KR20100035746A - Method for producing rice for reducing glucose using ggi-100 emx - Google Patents

Abstract

PURPOSE: A method for producing low-sugar rice is provided to manufacture the low-sugar rice capable of reducing a high blood sugar level y coating the rice with coating liquid consisting of mulberry leaf extract, onion juice, deep sea water, alcohol and sodium alginate. CONSTITUTION: A method for producing low-sugar rice comprises a step for manufacturing coating liquid consisting of 4~6 parts of mulberry leaf extract by weight, 60~70 parts of onion juice by weight, 18~20 parts of deep sea water by weight, 8~12 parts of alcohol by weight and 0.5~1.5 parts of sodium alginate by weight and a step for manufacturing the low-sugar rice by coating the rice with the 0.5 parts of coating liquid by weight. The mulberry leaf extract is manufactured by a thermal extraction and a filtering processes after adding mulberry leaf powder 1 kg and distilled water 4l.

Description

Method for producing low-sugar sugar using GI-100 EMG ＸMethod for producing rice for reducing glucose using GGI-100 EMX}

The present invention relates to a method for preparing low sugar using GGI-100 EMX, and more particularly, to a low sugar produced by coating rice with a mixture of mulberry leaf extract and onion juice and a method for producing the same.

Rice is a representative grain that is stocked by the people of many countries including Korea.

However, in recent years, cooking rice with rice is not just a means to solve meals, but it is also a supplementary means for health, that is, if you cook rice with rice that contains ingredients that are beneficial to your health, you can naturally eat the ingredients. I am trying to help.

According to the statistics of recent years, rice production has increased every year, and rice self-sufficiency has reached 100% .However, due to the westernization of dietary life, rice consumption per capita is less than 80 kg, so various measures are required for rice consumption. It is becoming. Functional rice can be an important alternative to satisfy the needs of consumers who value "quality" and "nutrition and function" rather than "quantity" while breaking the difficult reality of domestic agriculture.

Meanwhile, the US Centers for Disease Control (CDC) released statistics in 2001 that estimated that by 2050, the number of people with diabetes in the United States will reach 29 million.

In other words, there are about 16 million people with type 2 diabetes in the United States, and one in seven is potentially exposed to obesity type diabetes.

In Korea and Japan, the number of diabetic patients has recently increased rapidly, and despite the government's policy, the number of patients has not been braked. Therefore, the demand for healthy functional food as well as exercise or diet therapy is increasing.

Diabetes mellitus is a chronic disease that develops according to the development of the socio-economic economy, and is classified into insulin dependent diabetes mellitus (Type I) and insulin non-dependent diabetes mellitus (Type II), which are mainly caused by genetic defects. In addition, 90-95% of all diabetics are insulin-independent diabetes, and Type II, which occurs in adults, is growing rapidly in Asian and African countries including Korea.

In Korea, diabetes has increased significantly along with high economic growth in recent decades, which was only 0.2% in 1960, more than 3% in 1990, and according to recent epidemiologic survey, 8-10% of people over 30 years old. The prevalence of

Diabetes is now an important issue for public health, and prevention and management of diabetes is urgently needed.

Recently, the development of anti-diabetic agents has been active, and various types of therapeutic agents have been developed.

In the past, the use of oral hypoglycemic agents, such as fast-acting insulin or sulfonurea, has been the main treatment with simply lowering elevated blood sugar, and these therapies are difficult to normalize glucose metabolism and thus prevent complications.

Post-prandial epidemiologic investigations suggest a link between hyperglycemia and cardiovascular disease, and the importance of postprandial hyperglycemia control has been emphasized in diabetics.

Accordingly, the importance of the first secretion of insulin during the glycemic control is highlighted, while improving the drug and food for reducing the occurrence of hypoglycemia is attracting attention.

Therefore, the study on the production of functional rice by using a material such as mushroom mycelium or kelp, which is a natural food that can expect additional hypoglycemic effect when combined with current drugs for the purpose of controlling hyperglycemia after eating It is being implemented together.

Korean Laid-Open Patent Publication No. 2005-0104137 (Reproductive health food using germinated brown rice coated with mushroom extract, and a method of manufacturing the same), after coating the situation mushroom extract in brown rice, and manufacturing a reproductive health food using the same It is open to the public.

In Korean Patent Laid-Open Publication No. 2003-0062186 (Method for manufacturing clean rice containing mulberry leaf extract component), mulberry leaf extract is applied by spraying the mulberry leaf extract in the process of impregnating brown rice in the mulberry leaf extract first and then refining rice. A method for producing impregnated clean rice is disclosed.

Korean Patent Laid-Open Publication No. 2000-60498 discloses mulberry leaf rice, which is mainly composed of rice, mulberry leaves and optionally beta-glucan-containing grains, and Korean Patent Registration No. 10-653460 contains mulberry leaf extract and fenugreek extract. Antidiabetic compositions are disclosed.

The present invention has been completed by the above requirements, and completed the present invention by confirming that the rice coated with a coating solution consisting of mulberry leaf extract, onion juice, deep sea water, alcohol, and sodium alginate can lower blood sugar.

In order to solve the above problems, the present invention provides a low-sugar rice prepared by coating the rice with a mixture of mulberry leaf extract and onion juice.

The present invention also provides a method for producing the low sugar.

In addition, the present invention consists of 4 to 6 parts by weight of mulberry leaf extract, 60 to 70 parts by weight of onion juice, 18 to 20 parts by weight of deep seawater, 8 to 12 parts by weight of alcohol, and 0.5 to 1.5 parts by weight of sodium alginate, the composition for rice coating To provide.

According to the present invention, by coating the rice with a coating liquid consisting of mulberry leaf extract, onion juice, deep sea water, alcohol, and sodium alginate can provide a low-sugar rice is a functional rice with high blood sugar lowering effect.

In order to achieve the object of the present invention, the present invention provides a low-sweetness produced by coating rice with a mixture of mulberry leaf extract and onion juice.

In the specification of the present invention, "low sugar" refers to rice that lowers blood sugar.

In the low sugar content of the present invention, the mixture may further include deep sea water, alcohol and sodium alginate, the mixture is preferably 4 to 6 parts by weight of mulberry leaf extract, 60 to 70 parts by weight of onion juice, deep sea water 18 20 parts by weight, alcohol 8-12 parts by weight, and 0.5 to 1.5 parts by weight of sodium alginate, and more preferably 5 parts by weight of mulberry leaf extract, 65 parts by weight of onion juice, 19 parts by weight of deep sea water, 10 parts by weight of alcohol. , And 1 part by weight of sodium alginate.

In the low sugar content of the present invention, the coating ratio may be coated with 0.1 to 0.5 parts by weight of the mixture in 99.5 to 99.9 parts by weight of rice, preferably 0.5 parts by weight of the mixture in 99.5 parts by weight of rice.

The low sugar of the present invention is most preferably prepared by coating 99.5 parts by weight of rice with 0.5 parts by weight of a mixture consisting of 5 parts by weight of mulberry leaf extract, 65 parts by weight of onion juice, 19 parts by weight of deep sea water, 10 parts by weight of alcohol, and 1 part by weight of sodium alginate. Can be.

The rice which can be used in the present invention is a grain that can be mixed with stocks or stocks, and can be eaten and eaten by the general public, and thus does not require limitation to one particular kind.

Examples of such rice include one or two or more kinds of mixed rice selected from the group of brown rice, white rice, five rice bran, brown rice glutinous rice, white rice glutinous rice, black rice, barley rice and Goami.

As cereals that can be mixed with stocks, there are one or two or more mixed grains in the group of soybeans, red beans, crude, millet, sorghum, yulmu, and corn.

Mulberry leaves, the main component of the rice coating solution of the present invention is rich in various functional ingredients lacking in rice. Among them, GABA is a component that lowers blood pressure, and contains various kinds of quercetin-based and camphorol-based flavonoids, which enhances antioxidant and capillary-enhancing effects including lipid peroxidation. In addition, mulberry leaves contain a large amount of components that reduce blood sugar is currently being used in a variety of beverages, tea and food products for diabetics are increasing gradually.

Onion, which is the main component of the rice coating solution of the present invention, has been used in various foods as a vegetable effective for a long time. Onions are mainly edible, and the peculiar smell of scales is due to compounds such as propyl disulfide and allyl sulfide. It promotes the secretion of digestive juices physiologically and has an effect such as excitement, sweating and diuresis. In addition, the scales contain minerals such as calcium and phosphoric acid together with various vitamins to remove harmful substances in the blood. Scales are often used in salads, soups, and meat dishes, and are used as spices in various dishes.

Onions are known to clear blood. It is one of the active ingredients of onion 'Quercetin' has the effect of preventing atherosclerosis, and another ingredient 'emulsification profile' lowers triglyceride and cholesterol levels. Onions are also effective in healing turbid blood and damaged blood vessels. Onion is a fibrinolytic and lipid-lowering action that lowers the viscosity of the blood, making it clear and clean. Therefore, the blood circulation is improved and the body's supply of oxygen and nutrition is effective.

And onions lower blood pressure and prevent heart disease. When onions are heated, the petroleum profile is reduced, but depending on the degree of heating, it changes into a component called `` tristle '' and `` sepiene. '' These ingredients work to lower triglyceride and cholesterol levels and lower blood pressure. And the yellow pigment in the skin of onion 'Quercetin' ingredient strengthens capillaries and softens hardened arteries, which is effective in preventing heart disease.

Deep sea water is clear and clean water that exists at a depth of 200 meters or less where sunlight does not reach. Unlike general water available on land, deep sea water contains a variety of nutrients, including about 70 minerals and nutrients that are essential to our bodies. It is known that the composition of water is similar to the body fluids of the human body among the water that human beings can obtain in nature, and is most similar to the amniotic fluid of women.

Deep sea water is rich in minerals such as magnesium, potassium and sodium, and nutrients such as nutrients. In particular, the ratio of nutrients is similar to the amniotic fluid, which is the drinking water of the fetus, which is attracting much attention as food and medicine. To date, research shows that deep sea water has excellent medical effects such as maintaining the body's mineral balance, improving immune function, preventing skin aging, and preventing adult diseases such as cancer and heart disease. In addition, research has shown that atopy, which has recently become a major concern for modern people, has been improved by drinking and applying.

Sodium alginate is a natural polymer that makes up the cell membranes of brown algae, such as seaweed and kelp. Alginic acid, also called seaweed, is a carbohydrate called polysaccharide, just like starch and cellulose. Alginic acid is made by linking hundreds of monosaccharide molecules called manuronic acid and L-gluuronic acid, just like glucose is long and starch is formed. Specific components of alginic acid depend on the type of seaweed.

The present invention also provides

1) preparing a mulberry leaf powder using a mill of dried mulberry leaves;

2) adding water to the mulberry leaf powder and extracting hot water, followed by filtration to obtain hot water extract;

3) The hot water extract was dried to prepare an extract powder, and then dissolved in deep sea water, and then dissolved by adding sodium alginate, onion juice and alcohol, 4 to 6 parts by weight of mulberry leaf extract, 60 to 70 parts by weight of onion juice. Preparing a coating liquid comprising 18 to 20 parts by weight of deep sea water, 8 to 12 parts by weight of alcohol, and 0.5 to 1.5 parts by weight of sodium alginate; And

4) provides a method for producing low-sweetness sugar comprising the step of coating the prepared coating solution to 0.1 to 0.5 parts by weight relative to the weight of rice, followed by drying to prepare rice.

In the method for preparing low-sweet sugar of the present invention, the hot water extract in step 2) is preferably prepared by adding 4 L of distilled water to 1 kg of mulberry leaf powder, followed by filtration of hot water at 121 ° C. for 15 minutes.

In the method for preparing low-sweetness of the present invention, the coating solution is preferably composed of 5 parts by weight of mulberry leaf extract, 65 parts by weight of onion juice, 19 parts by weight of deep sea water, 10 parts by weight of alcohol, and 1 part by weight of sodium alginate.

The coating in step 4) is preferably carried out at room temperature, and the prepared coating liquid is coated using a known coating machine, for example, a rotary coating pan, spray coating device, or screwed. .

The present invention also comprises 4 to 6 parts by weight of mulberry leaf extract, 60 to 70 parts by weight of onion juice, 18 to 20 parts by weight of deep sea water, 8 to 12 parts by weight of alcohol, and 0.5 to 1.5 parts by weight of sodium alginate. To provide. Coating the composition on rice can produce a low sugar sugar to lower blood sugar. The coating composition may be preferably composed of 5 parts by weight of mulberry leaf extract, 65 parts by weight of onion juice, 19 parts by weight of deep sea water, 10 parts by weight of alcohol, and 1 part by weight of sodium alginate.

Hereinafter, the present invention will be described in detail by way of examples. However, the following examples are illustrative of the present invention, and the present invention is not limited to the following examples.

Example

Example  1: of the present invention Mortgage  Produce

Sodium alginate was extracted from kelp and sold as a food additive (Hyundai, Jeju).

The rice purchased organic 200 rice (Hongseong, Chungcheongnam-do, Chucheong rice) commercially.

Onion juice was purchased from Okban food, alcohol was used 10% alcohol alcohol.

1. The dried mulberry leaf was purchased to prepare a mulberry leaf powder using a grinder.

2. After adding 4L of distilled water to 1kg of mulberry leaf powder, hot water was extracted at 121 ° C. for 15 minutes and then filtered to obtain a hot water extract.

3. This hot water extract was poured into a spray dryer (BUCHI, B-197) controlled at an air temperature of 180 ° C. and an exhaust temperature of 125 ° C., followed by drying, to obtain an extract powder as a powder.

4. The extract powder obtained as described above is well dissolved in deep sea water, and then dissolved by adding sodium alginate, onion juice and alcohol, 5 parts by weight of mulberry leaf extract, 65 parts by weight of onion juice, 19 parts by weight of deep sea water, alcohol A coating solution consisting of 10 parts by weight and 1 part by weight of sodium alginate (hereinafter, referred to as "GGI-100 EMX") was prepared.

5. After adding 0.5 parts by weight of the coating solution prepared above to 99.5 parts by weight of rice, a coating process was performed once at 25 ° C. using a rotary pan granulator (Shinheung, South Korea), and then dried to prepare low sugar.

Example 2 Diabetes-Induced Experimental Animal Model (Type 2) by General Diet, High Fat Diet and STZ Administration of GGI-100 EMX Coating Solution of the Present Invention Hypoglycemic effect

1. Experiment Method

Five-week-old male Sprague Dawley rats were purchased from a central animal experiment and used for one week after being adapted. The experimental animals were bred in animal farms maintained at a humidity of 50% and a temperature of 24-26 ℃, and water and feed were freely consumed. As a diet, 45 kcal% fat (research diet) was used for the high fat diet and 5 kcal% fat (Superfeed. Inc) was used for the general diet. Feed volume and body weight of each animal were checked daily and weekly, respectively. The GGI-100 sample dose was orally administered at 170 mg / kg (based on DNJ content of 20 mg / kg).

The experiment was divided into three groups.

1.Groups administered orally with a 9-week diet

2. Group administered orally with the sample during high-fat diet for 9 weeks

3. Induced diabetes by intraperitoneal administration of 34 mg / kg of streptozotocin dissolved in 100 mM citrate buffer (pH 4.5) in fast-acting animals for 12 hours after high-fat diet for 4 weeks. After one week, blood glucose was measured using Roche's glucocheck, and only the experimental animals over 250 mg / dl were selected and the samples were orally administered for 18 days.

Oral glucose tolerance test (OGTT) for each group was performed as follows. After the administration of the sample, the general diet was administered for 7 weeks, the high-fat diet group was administered for 8 weeks, and the STZ-administered group was performed after 10 and 18 days. After fasting the experimental animals for 15 hours, blood glucose was checked for 0 hours, and glucose (2g / kg) was orally administered. Blood glucose was measured from the tail vein every 30 minutes, 1 hour, 2 hours, and 3 hours.

After 9 weeks of dietary and high-fat diets, the animals were fasted for 15 hours, and blood was collected from the orbital vein and centrifuged at 3,000 rpm for 10 minutes. In the STZ-administered group, hepatic and pancreas were extracted and fixed with 10% formalin for 18 days, followed by hematoxylin & Eosin staining. In addition, glycated hemoglobin from whole blood was analyzed by HLC-723 G7 (Tosoh Corporation, Tokyo, Japa) HPLC, and plasma was separated from the remaining blood for biochemical analysis.

2. Experimental Results

Oral glucose-load experiments were performed between the group receiving GGI-100 EMX and the group receiving carboxymethylcellulose (CMC) as a control. OGTT (oral glucose tolerance test) after 64 days of ingesting GGI-100 EMX in the diet and general diet showed 145-150mg / dL at 30 minutes after the ingestion of sugar, and GGI-100 EMX In the group of 120-127mg / dL GGI-100 diet group was found to lower the glucose absorption up to 20-25mg / dL (Figure 1).

In connection with the hypoglycemic effect of the diabetes-induced experimental animal model (Type 2) by high fat diet and STZ administration, the experimental group was administered with the HF-STZ-GGI-100 EMX group administered with the GGI-100 EMX coating solution prepared in Example 1, HF-STZ-CMC group administered carboxymethylcellulose (CMC), HF-STZ-Rosiglitazone group administered rosiglitazone, and HF-citrate buffer group not causing diabetes were performed.

As a result of OGTT (oral glucose tolerance test) after 11 days of sample administration, it can be seen that GGI-100 EMX shows similar efficacy with rosiglitazone, a drug currently used for improving insulin resistance (FIG. 2).

In addition, pancreatic tissue was observed morphologically by H & E staining. Figure 3 is a diagram showing the morphological observation of pancreatic tissue by H & E staining. The observation of pancreatic tissue is an important indicator of the number and shape of the islands of Langerhans in the production and supply of insulin. As can be seen in Figure 3, in the HF-citrate buffer control Langerhans Island is clearly identified, it was confirmed that 50% protection in the control group rosiglitazone group, 20-30% protection in the GGI-100EMX administration group It can be confirmed that there is an action.

Example 3 of the Invention Mortgage Cooking  Sensory test before

In order to determine the acceptability of low sugar content after 7 days of coating, the white sugar, shape, and radiance were investigated by comparing the original sugar content and the low sugar taste of Example 1 of the present invention according to the Food Sensory Standards (Korea Food Research Institute). The results are shown in Table 1 below.

Table 1. Sensory test results before cooking

Symbol White peach burnish shape Original song 4 4 3.5 Low sweetness of Example 1 4 4 3.5

* Preference degree; 1. very bad, 3. plain, 5. very good

Compared to the original grain as shown in Table 1, the preference of the low-sweetness of Example 1 of the present invention was investigated in the same way, there was no deterioration of rice quality before cooking by coating.

Example 4 of the Invention Mortgage Cooking  Sensory evaluation

As a general cooking technique for the electric pressure cooker, the original aroma and the low-sweetness of Example 1 of the present invention were cooked under the same conditions, and then the aroma, appearance and color, hardness and viscosity, and taste of the rice were compared. The results are shown in Table 2 below.

Table 2. Sensory test results after cooking

Symbol Scent Appearance and color Hardness and viscosity flavor Original song 4.0 4.0 4.5 4.0 Low sweetness of Example 1 5.0 4.5 5.0 4.5

* Preference degree; 1. very bad, 3. plain, 5. very good

As shown in Table 2 above, the preference after the cooking of the raw sugar and the low sugar taste of Example 1 of the present invention was investigated through sensory test, and it was found that the sweetness of the low sugar taste is better than the original grain, which is a measure for evaluating the uniqueness of rice. .

It is a result that people with diabetes who have lost their appetite due to excessive diet may prefer it.

1 is a measure of the post-prandial blood sugar lowering effect in the general diet of the GGI-100 EMX coating solution of the present invention.

Figure 2 measures the anti-diabetic effect in STZ-induced diabetic animals.

Figure 3 is a diagram showing the morphological observation of pancreatic tissue by H & E staining. The arrow represents the island of Langerhans.

Claims (9)

Low-sugar sugar prepared by coating rice with a mixture of mulberry leaf extract and onion juice. The low sugar content of claim 1, wherein the mixture further comprises deep sea water, alcohol and sodium alginate. According to claim 2, wherein the mixture is composed of 4 to 6 parts by weight of mulberry leaf extract, 60 to 70 parts by weight of onion juice, 18 to 20 parts by weight of deep sea water, 8 to 12 parts by weight of alcohol, and 0.5 to 1.5 parts by weight of sodium alginate. Mortgage rice characterized by. The low sugar content of claim 1, comprising 99.5 to 99.9 parts by weight of rice and 0.1 to 0.5 parts by weight of the mixture. According to claim 3, 5 parts by weight of mulberry leaf extract, 65 parts by weight of onion juice, 19 parts by weight of deep sea water, 10 parts by weight of alcohol, and 0.5 parts by weight of a mixture consisting of 1 part by weight of sodium alginate, low sugar sugar prepared by coating 99.5 parts by weight of rice . 1) preparing a mulberry leaf powder using a mill of dried mulberry leaves; 2) adding water to the mulberry leaf powder and extracting hot water, followed by filtration to obtain hot water extract; 3) The hot water extract was dried to prepare an extract powder, and then dissolved in deep sea water, and then dissolved by adding sodium alginate, onion juice and alcohol, 4 to 6 parts by weight of mulberry leaf extract, 60 to 70 parts by weight of onion juice. Preparing a coating liquid comprising 18 to 20 parts by weight of deep sea water, 8 to 12 parts by weight of alcohol, and 0.5 to 1.5 parts by weight of sodium alginate; And 4) The method of preparing low-sweetness rice comprising the step of coating the prepared coating solution to 0.1 to 0.5 parts by weight of rice, and then drying the rice to produce rice. The method of claim 6, wherein in the step 2), the hot water extract solution is prepared by adding 4 L of distilled water to 1 kg of mulberry leaf powder and then hot water extracting at 121 ° C. for 15 minutes, followed by filtration. The method of claim 6, wherein the coating solution comprises 5 parts by weight of mulberry leaf extract, 65 parts by weight of onion juice, 19 parts by weight of deep sea water, 10 parts by weight of alcohol, and 1 part by weight of sodium alginate. Mulberry leaf extract 4-6 parts by weight, onion juice 60-70 parts by weight, deep sea water 18-20 parts by weight, alcohol 8-12 parts by weight, and sodium alginate 0.5-1.5 parts by weight, the composition for rice coating.

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