KR101799436B1 - Anti-bacterial cosmetic composition - Google Patents

Abstract

The present invention discloses an antimicrobial cosmetic composition comprising a powder coated with salicylic acid.

Description

[0001] Anti-bacterial cosmetic composition [0002]

The present invention relates to an antimicrobial cosmetic composition.

The pores, which are connected to the pilosebaceous tube that carries Sebum produced from the sebaceous glands, secrete sebum to form the sebaceous membrane, a skin barrier. Through these pores, crusts of keratin are released to the outside together with sebum secretion material. At this time, if the crumbs are not discharged, the pores are clogged. In this case, the sebum is accumulated in the skin because it can not be discharged from the pores. In sebaceous dead skin, the anaerobic acne bacteria ( Propionibacterium acnes ) is accelerated, and in the process toxic substances that stimulate the skin are secreted. Inflammation caused by this causes pus, red rash, etc., further damage the skin.

The present invention is to provide a cosmetic composition having excellent antibacterial activity and excellent feeling of use.

One aspect of the present invention provides an antimicrobial cosmetic composition comprising a powder coated with salicylic acid.

The cosmetic composition according to the present invention contains a powder coated with salicylic acid, thereby exhibiting excellent antibacterial activity, excellent feeling of use and stability. Therefore, the composition according to the present invention can effectively prevent or ameliorate inflammatory skin diseases such as acne, acne rash, atopic dermatitis or seborrhoeic dermatitis. In addition, the cosmetic composition according to the present invention, unlike the general cosmetic composition, is excellent in antimicrobial effect especially against acne bacterium, so that a person having acne skin can use it freely.

Acne, acne spots, atopic dermatitis, or seborrheic dermatitis are inflammatory skin diseases that cause inflammation in the skin epithelium and cause skin symptoms such as itching, edema, erythema, and peeling. In order to treat such inflammatory skin diseases, the inflammation should first be settled and the clogged pores should be opened so that the sebum can be discharged well. A typical method for this is to remove the dead skin cells from the hair follicles and open the pores. Specifically, there is a method of removing the keratinized old keratinocyte. Salicylic acid is a commonly used substance.

Salicylic acid can be represented by o-oxybenzoic acid, the formula of which is C ₇ H ₆ O ₃ , and the molecular weight is 138.12. It has been used since ancient times to remove pathological proliferation of keratin, warts, corns, and the like. Salicylic acid is also an oil-soluble ingredient that dissolves in boiling water, alcohol, or ether. Due to such solubility characteristics, when it is desired to include salicylic acid in a cosmetic composition such as toner, lotion or cream containing oil, a method of dissolving salicylic acid in oil may be used. When salicylic acid is intended to be contained in a cosmetic composition such as toner, which is a solubilized formulation using only a small amount of oil, salicylic acid may be dissolved in alcohol to be solved. However, when the amount of the oil or alcohol contained in the cosmetic composition is insufficient, it is difficult to produce a stable cosmetic composition because salicylic acid is easily precipitated due to low solubility.

Many cosmetic compositions for improving acne which are currently on the market include cosmetic compositions for skin care such as toners and lotions, but most acne patients use cosmetic compositions to improve the symptoms of acne, and at the same time, I want to hide. There is a demand for a makeup cosmetic composition containing salicylic acid having an acne improvement effect. In the case of foundation, BB cream, cover cake, etc., which can contain a large amount of oil, salicylic acid can be easily prepared by dissolving it in oil. On the other hand, in the case of the powder type cosmetic composition, loose powder contains 3% or less of pressed powder, and pressed powder contains a small amount of oil of 10% or less, and mainly contains a silicone-based component which is resistant to perspiration and sebum as a binder . Even if the silicone-based component contains oil, the use of salicylic acid is inevitable because salicylic acid is not well soluble in the silicone-based component.

Another method for incorporating salicylic acid into a powder type cosmetic composition is to mix the powdered salicylic acid as it is in a cosmetic composition. In this case, however, salicylic acid is not uniformly dispersed in the composition, and the effect is not uniformly exhibited, and there is a disadvantage that the cosmetic composition is poorly used when applied to the skin due to the rough salicylic acid.

Hereinafter, the present invention will be described in more detail.

One aspect of the present invention provides an antimicrobial cosmetic composition comprising a powder coated with salicylic acid. The composition not only exhibits excellent antibacterial activity including powder particles coated with salicylic acid but also has a feeling of soft feeling because it contains almost no foreign substance even though it contains salicylic acid.

The antimicrobial cosmetic composition according to one aspect of the present invention may further comprise a stabilizer. The stabilizer includes tetra sodium EDTA. In another aspect of the present invention, the stabilizing agent inhibits the salicylic acid from being combined with the metal ion of the powder component to be denatured, so that the antimicrobial activity of the composition can be further enhanced.

The composition according to one aspect of the present invention can exhibit an antibacterial effect against general bacteria living in the skin. Specifically, the bacterium is selected from the group consisting of Propionibacterium acnes , Escherichia coli , Pseudonomas < RTI ID = 0.0 > aeruginosa , Staphylococcus aureus , or candida albicans . The composition according to one aspect of the present invention can exhibit a strong antibacterial activity particularly against Propionibacterium acnes, which is a causative microorganism of acne.

The composition according to one aspect of the present invention may comprise from 0.2% to 5.0% by weight, specifically from 0.2% to 3.0% by weight, more specifically from 0.2% to 0.5% by weight, of salicylic acid, based on the total weight of the composition . When it is contained in the above weight percentage, it is not only suitable for exhibiting the intended effect of the present invention but also can satisfy all the stability and safety of the composition, and may be suitably included in the above range in terms of cost effectiveness. Specifically, when salicylic acid is contained in an amount of less than 0.2% by weight, it is difficult to exhibit anti-inflammatory, skin-soothing effect, and if it exceeds 5.0% by weight, excessive skin irritation may be caused. On the other hand, in domestic laws, salicylic acid in the cosmetic composition is regulated to be 0.5% by weight or less based on the total weight of the composition.

In one aspect of the invention, the powder may be coated with 0.025 wt% to 7 wt%, specifically 0.025 wt% to 5 wt% of salicylic acid, based on the total weight of the powder. When the powder particles are coated with salicylic acid of less than 0.025% by weight based on the total weight of the powder, the amount of the powder component to be contained in the entire cosmetic composition is more than 80% by weight in order to exert the effect of salicylic acid. There are disadvantages. When the powder particles are coated with salicylic acid in an amount of more than 7% by weight based on the total weight of the powder, salicylic acid is not uniformly coated on the surface of the powder particles and the powder is clumped thickly to cause the powder to be clustered. And salicylic acid, which is relatively located inside, is delayed in delivery to the skin, and the effect is reduced.

In one aspect of the present invention, the powder is selected from the group consisting of talc powder, mica powder, synthetic mica powder, sericite powder, boron nitride powder, barium sulfate powder, nylon powder, silica powder, polymethyl methacrylate ) Powder, silicon based powder, titanium dioxide powder, zinc oxide powder, boron nitride powder, magnesium stearate powder, calcium stearate powder, zinc stearate powder, calcium carbonate powder, aluminum stearate powder, alumina powder and plant derived powder And at least one selected from the group consisting of

The composition according to one aspect of the present invention comprises 0.01% to 2.0% by weight, specifically 0.05% to 1.5% by weight, more specifically 0.1% to 1.0% by weight, based on the total weight of the composition, . When it is contained in the above weight percentage, it is not only suitable for exhibiting the intended effect of the present invention but also can satisfy all the stability and safety of the composition, and may be suitably included in the above range in terms of cost effectiveness.

The formulation of the cosmetic composition according to one aspect of the present invention includes all cosmetic composition formulations including a powder, specifically a powder type cosmetic composition. The formulation of the cosmetic composition according to another aspect of the present invention includes formulations such as loose powder, pressed powder, foundation, cover cake, concealer, blusher, eye shadow or powder type sunscreen.

The cosmetic composition according to one aspect of the present invention can effectively prevent or improve inflammatory skin diseases. The cosmetic composition according to another aspect of the present invention can effectively prevent or ameliorate inflammatory skin diseases such as acne, acne rash, atopic dermatitis or seborrheic dermatitis. In particular, when the cosmetic composition is a cosmetic composition for make-up, unlike other cosmetic compositions, it is excellent in antimicrobial effect, so that a person having a skin trouble can use it freely.

Hereinafter, the constitution and effects of the present invention will be described in more detail with reference to examples, comparative examples and test examples. However, the following examples, comparative examples and test examples are provided for illustrative purposes only in order to facilitate understanding of the present invention, and the scope and scope of the present invention are not limited thereto.

EXAMPLES AND COMPARATIVE EXAMPLES Preparation of Powder

Each component was prepared as shown in Table 1 below. Salicylic acid was dissolved in ethanol, mixed with talc, and then dried to prepare Example 1, which was a talc powder coated with salicylic acid. Example 2 was prepared in the same manner as in Example 1 except that salicylic acid and tetrasodium EDTA were used together instead of salicylic acid. Unmixed talc and salicylic acid were designated as Comparative Examples 1 and 2, respectively.

ingredient Example 1
(weight%) Example 2
(weight%) Comparative Example 1
(weight%) Comparative Example 2
(weight%) Talc 96 95 100 - Salicylic acid 4 4 - 100 When tetrasodium is added to the dithia - One - -

[Test Example 1] Evaluation of antibacterial activity

1) Test bacteria, use medium and culture conditions

The test bacterium, use medium and culture conditions are shown in the table below. Each strain was stored at -70 ° C and used 3 days before the experiment.

Test strain Use badge Culture conditions Propionibacterium acnes )
(Accession No .: KCTC3314)
(Available from: Gene Bank) Brain heart leaching badge
(Brain heart infusion medium)
(Difco, USA) 35 ℃, 3 days
Anaerobic N ₂ culture Escherichia coli )
(Accession No .: ATCC 8739)
(Available from the National Institutes of Health) Trypticase sobros
(Trypticase Soy Broth)
(Difco, USA) 32 ° C, 1 day
Aerobic culture Pseudonomas aeruginosa )
(Accession No .: ATCC 9027)
(Available from the National Institutes of Health) Trypticase sobros
(Trypticase Soy Broth)
(Difco, USA) 32 ° C, 1 day
Aerobic culture Staphylococcus ( Staphylococcus aureus) aureus )
(Accession No .: ATCC 6538)
(Available from the National Institutes of Health) Trypticase sobros
(Trypticase Soy Broth)
(Difco, USA) 32 ° C, 1 day
Aerobic culture Candida albicans ( candida albicans )
(Accession No .: ATCC 10231)
(Available from the National Institutes of Health) Saburo Dextrose Bros
(Sabouraud dextrose broth)
(Difco, USA) 25 ℃, 2 days aerobic culture

2) Preparation of sample liquid and test bacterium

20% by weight of each of Example 1 and Example 2 and 0.8% by weight of Comparative Example 1 and Comparative Example 2 were suspended in DMSO to prepare a sample solution. 0.15 [mu] l of each of the test broths (medium) was added to 15 [mu] l of each broth and mixed well.

3) Test methods and results

2, and Example 1, Example 2, and Comparative Example 2 were added so as to contain the same concentration of salicylic acid, and then 200 쨉 l of each of the wells was placed in a 96 well plate. Comparative Example 1 was diluted in the same manner as in Comparative Example 2, and then 200 μl was added. 100 쨉 l of the medium was loaded from the 2nd line to the 8th line. Mix the solution of line 1 well, then take 100 μl, place in line 2 and mix well. 100 占 퐇 of the solution in the second row was taken and the solution was again diluted to the 8th row in a manner of putting it into the third row. In each row, 10 μl of the test solution prepared in 2) was added, and the cells were incubated for 24 hours and 48 hours under the culture condition of each test organism. The concentration without growth of the bacteria confirmed by microscopic observation was determined as the minimum concentration MIC value Respectively. The MIC value results are shown in the table below.

Test strain Example 1 Example 2 Comparative Example 1 Comparative Example 2 Propionibacterium acnes 0.4% 0.2% > 0.8% 0.1% Escherichia coli 0.4% 0.4% > 0.8% 0.2% Pseudomonas aeruginosa 0.4% 0.4% > 0.8% 0.4% Stefiro Kocciareus 0.2% 0.1% > 0.8% 0.2% Candida albicans 0.1% 0.2% > 0.8% 0.4%

It can be seen that Examples 1 and 2, which are powders coated with salicylic acid, have better antibacterial activity than Comparative Example 1 which does not contain salicylic acid. Further, Examples 1 and 2 exhibited excellent antibacterial activity almost similar to Comparative Example 2, which is salicylic acid. On the other hand, the antibacterial effect of Example 2 containing tetrasodium dithiene was superior to that of Example 1, which was a powder coated with salicylic acid only. Salicylic acid can be easily modified with metal ions of powders, for example, talc. In Example 2, tetrasodium serving as a stabilizer contains dithiene, thereby inhibiting the denaturation of the powder. It is considered. This denaturation inhibition can be readily discerned by confirming that Example 1, which does not contain tetrasodium dithiene, exhibits a yellow color as compared to Example 2. [

[Examples and Comparative Examples] Preparation of cosmetic composition

The cosmetic compositions of Examples 3 and 4 and Comparative Examples 3 and 4 were prepared with the ingredients listed below. Example 3 includes a powder coated only with salicylic acid, and Example 4 includes talc powder coated with salicylic acid and tetrasodium dithiocyanate. Comparative Example 3 contains salicylic acid as a powder form, and Comparative Example 4 does not contain salicylic acid.

The specific manufacturing method is as follows. Components 1 to 10 were weighed in a mixer and mixed for 2 minutes. Separately, Components 11 and 12 were weighed and then heated to 70-80 ° C. The mixture of Components 1 to 10 was sprayed with a mixture of Components 11 and 12 and mixed and pulverized for 1 to 2 minutes at 500 to 1000 rpm using a Henschel mixer. This was mixed again at a high speed of 1500 to 2000 rpm for 2 minutes. Thereafter, it was pulverized at 50 horsepower and then filtered. Each of the examples and comparative examples was prepared by appropriately adding the fragrance.

no. Component (% by weight) Example 3 Example 4 Comparative Example 3 Comparative Example 4 One Talc To 100 To 100 To 100 To 100 2 Mica 20 20 20 20 3 Nylon Powder 5 5 5 5 4 Silica 5 5 5 5 5 Organic spherical powder 5 5 5 5 6 Red iron oxide 0.2 0.2 0.2 0.2 7 Yellow iron oxide 0.3 0.3 0.3 0.3 8 Black iron oxide 0.05 0.05 0.05 0.05 9 Example 1 10 - - - 10 Example 2 - 10 - - 11 Salicylic acid powder - - 0.4 - 12 Silicone oil 10 10 10 10 13 Spices 0.2 0.2 0.2 0.2

[Test Example 2] Evaluation of antibacterial activity of cosmetic composition

The test bacteria used were the propionibacterium acnes ) (Accession No .: KCTC3314) was used, and the culture medium, culture conditions, and method of preparing the bacterial solution were the same as those of Test Example 1.

(10 ⁶ CFU) of 10 μl of the test strain was added to a cellulose nitrate membrane disk (diameter 13 mm, 0.22 μm, WCN type, Wattman 7182 001) The disks were placed in the direction of contact with the cosmetic composition of Comparative Examples 3 and 4, and the weight was placed on the membrane. The cells were cultured in an incubator under anaerobic conditions at a temperature of 35 ° C. Three days after the inoculation day, the disk was taken and diluted with sterilized ionized water and the viable cell count was measured. The mortality rate of the bacteria at the time of inoculation was calculated and shown in the table below.

Example 3 Example 4 Comparative Example 3 Comparative Example 4 Deadly rate after 3 days 80% 99.9% 50% <10% Mortality rate after 7 days 90% 99.9% 90% <10%

As can be seen from the above results, in Examples 3 and 4, cosmetic compositions showed higher mortality rate of inoculated Propionibacterium acnes, which is superior to Comparative Examples 3 and 4. Particularly, the powder was coated with salicylic acid and the mortality of Example 4 containing tetrasodium dithiene was excellent. On the other hand, in the case of Comparative Example 4 which did not contain salicylic acid, bacterial death was hardly occurred.

That is, it can be confirmed that the cosmetic composition comprising the powder coated with salicylic acid exhibits an excellent antibacterial effect as compared with the case of containing salicylic acid powder separately.

[Test Example 3] Evaluation of use feeling

The results of the comparative evaluation of the uniformity, feeling of use (softness) and overall satisfaction of the cosmetic compositions of Examples 3 and 4 and Comparative Examples 3 and 4 were given to 30 professional panelists. The results are shown in the table below.

Metrics Example 3 Example 4 Comparative Example 3 Comparative Example 4 Coating uniformity 4.3 4.2 3.5 4.3 Feeling (softness) 4.2 4.3 3.8 4.1 Overall satisfaction 4.5 4.7 4.0 4.8

5: very good, 4: slightly better, 3: moderate, 2: slightly poor, 1: very poor

As can be seen from the above results, in Examples 3 and 4 including the powder coated with salicylic acid, the rough feeling of salicylic acid itself was removed, and uniform and smooth application was possible. Similar satisfaction is shown. On the other hand, in the case of Comparative Example 3 containing the salicylic acid powder, the rough feeling of salicylic acid itself is maintained, so that the feeling of foreign matter in the hard granule is felt at the time of application, and the overall satisfaction is remarkably low.

As described above, the cosmetic composition containing the powder coated with salicylic acid is excellent in antibacterial activity, and the rough feeling of salicylic acid itself is removed, so that the feeling of use as a cosmetic composition is excellent.

Claims (9)

A surface-coated powder with salicylic acid,
Wherein the coated powder is coated with 0.025 wt% to 7 wt% of salicylic acid based on the total weight of the powder.
The method according to claim 1,
Wherein the composition further comprises a stabilizer.
3. The method of claim 2,
Wherein the stabilizing agent comprises tetra sodium EDTA.
The method according to claim 1,
The composition may include Propionibacterium &lt; RTI ID = 0.0 &gt; acnes , Escherichia coli , Pseudonomas &lt; RTI ID = 0.0 &gt; aeruginosa , Staphylococcus ( Staphylococcus aureus) aureus , and candida albicans . The cosmetic composition according to claim 1, wherein the antimicrobial agent is an antimicrobial agent.
The method according to claim 1,
Wherein the composition comprises from 0.2% to 5.0% by weight salicylic acid, based on the total weight of the composition.
The method according to claim 1,
Wherein the coated powder is coated with 0.025% to 5% by weight of salicylic acid based on the total weight of the powder.
3. The method of claim 2,
Wherein the composition comprises from 0.01% to 2.0% by weight of stabilizing agent based on the total weight of the composition.
The method according to claim 1,
The powder may be selected from the group consisting of talc powder, mica powder, synthetic mica powder, sericite powder, boron nitride powder, barium sulfate powder, nylon powder, silica powder, polymethylmethacrylate (PMMA) powder, At least one member selected from the group consisting of calcium carbonate powder, calcium carbonate powder, aluminum stearate powder, alumina powder and plant-derived powder, Or a pharmaceutically acceptable salt thereof.
9. The method according to any one of claims 1 to 8,
Wherein the composition prevents or alleviates one or more of acne and acne scars.