JP2000212061A - Whitening cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a whitening cosmetic which has an excellent effect for improving spots and freckles and can retain the stability of a tatary buckwheat extract against heat and light for a long period. SOLUTION: This whitening cosmetic contains the extract of tatary buckwheat and a chelating agent and/or an antioxidant. The pH of the whitening cosmetic is preferably 2 to 6. The chelating agent is preferably at least one compound selected from the group consisting of edetic acid, disodium edetate, disodiumpotassium edetate, tartaric acid, gluconic acid and phytic acid. The antioxidant is preferably vitamin E and/or dibutylhydroxytoluene.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic comprising a buckwheat buckwheat extract and a chelating agent and / or an antioxidant. More specifically, the present invention relates to a heat and light stability of a buckwheat buckwheat extract. The present invention relates to a whitening cosmetic capable of maintaining the effect of improving spots and freckles for a long period of time by improving the whitening cosmetic.

[0002]

2. Description of the Related Art It is known that spots such as spots and freckles appearing on human skin are mainly caused by deposition of melanin. Research on cosmetics and therapeutic agents that suppress the production of melanin, which causes such spots and freckles, has been conducted for a long time. Examples thereof include blending peroxides such as hydrogen peroxide and zinc perborate into cosmetics, and blending vitamin C, cysteine, and colloidal sulfuric acid into cosmetics. However, none of them have a good balance in terms of preservability, safety and whitening effect.

[0003] The present inventors have been studying, for many years, whitening cosmetics for removing spots and freckles such as freckles appearing on human skin and enhancing the whitening effect of the entire skin. In addition, we found that factors that affect normal human skin color include melanin, carotene, blood flow (oxidized and reduced hemoglobin), skin thickness and transparency, and that light It reflects, absorbs, and scatters the color of the skin.Of these, melanin, especially brown or black melanin, has been elucidated to be the largest cause of pigmentation. We have been searching for substances to suppress. During the research, it was found that kojic acid and / or its derivative exhibited an extremely excellent melanin production inhibitory action. For example, JP-A-53-6432, JP-A-54-92632, and JP-A-54-92632. As disclosed in JP-A-56-7776 and JP-A-4-46191, there have been proposed inventions relating to fair-skin cosmetics containing these as active ingredients.

However, in recent years, Japanese Patent Laid-Open Publication No.
As disclosed in Japanese Patent No. 3022, it has been discovered that an extract extracted from buckwheat kernel has a tyrosinase inhibitory action. When this buckwheat buckwheat extract is formulated as a cosmetic, coloring and decomposition of the buckwheat buckwheat extract immediately proceed, especially in a neutral pH range to a weakly alkaline range, resulting in a decrease in the tyrosinase inhibitory effect and a decrease in spots and freckles. However, there is a problem in that the effect of improving the quality of the product is reduced and the product value is reduced due to coloring of the product.

[0005]

SUMMARY OF THE INVENTION An object of the present invention is to solve the above-mentioned problems, and has an excellent effect of improving spots and freckles. An object of the present invention is to provide a whitening cosmetic which can maintain its effects for a long period of time.

[0006]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies based on the recognition of the prior art, and as a result, by blending a chelating agent and / or an antioxidant with a buckwheat buckwheat extract. It has been found that the stability and effect of the buckwheat buckwheat extract against heat and light are maintained for a long period of time, and furthermore, it has been found that an excellent effect can be obtained by adjusting the pH to 2 to 6, thereby completing the present invention. I came to.

[0007] That is, according to the present invention, there is provided a skin-whitening cosmetic characterized by comprising a buckwheat extract and a chelating agent and / or an antioxidant. Further, according to the present invention, there is provided the above whitening cosmetic having a pH of 2 to 6. According to the present invention, the chelating agent is at least one selected from the group consisting of edetic acid, disodium edetate, calcium disodium edetate, tartaric acid, gluconic acid, and phytic acid. Is provided. Further, according to the present invention, there is provided the above-mentioned whitening cosmetic wherein the above-mentioned antioxidant is vitamin E and / or dibutylhydroxytoluene.

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The buckwheat extract of the present invention can be used as long as it is extracted from buckwheat seeds with a lower alcohol-based solvent and / or a lower ketone-based solvent. The obtained crude extract is washed with ether and / or water, and the purified one is preferably used.

The chelating agents used in the present invention include edetic acid, disodium edetate, calcium disodium edetate, trisodium edetate, hydroxyethanediphosphonic acid, citric acid, sodium citrate, tartaric acid, and gluconic acid. And phytic acid, among which edetic acid, disodium edetate, calcium disodium edetate, tartaric acid, gluconic acid and phytic acid are particularly preferred. The above chelating agents can be used alone or in combination of two or more.

The antioxidants used in the present invention include vitamin E, butylhydroxyanisole,
Examples thereof include dibutylhydroxytoluene, propyl gallate, sodium bisulfite, p-hydroxyanisole, and tea extract. Vitamin E and dibutylhydroxytoluene are particularly preferred. The above antioxidants can be used alone or in combination of two or more.

In the present invention, the compounding amount of the buckwheat buckwheat extract is based on the total amount of the preparation when used as a cosmetic such as cream, lotion, emulsion, pack, lotion, essence powder, foundation, sun care, bath salt and the like. It is added in the range of 0.001 to 3% by weight, preferably 0.01 to 1.0% by weight. The compounding amount of the chelating agent is 0.001 to 1.0% by weight, preferably 0.01 to 0.10% by weight, based on the whole preparation. The compounding amount of the antioxidant is 0.001 to 1.0% by weight, preferably 0.01% by weight, based on the whole preparation.
1 to 0.1% by weight is blended.

In preparing the cosmetic of the present invention, various known active ingredients usually used, for example, carpronium chloride, cepharanthin, vitamin E, vitamin E nicotinate, nicotinic acid, nicotinamide, benzyl nicotinate, and show Peripheral vasodilators such as tincture tincture and pepper tincture, cooling agents such as camphor and menthol, antibacterial agents such as hinokitiol, benzalkonium chloride, undecylenic acid, anti-inflammatory agents such as lysozyme chloride, glycyrrhizin, allantoin, ascorbic acid, arbutin, Animals such as whitening agents such as kojic acid, assembly extract, garlic extract, carrot extract, gongo extract, rosemary extract, aloe extract, luffa extract, ginkgo extract, placenta extract, liver extract, lactic acid bacteria culture extract, etc. Various extractions from plants and microorganisms Goods and the like can be used arbitrarily added.

Alternatively, in addition to known active ingredients, surfactants, base components such as oils and fats, etc., if necessary, known humectants, thickeners, preservatives, chelating agents, pH adjusters, fragrances, coloring Various additives such as agents can be used in combination. Examples of humectants include NMF components such as amino acids, sodium lactate and sodium pyrrolidone carboxylate, hyaluronic acid, collagen, elastin, chondroitin sulfate, dermatan sulfate, fibronectin, ceramides, heparin-like substances, chitosan and other water-soluble humectants. Molecular substances and the like can be exemplified.

Examples of the thickener include sodium alginate, xanthan gum, aluminum silicate, quince seed extract, tragacanth gum, natural polymer substances such as starch, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, soluble starch, cationized cellulose and the like. And a synthetic polymer such as carboxyvinyl polymer and polyvinyl alcohol.

Examples of preservatives include benzoate, salicylate, dehydroacetate, p-hydroxybenzoate, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 3,4,4'-trichlorocarba Nide, benzalkonium chloride, hinokitiol, resorcin and the like can be exemplified.

[0016]

EXAMPLES Next, examples of the present invention and test examples for explaining the effects thereof will be described, but these do not limit the present invention at all.

<Production Example 1> (Production example of buckwheat buckwheat extract) 20 L of 40% acetone water was added to 2 kg of peeled buckwheat buckwheat seeds, allowed to stand at room temperature for one week, and the supernatant was centrifuged. A centrifugal supernatant (14 L) is obtained, and the liquid is concentrated under reduced pressure until the liquid volume is reduced to one third to obtain a yellow precipitate. After air-drying the yellow precipitate, ether 300m
L and further washed with 300 mL of water to obtain 19 g of a buckwheat extract.

<Production Example 2> (Production example of buckwheat buckwheat extract) 30 L of 50% ethanol water was added to 3 kg of the peeled ground buckwheat seeds and stirred at room temperature for 2 hours to obtain 22 L of filtrate. When the filtrate is concentrated under reduced pressure until the liquid volume is reduced to one third, yellow insolubles precipitate. The yellow precipitate is separated by filtration and dried at 60 ° C. for 20 hours to obtain 74 g of a buckwheat extract.

<Production Example 3> (Production example of buckwheat buckwheat extract) 50% was added to 200 g of the ground buckwheat seeds after peeling.
2 L of acetone water was added, and the mixture was stirred at room temperature for 2 hours.
570 mL was obtained, and the filtrate was concentrated under reduced pressure until the liquid volume reached 600 mL to obtain a yellow precipitate. This is dried under vacuum to obtain 5.5 g of buckwheat extract.

<Test Example 1> Stability confirmation test of buckwheat extract a) Test method 100 mg of buckwheat extract obtained in Production Example 1 was added to 5
Dissolve in 80 mL of 0% ethanol and add p with citric acid aqueous solution.
H is adjusted to pH 2-8 and 10% with 50% ethanol.
It was 0 mL. 20 mL of each solution of pH 2 to 8 was transferred to a glass sample tube and left at 50 ° C. for 1 week.
One week later, the color tone of each sample solution was visually observed. b) Test results The results are shown in Table 1. c) Consideration The higher the pH, the more the browning tendency was observed.
Coloring does not easily occur in the vicinity, optimal p that can maintain stability
It was found that there was an H region.

[0021]

[Table 1]

<Test Example 2> Stability confirmation test of buckwheat extract a) Test method 100 mg of buckwheat extract obtained in Production Example 2
Dissolve in 80 mL of 0% ethanol, add 10 mg of disodium edetate as a chelating agent and 40 mg of vitamin E as an antioxidant as shown in Table 2, and adjust the pH with an aqueous citric acid solution.
Was adjusted to pH 2 to 7, and 100% with 50% ethanol.
mL, and each sample product was prepared. 20 samples each
Each mL was transferred to a glass sample tube and left at 50 ° C. for 2 weeks. Immediately after the preparation and after standing for 2 weeks, the color tone of each sample solution was observed and the main peak content was measured by HPLC [CCPM pump, UV8011 detector / Tosoh]. went. b) Test results The results are shown in Tables 3 and 4. c) Consideration From the results of visual observation of the color tone and the result of measuring the content of the main peak, when the pH is increased to 7, the contribution of the disodium edetate (chelating agent) and vitamin E (antioxidant) to the improvement in stability is extremely low. . In the pH range of 2 to 6,
Although the chelating agent alone maintains considerable stability, the combined use of an antioxidant further improves the stability.

[0023]

[Table 2]

[0024]

[Table 3]

[0025]

[Table 4]

<Test Example 3> Preparation stability test a) Test method 0.1% buckwheat extract obtained in Production Example 2 was blended,
Cream containing 0.01% disodium edetate and 0.04% d-δ-tocopherol (pH 5.5) [Cream of Formulation Example 1] and cream containing 0.1% tartary buckwheat extract (pH 5.5) as a comparative example ) [Cream prepared by removing disodium edetate and d-δ-tocopherol from Formulation Example 1], irradiating it with 1.2 million Lux · hr light, observing cream color tone and HPLC [CCPM pump,
UV8011 detector / manufactured by Tosoh Corporation]. b) Test results The results are shown in Table 5. c) Discussion In the cream containing no disodium edetate and d-δ-tocopherol, a decrease in quercetin content and coloring were observed after light irradiation, but disodium edetate and d-δ-
In the cream containing tocopherol, no change was observed in both the main peak content and the color tone.

[0027]

[Table 5]

[0028]

[Formulation Examples] Formulation examples of the complexion of the present invention are shown below. In the formulation examples, “appropriate amount” indicates a ratio of 100% by weight in the entire formulation.

Formulation Example 1 Cream 1 (% by weight) 1. Buckwheat buckwheat extract 0.10 2. polyoxyethylene cetyl ether 2.50 Glycerin monostearate 1.50 4. Behenyl alcohol 5.00 5. Liquid paraffin 7.00 6. 6. Cetyl octanoate 5.00 7. methyl polysiloxane 0.50 Paraoxybenzoate 0.70 9. d-δ-tocopherol 0.04 10. Carboxyvinyl polymer 0.05 11. Xanthan gum 0.01 12. Disodium edetate 0.01 13. Sodium hydroxide 0.02 14. Purified water qs

Formulation Example 2 Cream 2 (% by weight) 1. Buckwheat buckwheat extract 0.50 2. Aqueous sodium hyaluronate solution 2.00 Polyethylene glycol 400 3.00 4. 4. Polyoxyethylene cetyl ether (25EO) 2.00 Stearic acid 5.00 6. Avocado oil 1.00 7. 7. Almond oil 10.00 8. dl-pyrrolidone carboxylate sodium solution 5.00 Paraoxybenzoate 0.70 10. Disodium edetate 0.05 11. Sodium hydroxide 0.05 12. Purified water qs

Formulation Example 3 Cream 3 (% by weight) 1. Buckwheat buckwheat extract 0.20 2. Polyethylene glycol monostearate (40EO) 5.00 3. Self-emulsifying glyceryl monostearate 2.00 Stearic acid 5.00 5. Behenyl alcohol 1.00 6. Liquid paraffin 10.00 7. Glyceryl trioctanoate 10.00 8. Glycerin 5.00 9. Paraoxybenzoic acid ester 0.10 10. Dibutylhydroxytoluene 0.05 11. Purified water qs

Formulation Example 4 Emulsion 1 (% by weight) 1. Buckwheat buckwheat extract 0.10 2. Octyldodecanol 3.00 Polyoxyethylene cetyl ether (25EO) 0.50 4. 4. Polyoxyethylene oleyl ether (20EO) 1.00 5. Sorbitan monooleate 1.00 Stearic acid 0.50 7. Shea butter 0.50 8. Avocado oil 4.00 9.4-tert-butyl-4'-methoxy- 5.00 dibenzoylmethane 10. Paraoxybenzoate 0.20 11. Quince seed extract 5.00 12. Xanthan gum 0.14 13. 13. Disodium edetate 0.02 Phytic acid 0.02 15. d-δ-tocopherol 0.01 16. Purified water qs

Formulation Example 5 Emulsion 2 (% by weight) 1. Buckwheat buckwheat extract 0.01 2. Glycerin monostearate 1.50 3. Bacyl alcohol 3.50 Kojic acid 1.005. Stearic acid 0.50 6. Myristic acid 0.50 7. 7. Avocado oil 4.00 8. Octyl methoxycinnamate 2.00 Natural vitamin E 0.04 10. Paraoxybenzoate 0.20 11. Sodium hyaluronate 5.00 12. Ougon extract 0.14 13. Gluconic acid 0.50 14. Carboxyvinyl polymer 0.30 15. Sodium hydroxide 0.04 16. Purified water qs

Formulation Example 6 Lotion (% by weight) Tartary buckwheat extract 0.05 2. 2. Ethanol 15.00 Paraoxybenzoate 0.10 4. Citric acid 0.10 5. Sodium citrate 0.30 6.1,3-butylene glycol 4.00 7. 7. edetic acid 0.10 Purified water qs

Formulation Example 7 Cream pack (% by weight) 1. Buckwheat buckwheat extract 0.50 2. polyethylene glycol 1500 5.00 3. Stearic acid diethanolamide 5.00 Stearic acid 5.00 5. Myristic acid 5.00 6. Coconut oil 15.00 7. 7. Natural vitamin E 0.04 8. paraoxybenzoate 0.20 9. dl-pyrrolidone carboxylate sodium solution 5.00 10. disodium calcium edetate 0.01 Purified water qs

Formulation Example 8 Essence (% by weight) 1. Buckwheat buckwheat extract 1.00 3. Urocanic acid 0.50 3.1,3-butylene glycol 5.00 Benzyl alcohol 0.05 5. Kefiran aqueous solution 1.50 6. 6. Palm oil fatty acid monoethanolamide 2.00 Stearic acid 0.50 8. Myristic acid 0.50 9. Avocado oil 2.00 10. 10. Jojoba oil 3.00 Natural vitamin E 0.10 12. 13. Paraoxybenzoate 1.00 13.1% carboxyvinyl polymer aqueous solution 5.00 Placenta extract 0.14 15. Disodium edetate 0.03 16. Purified water qs

[0037]

According to the present invention, there is provided a whitening cosmetic composition comprising a buckwheat buckwheat extract as an active ingredient, and the whitening cosmetic composition maintains the heat, light stability and whitening effect of the buckwheat buckwheat extract for a long time. It can be a whitening cosmetic.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 EH

Claims (4)

[Claims] 1. A whitening cosmetic comprising a buckwheat extract and a chelating agent and / or an antioxidant. 2. The whitening cosmetic according to claim 1, wherein the pH is 2 to 6. 3. The chelating agent is at least one selected from the group consisting of edetic acid, disodium edetate, calcium disodium edetate, tartaric acid, gluconic acid and phytic acid. 3. The whitening cosmetic according to 1 or 2. 4. The whitening cosmetic according to claim 1, wherein the antioxidant is vitamin E and / or dibutylhydroxytoluene.