,
The cosmetic composition is
Purified water, anti-wrinkle agent, anti-aging agent, antioxidant, elasticity improver, whitening agent, moisturizer, sunscreen, anti-inflammatory agent, atopic dermatitis improver, acne improver, sebum secretion inhibitor, trouble preventing agent, fatty substance, organic solvent, solubilizer, thickening agent, gel Agents, emollients, suspending agents, stabilizers, blowing agents, fragrances, surfactants, emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, wetting agents, oils, dyes, pigments, fragrances, hydrophilic or lipophilic actives, and A pH-sensitive cosmetic composition for improving acne, characterized in that it further comprises an additive comprising at least one selected from the group consisting of lipid vesicles.

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