KR20090061055A - 결정질 및 비결정질 이매티닙 염기, 이매티닙 메실레이트 및 이들의 제조 방법 - Google Patents

결정질 및 비결정질 이매티닙 염기, 이매티닙 메실레이트 및 이들의 제조 방법 Download PDF

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Publication number
KR20090061055A
KR20090061055A KR1020097008048A KR20097008048A KR20090061055A KR 20090061055 A KR20090061055 A KR 20090061055A KR 1020097008048 A KR1020097008048 A KR 1020097008048A KR 20097008048 A KR20097008048 A KR 20097008048A KR 20090061055 A KR20090061055 A KR 20090061055A
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KR
South Korea
Prior art keywords
imatinib
formula
desmethyl
base
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020097008048A
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English (en)
Korean (ko)
Inventor
피터 린드세이 맥도널드
피에르루이지 로세토
알렉산드르 제고로프
안드레아 지오리토
다리오 텐토리오
아우구스토 카나베시
알레스 가벤다
Original Assignee
시코르, 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 시코르, 인크. filed Critical 시코르, 인크.
Publication of KR20090061055A publication Critical patent/KR20090061055A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020097008048A 2006-10-26 2007-10-26 결정질 및 비결정질 이매티닙 염기, 이매티닙 메실레이트 및 이들의 제조 방법 Ceased KR20090061055A (ko)

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US85477406P 2006-10-26 2006-10-26
US60/854,774 2006-10-26
US86062406P 2006-11-22 2006-11-22
US60/860,624 2006-11-22
US87442006P 2006-12-11 2006-12-11
US60/874,420 2006-12-11
US93491107P 2007-06-14 2007-06-14
US60/934,911 2007-06-14
US95836707P 2007-07-05 2007-07-05
US60/958,367 2007-07-05
US96323807P 2007-08-02 2007-08-02
US60/963,238 2007-08-02
US96761707P 2007-09-05 2007-09-05
US60/967,617 2007-09-05
US99533207P 2007-09-25 2007-09-25
US60/995,332 2007-09-25
US99784907P 2007-10-05 2007-10-05
US60/997,849 2007-10-05
US97925607P 2007-10-11 2007-10-11
US60/979,256 2007-10-11

Publications (1)

Publication Number Publication Date
KR20090061055A true KR20090061055A (ko) 2009-06-15

Family

ID=39027276

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020097008519A Ceased KR20090061068A (ko) 2006-10-26 2007-10-26 이매티닙의 제조 방법
KR1020097008048A Ceased KR20090061055A (ko) 2006-10-26 2007-10-26 결정질 및 비결정질 이매티닙 염기, 이매티닙 메실레이트 및 이들의 제조 방법

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020097008519A Ceased KR20090061068A (ko) 2006-10-26 2007-10-26 이매티닙의 제조 방법

Country Status (6)

Country Link
US (2) US20080103305A1 (enExample)
EP (2) EP2076507A2 (enExample)
JP (2) JP2009503120A (enExample)
KR (2) KR20090061068A (enExample)
MX (1) MX2008008447A (enExample)
WO (2) WO2008051597A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2530077A1 (en) 2011-05-30 2012-12-05 Bcworld Pharm. Co. Ltd. Novel method for preparing imatinib base

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US8414918B2 (en) * 2007-09-25 2013-04-09 Teva Pharmaceutical Industries Ltd. Stable imatinib compositions
US20100330130A1 (en) * 2009-05-22 2010-12-30 Actavis Group Ptc Ehf Substantially pure imatinib or a pharmaceutically acceptable salt thereof
EP2509973A1 (en) 2009-12-10 2012-10-17 Arch Pharmalabs Limited Process for the preparation of imatinib and salts thereof
WO2011095835A1 (en) 2010-02-02 2011-08-11 Actavis Group Ptc Ehf Highly pure imatinib or a pharmaceutically acceptable salt thereof
EP2582689B1 (en) 2010-06-18 2017-03-01 KRKA, D.D., Novo Mesto New polymorphic form of imatinib base and preparation of salts thereof
US20130203990A1 (en) * 2010-07-29 2013-08-08 Dr. Reddy's Laboratories, Inc. Process for the preparation of imatinib mesylate
CN101899035B (zh) * 2010-09-03 2012-09-05 天津市炜杰科技有限公司 一种高纯度伊马替尼的制备方法
GB2488788B (en) * 2011-03-07 2013-07-10 Natco Pharma Ltd Oral formulation of phenylaminopyrymidine compound with enhanced bioavailability and pharmacological response
JP2014509642A (ja) 2011-03-31 2014-04-21 アイエヌディー−スイフト ラボラトリーズ リミテッド イマチニブ及びそのメシル酸塩の生成のための改良方法
WO2013008242A1 (en) * 2011-07-12 2013-01-17 Natco Pharma Limited A process for the preparation of highly pure 4-(4-methyl piperazinomethyl) benzoic acid dihydrochloride
CN102850297B (zh) * 2012-10-10 2014-07-23 山东金城医药化工股份有限公司 伊马酸的制备方法
KR101558960B1 (ko) 2013-07-18 2015-10-08 하나제약 주식회사 Ν-5-(4-[4-메틸-피페라지노-메틸]-벤조일아미도)-2-메틸페닐-4-[3-피리딜]-2-피리미딘-아민의 신규한 제조방법
AU2014296032A1 (en) 2013-07-31 2016-03-17 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
CN103483314B (zh) * 2013-09-16 2015-02-18 南京优科生物医药研究有限公司 一种便捷的制备甲磺酸伊马替尼α晶型的方法
SE539450C2 (en) * 2016-02-29 2017-09-26 Imatinib for use in the treatment of stroke
AU2020274521A1 (en) 2019-05-16 2021-12-16 Aerovate Therapeutics, Inc. Imatinib formulations, manufacture, and uses thereof
US11464776B2 (en) 2019-05-16 2022-10-11 Aerovate Therapeutics, Inc. Inhalable imatinib formulations, manufacture, and uses thereof
CN115850258B (zh) * 2022-12-27 2024-09-24 东北林业大学 一种马赛替尼的合成方法

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US4623486A (en) * 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
TW225528B (enExample) * 1992-04-03 1994-06-21 Ciba Geigy Ag
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
GB0022438D0 (en) * 2000-09-13 2000-11-01 Novartis Ag Organic Compounds
EP1425577A4 (en) * 2001-08-10 2004-12-29 Symyx Technologies Inc APPARATUSES AND METHODS FOR PREPARING AND TESTING PRE-FORMULATIONS AND CORRESPONDING SYSTEMS
JP2003119184A (ja) * 2001-10-11 2003-04-23 Toray Ind Inc 置換ピペラジニルメチル芳香族酸誘導体の製造方法
GB0201508D0 (en) * 2002-01-23 2002-03-13 Novartis Ag Organic compounds
GB0202873D0 (en) * 2002-02-07 2002-03-27 Novartis Ag Organic compounds
GB2398565A (en) * 2003-02-18 2004-08-25 Cipla Ltd Imatinib preparation and salts
AU2003232650A1 (en) * 2003-05-06 2004-11-26 Il Yang Pharm Co., Ltd. N-phenyl-2-pyrimidine-amine derivatives and process for the preparation thereof
WO2004106326A1 (en) * 2003-06-02 2004-12-09 Hetero Drugs Limited Novel polymorphs of imatinib mesylate
US7507821B2 (en) * 2004-12-30 2009-03-24 Chemagis Ltd. Process for preparing Imatinib
US20060223816A1 (en) * 2006-05-08 2006-10-05 Chemagis Ltd. Imatinib mesylate alpha form and production process therefor
US20060223817A1 (en) * 2006-05-15 2006-10-05 Chemagis Ltd. Crystalline imatinib base and production process therefor
US7550591B2 (en) * 2007-05-02 2009-06-23 Chemagis Ltd. Imatinib production process

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2530077A1 (en) 2011-05-30 2012-12-05 Bcworld Pharm. Co. Ltd. Novel method for preparing imatinib base

Also Published As

Publication number Publication date
KR20090061068A (ko) 2009-06-15
JP2009503120A (ja) 2009-01-29
MX2008008447A (es) 2008-09-15
WO2008057291B1 (en) 2008-08-21
JP2009514988A (ja) 2009-04-09
WO2008057291A2 (en) 2008-05-15
WO2008051597A1 (en) 2008-05-02
EP2076507A2 (en) 2009-07-08
US20080207904A1 (en) 2008-08-28
EP1966186A1 (en) 2008-09-10
US20080103305A1 (en) 2008-05-01
WO2008057291A3 (en) 2008-07-03

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Patent event date: 20090420

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