KR20090091589A - 포스파티딜세린과 특이적으로 결합하는 폴리펩티드 및 이의용도 - Google Patents
포스파티딜세린과 특이적으로 결합하는 폴리펩티드 및 이의용도 Download PDFInfo
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- KR20090091589A KR20090091589A KR1020080016944A KR20080016944A KR20090091589A KR 20090091589 A KR20090091589 A KR 20090091589A KR 1020080016944 A KR1020080016944 A KR 1020080016944A KR 20080016944 A KR20080016944 A KR 20080016944A KR 20090091589 A KR20090091589 A KR 20090091589A
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- phosphatidylserine
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Abstract
Description
Claims (17)
- 서열번호 1로 표시되는 아미노산 서열을 가지며, 포스파티딜세린과 특이적으로 결합하는 폴리펩티드.
- 제1항의 폴리펩티드를 암호화하는 염기서열을 가지는 폴리뉴클레오티드.
- 제2항의 폴리뉴클레오티드를 포함하는 벡터.
- 제3항의 벡터로 형질전환된 형질전환체.
- 제1항의 폴리펩티드를 유효성분으로 포함하는 포스파티딜세린 검출용 조성물.
- 제5항에 있어서, 상기 폴리펩티드는 발색효소, 방사성동위원소, 크로모포 어(chromophore), 발광물질 및 형광물질(fluorescer)로 이루어진 군에서 선택되는 하나로 표지된 것을 특징으로 하는 조성물.
- (a) 제1항의 폴리펩티드를 시료와 혼합하는 단계;(b) 미결합되거나 비특이적으로 결합된 상기 폴리펩티드를 제거하는 단계; 및(c) 상기 폴리펩티드의 결합 여부 및 위치를 확인하는 단계를 포함하는 포스파티딜 세린의 검출 방법.
- 제1항의 폴리펩티드를 유효성분으로 포함하는 사멸세포(apoptotic cell) 검출용 조성물.
- 제1항의 폴리펩티드를 유효성분으로 포함하는 약물 전달용 조성물.
- 제9항에 있어서, 상기 조성물은 종양성 질환에 특이적인 것임을 특징으로 하는 조성물.
- 제10항에 있어서, 상기 종양성 질환은 대장암, 폐암, 위암, 식도암, 췌장암, 담낭암, 신장암, 방광암, 전립선암, 고환암, 자궁경부암, 자궁내막암, 융모암, 난소암, 유방암, 갑상선암, 뇌암, 두경부암, 악성흑색종, 피부암, 간암, 백혈병(leukemia), 림프종(lymphoma), 복합 골수종(multiple myeloma), 만성 골수성 백혈병(chronic myelogenous leukemia), 신경아종(neuroblastoma), 재생불량성 빈혈로 이루어진 군에서 선택된 것임을 특징으로 하는 조성물.
- 제9항에 있어서, 상기 폴리펩티드는 파클리탁셀, 독소루비신, 빈크리스틴, 다우노루비신(daunorubicin), 빈블라스틴(vinblastine), 액티노마이신-D(actinomycin-D), 도세탁셀(docetaxel), 에토포사이드(etoposide), 테니포사이드(teniposide), 비산트렌(bisantrene), 호모해링토닌(homoharringtonine), 글리벡(Gleevec; STI-571), 시스플라틴(cisplain), 5-플로오우라실(5-fluouracil), 아드리아마이신(adriamycin), 메토트렉세이트(methotrexate), 부설판(busulfan), 클로람부실(chlorambucil), 시클로포스파미드(cyclophosphamide), 멜팔란(melphalan), 니트로겐 무스타드(nitrogen mustard), 니트로소우레아(nitrosourea)로 이루어진 군에서 선택된 항-종양성 질환 제제와 결합된 것을 특징으로 하는 조성물.
- 제1항의 폴리펩티드 및 이와 결합된 항-종양성 질환 제제를 유효성분으로 포함하는 종양성 질환 예방 및 치료용 약학적 조성물.
- 제13항에 있어서, 상기 항-종양성 질환 제제는 파클리탁셀, 독소루비신, 빈크리스틴, 다우노루비신(daunorubicin), 빈블라스틴(vinblastine), 액티노마이신-D(actinomycin-D), 도세탁셀(docetaxel), 에토포사이드(etoposide), 테니포사이드(teniposide), 비산트렌(bisantrene), 호모해링토닌(homoharringtonine), 글리벡(Gleevec; STI-571), 시스플라틴(cisplain), 5-플로오우라실(5-fluouracil), 아드리아마이신(adriamycin), 메토트렉세이트(methotrexate), 부설판(busulfan), 클로람부실(chlorambucil), 시클로포스파미드(cyclophosphamide), 멜팔란(melphalan), 니트로겐 무스타드(nitrogen mustard), 니트로소우레아(nitrosourea)로 이루어진 군에서 선택된 것임을 특징으로 하는 조성물.
- 제1항의 폴리펩티드를 유효성분으로 포함하는 종양성 질환 부위의 영상화용 조성물.
- 제15항에 있어서, 상기 폴리펩티드는 발색효소, 방사성동위원소, 크로모포어(chromophore), 발광물질, 형광물질(fluorescer), 상자성입자(super paramagnetic particles) 및 초상자성입자(ultrasuper paramagnetic particles)로 이루어진 군에서 선택되는 하나로 표지된 것을 특징으로 하는 조성물.
- 제1항의 폴리펩티드를 유효성분으로 포함하는 스코트 증후군(Scott syndrome), 항인지질 증후군(antiphospholipid syndrome), 겸상 적혈구 빈혈증(sickle cell anemia), 탈라세미아(thalathemia), 스토마토싸이토시스(stomatocytosis), 요독증(uremia), 신장결석(kidney stone disease), 당뇨병(diabetes), 고혈당증(hyperglycemia), 바이러스 감염 및 미생물 감염, 말라리아(malaria), 전-자간증(pre-eclampsia), 고빌리루빈혈증(hyperbilirubinemia), 신생물 종양(neoplasia)으로 이루어진 군에서 선택된 질환의 진단용 조성물.
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KR1020080016944A KR100968839B1 (ko) | 2008-02-25 | 2008-02-25 | 포스파티딜세린과 특이적으로 결합하는 폴리펩티드 및 이의용도 |
US12/391,857 US8133971B2 (en) | 2008-02-25 | 2009-02-24 | Polypeptide specifically bound to phosphatidylserine and the use thereof |
PCT/KR2009/000882 WO2009107971A2 (ko) | 2008-02-25 | 2009-02-25 | 포스파티딜세린과 특이적으로 결합하는 폴리펩티드 및 이의 용도 |
JP2010547569A JP5055438B2 (ja) | 2008-02-25 | 2009-02-25 | ホスファチジルセリンと特異的に結合するポリペプチド及びこれの用途 |
EP09714117.0A EP2280024B1 (en) | 2008-02-25 | 2009-02-25 | Polypeptide specifically binding to phosphatidylserine and use thereof |
CN200980106312.8A CN101965356B (zh) | 2008-02-25 | 2009-02-25 | 以特异方式与磷脂酰丝氨酸结合的多肽及其用途 |
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EP3524617B1 (en) * | 2013-03-15 | 2023-04-12 | GLAdiator Biosciences, Inc. | Gla domains as therapeutic agents |
WO2016117949A1 (ko) | 2015-01-21 | 2016-07-28 | (의료)길의료재단 | 포스파티딜이노시톨포스페이트 결합 물질의 세포 사멸 검출 용도 |
SG11202001535RA (en) | 2017-09-05 | 2020-03-30 | Gladiator Biosciences Inc | Method of targeting exosomes |
CN115364111B (zh) * | 2021-05-17 | 2024-04-02 | 中国医学科学院基础医学研究所 | 甘油磷脂类化合物在治疗肿瘤中的用途 |
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WO2002082044A2 (en) * | 2001-04-03 | 2002-10-17 | The Board Of Trustees Of The Leland Stanford Junior University | Method of imaging cell death in vivo |
AU2002361642A1 (en) | 2001-11-16 | 2003-06-10 | The University Of Tennessee Research Corporation | Recombinant antibody fusion proteins and methods for detection of apoptotic cells |
WO2006010070A2 (en) | 2004-07-10 | 2006-01-26 | Board Of Regents, The University Of Texas System | Compositions and methods related to peptides that selectively bind leukemia cells |
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EP2280024B1 (en) | 2014-12-17 |
WO2009107971A2 (ko) | 2009-09-03 |
EP2280024A2 (en) | 2011-02-02 |
CN101965356B (zh) | 2014-03-26 |
US8133971B2 (en) | 2012-03-13 |
JP2011515075A (ja) | 2011-05-19 |
CN101965356A (zh) | 2011-02-02 |
JP5055438B2 (ja) | 2012-10-24 |
EP2280024A4 (en) | 2011-03-30 |
WO2009107971A3 (ko) | 2009-11-26 |
US20090214430A1 (en) | 2009-08-27 |
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