KR20100025038A - Protection of hair using natural ingredients, hair loss hair prevention and improvement composition - Google Patents

Abstract

PURPOSE: A composition containing a natural material for improving hair is provided to remove dandruff and to repair hair and scalp. CONSTITUTION: A composition for improving skin contains 1-20 weight% of phytosphingosin ascobate, 1-30 weight% of bamboo leaves; 1-30 weight% of beta-glucan, and 40-60 weight% of crystal 3-O ascorbic acid. The beta glucan has molecular weight of 30,000-100,000 Da isolated from Schizophyllum commune.

Description

Protection of hair using natural ingredients, hair loss hair prevention and improvement composition

The present invention relates to a composition for improving hair using natural materials and a hair improver using the same.

The present invention is to provide an excellent hair improver without the hair loss prevention effect, hair growth effect, wool effect, hair protection using natural materials, as well as hair wetting effect, hair and scalp recovery, hair improvement effect and side effects will be.

Hair is only a mammal, and as an appendage to the skin, hair development starts from 9 to 12 weeks of birth and is inherited by parental inheritance. Hair repeats the hair cycles of growth, degeneration, rest, and growth. Hair grows only in the growth phase, and each hair growth cycle is independent and has its own cycle. . There are 70 to 120 hairs per day, which naturally fall out every day. Hair cycles are divided into five to six years of growth, two to three weeks of degeneration, and two to three months of rest. Hair growth is affected by a number of internal and external factors, including the nutritional status of the individual, hormonal temperature consistent systemic and disease, and various chemicals, especially when the epidermal overgrowth of the scalp is caused by some cause. It is known to make.

Hair protects and protects the body from external stimuli such as buffering and external stimuli such as ultraviolet rays, temperature, and friction. It also absorbs unnecessary arsenic, mercury, zinc, and other heavy metals from the body. .

Hair plays a very important role for hair owners in terms of health and beauty, but due to various causes such as environmental, genetic, mental, and physical, the physical rhythm is broken and unbalanced. It causes hair damage such as hair loss.

Therefore, research is being conducted on compositions that can improve the condition of the scalp and hair by preventing abnormalities of the scalp and hair, including hair loss, and in order to give gloss and smoothness to the hair, high molecular weight dimethyl polysiloxane and high molecular weight methylphenyl polysiloxane. Oil components, such as these, are used. Of these, silicone oil has been widely used because of its low surface tension, its familiarity with hair, and its gloss. However, since most chemical elements are added in a large amount, there is a problem of causing side effects such as irritation or damage when used for a long time.

Therefore, it is very effective in preventing hair loss, hair growth effect, wool effect, hair protection, as well as hair wetting effect, hair and scalp recovery, and hair improvement effect. There is a need for the development of a modifier composition.

The present invention aims to provide an excellent hair improvement composition without hair loss prevention effect, hair growth effect, wool effect, hair protection, as well as hair wetting effect, hair and scalp recovery, hair improvement effect and side effects.

In addition, the present invention has no side effects even when used for a long time, to provide a hair improvement composition that can improve the condition of the scalp and hair by preventing abnormal symptoms of the scalp and hair.

The present invention relates to a composition for improving hair, and to a composition for improving hair which can achieve a desired effect even with a small effective amount.

The present invention relates to a composition for improving hair comprising phytosphingosin ascobate, phytosphingosin ascobate, bamboo leaf extract, betaglucan, and crystalline 3-O-substituted ascorbic acid.

More specifically, the present invention is phytosphingosin ascobate (phytosphingosin ascobate) 1 to 20% by weight of the active ingredient, 20 to 50% by weight of bamboo leaf extract, 1 to 30% by weight of beta glucan, crystalline 3-O-substituted It relates to a hair improvement composition comprising 40 to 60% by weight of ascorbic acid.

The hair improvement composition contains 0.0001 to 50% by weight of the active ingredient.

The present inventors, when mixed with phytosphingosin ascobate, bamboo leaf extract, betaglucan, crystalline 3-O-substituted ascorbic acid, prevents abnormal symptoms of the scalp and hair by their synergistic effect The present invention has been found to be effective in preventing hair loss, hair growth effect, wool effect, hair protection, as well as hair wetting effect, hair and scalp recovery, hair improvement effect, improvement of scalp and hair condition. .

Hereinafter, the present invention will be described in more detail.

The phytosphingosin ascobate (phytosphingosin ascobate) is a unit compound combining phytosphingosine and vitamin C is a complex efficacy component having the efficacy of both materials at the same time. This is the starting material phytosphingosine (2S, 3S4R-2-Amino-1,3,4-octadecanetriol) is one of the sphingolipids, the skin component of phosphoric acid, extracted through yeast fermentation and skin active substance Vitamin C (L-ascorbic acid), also known as L, is obtained from fruits.

A method for manufacturing such phytosphingosine ascorbate is already known, but is not limited thereto, and may be prepared by, for example, the method disclosed in Korean Patent Publication No. 10-0528387.

The phytosphingosine ascorbate is preferably used 1 to 20% by weight of 100% by weight of the active ingredient, when used in the above range can achieve an excellent hair growth and scalp improvement effect by synergistic with other components.

The bamboo leaf extract is used to moisturize, nourish, antibacterial, antioxidant and anti-aging of the skin because it contains a large amount of polyphenolic ingredients, using low temperature and high pressure compression using bamboo leaves grown in an uncontaminated area. What was prepared by the extraction method is used. For example, it can use what was extracted by the method of Unexamined-Japanese-Patent No. 2004-359698, but it is not limited to this. The method of the patent is a method of extracting all essential elements without any change in properties, and extracting without using water or any chemicals during all the extraction process. Extraction in this manner is preferable because it can obtain a high-purity substance without damaging the main components of nutrients or functional substances. Moreover, since extraction is possible, maintaining the original property of an amino acid which is impossible by the extraction method using water or alcohol, it is more preferable.

The content of the bamboo extract is used 20 to 50% by weight of 100% by weight of the active ingredient, when used in the above range can achieve an excellent hair growth and scalp improvement effect by synergy with other components.

The beta glucan is used to activate the hair follicle cells in the resting state, it is preferable to use a molecular weight extracted from Schizophyllum commune low molecular weight 30,000 ~ 100,000 Da. In the case of using a low molecular weight, it can be easily absorbed by the human body, thereby increasing the effect, and it is appropriate to manufacture in the above range.

Since the beta glucan is not toxic to the human body, its compounding amount is not limited and can be widely selected and used, but when used in an amount of 1 to 30% by weight of 100% by weight of the active ingredient, synergistic effect with other ingredients is achieved. By this, sufficient effect can be achieved.

The crystalline 3-O-substituted ascorbic acid is not easily oxidized by air, especially oxygen and external environment such as heat and light, so that its activity is maintained and stabilized for a long time in an unoxidized state. As vitamin C, the starting material, 3-O-substituted 5,6-hydroxy group, is ascorbic acid that can be obtained in high yield while reducing the stage of protected ascorbic acid synthesis.

Crystalline 3-O-substituted ascorbic acid represented by Formula 1 has a pigmentation inhibitory effect, which is achieved by inhibiting the production of melanin which is closely related to pigmentation. Crystalline 3-O-substituted ascorbic acid improves pigmentation symptoms by melanin by inhibiting the activity of tyrosinase, which is important for melanin formation, and reducing the oxidized melanin formed by the oxidation process to reduce melanin. It has an effect.

A method for preparing such crystalline 3-O-substituted ascorbic acid is already known, but is not limited thereto. For example, the crystalline 3-O-substituted ascorbic acid may be prepared by the method disclosed in Korean Patent Publication No. 10-0761959.

This can achieve a sufficient effect by synergy with other components when using 40 to 60% by weight of 100% by weight of the active ingredient.

Hair improvement composition of the present invention as an active ingredient, including the phytosphingosin ascobate (phytosphingosin ascobate), bamboo leaf extract, beta glucan, crystalline 3-O-substituted ascorbic acid, a composition for improving hair , Preferably the active ingredient is contained in 0.1 to 50% by weight.

The single dose of the hair improvement composition thus prepared may be appropriately adjusted according to individual differences, formulations, and shapes such as age and the extent of lesions, and effective for 0.01 to 1000 mg twice a day for a general adult. Use in content.

The hair improver may be prepared in general in any dosage form applicable to the scalp and hair, and may be prepared in a dosage form selected from the group consisting of solutions, suspensions, emulsions, gels, creams, pastes, lotions, and sprays. The components for preparing these formulations may be prepared by a combination of conventionally known ingredients.

In addition to the composition for improving hair, which is the main component, the hair improver may contain various known materials that are normally blended into cosmetics that are expected to have hair growth and hair growth effects. For example, antimicrobial agents, coolants, moisturizers, penetration enhancers, blood flow promoters, follicle inactivators, scalp nutrients, anti-itch agents, or mixtures thereof may be used.

Examples of the antimicrobial agent include hinoki chiol, chitosan, polyrizine, sodium benzoate, parabens, and the like. As the moisturizing agent, one or a mixture of two or more selected from polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, mannitol, and polyethylene glycol can be used. Penetration accelerator and blood flow promoting agent may be specifically used iris extract, Angelica extract, Salvia herb extract, Cheongung extract, chamomile extract and the like. Specifically, the blanket rejuvenating agent may be a clove extract, an acid extract, a sulfur extract, or the like. Scalp nutrients are specifically one or more vitamin or vitamin precursors consisting of iron, manganese, essential amino acids, manganese, biotin, vitamins B1, B2, B6, D and folic acid, keratin, amino acids, menthol die-panthenol, cyclopentasiloxane / Various minerals other than dimethicone can be used. Specifically, the itch inhibitor may be used peppermint, gum extract, panchae extract and mixtures thereof.

The hair improvement composition of the present invention is phytosphingosin ascobate (phytosphingosin ascobate), bamboo leaf extract, beta glucan extracted from yeast, crystalline 3-O-substituted ascorbic acid by the synergistic effect of using a mixture, hair growth As well as effect, wool effect, dandruff removal effect, hair protection, wetting effect of hair, recovery of hair and scalp, adding softness and shine to hair, and remarkably recovering damage of hair and scalp It can be usefully applied as a hair improver composition which does not cause side effects even in use.

Hereinafter, the present invention will be described by way of example for specific description of the present invention, but the present invention is not limited to the following examples.

[Production Example 1]

Preparation of Phytosphingosine Ascorbate

18 g (0.057 mol) of phytosphingosin was added to a dried 1 L round neck flask, and 350 ml of a mixture of methanol and chloroform [1: 1 (v / v)] was added to the flask. Dissolve completely under stirring. Into a 200 ml Erlenmeyer flask, 100 ml of a 1: 1 mixed solution of methanol and chloroform and 10 g (0.057 mol) of L-ascorbic acid (vitamin C) were dissolved, and then the completely dissolved vitamin C solution was transferred to a dropping funnel. It was stirred slowly dropwise to the mixed solution.

After all of the L-ascorbic acid mixed solution was added, the mixture was stirred at room temperature for 2.5 hours. The reaction solution was concentrated under a reduced pressure using a Rotavapor at a temperature of 40 ℃ to remove the solvent to obtain a pale gray white powder of phytosphingosine ascorbate. The obtained phytosphingosine ascorbate was put into methanol, recrystallized, washed with a cold solvent, filtered again and dried in a vacuum oven at 40 ° C. to obtain phytosphingosine ascorbate.

Melting Point = 145 ~ 155 ℃

R _f = 0.40 (CHCL ₃ : MeOH: H ₂ O: CH ₃ COOCH ₃ )

FT-1R (KRr): 3412.4, 2918.7, 2849.3, 1754.9, 1653.6, 1561.1, 1468.5, 1379.8, 1322, 1140.7, 1073.2, 1025.9 (cm ^-1 )

¹ H NMR (DMSO-d ₆ , 600 MHz) & 0.87 to 0.90 (t, 3H), 1.27 to 1.4 (m, 22H0, g 1.4 to 1.5 (m, 2H), 1.50 to 1.53 (M, 2H), 3.3 to 3.4 (s, 1H), 3.44 to 3.48 (s, 2H), 3.5 to 3.6 (m, 2H), 3.72 to 3.73 (m, 1H), 3.8 to 3.9 (m, 1H), 4.19 to 4.21 (m, 1H ), 4.7 (s, 1H), 7.53 to 7.55 (m, 3H)

[Production Example 2]

Preparation of Bamboo Leaf Extract

The low temperature, high pressure compression extraction method is used. 50 kg of leaves of fresh bamboo ( Phyllostachys nigra var. Distillation gave 3.1 kg of the effluent. In this manufacturing process, bamboo leaf effluent with sufficient storage stability was obtained, and a highly transparent bamboo leaf extract was obtained by fine filtration using a filter of 0.45 탆 to avoid mixing of various bacteria.

[Production Example 3]

Preparation of Crystalline 3-O-Substituted Ascorbic Acid

100 ml of dimethyl sulfoxide was added 17.6 g of L-ascorbic acid, 15.6 g of 1,2-dimethoxypropane and 1.2 g of p-tolusulfonic acid to a mixed solvent of 40 ml of acetone. After stirring at 50 ° C. for 5 hours, the resulting mixture was distilled under reduced pressure at 20 ° C. to remove 1,2-dimethoxypropane which had not reacted with the remaining acetone, resulting in 20.5 g (95% yield) of 5,6-O-iso. Propyldene ascorbic acid was prepared. 20.5 g (0.095 mol) of prepared 5,6-O-isopropylidene ascorbic acid and 1.0 g of an anion exchange resin adsorbed with iodine anion were added to 100 ml of DMF and stirred, while stirring 12.3 g (0.11 mol) of ethyl bromide at room temperature. Dropping slowly. After dropping, the mixture was stirred at room temperature for 3 hours, and then filtered through anion exchange resin adsorbed with iodine anion from the reaction mixture, followed by distillation under reduced pressure to remove DMF and ethyl bromide, followed by 180 ml of water and acetyl acetate (120 ml x 2) is added to separate the organic layer and recovered. The recovered organic layer was concentrated under reduced pressure and the resulting residue was recrystallized in ethyl acetate / hexane (1: 1) to give 22.0 g (95%) of 3-O-ethyl-isopropylidene ascorbic acid.

mp: 105-106 ° C. ¹ H NMR (MeOH-d ₄ ,) ppm, δ 1.28 (6H, S) 1.34 (3H, t) 4.12 (3H, m) 4.51 (2H, q) 4.65 (1H, d, 3 Hz)

10 ml of aqueous 2N hydrochloric acid solution in which 12.4 g of the obtained 3-O-ethyl-isopropylidene ascorbic acid was dissolved in 100 ml of supernatant water was added. The reaction mixture is reacted at 60 ° C. for 2 hours and concentrated under reduced pressure to give a viscous liquid. Ethanol was added to the barbell and concentrated to obtain 3-ethyl-ascorbic acid as coarse crystals. Coarse crystals of 3-ethyl-ascorbic acid were recrystallized in ethyl acetate / ethanol (8: 2) to give the title compound as white crystals.

mp: 113 to 114 ° C. ¹ H NMR (MeOH-d ₄ ,) ppm, δ 1.36 (3H, t) 3.58 to 3.67 (2H, m) 3.77 to 3.85 (1H, m) 4.54 (2H, q) 4.75 ( 1H, d, 1.3 Hz)

[Production Example 4]

Low molecular weight  Beta Glucan  Produce

Low molecular weight water-soluble beta- (1,3 / 1,6) glucan was prepared using beta- (1,3 / 1,6) glucan extracted from Schizophyllum commune as follows.

6 g of beta- (1,3 / 1,6) glucan powder was suspended in 150 ml of 85% formic acid, and hydrolysis reaction was performed at 88 ° C. for 20 minutes. Under these conditions, beta- (1,3 / 1,6) glucan powder is partially hydrolyzed or dissolved into water-soluble beta- (1,3 / 1,6) glucan with a planned molecular weight distribution. The dissolved beta- (1,3 / 1,6) glucan was precipitated with 1.5 times ethanol and the water-soluble beta- (1,3 / 1,6) glucan was isolated by centrifugation or filtration. Water-soluble beta- (1,3 / 1,6) glucan is dissolved in the same amount of distilled water and residual formic acid is removed by heating for 3 hours, and water-soluble beta- (1,3 / 1,6) glucan by ultrafiltration. Purified to have a molecular weight of 30,000 to 100,000 Da.

Example 1-4 Preparation of a Hair Improvement Composition

To improve the hair composition using the ingredients and the formulation shown in Table 1 below.

[Example 5-8, Comparative Example 5-8]

As shown in Table 2 below, the composition prepared in Examples 5 to 8 and the composition prepared in Comparative Examples 5 to 8 were contained in 5 wt%, and ethanol: distilled water was mixed with the remaining components in a 50:50 weight ratio. A solubilized hair tonic hair improver was prepared by mixing the solvent at 95 wt%.

[Effect Test Example 1]

Human hair growth test

The hair tonic prepared in Examples 5 to 8 was used to test the hair regrowth effect on humans, and the test results are shown in Table 3 below.

Ten patients with various types of alopecia of male and female were divided into four groups so that each group was similar, and the efficacy was evaluated after treating the hair repellent composition prepared in Examples 5-8 and Comparative Examples 5-8. Scalp administration was performed twice a day for 3 months, and hair growth was evaluated after 2 months.

The evaluation criteria were expressed on the five-point scale by measuring the items of newborn hair visible (hair growth), hair loss, and hair loss. The results were divided into very good (5 points), good (4 points), good (3 points), normal (2 points), bad (1 point), and very bad (0 points) and expressed as average values.

From the results of Table 2, the hair regrowth agent according to the present invention had a higher improvement rate than the control group, and it was confirmed that the overall hair regrowth effect was 30 to 95%. It can be confirmed that there is sufficient effect in synergy with the field.

[Effect Test Example 2]

Subsequently, to test the human hair protein, scalp protection and restorative effect, allergy, and itching of the gastric hair improver, 30 kinds of hair regrowth compositions prepared in Example 5 were administered to 30 men and women showing signs of hair loss in Daejeon. After using it for months, each item was evaluated on a 5-point scale as shown in Table 4 below. The results were very good (5 points), excellent (4 points), good (3 points), and moderate (2 points). It was divided into bad (1 point) and very bad (0 point), and expressed as an average value.

As can be seen from Table 4, the prepared hair regrowth composition of the present invention confirmed the excellent improvement effect for alopecia patients in all items of feeling, scalp recovery, dandruff removal, allergy improvement, hair loss prevention, hair growth, hair softness and shine . In addition, the hair improver composition of the present invention did not show side effects such as skin abnormalities of the scalp caused by the drug in any group during the three-month use period of the test.

Claims (6)

Phytosphingosin ascobate (phytosphingosin ascobate) as an active ingredient, a composition for improving hair comprising bamboo leaf extract, beta glucan, crystalline 3-O-substituted ascorbic acid. The method of claim 1, Phytosphingosin ascobate (phytosphingosin ascobate) in 100% by weight of the active ingredient, 20 to 50% by weight of bamboo leaf extract, 1 to 30% by weight of beta glucan, crystalline 3-O-substituted ascorbic acid 40 ~ Hair improvement composition comprising 60% by weight. The method of claim 2, The beta glucan is extracted from the skirt mushroom, the composition for hair improvement having a molecular weight of 30,000 ~ 100,000 Da. The method according to any one of claims 1 to 3, The content of the active ingredient in the hair improving composition is 0000.1 to 50% by weight of the hair improving composition. The method of claim 4, wherein The dosage of the composition for improving hair is 0.01 ~ 1000mg / 1 times the hair improving composition. The method of claim 5, The hair improvement composition is a composition for improving hair which is a formulation selected from the group consisting of solutions, suspensions, emulsions, gels, creams, pastes, lotions and sprays.