CN104414929A - Tranexamic acid mask and preparation method thereof - Google Patents

Abstract

The invention relates to a tranexamic acid mask and a preparation method thereof. A tranexamic acid pharmaceutical composition comprises the following components in percentage by weight: 1.5%-3% of tranexamic acid, 3%-10% of a skin conditioning agent, 6.5%-17% of an emollient, 75%-85% of a solvent, 0.5%-1.5% of an antioxidant, 0.1%-1% of a thickener, 0.1%-1% of a pH regulator, 0.1%-1% of an emulsifier and 3%-6% of a moisturizer. The tranexamic acid mask provided by the invention has the advantages of good whitening effect, no side effects, simple preparation process and convenience in use.

Description

Tranexamic acid facial film and preparation method thereof

Technical field

The present invention relates to cosmetic field, particularly relate to tranexamic acid facial film and preparation method thereof.

Background technology

In many areas in the world, there is more shallow and even skin color and very appreciate by people.Most people in women wish there is more shallow skin color.In addition, many hyperpigmented skin imbalance situation such as skin hyperpigmentation after chloasma, inflammation and senile freckle can worsen through sun exposure.Light color and even skin tone and effective ways alleviating skin hyperpigmentation are kept to be smear sunscreen cream or put on protective clothing to avoid sun exposure.Skin expert advice regularly uses protective action product, can make skin lightening like this, because this method can remove the main excimer making the spontaneous synthesis of melanin, and the pigment existed in epidermis can by the loss that comes off of horn cell.The startup of melanic generation is at first by tyrosinase catalysis oxidizing tyrosine to DOPA quinone.This is the rate-limiting step in melanin synthesis process, because of the residue that for this reason reacts can under at physiological ph the ensuing course of reaction of spontaneous generation.By Auto-oxidation reaction, the DOPA quinone of generation can change into DOPA and dopachrome, and finally, a series of oxidation reaction can cause the synthesis of eumelanin.Some skin-protection products of commercialized supply contain effective skin lightening agent, and they suppress in every way or prevent melanic generation.

Foremost skin lightening agent is still hydroquinone, so far its existing use history more than 50 years, although some was about its negative report in recent years.Long-term high concentration uses hydroquinone to have side effects, and as ochronosis, namely skin is thickening and darken, and particularly the people of dark skin has this situation, and the Generally Recognized as safe sex chromosome mosaicism that it relates to has received the concern of whole world supervision department.Therefore, market still needs safe and effective skin lightening product, and market following enthusiasm and will continue the agent of natural skin brilliant white.

Tranexamic acid has the effect of restraint of tyrosinase activity, tranexamic acid disturbs the contact between melanocyte and keratinocyte by suppressing plasminogen to be converted into fibrinolysin, thus reduce melanocyte generation melanin, be the good candidate of skin-whitening agents.Under 2.0% concentration, tranexamic acid has the whitening function same with hydroquinone on the guinea pig skin of uv light exposure.Meanwhile, experiment proves, under 2.0% concentration, it has than kojic acid and the stronger whitening function of arbutin.

Summary of the invention

The object of the present invention is to provide the tranexamic acid facial film that a kind of whitening effect is good, easy to use;

Another object of the present invention is to the preparation method that a kind of tranexamic acid facial film is provided.

In order to realize foregoing invention object, the present invention adopts following technical scheme:

Tranexamic acid facial film, be loaded on face paper by tranexamic acid pharmaceutical composition and prepare, described tranexamic acid pharmaceutical composition comprises tranexamic acid, the skin conditioning agent of 3% ~ 10%, emollient, the solvent of 75% ~ 85%, antioxidant, the thickening agent of 0.1% ~ 1%, PH regulator, the emulsifying agent of 0.1% ~ 1%, the wetting agent of 3% ~ 6% of 0.1% ~ 1% of 0.5% ~ 1.5% of 6.5% ~ 17% of 1.5% ~ 3% by weight percentage.

The present invention can also comprise the anti-allergic agent 0.05% ~ 0.1% of 0.05% ~ 0.1% aminoacid, 0.05% ~ 0.60% solubilizing agent, the chelating agen of 0.05% ~ 0.20%, one or more combinations in the antiseptic of 0.50% ~ 1% and 0.05% ~ 0.1% essence.

Described skin conditioning agent is one or more combinations in Fructus Chaenomelis extract, Fructus Pruni juice, PEG/PPG-14/7 dimethyl ether, Single Roxburgh Rose Fruit extract, Alpinia coriandriodora D. Fang. extract, dog rose flower extract, scutellariae,radix extract, dog rose berry extract, Uncaria gambier Roxb. extract, Herba thymi vulgaris extract.

Described emollient is one or more combinations in ring five polydimethylsiloxane, phenyl dimethicones, isostearic acid, squalane.

Described solvent is water and dipropylene glycol.

The invention also discloses the preparation method of tranexamic acid facial film, it is characterized in that comprising the steps:

(1) take and get tranexamic acid in prescription, wetting agent, anti-allergic agent, thickening agent, chelating agen etc., be dissolved in solvent, heated and stirred is to dissolving to obtain aqueous phase completely; Take emulsifying agent, emollient etc. to be heated with stirring to and to dissolve to obtain oil phase completely;

(2) respectively aqueous phase and oil phase are pumped in emulsifying pot, stir after 3 ~ 5 minutes homogenizing 5 minutes; Add antiseptic after homogenizing, and regulate pH value to be 6 ~ 7, stir cooling;

(3) when temperature is lower than 45 DEG C, add skin conditioning agent etc., stir to obtain tranexamic acid pharmaceutical composition;

(4) the tranexamic acid pharmaceutical composition obtained is loaded on face paper namely obtains tranexamic acid facial film.

 

Tranexamic acid facial film of the present invention has good whitening effect, and can not have side effects, and preparation technology is simple, easy to use.

Embodiment: prepare tranexamic acid facial film and adopt following prescription:

Preparation method:

1, carbomer is first water-soluble, after disperseing completely, add glycerol, xanthan gum, dipropylene glycol, tranexamic acid, disodium glycyrrhizinate, hyaluronate sodium, sodium citrate, EDETATE SODIUM, heated and stirred is to dissolving to obtain aqueous phase substance completely, and temperature controls at 80 DEG C ± 2 DEG C;

2, isostearic acid, lauryl betaine, phenyl dimethicones, ring five polydimethylsiloxane, squalane are heated to 80 DEG C ± 2 DEG C, are stirred to and dissolve to obtain oil phase substance completely;

3, by oil phase, aqueous phase, be pumped in emulsifying pot respectively, after stirring, homogenizing 5 minutes, adds phenoxyethanol, and regulates pH value to be 6.5 with potassium hydroxide, stirs cooling;

4, when temperature is lower than 45 DEG C, add Fructus Chaenomelis berry extract, Fructus Pruni juice, serine, Single Roxburgh Rose Fruit extract, Alpinia coriandriodora D. Fang. extract, dog rose flower extract, ethylascorbyl, Radix Scutellariae extract, dog rose berry extract, Uncaria gambier Roxb. extract, Herba thymi vulgaris extract, stir after 10 minutes, add essence, stir to obtain tranexamic acid compositions;

5, namely tranexamic acid composition loaded step 4 obtained obtains tranexamic acid facial film to face paper.

The tranexamic acid facial film that the embodiment of the present invention prepares, has good whitening effect, and solves the side effect existed in some whitening products described in background technology; Preparation method is simple, easy to use.

Experimental example: tranexamic acid white-skinned face function is tested.

1. 1 study subject Medical Center of Fudan University female student enrollment 10.Skin type genotype, unglazed allergies, without cosmetic allergic contact dermatitis history.

1. 2 test instrunments adopt Lab colorimeter system spectrophotometer (Minolta spectrophotometer CM-2002) to measure the change of skin color.

1. 3 test index L=116 (Y/ Yn) 1/ 3-16; A=500 [(X/Xn) 1/ 3-(Y/Yn) 1/ 3]; B=200 [(Y/ Yn) 1/ 3-(Z/ Zn) 1/ 3]; Cab=(a2+ b2) 1/ 2; Hab=arctg is (b/ a), in formula: L, a, b are the coordinate figure of three-dimensional cartesian coordinate system system; X, Y, Z are the tristimulus values of XYZ colour system; Xn, Yn, Zn are the tristimulus values of persect reflecting diffuser.L: be brightness, be worth larger, color is more partial to white, otherwise, deflection black.A: be red, green product ,+a is red direction, and-a is green direction.B: be yellow, blue product ,+b is yellow direction, and-b is blue direction.C: be saturation, in order to represent the deep or light of color of object surface.H: be hue angle, represents colored characteristic of dividing mutually each other.

In Lab colorimeter system, represent the aberration Δ Eab between two kinds of stimulations with difference Δ L, the Δ a of coordinate L, a, b, Δ b, the distance namely between the colour space two color dot.ΔEab = [ ( ΔL)2+ ( Δa)2+ ( Δb)2]1/ 2。

In formula: because Δ Eab is the aggregative index of L, a, b, represent the solid change of colourity, so be the comparatively appropriate criteria evaluating colour of skin change.

1. 4 using method tested objects use tranexamic acid facial film 90 d of embodiment of the present invention gained continuously, and use at face after washing one's face before sleeping in every morning, evening, cervical region does not use.Be used as own control.

1. the change of 5 testing times 1 d, rear 30th, 60,90 d use spectrophotometers measurement skin colors of use before using this product.Follow-on test 3 times, averages.

1. 6 tests position forehead (above place between the eyebrows 2 cm); Left and right buccal (the cheekbone back lower place 1 cm); Cervical region (below Adam's apple 2 cm).

2 results

2. 1 different parts is used in the aberration of different time:

Table 1 different parts uses the comparison (x ± s) of tranexamic acid facial film different time aberration Δ E

Test position	30d	60d	90d
				Forehead	3. 09±1. 28	3. 12±0. 98	3. 56±1. 26
Buccal	4. 85±1. 70	5. 21±2. 42	6. 77±2. 08*
				Cervical region	3. 66±1. 51	3. 22±1. 29	3. 19±2. 06

Compare with before use: * P < 0.05

Table 1 shows, and buccal aberration raises after use tranexamic acid facial film, and after using 90 d, the change of buccal aberration has significance (t=21721, P < 0105).And the change at all the other each positions is without significance.

The change of 2.2 use different time skin of cheek color values:

Table 2 uses the comparison (x ± s) of tranexamic acid facial film different time skin of cheek color value

Index	0d	30d	60d	90d
					L	63.11±2.54	64.29±2.77*	66.45±2.74**	66.79±3.05**
a	10.15±1.74	10.96±2.16	8.00±2.10**	8.24±1.50**
					b	19.87±2.05	23.96±1.51**	21.43±3.36*	23.41±1.56**
c	22.15±1.60	23.59±2.11**	22.51±1.37	22.84±1.49
					h	62.95±6.49	61.94±6.28	62.17±7.42	64.37±3.39

Compare with before use: * P < 0105; * P< 0101.

Table 2 shows, and after using tranexamic acid facial film 30,60,90 d, the L value of buccal and b value all raise, with use before compare, difference has significance (t=21853,31998,41099, P < 0105).A value all reduces after use 60,90 d, compares, have pole significant difference (t=3123,51865, P < 0101) with before use.C value has pole significant change (t=41175, P=01002) after use 30 d.And h value changes after use 30,60,90 d, and there are no significant (t=01486,01319,01419, P > 0105).

Obtained by above-mentioned experiment, the tranexamic acid facial film of embodiment of the present invention gained has possessed good whitening effect.

Claims (6)

1. tranexamic acid facial film, be loaded on face paper by tranexamic acid pharmaceutical composition and prepare, described tranexamic acid pharmaceutical composition comprises tranexamic acid, the skin conditioning agent of 3% ~ 10%, emollient, the solvent of 75% ~ 85%, antioxidant, the thickening agent of 0.1% ~ 1%, PH regulator, the emulsifying agent of 0.1% ~ 1%, the wetting agent of 3% ~ 6% of 0.1% ~ 1% of 0.5% ~ 1.5% of 6.5% ~ 17% of 1.5% ~ 3% by weight percentage.

2. tranexamic acid facial film according to claim 1, characterized by further comprising the aminoacid of the anti-allergic agent 0.05% ~ 0.1% of 0.05% ~ 0.1%, 0.05% ~ 0.60% solubilizing agent, the chelating agen of 0.05% ~ 0.20%, one or more combinations in the antiseptic of 0.50% ~ 1% and 0.05% ~ 0.1% essence.

3. tranexamic acid facial film according to claim 1, is characterized in that described skin conditioning agent is one or more combinations in Fructus Chaenomelis extract, Fructus Pruni juice, PEG/PPG-14/7 dimethyl ether, Single Roxburgh Rose Fruit extract, Alpinia coriandriodora D. Fang. extract, dog rose flower extract, scutellariae,radix extract, dog rose berry extract, Uncaria gambier Roxb. extract, Herba thymi vulgaris extract.

4. tranexamic acid facial film according to claim 1, is characterized in that described emollient is one or more combinations in ring five polydimethylsiloxane, phenyl dimethicones, isostearic acid, squalane.

5. tranexamic acid facial film according to claim 1, is characterized in that described solvent is water and dipropylene glycol.

6., according to the preparation method of the tranexamic acid facial film of claim 1 ~ 4 described in any one, it is characterized in that comprising the steps:

(1) take and get tranexamic acid in prescription, wetting agent, anti-allergic agent, thickening agent, chelating agen etc., be dissolved in solvent, heated and stirred is to dissolving to obtain aqueous phase completely; Take emulsifying agent, emollient etc. to be heated with stirring to and to dissolve to obtain oil phase completely;

(2) respectively aqueous phase and oil phase are pumped in emulsifying pot, stir after 3 ~ 5 minutes homogenizing 5 minutes; Add antiseptic after homogenizing, and regulate pH value to be 6 ~ 7, stir cooling;

(3) when temperature is lower than 45 DEG C, add skin conditioning agent etc., stir to obtain tranexamic acid pharmaceutical composition;

(4) the tranexamic acid pharmaceutical composition obtained is loaded on face paper namely obtains tranexamic acid facial film.