KR20090130905A - The cosmetic composition for improvement of acne containing a phytantriol and the natural antibiotic-complex - Google Patents

Abstract

PURPOSE: A cosmetic composition containing phytantriol and natural antibacterial complex for treating acne is provided to enhance antibacterial activity and treat acne. CONSTITUTION: A cosmetic composition for treating acne contains phytantriol, and natural antibacterial complex isolated from Nelumbo nucifera, Kochia scoparia and Lydium chinense as an active ingredient. The phytantriol is contained in 0.01-10.0 weight% based on total weight of cosmetic composition. The weight ratio of Nelumbo nucifera, Kochia scoparia and Lydium chinense is 6~9 : 0.05~2 : 0.05~2. The natural antibacterial complex is contained in 0.001-20.0 weight% based on total weight of cosmetic composition. The cosmetic composition is used in the form of astringent lotion, eye cream, nutrition cream, cleansing cream, cleansing foam, cleansing water, essence or pack.

Description

The cosmetic composition for improvement of acne containing a Phytantriol and the natural antibiotic-complex}

The present invention relates to a cosmetic composition for improving acne containing phytantriol and a natural antibacterial complex, and more specifically, phytanicol perturbates the cell membrane of propionibacterium acnes , which is the causative agent of acne. It relates to an anti acne cosmetic composition effective in improving acne by increasing the antibacterial activity of the natural antibacterial complex extracted from the branch, branch, phalanges.

In general, acne has an inflammatory response caused by stimulation of free fatty acids produced by lipase of propionibacterium acne, an excess of sebum secretion, excess keratinization, and anaerobic dermatitis. It is known as the cause. Drugs in the form of oral or external preparations have been used to treat acne, for example, anti-androgens that inhibit sebum production, nonsteroidal anti-inflammatory agents that act as anti-inflammatory agents, and lesocinols, sulfur, salicylic acid, and benzoyl peroxide. And antimicrobial agents such as isotretinoin, keratin release agents, tetracycline, erythromycin, and methods of inhibiting the activity of propionibacterium acne by antibiotics such as methacycline. On the other hand, recently, a treatment method using a vitamin A derivative such as retinoic acid and a method using azelaic acid are also widely used. In addition, a technology related to cosmetics effective for acne using myrrh, which has been used as a medicinal herb for a long time, was also introduced in Korea Patent Publication No. 95-8762 (Lee Jae-jae, etc.).

However, the methods described above have some results in acne treatment, but there are some problems in terms of effectiveness, side effects, and usability. In other words, the use of hormonal agents has been reported to inhibit epidermal growth and other hormonal abuse side effects, and keratin exfoliants such as retinoic acid and benzoyl peroxide have concerns about skin irritation and contact dermatitis due to exfoliation. The antibiotics mentioned above are known for the emergence of resistant bacteria and for the possibility of photosensitivity. In particular, isotretinoin is known to have a teratogenic effect on the fetus. In addition, cosmetic compositions effective for acne using conventional oriental herbal plant extracts, such as myrrh, may be effective in acknowledgment, but may have an allergic hypersensitivity reaction to acne-sensitive skin in some cases. I have a problem.

Therefore, the necessity of developing a safe and effective product for the human body in acne skin is steadily emerging.

It is an object of the present invention to provide a cosmetic composition that can improve skin with acne by inhibiting propionibacterium acne, which is a cause of acne, containing natural antibacterial complexes extracted from phytantriol and lotus leaf, branch, and phalanges will be.

In order to achieve the above object, the present invention is pitantriol; It provides a cosmetic composition for improving acne containing a natural antibacterial complex extracted from lotus leaf, branch, Gigolpi as an active ingredient.

The phytantriol is characterized in that it contains 0.01 to 10.0% by weight relative to the total weight of the cosmetic composition, the weight ratio of the lotus leaf, branch and golgolpi is 6 to 9: 0.05 to 2: 0.05 to 2.

In addition, the natural antibacterial complex is characterized in that it contains 0.001 to 20.0% by weight based on the total weight of the cosmetic composition.

In addition, the cosmetic composition is selected from the group consisting of supple cosmetics, astringent cosmetics, nourishing cosmetics, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, solid soap, liquid soap, powder, essence and pack It is characterized by having a formulation.

The present invention contains a natural antibacterial complex extracted from phytantriol and lotus leaf, branch, and phalanges to provide an effect that can improve the skin with acne by inhibiting propionibacterium acne, the cause of acne.

Hereinafter, the present invention will be described in more detail.

The inventors have found that the natural antibacterial complex extracted from phytantriol, lotus leaf, branch, and phalanges exhibits excellent antibacterial activity against propionibacterium acne, the cause of acne, and the effect is also excellent.

The phytantriol used in the present invention is a conventional name for a compound known as 3,7,11,15-tetramethylhexadecane-1,2,3-triol, wherein the aliphatic phytantriol is a chemical formula of C ₂₀ H ₄₂ O ₃ and a molecular weight of 330.55. A yellow viscous liquid that is easy to dissolve in oils and alcohols. Phytantriol, when added to hair products, is known to improve the hair's moisturizing ability, improve the hair's adsorption capacity of amino acids, improve the hair's strength and protect the hair from the hot air of the hair dryer, and is also reported as a penetration enhancer (Kozment (Spec. Issue. ), 19-25 (1994)).

 The content of phytantriol used in the present invention is characterized by containing 0.01% to 10.0% by weight based on the total weight of the cosmetic composition. If the amount is less than 0.01% by weight, the effect is insignificant. If it is added in excess of 10.0% by weight, problems of precipitation due to solubility may occur.

On the other hand, the lotus leaf used in the present invention is a perennial plant of the genus Amanaceae nucifera ). It contains vitamin C and vitamin B ₁₂ and amino acids such as asparagine, arginine, tyrosine, etc., which are effective for fatigue recovery and skin care, as well as analgesic sedation of roemerine and nuciferine. It is effective in hypersensitivity and stress, and has been known to be used by snakes and poisonous insects as well as pneumonia, bronchial asthma, gonorrhea, tonic, and indigestion.

Lotus leaves are harvested from early June to mid-October. Normally, lotus leaves start in early June and fall in mid-October. Lotus leaf used in the present invention, also known as the lower lobe (荷葉) and as a pharmacological action is used for diarrhea, headache and dizziness, hemostasis, nosebleeds such as bleeding, postpartum blood treatment, enuresis, and neutralizes various toxic substances . In particular, smokers have a detoxifying action to remove nicotine. In addition, lotus leaf generally clears blood with detoxification effect, and it is known to have hemostatic, antibacterial and blood pressure lowering effect. Especially in Dongbobogam, the leaf of lotus leaf is called especially hobby, and this part is pregnant women. It is said to have the effect of relaxing the appearance and get rid of bad blood. Teas using lotus leaf include Chinese whale Gambibi (減肥 減) (containing lotus leaf, yulmu, mountain lion, dermis, etc.), which is known to be effective for diet and skin beauty.

Branches used in the present invention ( Kochia scoparia ) is a dicotyledonous plant of the family Dana, and is called Dapsari, Nakpochu, Cheonduja and its origin is Europe and Asia. At the beginning of the year, the stem is hard and its height is around 1M, and the stem is initially green and then red. Leaves grow alternately lanceolate or linear lanceolate, both ends are narrow, the edges are flat, and there are three veins. The length is 2-5cm and the width is 2-8mm with long hairs. Flowers bloom in light green in July-August, and several flowers without stems are gathered on the leaf axils. There are poins under the flowers, and the leaves at the top are small like poins. do. Bisexual flowers and female flowers run together, and the calyx grows after flowering and grows around the fruit, and the rear one becomes like a wing. There are 5 stamens and the ovary is wide egg-shaped.

Plants are dried and then made brooms, and seeds are used for medicinal purposes. Fruits are called branched fruit or cheonduja, or Nakchuja. The seeds are cold and tasteless and have no poison. It is taken as a tonic and used as a tonic to treat the genitals, tree species, chest pain, pain, dentifrice, medicine, redness, gonorrhea, diuresis, cystitis, urinary tract, stool, nominal, fruit poisoning, constipation, etc. It is also effective in eczema, intestines, scabies and ringworm. Also, Dapsari leaves are branched leaves (地 복용 葉), and when taken in April and May of the lunar calendar, they take the bowels and stop diarrhea, release the venom of the spear, and wash the eyes. It is said that they do not see and have night blindness, and heals the sick.

The phalanx ( Lycium chinense ) used in the present invention is a dried bark of a wolfberry tree, which is named after being contained in the ground and removing only the bones of the root bark. The Gojija is a deciduous shrub of the dicotyledon and flowering plant. The stem grows at an angle and sags downward. Often there are thorns, but some are not. Twigs are yellowish gray and have no hairs. Leaves alternate, several clustered, broad egg-shaped or oval-shaped. In June-September, purple flowers come out from 1-4 leaf axils, and corollas are bell shaped and divided into 5 branches with pointed ends. Fruits are berry, oval or oval, ripened in August to September.

In oriental medicine, fruit and roots are harvested in the autumn and dried in the sun. The dried fruit is called Gojija, and the dried root bark is called Jigolpi. The phalanx of the phalanx is tubular or sculptural, the outer side is yellow, grayish brown, the inner side is gray, and the shell is scaly and easily peeled off.

The phalanges are sweet and boring, and the upper part of the upper lung (肺熱) to hit the haecheon (咳喘) to treat the lower fever (신) to treat the osteopathy (骨蒸). In the herbaceous tree, goji leaves are said to eliminate sputum of upper vinegar and phalanges to lower ischemia of lower sage. Pharmacological action has been reported to reduce blood pressure and blood sugar of the cardiovascular system, and it is good for cold sweating, sea water, asthma, hemostasis, nosebleeds, urine bleeding, high blood sugar, high blood pressure, neuralgia, headache, shoulder pain, muscle pain Used for low back pain, waist and knee weakness.

Natural antimicrobial complexes extracted from lotus leaf, branch, and phalanges provided in the present invention can be obtained using a variety of extraction methods known in the art, preferably, (a) water, (b) having 1 to 4 carbon atoms Anhydrous or hydrous lower alcohol (methanol, ethanol, propanol, butanol, etc.), (c) a mixed solvent of the lower alcohol with water, (d) acetone, (e) ethyl acetate, (f) chloroform or (g) 1 , 3-butylene glycol and the like can be obtained as an extraction solvent.

On the other hand, the term "natural antimicrobial complex" used in the present invention is an extract extracted from lotus leaf, branch, and phalanges, including the other components that do not substantially interfere with the effect of the present invention to increase the antibacterial activity to improve acne It will be apparent to those skilled in the art that the natural antimicrobial complex used as the present invention and extracts exhibiting substantially the same effects can be obtained using not only the aforementioned extraction solvent but also other extraction solvents.

In addition, the natural antimicrobial complex of the present invention includes not only the extract by the aforementioned extraction solvent, but also the natural antimicrobial complex that has undergone a conventional purification process. Obtained by various additional purification methods, such as, for example, separation using ultrafiltration membranes having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity). The fraction is also included in the natural antibacterial complex of the present invention.

The natural antimicrobial complex of the present invention may be prepared in a powder state by an additional process such as vacuum distillation and freeze drying or spray drying.

The blending weight ratio of lotus leaf, branch and Jagolpi to produce the natural antibacterial complex is preferably used in a mixture of 6 ~ 9: 0.05 ~ 2: 0.05 ~ 2, if the composition ratio is out of the problem of improving acne There is.

In addition, the cosmetic composition of the present invention preferably comprises 0.001 to 20.0% by weight of the total natural cosmetic composition of the extract is a natural antibacterial complex. When the cosmetic composition of the present invention contains the extract at less than 0.001 weight, it is difficult to expect a substantial acne improvement effect of the cosmetic composition, and when added in excess of 20.0% by weight, it affects the stability of the formulation and the product, and is excessively added. It is not economical because of the small synergy effect. More preferably, the cosmetic composition of the present invention preferably comprises 0.01 to 10.0% by weight of the extract, even more preferably 0.1 to 5.0% by weight.

The cosmetic composition containing the phytantriol and the natural antibacterial complex may be prepared in any formulation commonly prepared in the art, for example, softening water, astringent makeup, nourishing cosmetics, eye cream, nutrition cream, massage The cream, cleansing cream, cleansing foam, cleansing water, powder, essence, pack, etc. are not particularly limited in the formulation, and may be prepared according to the formulation or purpose of use of the cosmetic.

Hereinafter, the present invention will be described in more detail with reference to Preparation Examples, Examples, Comparative Examples, and Experimental Examples, but only for explaining the present invention in more detail, and the scope of the present invention is defined in these examples. It will be apparent to those skilled in the art that the present invention is not limited thereto.

Preparation Example 1 Preparation of Natural Antibacterial Complex

10 times distilled water was added to 400 g of lotus leaf, 100 g of branch and 100 g of phalanges purchased at Gyeongdong Market, and reflux-cooled at 85 ° C. for 3 hours to separate the supernatant and sediment and extracted three times. Each extract was centrifuged, filtered and concentrated to obtain a freeze-dried natural antimicrobial complex extract was used as a sample of this experiment while storing in the refrigerator.

Experimental Example 1 Antibacterial Effect of Phytantriol and Natural Antibacterial Complex

In order to measure the antimicrobial effect of the phytantriol and the natural antibacterial complex used in the present invention against acne bacteria, inoculated with propionibacterium acne ATCC 6919 in brain heart infusion medium and cultured for 24 hours in a 37 ℃ shaking incubator OD After measuring the concentration to 600nm value was inoculated in a medium containing 10 ~ 10000ppm of the sample shown in Table 1 at a final concentration of 10 ⁷ CFU / ml. Then, after incubating at 37 ° C. and 200 rpm for 48 hours, the antimicrobial activity was measured by using a minimum inhibitory concentration (MIC) as a concentration that significantly reduced the number of bacteria inoculated.

Minimum growth inhibitory concentration ( MIC ) Sample Name MIC (ppm) Natural Antibacterial Complex 200 Phytantriol > 10000 Phytantriol, natural antibacterial complex 100

As can be seen in Table 1, phytantriol itself has no antimicrobial activity against acne bacteria, but when used simultaneously with the natural antibacterial complex, it was confirmed that the antimicrobial activity was superior to the use of the natural antibacterial complex alone, phytantriol and natural antibacterial complex Cosmetic compositions containing at the same time is also believed to have excellent acne healing effect.

Therefore, in order to measure the acne improvement effect and skin irritation of the acne improvement cosmetic composition containing phytantriol and the natural antibacterial complex, acne cosmetic compositions were prepared according to the examples and Comparative Examples 1 to 3, respectively, according to a conventional method. And the composition is shown in Table 2 below.

Example  And Comparative example  1 to 3 Ingredient Example Comparative Example 1 Comparative Example 2 Comparative Example 3 Natural Antibacterial Complex 1.0 1.0 - - Phytantriol 0.1 - 0.1 - Propylene glycol 6.0 6.0 6.0 6.0 glycerin 4.0 4.0 4.0 4.0 Triethanolamine 1.2 1.2 1.2 1.2 Tocophenyl Acetate 3.0 3.0 3.0 3.0 Liquid paraffin 5.0 5.0 5.0 5.0 Squalane 3.0 3.0 3.0 3.0 Macadamia Nut Oil 2.0 2.0 2.0 2.0 Polysorbate 60 1.5 1.5 1.5 1.5 Sorbitan sesquioleate 1.0 1.0 1.0 1.0 Xanthan Gum 0.3 0.3 0.3 0.3 Incense, preservative a very small amount a very small amount a very small amount a very small amount Purified water To 100 To 100 To 100 To 100

Experimental Example 2 Measurement of Improvement of Acne

In order to confirm the effect of the acne treatment of the present invention, 40 men and women aged 18 to 28 years old were divided into four groups to use Examples and Comparative Examples 1 to 3 in the same manner as the daily lotion use for 4 weeks. The degree of improvement was judged according to the following evaluation criteria. The test results are shown in Table 3 below.

[Evaluation standard]

+++: Very good improvement.

++: Significant improvement.

+: A slight improvement.

±: No improvement but no weakening.

-: No improvement, rather weakened.

term Example Comparative Example 1 Comparative Example 2 Comparative Example 3 1 week + + ± ± 2 weeks ++ + ± ± 3 weeks +++ ++ ± ± 4 Weeks +++ +++ ± ±

As can be seen in Table 3, the cosmetic composition (example) containing both phytantriol and the natural antibacterial complex at the same time compared to the cosmetic composition (comparative example 1) using the natural antibacterial complex alone (comparative example 1) Was confirmed to be superior.

Experimental Example 3 Skin Patch Test (Patch Test)

In order to measure the skin safety of the cosmetic composition containing the phytantriol and the natural antibacterial complex of the present invention (Example) and Comparative Examples 1 to 3, 20 subjects (mean age 29 years, age distribution 23-39 years) The skin patch experiment was carried out on the upper arm using the Example and Comparative Examples 1-3. However, psoriasis, eczema, and other skin lesion holders, pregnant women, lactating or contraceptives, antihistamines, etc. were excluded from the experiment.

First, the test site was wiped with 70% ethanol, dried, and the prepared test substance was added dropwise into the pin chamber (Finn chamber, 100x10, EPITEST, Finland) by 15 µg, and then sealed in the inner portion of the subject's forearm. The patch was marked for 24 hours, the patch was removed, and the test site was marked with a pen. After 1 hour and 24 hours after the marking, the magnification (8MC-150, DAZOR, United States of America) was used to observe the test site, and erythema and edema were observed.

The skin response was determined according to the regulations of the International Contact Dermatitis Research Group (ICDRG), and the mean skin response rate was calculated according to Equation 1. The results are shown in Table 4.

* Evaluation criteria and score of skin reaction

sign score Evaluation standard - 0 No response ± 0.5 Faint or light erythema + One Boundary but weak erythema, edema and papules ++ 2 Pronounced erythema, papules and vesicles +++ 3 Severe erythema and alveolar, scleroderma

Mean skin responsiveness (mean score) = (score × number of responses × 100 × 1/2) / [3 (maximum score) × total number of subjects (n)]

Test substance After 1 hour 24 hours later % Reactivity (n = 20) ± + ++ ± + ++ Example One - - - - - 0.42 Comparative Example 1 One - - - - - 0.42 Comparative Example 2 One - - - - - 0.42 Comparative Example 3 One - - - - - 0.42

As can be seen in Table 4, the cosmetic composition (Example) containing the phytantriol and the natural antibacterial complex of the present invention is similar to Comparative Example 3 and the degree of irritation to the skin can be seen that almost no skin irritation.

Hereinafter, various formulation examples of the cosmetic composition containing the phytantriol and the natural antibacterial complex of the present invention are prepared according to a manufacturing method in the conventional cosmetic field. However, the composition of the present invention is not limited to the following formulation examples.

Formulation Example 1 Preparation of Soft Cosmetics (Skin)

To prepare a flexible lotion containing the phytantriol and the natural antibacterial complex of the present invention, it is blended as described in Table 5 below and prepared according to a manufacturing method in a conventional cosmetic field.

Ingredient Content (% by weight) Natural Antibacterial Complex 0.5 Phytantriol 0.1 1,3-butylene glycol 6.0 glycerin 4.0 Oleyl alcohol 0.1 Polysorbate 20 0.5 ethanol 15.0 Benzophenone-9 0.05 Incense, preservative a very small amount Purified water To 100

Formulation Example 2-nourishing lotion (milk lotion)

To prepare a nutrient lotion containing a phytantriol and a natural antibacterial complex of the present invention, it is blended as described in Table 6 below and prepared according to a manufacturing method in a conventional cosmetic field.

Ingredient Content (% by weight) Natural Antibacterial Complex 1.0 Phytantriol 0.1 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 1.2 Tocophenyl Acetate 3.0 Liquid paraffin 5.0 Squalane 3.0 Macadamia Nut Oil 2.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.0 Xanthan Gum 0.3 Incense, preservative a very small amount Purified water To 100

Formulation Example 3 Preparation of Nutritional Cream

To prepare a nourishing cream containing phytantriol and a natural antibacterial complex of the present invention, it is blended as described in Table 7 below and prepared according to a manufacturing method in a conventional cosmetic field.

Ingredient Content (% by weight) Natural Antibacterial Complex 1.0 Phytantriol 0.1 vaseline 7.0 Liquid paraffin 10.0 Beeswax 2.0 Polysorbate 60 2.5 Sorbitan sesquioleate 1.5 Squalane 3.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Xanthan Gum 0.5 Tocophenyl Acetate 0.1 Incense, preservative a very small amount Purified water To 100

Formulation Example 4 Preparation of Massage Cream

To prepare a massage cream containing a phytantriol and a natural antibacterial complex of the present invention, it is blended as shown in Table 8 and prepared according to a manufacturing method in a conventional cosmetic field.

Ingredient Parts by weight (%) Natural Antibacterial Complex 0.5 Phytantriol 0.1 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Beeswax 2.0 Tocophenyl Acetate 0.1 Polysorbate 60 3.0 Sorbitan sesquioleate 2.5 Cetearyl Alcohol 2.0 Liquid paraffin 30.0 Xanthan Gum 0.5 Incense, preservative a very small amount Purified water To 100

Formulation Example 5 Pack Preparation

To prepare a pack containing the phytantriol of the present invention and the natural antibacterial complex, it is combined as described in Table 9 and prepared according to a manufacturing method in a conventional cosmetic field.

Ingredient Content (% by weight) Natural Antibacterial Complex 0.5 Phytantriol 0.1 Propylene glycol 2.0 glycerin 4.0 Polyvinyl alcohol 10.0 ethanol 7.0 Fiji-40 Hydrogenated Castor Oil 0.8 Triethanolamine 0.3 Incense, preservative a very small amount Purified water To 100

Claims (5)

Phytantriol; Acne improvement cosmetic composition containing a natural antibacterial complex extracted from lotus leaf, branch, Gigolpi. The cosmetic composition according to claim 1, wherein the phytantriol contains 0.01 to 10.0 wt% based on the total weight of the cosmetic composition. The cosmetic composition according to claim 1, wherein the weight ratio of the lotus leaf, the branch, and the phalanx is 6-9: 0.05-2: 0.05-2. The cosmetic composition according to claim 1, wherein the natural antibacterial complex contains 0.001 to 20.0 wt% based on the total weight of the cosmetic composition. The cosmetic composition according to any one of claims 1 to 4, wherein the cosmetic composition is a softening cream, astringent cream, nutrient cream, eye cream, nutrition cream, massage cream, cleansing cream, cleansing foam, cleansing water, solid soap, liquid soap, Cosmetic composition, characterized in that it has a formulation selected from the group consisting of powder, essence and pack.