KR20090055078A - The cosmetic composition containing the germinated and uncleaned rice - Google Patents

Abstract

A cosmetic composition containing unpolished rice extract is provided to have effects of inhibition of cortisol secretion, enhancement of beta-endorphin generation, and reduction of cholesterol content. A cosmetic composition for enhancing skin elasticity and luster comprises an unpolished rice extract as an active ingredient. The content of the unpolished rice extract is 0.001-20.0 weight%. The composition is used in a form of skin, essence, lotion, cream, pack, gel, ointment, patch, or spray. A method for producing the unpolished rice extract comprises: a step of washing and pulverizing an unpolished rice; a step of filtering at 50-150 mesh; a step of stirring and heating the pulverized rice with 2L of 75% ethanol at 75°C for four hours; a step of centrifuging at 3000 rpm for 10 minutes to remove precipitate; a step of compress-concentrating with rotary evaporator at 60°C 700mmHg; and a step of collecting the extract.

Description

The cosmetic composition containing the germinated brown rice extract

The present invention relates to a cosmetic composition containing a germinated brown rice extract, wherein the germinated brown rice extract inhibits the secretion of cortisol, which is a type of stress hormone, promotes the production of beta-endodorphin, reduces stress and cholesterol content in the blood, and sleep By prolonging the time, it is very effective in improving rough skin condition and enhancing skin elasticity and skin shine.

The skin is the largest organ of the human body, occupying about 16% of the body's volume and is important in protecting the body from many deadly harmful factors, such as temperature, humidity, and ultraviolet radiation, which are in direct contact with the external environment and are likely to enter the body. Act as a shield. However, when the skin loses its function balance due to external chemical and physical stimuli, stress, insomnia and malnutrition, the activity of the cells present in the skin is reduced, and the components do not maintain their original stable structure. Its elasticity is reduced and the skin's shine is reduced. In other words, if this imbalance of skin function is prolonged, abnormally generated or degraded cells such as fibroblasts and endothelial cells constituting skin dermis and extracellular matrix substances such as collagen, elastin and fibronectin are produced. This affects the structure of the entire skin, which ultimately promotes aging such as wrinkles or reduced elasticity.

The human body secretes a stress hormone called cortisol due to external chemical and physical stimuli, stress, insomnia and malnutrition. When the human body is stressed, corticotropin releasing hormone (CRH) is first produced in the hypothalamus, which stimulates the pituitary gland to promote the production of adrenocorticotropic hormone (ACTH). Again, the hormone stimulates the adrenal cortex and secretes an adrenal cortex hormone called cortisol. This hormone acts on the increase of glucose neosynthesis, decreased immune function, inhibition of growth hormone and sex hormone production, increased blood cholesterol and platelet aggregation in various tissues of the human body.

Cortisol, as opposed to melatonin, a sleep control hormone, is known to increase production during the day and decrease production at night. Usually, secretion is the lowest at around 1-3 am, and blood levels begin to rise again around 6 am. Cortisol is also known to affect sleep, caffeine ingestion of caffeine stimulates the adrenal cortex and increases the amount of cortisol secretion interferes with sleep. In the human body, cell regeneration is best at sleep, metabolism is active, immune cells are also active, blood hormone levels are highest, and beta-endorphin (β-endorphin) secretion is increased.

Beta-Endorphin is a 32-amino acid small protein produced in the hypothalamus that is similar in function to drugs like morphine. When beta-endorphin is produced during physical or mental stress, it improves mood and relieves pain. When beta-endorphin is produced when the mind and body are calm and comfortable, it has an anticancer effect and smoothes metabolism.

It is believed that healthy skin can be maintained through the effects obtained from sleep.

On the other hand, since the rice contains many nutrients have been used for many purposes such as nutrition and beauty. Rice that is dried and threshed and then stripped of rice husk is called brown rice. Brown rice is divided into rice bran, rice snow, and endosperm. Rice bran is rich in fats, proteins, essential fatty acids, essential amino acids, vitamins, dietary fiber and minerals. Vitamins in rice bran also contain vitamin B, such as myoinositol, choline, and niacin, and tocopherol, an antioxidant that prevents cell aging and damage. Minerals include phosphorus, potassium, magnesium and calcium. Rice bran also contains proteins known to lower blood cholesterol, cytosterol and dietary fiber, while gamma-orizanol contains blood circulation, skin metabolism, It is also known to have whitening and sunscreen effects. Rice bran, which accounts for most of the nutrients in brown rice, contains not only essential amino acids, tocopherols (vitamin E), vitamins B1, B2, and B6, but also calcium, magnesium, potassium, and iron. Vitamin E improves blood circulation in peripheral blood vessels, transports oxygen and nutrients to cells, exports waste and carbon dioxide, and inhibits the increase of lipid peroxide, which prevents the oxidation of fat in the body and weakens cellular movement.

Accordingly, it is an object of the present invention to provide a cosmetic composition for enhancing skin elasticity and skin lust containing germinated brown rice extract.

The present inventors have conducted a lot of research on how to keep the rough skin, elasticity and moisture-reduced skin in a healthy state due to chemical, physical stimulation, stress, insomnia, malnutrition, etc. from the outside, germination The present invention was completed by confirming that the brown rice extract is effective in reducing cortisol and blood cholesterol and increasing the synthesis of beta-endorphin to enhance skin elasticity and skin shine.

 The cosmetic composition containing the germinated brown rice extract according to the present invention suppresses the secretion of cortisol, which is a type of stress hormone, promotes the production of beta-endorphin, reduces stress and cholesterol content in blood and prolongs sleep time. It is very effective in improving skin condition and enhancing skin elasticity and skin shine.

The present invention is described in more detail as follows.

The cosmetic composition according to the present invention is characterized as containing a germinated brown rice extract.

Germinated brown rice is sprouted by preserving the seeds of brown rice and supplying appropriate temperature, oxygen, and moisture. The germinated brown rice is sprouted to 2-5mm after initiation or growth and freeze-dried. Seeds, also called embryos, contain about 60% of the nutrients in brown rice, but they are almost lost in homes through milling and washing.

Germinated brown rice is beneficial for skin that is distinguished from normal reproduction during grain germination, and various enzymes are activated, and vitamins B1, B2, B6, B12, pantothenic acid, nicotinic acid, and folic acid are increased as grains sprout. It is reported. In addition, the immune-related substances in the human body reacts with each other by the action of enzymes produced during germination to generate an immune increasing substance such as arabinoxysilane. Dietary fiber in regular and germinated brown rice is different. Germinated brown rice has high adsorption capacity of activated carbon or sponge and has high adsorption capacity of harmful substances. It also absorbs nutrients and helps them to be absorbed slowly, allowing skin cells to fully utilize the nutrients. In addition, the gamma-orizanol, which is a rice-eye component, is low-molecularized by enzymes during germination, and thus has a good affinity with skin lipids to diffuse into the skin and form a sufficient film. The result is a good ultraviolet protective effect. In particular, it absorbs the wavelength of 300-310 nm, and produces an erythema soothing effect.

The germinated brown rice extraction method according to the present invention is not particularly limited, but may preferably be obtained by performing organic solvent extraction or hydrothermal extraction.

Germinated brown rice extraction method by organic solvent extraction is finely pulverized germinated brown rice with a pulverizer, and then filtered through a 50 ~ 150 mesh filter network, 0.5 to 10 times ethanol, methanol, isopropyl alcohol in 1 kg of the germinated brown rice crushed Usable organic solvents, such as these, are added, followed by extraction by heating at 50 to 95 ° C. for 30 minutes to 12 hours or more. The extract may be concentrated under reduced pressure according to a conventional method and then lyophilized to obtain the extract.

As another method of extracting germinated brown rice, 0.5 to 10 times of water is added to 1 kg of germinated brown rice pulverized powder obtained in the same manner as the organic solvent extraction method, and then extracted by heating at 100 ° C. for 30 minutes to 12 hours or more. After concentration under reduced pressure according to the method of lyophilization, a method of obtaining an extract may be used.

In addition, the cosmetic composition of the present invention preferably comprises 0.001 to 20.0% by weight of the germinated brown rice extract based on the total cosmetic composition. More preferably, the cosmetic composition of the present invention comprises 0.01 to 10.0% by weight of the extract, even more preferably 0.1 to 5.0% by weight.

When the amount of the germinated brown rice extract is less than 0.001% by weight relative to the total cosmetic composition, the effect of addition is weak, and when used in excess of 20.0% by weight, the synergistic effect is weak.

Cosmetic composition containing the germinated brown rice extract may be prepared in any formulation commonly prepared in the art, for example, supple cosmetics, astringent cosmetics, nourishing cosmetics, eye cream, nutrition cream, massage cream, cleansing cream It is not particularly limited in the formulation of the cleansing foam, cleansing water, powder, essence, pack and the like, and may be prepared according to the formulation or use purpose of the cosmetic.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident. In the following Preparation Examples, Examples, Comparative Examples, Experimental Examples and Formulation Examples, the blending amount is expressed by weight%.

Production Example  1: Preparation of Germinated Brown Rice Extract (Ethanol Extract)

The germinated brown rice was washed with water, dried naturally, finely ground with a grinder, and then filtered through a 50-150 mesh filter network. 2 L of 75% ethanol was added to 1 kg of the ground and heated with stirring at 75 ° C. for 4 hours. The heated extraction solution was removed by centrifugation at 3000 rpm for 10 minutes to precipitate the residue, and the ethanol extract solution from which the residue was removed was used at a temperature of 700 mmHg at 60 ° C. using a rotary evaporator (Iylasa, Japan). The ethanol was removed by concentrating under reduced pressure, and the extract solution from which the ethanol was removed was dried to obtain a brown rice extract.

Production Example  2: preparation of germinated brown rice extract ( Hydrothermal  extraction)

The germinated brown rice was washed with water, dried naturally, finely ground with a grinder, and then filtered through a 50-150 mesh filter network. 1 L of water was added to 1 kg of the ground product, followed by heating with stirring at 100 ° C. for 2 hours to extract water-soluble physiologically active ingredients contained in germinated brown rice. The heated extraction solution was removed by centrifugation at 3000 rpm for 10 minutes to precipitate the residue. The hot water extract solution from which the residue was removed was subjected to a rotary evaporator (Iylasa, Japan) under conditions of 700 mmHg at 60 ° C. Water was removed by concentration under reduced pressure, and the extract solution from which the water was removed was dried to obtain a germinated brown rice extract.

Production Example  3: Preparation of Common Brown Rice Extract (Ethanol Extract)

General brown rice extract was prepared in the same manner as in Preparation Example 1, except that general brown rice was used.

Production Example  4: Preparation of common brown rice extract Hydrothermal  extraction)

General brown rice extract was prepared in the same manner as in Preparation Example 2, except that general brown rice was used.

Experimental Example  1: component analysis of extract

Germinated brown rice and general brown rice extracts were analyzed according to the provisions of No. 2000-18 of the Korea Food and Drug Administration, and the results are shown in Table 1. As a result of comparing the components, the contents of protein and fat were higher in ethanol extraction than in hot water extraction, and fiber and carbohydrate contents were extracted in hot water.

Preparation Example 1 Preparation Example 2 Preparation Example 3 Preparation Example 4 moisture(%) 8.2 7.0 8.2 8.0 Ash content (%) 3.5 3.5 3.2 3.3 protein(%) 9.0 6.8 6.5 5.7 Fat(%) 0.5 0.2 0.4 0.2 fiber(%) 0.3 0.6 0.2 0.4 carbohydrate(%) 78.5 81.9 81.5 82.4

Experimental Example  2: germinated brown rice extract Rat Cortisol , Endorphins, and effects on blood cholesterol levels

The effect of the germinated brown rice extract of Preparation Example 1 on the levels of cortisol, endorphin, and blood cholesterol levels in rats was measured.

In order to determine whether germinated brown rice extract affects changes in cortisol secretion, endorphin secretion, cholesterol content, etc. to stress, adaptation and alleviation of stress, immobilization of 150-180mg male rats for 16 hours prevents them from moving. Caused stress. Under such conditions, it is known that secretion of antistress hormone cortisol and endorphin due to stress increases cholesterol content in blood. In order to investigate the effect of germinated brown rice extract on rats' cortisol, endorphin and cholesterol level in blood, the germinated brown rice extract of Preparation Example 1 was fixed orally at 10 mg / kg in rats, and then fixed for 16 hours. Cortisol, endorphins, cholesterol was measured, and the results are shown in Table 2 below.

Survey subject Steady state Control group (stress induced) Germinated brown rice extract (10mg / kg) Plain Brown Rice Extract (10mg / kg) Endorphin (pg / ml) 14.61 ± 2.35 13.16 ± 3.62 17.69 ± 3.78 17.02 ± 3.66 Cortisol (ug / ml) 2.21 ± 1.04 2.88 ± 1.15 2.30 ± 1.10 2.34 ± 1.12 Cholesterol (mg / ml) 13.00 ± 0.61 27.72 ± 1.35 16.72 ± 1.31 17.30 ± 1.21

As can be seen from Table 2, when the germinated brown rice extract of the present invention was administered, the production of endorphin was increased by 34.4% compared to the control group, and cortisol and blood cholesterol were decreased by 20.1% and 39.7%, respectively. In addition, the normal brown rice extract increased the production of endorphins by 29.3% compared to the control, cortisol and blood cholesterol decreased by 18.8% and 37.6%, respectively. Therefore, it can be seen that the germinated brown rice extract increases the production of endorphin and reduces the cortisol and cholesterol levels than the ordinary brown rice extract.

Experimental Example  3: effect of prolonging sleep time of germinated brown rice extract

For the germinated brown rice extract of Preparation Example 1, the effect of prolonging sleep time induced by hexobbital in mice was measured.

In order to check whether the germinated brown rice extract has a prolonged sleep time, four male mice (20-30 g) per group were intraperitoneally injected with a well-known sleeping agent hexobarbital at 50 mg / kg body weight, and then in Preparation Example 1 The germinated brown rice extract was injected with 5mg, 10mg and 20mg per 1kg of body weight to investigate the effect of prolonging sleep time. As a control, hexobarbital was injected intraperitoneally, and germinated brown rice extract was not injected, and the results are shown in Table 3 below.

Sleep time (minutes) effect (%) Control 29.4 ± 3.4 - 5mg / kg 39.5 ± 3.7 34.4 10mg / kg 45.3 ± 3.6 54.1 20mg / kg 46.1 ± 4.0 56.8

As can be seen from Table 3, the germinated brown rice extract showed an effect of prolonging the sleep time of the mouse induced by the known sleeping agent hexobarbital, the sleep time at the concentration of 5mg / kg, 10mg / kg Concentration-dependently increased, but higher concentrations did not show any longer sleep time.

Production Example  5: Example  And Comparative example

Examples and comparative examples in the composition of Table 4 using a method commonly used in the art to carry out a clinical trial for increasing the elasticity and shine of the cosmetic containing the germinated brown rice extract of the present invention Was prepared.

ingredient Content (% by weight) Example Comparative example vaseline 7.0 7.0 Liquid paraffin 5.0 5.0 Beeswax 2.0 2.0 Polysorbate-60 2.0 2.0 Sorbitan sesquioleate 2.5 2.5 Squalane 3.0 3.0 Propylene glycol 6.0 6.0 glycerin 4.0 4.0 Triethanolamine 0.5 0.5 Carboxy Vinyl Polymer 0.5 0.5 Tocopherol Acetate 0.1 0.1 Purified water To 100 To 100 Germinated Brown Rice Extract 3.0 - Incense, preservative a very small amount a very small amount

Experimental Example  4: skin elasticity effect

The skin elasticity enhancing effect of the cosmetic composition containing the germinated brown rice extract of the present invention was measured. 20 healthy women (average age 37 years) over 20 years old at a temperature of 24-26 ° C and a humidity of 75 were divided into two groups, with Examples in Group A and Comparative Formulations in Group B, respectively. After applying twice a day (morning and evening) for 12 weeks, skin elasticity was measured using Cutometer MPA580 (Courage + Khazaka, Germany), and skin moisture was applied using Colorimeter CR-300 (Minolta, Japan). Measured. The test results are described as R8 (R8 (12 weeks) -R8 (0 weeks)) values of the cutometer MPA580, where R5 values represent the properties of net elasticity, and the results are shown in Table 5 below.

Experimental Formulation Skin elasticity effect Skin Moisturizing Effect Example 0.67 58.4 Comparative example 0.41 53.1

As can be seen from Table 5, it was confirmed that the skin elasticity and moisturizing effect of the example containing the germinated brown rice extract was increased compared to the comparative example.

Experimental Example  5: Stability test of formulation

The stability test for the cosmetic containing the germinated brown rice extract of the present invention was carried out by the following method.

To test the stability of the cosmetics, the Examples and Comparative Examples were kept in an opaque glass jar in a thermostat kept at 45 ° C. for 12 weeks and stored in a completely shaded refrigerator kept constant at 4 ° C. After storing for 12 weeks in a container, the discoloration, the smell, the degree of separation was measured. The results are summarized in Table 6 below. At this time, the degree of discoloration, odor and separation of the product were evaluated by classifying into the following six grades.

0: no change

1: very little separation (discoloration)

2: A little separation (discoloration)

3: Slightly separated (discolored)

4: severely separated (discolored)

5: extremely severe separation (discoloration)

division Formulation Stability Example Comparative example 45 ℃ 4 ℃ 45 ℃ 4 ℃ discoloration 0 0 0 0 Deodorant 0 0 0 0 detach 0 0 0 0

As can be seen in Table 6, Examples and Comparative Examples were stable at 45 ° C. with little discoloration, discoloration or separation, indicating that the germinated brown rice extract was present in a stable state in the formulation.

Hereinafter, based on the results of the above experimental example, to present a cosmetic composition containing the germinated brown rice extract of the present invention. However, the composition of the present invention is not intended to be limited to the following formulation examples.

Formulation example  1: Flexible Cosmetic (Skin Lotion)

To the flexible composition according to the composition shown in Table 7 was prepared according to a conventional method.

Compounding ingredients Content (% by weight) Germinated Brown Rice Extract 0.5 1.3-butylene glycol 6.0 glycerin 4.0 Oleyl alcohol 0.1 Polysorbate 20 0.5 ethanol 15.0 Benzophenone-9 0.05 Incense, preservative a very small amount Purified water to 100

Formulation example  2: nutritional cosmetics ( Milk Croissant )

Nutrients according to the composition shown in Table 8 was prepared according to a conventional method.

Compounding ingredients Content (% by weight) Germinated Brown Rice Extract 1.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 1.2 Tocophenyl Acetate 3.0 Liquid paraffin 5.0 Squalane 3.0 Macadamia Nut Oil 2.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.0 Carboxyvinyl Polymer 1.0 Bietchiti 0.01 EDTA-2Na 0.01 Incense, preservative a very small amount Purified water to 100

Formulation example  3: nutrition cream

To the nutrition cream was prepared according to the composition shown in Table 9 according to a conventional method.

Compounding ingredients Content (% by weight) Germinated Brown Rice Extract 2.0 Cetostearyl alcohol 2.0 Glyceryl Stearate 1.5 Trioctanoine 5.0 Polysorbate 60 1.2 Sorbitan stearate 0.5 Squalane 5.0 Floating paraffin 3.0 Cyclomethicone 3.0 BH 0.05 Delta-tocopherol 0.2 Concentrated glycerin 4.0 1,3-butylene glycol 2.0 Santa sword 0.1 EDTA-2Na 0.05 Incense, preservative a very small amount Purified water to 100

Formulation example  4: massage cream

Massage cream was prepared according to the conventional method in the composition shown in Table 10 below.

Compounding ingredients Content (% by weight) Germinated Brown Rice Extract 0.5 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Beeswax 2.0 Tocopheryl Acetate 0.1 Polysorbate 60 3.0 Sorbitan sesquioleate 2.5 Cetearyl Alcohol 2.0 Liquid paraffin 30.0 Carboxy Vinyl Polymer 0.5 Incense, preservative a very small amount Purified water to 100

Formulation example  5: pack

The pack was prepared according to a conventional method with the composition shown in Table 11 below.

Compounding ingredients Content (% by weight) Germinated Brown Rice Extract 1.0 Propylene glycol 2.0 glycerin 4.0 Carboxyvinyl Polymer 0.3 ethanol 7.0 Fiji-40 Hydrogenated Castor Oil 0.8 Triethanolamine 0.3 Bietchiti 0.01 EDTA-2Na 0.01 Incense, preservative a very small amount Purified water to 100

Claims (4)

Cosmetic composition for enhancing skin elasticity and skin shine, characterized in that it contains a germinated brown rice extract as an active ingredient. The cosmetic composition of claim 1, wherein the composition exhibits the action of inhibiting the secretion of cortisol, promoting the production of beta-endorphin, decreasing the content of cholesterol, prolonging sleep time, or a combination thereof. The method according to claim 1 or 2, wherein the germinated brown rice extract is a cosmetic composition for enhancing skin elasticity and skin shine, characterized in that it contains 0.001 ~ 20.0% by weight based on the total weight of the composition. The cosmetic composition of claim 1, wherein the cosmetic composition has a formulation of a lotion, essence, lotion, cream, pack, gel, ointment, patch, or spray.