KR102125790B1 - Multifunctional mask pack and preparation method thereof - Google Patents

Abstract

The present invention relates to a multifunctional sheet mask and a preparation method thereof. More particularly, the present invention relates to a multifunctional sheet mask which includes a clathrate compound of tranexamic acid and beta-cyclodextrin and polyphosphoric acid, lavender water, and citric acid as functional cosmetic ingredients to treat melisma, and has far infrared ray emission, dead skin cell removal, skin soothing, and skin temperature reduction effects.

Description

Multifunctional mask pack and its manufacturing method {Multifunctional mask pack and preparation method thereof}

The present invention relates to a multi-functional mask pack and a method of manufacturing the same, which emits far infrared rays, at the same time relieves blemishes, reduces skin temperature, soothes skin, and exfoliates.

In general, the mask pack serves to supply a variety of nutrients and moisture to the skin, and currently exceeds the purpose of supplying nutrients and moisture, whitening, wrinkle improvement, moisturizing, skin vitality, skin soothing, keratin relief, pore care, etc. A mask pack emphasizing is appearing. In particular, as mask packs are receiving attention due to easy skin care methods of busy modern people, interest and demand for mask packs are increasing.

In addition to the increased demand for these mask packs, various research and development are being conducted to improve the functionality of the mask pack. At this time, even if the efficacy of the functional components of the mask pack is excellent, it is effective because it cannot exert the expected efficacy if it cannot be delivered into the skin. The skin penetration power of the ingredients acts as a very important factor for the effectiveness of the mask pack. In fact, the efficacy of the functional component is excellent, but it is not often absorbed by the skin, so it often occurs that it does not have a practical effect. Accordingly, a technique for improving the transdermal absorption of the functional component is required.

On the other hand, Tranexamic acid (TA) has been used as a medicament drug as a plasmin inhibitor, which blocks the lysine binding site of the plasminogen molecule and inhibits the plasminogen activator, thereby causing plasminogen to be plasmid. Cosmetics containing tranexamic acid as an active ingredient have been developed because it has the effect of reducing the production of melanin by preventing the conversion to min. However, tranexamic acid has a problem that it is difficult to penetrate into cells or be easily absorbed into tissues due to its unique molecular properties, and thus does not exhibit a sufficient effect, and problems are also pointed out in terms of usability and stability. Accordingly, in order to improve the skin permeation of tranexamic acid, a transdermal absorption accelerator was used together or a tranexamic acid carrier was developed, but this also has limitations in satisfying skin stability and skin permeation simultaneously.

On the other hand, beta-cyclodextrin (β-Cyclodextrin, β-CD) is a host compound that can invade various compounds in the hydrophobic cavity, and forms the inclusion compound by the host-guest reaction to form the inside of the hydrophobic cavity. It is ideal for use as a molecular carrier due to its dual nature of and hydrophilicity. In addition, it has a sustained release effect, so that the active compound can be released to improve absorption of the active ingredient into the skin.

On the other hand, far-infrared rays have been shown to promote blood circulation and stabilize the physiological functions of the human body, increase tissue regeneration capacity, strengthen metabolism, and maintain human body homeostasis. In addition, lavender has many effects in the treatment of skin diseases because it has the effect of reducing skin temperature, anti-inflammatory, sterilization, promoting cell growth, controlling sebum secretion, and preventing skin keratinocyte damage.

Accordingly, the present inventor has completed the present invention to provide a multi-functional mask pack having far-infrared rays, spot treatment, exfoliation peeling and skin temperature reduction simultaneously.

Korean Registered Patent No. 10-1775266

The present invention is to develop a mask pack with increased penetration and absorption in the skin, including the inclusion compound, the purpose of which is to apply the inclusion compound of tranexaminic acid and beta-cyclodextrin to the mask pack, and also far infrared The purpose of the present invention is to provide a multi-functional mask pack and a method of manufacturing the same, which have a bacteriostatic and skin-cleansing effect by releasing the skin, including a skin temperature reduction and skin soothing effect.

The present invention tranexamic acid (tranexamic acid): beta-cyclodextrin inclusion compound (β-cyclodextrin inclusion compound); Polyphosphoric acid; Lavender water; And citric acid; provides a multi-functional mask pack composition comprising, the multi-functional mask pack composition has a easing effect, far-infrared emission, skin temperature reduction, skin soothing, exfoliation effect.

Tranexamic acid: Tranexamic acid and beta-cyclodextrin in a beta-cyclodextrin inclusion compound are mixed in a 1:1 molar ratio, the inclusion compound; Polyphosphoric acid; Lavender water; And citric acid; is characterized in that it is mixed in a weight ratio of 0.5 to 2: 1.5 to 8: 4 to 20: 2 to 20.

The multifunctional mask pack composition further includes a cosmetically acceptable preservative, moisturizer, formulation, and fragrance.

The preservative is hydroxyacetophenone, 1,2-hexanediol, caprylyl glycol, glyceryl caprylate, p-anisic acid, pentylene glycol, ethylhexylglycerin, phenoxyethanol, imidazolidinylurea, clo It is characterized in that it is selected from at least one selected from the group consisting of lephenesine, methyl parahydroxybenzoate, ethyl parahydroxybenzoate, dihydroacetic acid, salicylic acid and benzoic acid.

The humectant is serine, glycerin, sorbitol, glutamine, mannitol, ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, polyethylene glycol, polypropylene glycol, diglycerin, betaine, glycereth-26 and methylgluceth-20 Characterized in that one or more selected from the group consisting of.

The formulation is characterized in that one or more selected from the group consisting of polyglyceryl-10-laurate, isopropyl alcohol and xanthan gum.

Also, in another aspect of the present invention, 1) tranexamic acid and beta-cyclodextrin are dissolved in purified water and then lyophilized to give tranexamic acid: beta-cyclodextrin inclusion compound. Manufacturing; 2) dissolving the inclusion compound in purified water; 3) preparing a composition for a mask pack by adding polyphosphoric acid, lavender water, citric acid, preservatives, moisturizing agents, formulations and fragrances to the mixture dissolved in step 2); 4) immersing the non-woven fabric in the composition for a mask pack; provides a method for manufacturing a multi-functional mask pack comprising a.

In step 1), tranexamic acid and beta-cyclodextrin react at a molar ratio of 1:1, and after freezing for 24 hours in step 1), freeze-drying at -80°C for 120 hours.

In addition, the present invention provides a multi-functional mask pack manufactured by the above manufacturing method.

The multifunctional mask pack according to the present invention increases the skin absorbency of tranexaminic acid by including a clathrate compound in which beta cyclodextrin encloses tranexamic acid, and the skin keratin or lipid is encapsulated in the hydrophobic cavity of cyclodextrin and peeling. It works. In addition, it activates the skin due to the far-infrared emission effect caused by polyphosphoric acid, and has the effect of skin soothing due to lavender water, skin temperature reduction, and skin disease alleviation.

Figure 1 shows the manufacturing process of the inclusion compound.
Figure 2 shows the SEM image, (a) TA, (b) beta-CD, (c) TA and beta-CD physical mixture, (d) inclusion compound.
Figure 3 shows the UV-vis spectra data of the inclusion compound.
4 shows a photograph of skin temperature measurement.
5 shows pictures before and after wearing the mask pack.
6 is a graph showing skin moisture content measurement according to wearing a mask pack.

Hereinafter, the multifunctional mask pack of the present invention and a method of manufacturing the same will be described in more detail. In describing the present invention, when it is determined that a detailed description of related known configurations or functions may obscure the subject matter of the present invention, the detailed description will be omitted.

The multifunctional mask pack composition according to the present invention includes: tranexamic acid: beta-cyclodextrin inclusion compound; Polyphosphoric acid; Lavender water; And citric acid; it is preferred that the tranexamic acid and the beta-cyclodextrin are mixed in a 1:1 molar ratio in the tranexamic acid: beta-cyclodextrin inclusion compound. .

The tranexaminic acid (TA) is an anti-fibrin solubilizing agent that has excellent therapeutic effect on hyperpigmentation after inflammation caused by stains and ultraviolet rays, and is used as a spice suppressant, an edible drug. If excessively produced melanin pigment to protect the skin, it causes gina or pigmentation, and when the tyrosinase enzyme is excessively stimulated, melanin pigment is excessively secreted. At this time, it is prostaglandin that plays an important role in stimulating tyrosinase, and tranexaminic acid suppresses the production of prostaglandin and exerts an effect on the treatment of spots. Tranexaminic acid is widely used in medicine because it has anti-inflammatory, anti-allergic, and hemostatic effects as well as a blemish treatment effect. It helps to restore the skin barrier and restore damaged skin cells through skin astringent action.

The beta-cyclodextrin (β-Cyclodextrin, β-CD) has 7 glucose residues in a cyclic structure linked by α-1,4 bonds. β-CD is structurally cut, and has a hydrophobic property in the internal cavity by hydrogen bonding by the hydroxyl group (-OH) bonded to the 2nd and 3rd carbon of the second -OH group, and, conversely, to a highly polar hydroxyl group. The outside has hydrophilic properties. Due to these properties, β-CD is known as a medium capable of increasing the solubility of hydrophobic materials, increasing the stability of unstable materials, and increasing the bioavailability of inclusion materials by forming inclusion compounds with hydrophobic materials.

The inclusion compound not only increases the skin absorption rate of tranexamic acid, but also has a peeling effect because it can induce skin keratin or lipid in the hydrophobic cavity of beta-cyclodextrin. In addition, due to the hydroxy group on the outer wall of beta-cyclodextrin, it is possible to increase the skin moisturizing rate.

In addition, in the multifunctional mask pack composition, the inclusion compound; Polyphosphoric acid; Lavender water; And citric acid; is preferably mixed in a weight ratio of 0.5 to 2: 1.5 to 8: 4 to 20: 2 to 20, and the multifunctional mask pack composition relieves blemishes, releases far infrared rays, reduces skin temperature, soothes skin, removes dead skin cells. It works.

The polyphosphoric acid may emit far infrared rays to activate the skin while the far infrared rays penetrate the skin, whereby a functional cosmetic ingredient can easily penetrate the skin.

The lavender has been used for the treatment of skin beauty and skin diseases since ancient times, anti-inflammatory, sterilization, cell growth promotion, sebaceous secretion control, prevention of skin keratinocyte damage caused by UVB irradiation and relief of inflammatory response in dermal tissue, inflammatory acne It has the effect of improving and relieving scars. In addition, it has been reported that lavender reduces melanin production by reducing the tyrosinase enzyme activity of melanocytes and inhibiting the formation of dendritic spinous processes, and more effectively whitening efficacy when depositing hyperpigmentation by inducing α-MSH (melanocyte stimulating hormone).

The citric acid is often referred to as citric acid, and helps to regulate the skin cycle to circulate to normal by promoting peeling, and the acidic component contained in citric acid acts on itching or inflammation of the skin to soothe the skin. In addition, it brightens the skin tone and has the effect of reducing toxins and skin aging symptoms caused by toxins.

It is preferable that the multifunctional mask pack composition further includes a cosmetically acceptable preservative, moisturizer, formulation, and fragrance.

The preservative is hydroxyacetophenone, 1,2-hexanediol, caprylyl glycol, glyceryl caprylate, p-anisic acid, pentylene glycol, ethylhexylglycerin, phenoxyethanol, imidazolidinylurea, clo It is preferred to select one or more from the group consisting of lephenesine, methyl parahydroxybenzoate, ethyl parahydroxybenzoate, dihydroacetic acid, salicylic acid and benzoic acid.

The humectant is serine, glycerin, sorbitol, glutamine, mannitol, ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, polyethylene glycol, polypropylene glycol, diglycerin, betaine, glycereth-26 and methylgluceth-20 It is preferred that one or more selected from the group consisting of.

The formulation is preferably selected from one or more of the group consisting of polyglyceryl-10-laurate, isopropyl alcohol and xanthan gum.

In another aspect of the present invention, 1) tranexamic acid and beta-cyclodextrin are dissolved in purified water and then lyophilized to prepare tranexamic acid: a beta-cyclodextrin inclusion compound. step; 2) dissolving the inclusion compound in purified water; 3) preparing a composition for a mask pack by adding polyphosphoric acid, lavender water, citric acid, preservatives, moisturizing agents, formulations and fragrances to the mixture dissolved in step 2); 4) immersing the non-woven fabric in the composition for a mask pack; provides a method for manufacturing a multi-functional mask pack comprising a.

In step 1), tranexamic acid and beta-cyclodextrin are preferably reacted at a molar ratio of 1:1, and step 1) is preferably freeze-dried at -80°C for 120 hours after freezing for 24 hours. .

In addition, the present invention provides a multi-functional mask pack manufactured by the manufacturing method of the multi-functional mask pack.

Hereinafter, the present invention will be described in more detail through examples. However, the following examples are intended to illustrate the present invention, and the scope of the present invention is not limited thereto.

Figure 1 shows the process of preparing the inclusion compound by the host-guest reaction of the guest compound TA and the host compound beta-CD, the hydrophobic cavity size of beta-CD is 0.78 nm, and the inclusion compound is excellent in TA. It is expected that the amine group and the carboxylic acid anion will exist while interacting strongly.

< Example 1> Inclusion compound Produce

Tranexamic acid (0.07 g, 0.45 mmol) and beta-Cyclodextrin (0.05 g, 0.45 mmol) were dissolved in 30 mL of distilled water, frozen for 24 hours, and lyophilized at -80°C for 120 hours to prepare an inclusion compound.

< Example 2> Versatility Mask Pack Coating solution production

After dissolving 1.10 g of the inclusion compound of Example 1 in 74.5 mL of tertiary distilled water, 4.35 g of polyphosphoric acid, 10.0 mL of lavender water, 0.60 g of Hydroxyacetophenone, 4.00 g of Butylene glycol, 0.50 g of Polyglyceryl-10 Laurate, Citric acid (10% ) 7.00 g and lavender fragrance 0.20 g were sequentially added to prepare a multi-functional mask pack coating solution.

< Example 3> Versatility Mask Pack Produce

A mask sheet (in-mask sheet company) was immersed in the coating solution of Example 1 at room temperature for 10 minutes to prepare a multifunctional mask pack.

< Test example 1> Inclusion compound Structural analysis

For evaluation of the inclusion compound according to the present invention, morphology was analyzed using an electric field scanning electron microscope (JSM-7800F, JEOL Ltd.), and comparative analysis was performed with a physical mixture of TA and beta-CD. Referring to FIG. 2, TA represents a hard rock shape by amine-carbonyl acid interaction, carbonyl-carbonyl interaction, amine-amine interaction, cyclohexane-cyclohexane interaction, and beta-CD It has a soft rock shape. When TA and beta-CD are mixed by grinding, the soft beta-CD shows a powder form, while the TA shows a small hard rock shape. On the other hand, in the case of Example 1, which is the inclusion compound produced by the host-guest reaction, it can be confirmed that it exhibits a rod shape, and the inclusion compound produced by the interaction of the amine cation and the carboxylic acid anion is wrapped in a layered layer to form a rod. It seems to indicate.

< Test example 2> Inclusion compound UV- vis spectra

The UV-vis spectra of the inclusion compound of Example 1 is shown in FIG. 3. As a result, while the carbonyl group peak of the guest compound TA appeared at 210 nm, it was confirmed that the wavelength of the inclusion compound produced by the host-guest reaction was shifted red, which is because the beta-CD encapsulates TA to form an amine cation. It is believed that the interaction of carboxylic acid anions is stabilized.

< Test example 3> Versatility Mask Pack Coating liquid hazardous substance evaluation and viscosity measurement

Evaluation and viscosity of harmful substances were measured for the multi-functional mask pack coating solution prepared in Example 2. As shown in Table 1 below, as a result of measuring the mass for the harmful substances Pb, Cd, Hg, Cr, PBBs, and BB, safety was confirmed as they were all detected to be less than 0.001 mg/kg. Did. The viscosity was very stable at 270-280 cP, and the pH was 6.92, indicating that the coating solution was suitable for manufacturing a mask pack as it exhibited weak acidity.

Evaluation items Measures Hazardous substances (Pb, Cd, Hg, Cr, PBBs, BB) Less than 0.001 mg/kg Viscosity 270-280 cP pH 6.92

< Test example 4> Far infrared emissivity and Radiation energy Measure

The far-infrared emissivity and radiant energy of the mask pack prepared in Example 3 were measured using the KFIA-FI-1005 test method, and the results are shown in Table 2 below. As far-infrared emissivity is measured to be 0.882 μm and far-infrared radiation energy is 3.40×10 ² W/m ² ·μm, it is expected that far-infrared rays penetrate the skin and give activity to the skin. It is expected to be possible.

Emissivity (5-20 μm) Radiated ether (W/m ² ·μm, 37℃) 0.882 3.40×10 ²

< Test example 5> Skin temperature Abatement Effect evaluation

15 minutes after wearing the mask pack to check the effect of reducing the skin temperature, the result of measuring the skin temperature using a thermal imaging camera (TiS20, Fluke Corp.) (Fig. 4, Table 3), the skin temperature when wearing a commercial mask pack While it showed 27-29°C, it was confirmed that when the mask pack according to the present invention was worn, the skin temperature reduction effect was excellent by showing a low temperature of 24-25°C. This is thought to be due to the volatility of the lavender extract, and can increase skin elasticity and suppress skin diseases by maintaining a low skin temperature.

Skin temperature after wearing a commercial mask pack Skin temperature after wearing the mask pack of the present invention 27-29℃ 24-25℃

< Test example 6> Evaluation of water supply effect

The result of measuring the moisture content of the skin using a moisture meter (MY-808S, Salar Corp.) after wearing the mask pack according to the present invention for 5 days for 10 test subjects (FIGS. 5 and 6), the mask The moisture content before wearing the pack was about 31%, but after wearing the mask pack for 5 days, it showed an average moisture content of 35.5%, confirming that the mask pack of the present invention has an excellent water supply effect, which is that of beta-CD and BG. It seems to be an influence.

< Test example 7> Skin irritation test evaluation

A skin irritation test was conducted on the mask pack of the present invention for 30 test subjects, and as a result, it was confirmed that no skin irritation was observed after 30 minutes, 24 hours, and 48 hours after wearing the mask pack.

The above description is merely illustrative of the present invention, and those skilled in the art to which the present invention pertains will be capable of various modifications without departing from the essential characteristics of the present invention. Accordingly, the embodiments presented herein are not intended to limit the present invention, but to explain the present invention, and the spirit and scope of the present invention are not limited by these embodiments. The scope of protection of the present invention should be interpreted by the following claims, and all technologies within the equivalent range should be interpreted as being included in the scope of the present invention.

Claims (12)

Tranexamic acid: beta-cyclodextrin inclusion compound; Polyphosphoric acid; Lavender water; And citric acid; containing, tranexamic acid and beta-cyclodextrin is a multi-functional mask pack composition, characterized in that mixed in a 1:1 molar ratio
delete The multifunctional mask pack composition of claim 1, wherein the multifunctional mask pack composition has an effect of relieving blemishes, emitting far infrared rays, reducing skin temperature, soothing skin, and exfoliating skin.
According to claim 1, The inclusion compound; Polyphosphoric acid; Lavender water; And citric acid; is a multifunctional mask pack composition, characterized in that mixed in a weight ratio of 0.5 to 2: 1.5 to 8: 4 to 20: 2 to 20
The multifunctional mask pack composition of claim 1, further comprising a cosmetically acceptable preservative, moisturizer, formulation, and fragrance.
The method according to claim 5, wherein the preservative is hydroxyacetophenone, 1,2-hexanediol, caprylyl glycol, glyceryl caprylate, p-anisic acid, pentylene glycol, ethylhexylglycerin, phenoxyethanol, already Multifunctional mask pack composition characterized by being selected from the group consisting of dazolidinylurea, chlorphenesin, methyl parahydroxybenzoate, ethyl parahydroxybenzoate, dihydroacetic acid, salicylic acid and benzoic acid
The method of claim 5, wherein the humectant is serine, glycerin, sorbitol, glutamine, mannitol, ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, polyethylene glycol, polypropylene glycol, diglycerin, betaine, glyceryl-26 And methylglucose-20, multifunctional mask pack composition, characterized in that it is selected from one or more groups.
The multifunctional mask pack composition according to claim 5, wherein the formulation is selected from polyglyceryl-10-laurate, isopropyl alcohol, and xanthan gum.
1) tranexaminic acid and beta-cyclodextrin dissolved in purified water and then lyophilized to prepare tranexamic acid: beta-cyclodextrin inclusion compound;
2) dissolving the inclusion compound in purified water;
3) preparing a composition for a mask pack by adding polyphosphoric acid, lavender water, citric acid, preservatives, moisturizing agents, formulations and fragrances to the mixture dissolved in step 2);
4) immersing the non-woven fabric in the composition for the mask pack; includes,
Method of manufacturing a multi-functional mask pack, characterized in that tranexamic acid and beta-cyclodextrin in step 1) are reacted at a molar ratio of 1:1.
delete 10. The method of claim 9, wherein the step 1) is frozen for 24 hours, and then freeze-dried at -80°C for 120 hours.
Multifunctional mask pack manufactured by the manufacturing method according to any one of claims 9 and 11

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