KR20090094268A - 치환된 퀴나졸린 - Google Patents

치환된 퀴나졸린

Info

Publication number
KR20090094268A
KR20090094268A KR1020097011682A KR20097011682A KR20090094268A KR 20090094268 A KR20090094268 A KR 20090094268A KR 1020097011682 A KR1020097011682 A KR 1020097011682A KR 20097011682 A KR20097011682 A KR 20097011682A KR 20090094268 A KR20090094268 A KR 20090094268A
Authority
KR
South Korea
Prior art keywords
compound
alkyl
group
anagrelide
formula
Prior art date
Application number
KR1020097011682A
Other languages
English (en)
Korean (ko)
Inventor
리차드 프랭클린
버나드 골딩
Original Assignee
샤이어 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 샤이어 엘엘씨 filed Critical 샤이어 엘엘씨
Publication of KR20090094268A publication Critical patent/KR20090094268A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020097011682A 2006-11-28 2007-11-19 치환된 퀴나졸린 KR20090094268A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0623750.7 2006-11-28
GBGB0623750.7A GB0623750D0 (en) 2006-11-28 2006-11-28 Substituted quinazolines

Publications (1)

Publication Number Publication Date
KR20090094268A true KR20090094268A (ko) 2009-09-04

Family

ID=37671460

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097011682A KR20090094268A (ko) 2006-11-28 2007-11-19 치환된 퀴나졸린

Country Status (14)

Country Link
EP (1) EP2099802A2 (zh)
JP (1) JP2010511030A (zh)
KR (1) KR20090094268A (zh)
CN (1) CN101558071B (zh)
AR (1) AR064002A1 (zh)
AU (1) AU2007327047B2 (zh)
BR (1) BRPI0719570A2 (zh)
CA (1) CA2670123A1 (zh)
EA (1) EA018259B1 (zh)
GB (1) GB0623750D0 (zh)
IL (1) IL198809A0 (zh)
MX (1) MX2009005579A (zh)
TW (1) TW200838537A (zh)
WO (1) WO2008065444A2 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8304420B2 (en) 2006-11-28 2012-11-06 Shire Llc Substituted quinazolines for reducing platelet count
GB0808944D0 (en) * 2008-05-16 2008-06-25 Shire Llc Substituted quinazolines
GB2462022B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof
GB0822970D0 (en) * 2008-12-17 2009-01-21 Shire Llc Process for the preparation of anagrelide and analogues
GB201004495D0 (en) 2010-03-18 2010-05-05 Shire Llc Subtituted quinazolines
GB201017783D0 (en) 2010-10-21 2010-12-01 Shire Llc Process for the preparation of anagrelide and analogues thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7807507A (nl) * 1977-07-25 1979-01-29 Hoffmann La Roche Tricyclische verbindingen.
ZA803535B (en) * 1979-06-20 1981-06-24 Hoffmann La Roche Novel quinazoline derivatives and pharmaceutical preparations
CA1131631A (en) * 1979-06-20 1982-09-14 Madhukar S. Chodnekar Quinazoline derivatives and pharmaceutical preparations
MXPA05007287A (es) * 2003-01-23 2005-12-12 Shire Holdings Ag Formulacion y metodos para el tratamiento de trombocitemia.
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US20060030574A1 (en) * 2004-08-04 2006-02-09 Shire Holdings Ag Quinazoline derivatives useful for the treatment of peripheral arterial disease and as phosphodiesterase inhibitors

Also Published As

Publication number Publication date
IL198809A0 (en) 2010-02-17
CA2670123A1 (en) 2008-06-05
AU2007327047B2 (en) 2012-08-30
CN101558071A (zh) 2009-10-14
WO2008065444B1 (en) 2008-10-09
EP2099802A2 (en) 2009-09-16
BRPI0719570A2 (pt) 2013-12-10
MX2009005579A (es) 2009-08-12
EA200900740A1 (ru) 2010-02-26
CN101558071B (zh) 2013-04-24
AU2007327047A1 (en) 2008-06-05
AR064002A1 (es) 2009-03-04
WO2008065444A2 (en) 2008-06-05
GB0623750D0 (en) 2007-01-10
EA018259B1 (ru) 2013-06-28
JP2010511030A (ja) 2010-04-08
TW200838537A (en) 2008-10-01
WO2008065444A3 (en) 2008-07-31

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Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application