KR20090046387A - Functional cosmetic composition comprising scutellaria,houttuynia,artemisia,citurs junos extract having antimicrobial activity - Google Patents

Abstract

The present invention relates to a natural antibacterial agent and a cosmetic composition having antiseptic activity using the same. More specifically, the present invention contains one or more extracts selected from the group consisting of 0.01 to 1.0% by weight of golden extract, 0.05 to 1.0% by weight of Echochocho extract, 0.01 to 1.0% by weight of mugwort extract, and 0.05 to 2.0% by weight of citron extract It relates to a cosmetic composition having antibacterial and antiseptic activity.

The cosmetic composition according to the present invention is a cosmetic composition in which the antimicrobial extract is mixed at an optimal prescription composition ratio, exhibiting a wide range of antimicrobial spectrums, having excellent cosmetic antiseptic activity, excellent cosmetic formulation compatibility, excellent formulation stability, and low skin irritation potential. .

Golden Extract, Echo Extract, Mugwort Extract, Citron Extract

Description

 Functional cosmetic composition comprising scutellaria, houttuynia, artemisia, citurs junos extract having antimicrobial activity

The present invention relates to a natural antibacterial agent by optimizing the composition ratio of gold, Echo vinegar, mugwort, citron extract, high antibacterial activity, broad antibacterial spectrum and excellent antimicrobial formulation stability.

In order to maintain the quality of many products such as food, medicine, and cosmetics for a long time, preservatives to prevent decay by microorganisms are essential, and the shelf life is relatively long, even in the case of cosmetic products with a lot of microbial nutrients. Even parabens preservatives, which are the safest as conventional preservatives and are widely used in cosmetics and medicines, are allergic to skin (Andrea Counti et al., Contact Dermatitis, 1997, 37; 35-36.) And their potential as environmental hormones (Edwin et al., Toxicology and Applied Pharmacology, 1998, 153; 12-19.), Food preservatives are also distrusted in the use of acceptable standards, and continued accumulation in the body raises the possibility of new problems such as acute, chronic toxicity and mutagenesis. (Shin Dong-hwa, Food Science and Industry, 1990, 23 (4) 68-72). Therefore, there is a need for a natural preservative that can improve the safety and economics of the product.

Research on natural antimicrobial substances has been studied by many researchers, and many natural antimicrobial substances have been reported from foods such as anticoagulants, milk and fish, essential oils and herbal medicines, and alkaloids, flavonoids and phytoalexins ( phytoalexin), antimicrobial peptides have been reported, and antimicrobial properties of organic acids and fatty acids have been reported, and the effects of acid pH and chelate are estimated to be the main mechanisms (EI-shenawy, MA et al., J.). Food Protec. 1989, 52 (11): 771-778) (Bizri, JN et al., J Food Science, 1994, 59 (1), 130-135).

However, due to the limitations of natural substances, namely, color, stability, narrow antibacterial spectrum, and formulation problems, most of them are not commercially available. However, commercially available natural antimicrobial agents include henokiitiol, a magnolia extract, and magnonole, a magnolia extract. Grapefruit seed extract DF-100 has been developed, but the antimicrobial activity of DF-100 is due to the synthetic preservatives (benzethonium chloride) contained in it, and other natural antimicrobial agents have problems of economic efficiency, antimicrobial spectrum and range of use. It is necessary.

Antibiotics are widely used to prevent and treat diseases in humans and livestock caused by microorganisms, but not to maintain products. However, various resistant strains have appeared due to misuse and abuse, and hospitals have been using high-level antibiotics to treat infections. It forms a vicious cycle, the susceptibility of causative bacteria to livestock, and the problem of antibiotic residue is emerging as a socially important issue in public health. Currently, two or more antibiotics may be used in combination to combat Methicillin Resistant Staphylococcus Aureus (MRSA) (Voss, A et al., Int J. Antimicrob. Agents, 1995, 5: 101-106) There are emerging strains that use vancomycin, but also to vancomycin, such as Vancomycin-resistant enterococci (Billot-klein D, Antimicrob. Agents. Chemother, 1992, 36: 1487-1490). have. Recently, it has been reported to increase sensitivity by using flavonoids in natural products to increase the sensitivity of antibiotics (IAIN X, LIU et al., J. Pharm.Pharmacol, 2000, 52: 361-366), antibacterial peptide (Giacometti). A et al., J. Antimicrob. Chemother 2000 Nov; 46 (5): 807-811), have been studied as alternatives, but antimicrobial peptides have only limited antimicrobial properties and problems in economic mass production methods (Lee JH et al.). , Protein.Expr.Purif, 1998 Feb; 12 (1), 53-60)

Accordingly, the present inventors have developed a new antimicrobial activity and a broad spectrum of natural materials from natural products, not synthetic compounds, and can be applied to foods, medicines, cosmetics, etc. as natural preservatives to improve the safety and stability of quality and multifunctionality in mammals including humans. As an antimicrobial agent, it is safe and does not induce resistance and to prepare a natural preservative of cosmetics to ensure safety.

In order to achieve the above object, the present invention relates to a natural antibacterial agent and a cosmetic composition having antiseptic activity using the same. More specifically, the present invention contains one or more extracts selected from the group consisting of 0.01 to 1.0% by weight of golden extract, 0.05 to 1.0% by weight of Echochocho extract, 0.01 to 1.0% by weight of mugwort extract, and 0.05 to 2.0% by weight of citron extract It relates to a cosmetic composition having antibacterial and antiseptic activity. A multifunctional natural antibacterial agent having high antibacterial activity, broad antibacterial spectrum and high antioxidant activity was prepared.

Multifunctional natural antimicrobial agent according to the present invention as a new material has antiseptic and antioxidant functions in food, pharmaceuticals, cosmetics, fiber, etc. to increase the safety and stability of the quality, and safe and resistant in mammals, including humans, without proper antioxidation function It has the effect of treating and preventing infectious diseases.

Multifunctional natural preservative of the present invention is preferably used as a natural extract 0.01% ~ 10%, and more preferably used in a concentration range of 0.1% ~ 5%.

In order to achieve the above object, the present invention relates to a natural antibacterial agent and a cosmetic composition having antiseptic activity using the same. More specifically, the present invention contains one or more extracts selected from the group consisting of 0.01 to 1.0% by weight of golden extract, 0.05 to 1.0% by weight of Echochocho extract, 0.01 to 1.0% by weight of mugwort extract, and 0.05 to 2.0% by weight of citron extract It relates to a cosmetic composition having antibacterial and antiseptic activity. A multifunctional natural antibacterial agent having high antibacterial activity, broad antibacterial spectrum and high antioxidant activity was prepared.

Scutellaria baicalensis belongs to Labiatae, which uses roots and is known to be effective for antipyretic, bile secretion, gastric secretion inhibition, atherosclerosis, antibacterial and antifungal, and antiviral. The main flavonoids are Baikal 4-5% Baicalin and other wogonin, 7-methoxy baicalein, oroxylin-A, school capflavone I, II Sterols include beta-sitosterol, campesterol, and sugars such as sucrose and D-glucose, and other resins and essential oils. In terms of antimicrobial activity, baicalein has a synergistic effect on methicillin resistant staphylococcus aureus (MRSA) in combination with beta-lactam antibiotics, which inhibits beta-lactamase and It is reported to be due to direct action against bacteria (IAIN X, LIU et al., J. Pharm. Pharmacol, 2000, 52: 361-366).

Antioxidant (Shieh DE, Anticancer Res, 2000 Sep-Oct; 20 (5A): 2861-2865) Anti-inflammatory and anti-allergic effects (Williamson EM, Potter New Cyclpaedia of Botanical Drug and Preparations, revised edn, 1988, p362) , The CWDaniel Co., Ltd, UK).

    Eoseongcho refers to the perennial herb (Houttuynia cordata Thunb), which belongs to more than three hundred, and has pharmacological effects such as antibacterial, diuretic, anti-toxic, hemostatic, analgesic, and tissue regeneration.Methyl-n-nonylketone , Laurylaldehyde, Capric acid, Kordarine, Isoquercitrin, quercitrin, Reynoutrin and Hyperrin Various effective medicinal ingredients such as) are contained throughout all parts of roots, stems, leaves, and flower sake. In addition to the above-mentioned medicinal ingredients, Echochocho, which has the above-mentioned efficacy, contains decanoyl acetaldehyde, which is a powerful ingredient that shows potent antibacterial activity and shows efficacy against pathogens such as ringworm fungus athlete's foot and iron scab. It also acts as a major causative agent that causes severe stickiness during eating by emitting smells like fishy fish.

      Artemisia Linne belonging to the Asteraceae family has more than 200 species in the northern hemisphere and 38 species in Korea are reported. Representatively, it includes wormwood, mugwort, mountain mugwort, cedar mugwort, yellow sea mugwort, injin mugwort, mugwort mugwort, and bush mulberry. Stems and petioles are medicinal, young leaves are edible and ordinary leaves are used to make moxa. White hair is used to scrape and make a pad,

It is also called white tiger (白 애), Bongae (애 艾), Aecho (艾草) or Bongho (蓬蒿). Mugwort is used as a hemostatic drug such as nosebleed and uterine bleeding in oriental medicine, and it is effective for digestion, lower abdominal pain, elimination of insects and odors, and is said to be effective in gastrointestinal diseases, constipation, neuralgia, cold disease, women's diseases and asthma, come. Artemisia spp. Has been grown as a wormwood in the province of Ganghwa, Korea.

It is derived from the description of lion ancestors in the souvenirs section of Ganghwadohobu in New Jeungdong Yeojiseungram, and the description of lion foot in the medicinal herb. The present inventors have studied wormwood plants for the purpose of developing high-functional natural preservatives from domestic aromatic plants, and found that the herb extracts of Artemisia spp. Strongly inhibit the growth of various bacteria, fungi and yeasts. As a result of using as a natural preservative in food, cosmetics, etc., it has been confirmed that it exhibits an excellent antiseptic effect comparable to conventional chemical preservatives.

I did it. Lion cucurbita is a perennial herb that has been inhabited in Ganghwa Island since ancient times. The leaves are wide and dark green, and grow up to about 70cm in height. The leaves are divided into lion-shaped leaves, and the nodes grow in shape, with white hairs on the back. Flowers are about 3㎜ in July-September, bloom in the shape of ear, and the color is light purple with reddish tinge. In the present invention, as a result of preliminary analysis of the components of lion cucurbita, the essential oil content was found to be 0.2-1.4%, cineole, tricyclene, α-terpinene, borneol, azunol, β-

myrcene, thujone, camphor, caryophyllene, murolene, logniverbene, camphene, ρ-cymene, 3-thujanone, α-terpinen-4-ol, cis-1-methyl-4 (1-methylethyl) -2- cyclohexen-1-ol Etc. were detected. Among these substances, cineole, borneol, camphor, chamazulene and menthol have been reported to have pharmacological effects such as sterilization, disinfection, antiseptic, hookworm, anti-inflammatory, diuresis and anticoagulant.

    Citrus junos used in the present invention is an evergreen shrub of Rutaceae, which grows throughout the country. Citron, the fruit of the citron tree, is widely used in ornamental, edible, medicinal and spices.

It has been widely used for medicinal purposes since the isotope nucleus. It is known to be effective in circulating diseases and various congestion. In the herbaceous wood, citron shells digest food and make the stomach feel good.

It is said to have the effect of digesting and detoxifying food poisoning. Citron is rich in vitamins B1, B2, C and various organic acids, as well as limonoid and blood vessel strengthening and liver detoxification, which are known to be excellent anticancer effects.

Hesperidine is known to be rich in dragons, anticancer, anti-inflammatory and antibacterial effects (Journal of Cardiovascular Pharmacology 1993 Aug; 22 (2): 225-30). It is extracted from.

It has antimicrobial and antiseptic activity, containing one or more extracts selected from the group consisting of 0.01-1.0% by weight of golden extract, 0.05-1.0% by weight of Echo herb extract, 0.01-1.0% by weight of mugwort extract, and 0.05-2.0% by weight of citron extract. It is about cosmetic preparations.

Example  One.

Natural extracts can usually be obtained by the method used to extract the active ingredient from the plant. That is, to 500 g of golden dried matter, methanol was added about 20 times of the pulverized product, and the extract was heated at 80 ° C for 1 day in an extractor equipped with a cooling capacitor to obtain an extract, and the filtrate was concentrated under reduced pressure to obtain a dried product. In order to fractionate the higher bioactive substance, water corresponding to 4 times the weight is added, 500 ml of ethyl acetate is added, the mixture is shaken vigorously, and the upper ethyl acetate layer is separated to obtain a dried product after concentration under reduced pressure. The organic solvents used in the present invention can also be selected from methanol, ethyl acetate, ethanol, chloroform, butanol, and acetone by extraction by the conventional extraction method as in the reference example. In addition, tannins can be removed in advance using sodium chloride for effective extraction, and the extraction conditions can be deposited for 2-7 days at room temperature rather than heating.

The present invention is explained in more detail by the following examples and experimental examples, but the present invention is not limited in any way by these.

Experimental Example  1. Antibacterial test (antibacterial and Antifungal activity  Collectively)

Bacterial mussels (Muller Hinton broth) was used and inoculated with the culture medium was incubated for 16-20 hours in a 37 ° C incubator. For fungal cultures, Sabouraud dextrose broth was used, inoculated with the culture medium, incubated for 5-7 days in a 22 ° C incubator, and potato for the Fusarium solani, a phytopathogen. Dextrose medium was used.

Strains for the determination of antimicrobial activity are as follows.

Gram-positive bacteria

   Staphylococcus aureus ATCC 6538P

   Bacillus subtilis ATCC 6633

   Micrococcus luteus ATCC 9341

   Methicillin resistant staphylococcus aureus (MRSA) C2207

Gram-negative bacteria

   Escherichia coli ATCC 10536

   Escherichia coli 0157: K88ac

   Pseudomonas aeroginosa ATCC 1636

   Klebsiella pneumoniae ATCC 10031

leaven

  Candida albicans ATCC 10231

Fungus

  Aspergillus niger ATCC 9029

  Trichophyton mentagrophytes (KCTC 6077)

  Fusarium solani

Cultivation of the strain is as follows. That is, the Agar Serial Dilution Method was used to measure the antimicrobial activity. In other words, a method of spreading a large number of strains on an agar plate is to make a 2-fold dilution series of an antimicrobial solution, put it in a Petri dish, and inoculate an appropriate amount of medium, and then inoculate test bacteria.

In the case of general bacteria, Muller Hinton broth (Difco) is used for preculture, and Muller Hinton agar is used for the medium for producing flat plates.Average 1.5% of agar is put well, then sterilized and cooled to 50 degrees. do.

Pre-culture: Inoculate bacteria (2 * 106 CFU / ml) in Müllerton juice and incubate at 37 ° C for 16-24 hours ago. Meanwhile, 2 ml of 0.8mg / ml-6μg / ml antimicrobial solution (5% DMSO; Dimethylsulfoxide physiological saline solution) was added to the sterilized petri dish twice, and 2ml of sterile distilled water was added to the control group.Amocla: Amoxicillic salt Add 2 ml of Kunil Pharmaceuticals). Sterilize each Petri dish and mix it with 18 ml of Muller Hinterton's hot melt media cooled to 50 degrees and rotate the bottom of the Petri dish. Afterwards, pre-cultivated bacteria are plated about 5mm using platinum teeth. Bacteria were incubated for 16-24 hours at 37 ° C, fungi and yeasts were incubated for 5-7 days in a 22 ° C incubator, and then colony formation was observed in each compartment to minimize the minimum antimicrobial concentration of the plate where growth was not recognized. (MIC, Minimum inhibitory concentration). Once the primary MIC is determined, narrow each concentration step to find the secondary MIC.

Table 1

Antimicrobial test results (minimum concentration concentration, ppm)

B. subtilis S. aureus M. luteus MRS A E. coli E.coli 0157: K88ac P. aerosinosa K. pneumonia C. albicans A. niger T. mentagro-phyte F.solani Golden Extract (0.01 to 1.0% by weight) 250 250 250 1000 750 750 750 500 250 750 750 500 Urchincho extract (0.05 to 1.0% by weight) 500 250 250 500 750 750 750 750 500 1000 750 500 Mugwort extract (0.01 to 1.0% by weight) 750 250 500 750 1000 750 750 750 750 750 1000 750 Citron extract (0.05 to 2.0% by weight) 500 500 500 1000 750 1250 1250 500 750 750 1000 750 Golden Extract Eocho Extract 250 250 500 750 750 750 750 750 250 500 500 500 Golden Extract Mugwort Extract 500 250 250 500 750 750 750 500 500 500 500 250 Golden Extract Citron Extract 500 500 250 500 750 1000 750 500 500 500 750 500 Golden Extract Eungchocho Extract Wormwood Extract 250 250 250 500 500 750 750 500 250 500 500 250 Golden extract Eochocho extract Citron extract 250 500 250 250 500 750 750 750 250 500 500 250 Golden extract Eungseongcho extract Mugwort extract Citron extract 250 250 250 250 250 500 500 500 250 250 500 250

As can be seen from the above results, the antimicrobial activity of the golden extract was the highest with respect to the other extracts. However, the antimicrobial spectra of the golden extract, erectile vinegar extract, and wormwood extract also showed the specificity of the fungal species, such as gram-positive bacteria and gram-negative bacteria (Bacillus subtilis or E. coli and Pseudomonas aeruginosa). It was confirmed that the antimicrobial activity was increased by using a combination of golden extract, Eochocho extract, mugwort extract and citron extract (hereinafter referred to as complex natural extract).

Experimental Example  2. Natural antibacterial agent Resistance

The strain used in the experiment was Escherichia coli 0157: K88ac isolated from piglets, inoculated in lactose juice (0.5% yeast extract, tryptone, 1% sodium chloride), incubated at 37 ° C, 150rpm for 12 hours, and centrifuged (500 * g, 4). The bacteria were separated and diluted with phosphate buffer solution (0.1M, pH 7.0) to adjust the number of bacteria. In 20 ml of lactose broth, B-MB4 0.05 ppm or less of lethal concentration was added and the concentration of bacteria was inoculated to 2 * 106. It was. The erythromycin treatment group was incubated with erythromycin at 0.05 ppm for 12 hours, followed by centrifugation of the bacteria in the same manner, and then inoculated to the same concentration in the culture medium containing the same concentration of antimicrobial agent. After repeating the above procedure five times, the antimicrobial activity of the antimicrobial agent in the initial state and the antimicrobial activity of the six times incubation were compared.

After 12 hours, 10 μl of the culture solution was aliquoted and placed in a test tube containing 990 μl of phosphate buffer solution, and 50 μl was plated on a membrane-concentrated agar medium to compare the number of surviving colonies.

TABLE 2

Induced resistance (minimum inhibitory concentration, ppm)

Subculture Culture After six days of subculture AI Complex natural extract 250 250 1.0 Erythromycin 125 1250 10.0

* AI (Adaptation Index) = MIC after subculture / MIC before subculture

As shown in Table 2, the adaptation index, or resistance-induced resistance, was 1 because it did not induce any resistance in the complex natural extract. However, the antibiotics in the control group induced resistance and increased the minimum inhibitory concentration from the initial level to 10.0.

TABLE 3

Nourishing Cosmetic Type

ingredient Composition ratio (%) Glyceryl stearate 1.50 Squalane 7.00 Mineral oil 7.00 Cetearyl alcohol 1.20 Sorbitan stearate 0.30 Polysorbate 60 1.00 Carbomer 0.12 Glycerin 10.00 Natural Antibacterial 0.001%-10% Deionized water balance system 100.00

Experimental Example  3. In the product Antiseptic

After adding natural antimicrobial agents in the nutrient cosmetics formulations as shown in Table 3, inoculating the mixture of bacteria, fungi and yeast in Experimental Example 1 to 2 * 106 CFU / ml in the product, and observed the increase and decrease of the number of bacteria over time. The antiseptic force in the product was examined.

Table 4

Hourly bacterial count in nutrient lotion

Natural Antibacterial Time At the time of inoculation 1 day later 3 days later 1 week later 2 weeks later 4 weeks later Antimicrobial agent methyl paraben 0.2% propyl paraben 0.1% Germal 115 0.2%

2.0 *

3.0 *

1.5 *

 7.0 * 10  20  0 Natural Antibiotic Exclusion Control 2.0 *

4.5 *

4.8 *

8.5 *

2.0 *

7.5 *

Natural extract 0.5% 2.0 *

2.0 *

2.9 *

6.4 *

4.1 *

2.3 *

Natural Extract 1.0% 2.0 *

2.6 *

4.0 *

3.8 *

6.9 * 10 35 Natural extract 1.5% 2.0 *

1.0 *

6.8 *

4.7 * 10 0 0 Natural Extract 2.0% 2.0 *

5.5 *

4.5 *

0 0 0 Natural extract 2.5% 2.0 *

2.5 *

3.7 *

0 0 0 Natural Extract 3.0% 2.0 *

1.0 *

 9.2 * 10 0 0 0

As can be seen from the above test results, it shows the antiseptic force in the product in which the viable cell count is not detected after one week at the concentration of more than 2.0% of the composite natural extract. However, the preservatives at 2.5% to 3.0% show a slightly increased bactericidal rate, but the formulation stability, sensory aspect, and acceptance criteria for cosmetic preservation tests (with a viable cell count of less than 102cfu / ml after 1 week of inoculation are grade A). In consideration of), it would be effective to prescribe 2.0% of natural extracts for cosmetic formulations.

Experimental Example 4. Antioxidant Effect

Blood collected from rabbits was centrifuged (8,000 rpm, 5 minutes), washed, and the obtained red blood cells were diluted with physiological saline to prepare a red blood cell suspension (60 million red blood cells / 4 ml). Nine 10 ml Pyrex test tubes with a diameter of 1.0 cm are prepared, and 4 ml of red blood cell suspension is added to each.

One of the nine test tubes was added 50 μl of ethanol as a control and the other eight were added 50 μl of the sample as a treatment group and allowed to hydrate in the dark for 30 minutes. After fusion, add 50 μl of aqueous solution of Hematoporphyrin (80 μM) as a photosensitizer, seal the inlet with parafilm, and install a 20 W fluorescent lamp in a box of 50 cm * 20 cm * 25 cm rectangular black painted inside. The tubes were arranged at a distance of 5 cm from the fluorescent tube and irradiated with light for 15 minutes. After light irradiation, the absorbance was measured at 700 nanometers at 15 minute intervals while leaving the test tubes in the dark. The increase in the transmittance of the red blood cell suspension at this wavelength is proportional to the hemolysis of the red blood cells. All experiments were conducted in a 27 ° C thermostat and the activity of the sample to protect the cells from free radicals was defined as the time (in minutes) for 50% of the red blood cells added under the above measurement conditions.

Table 5

Antioxidant Effect of Natural Antibiotic (Composite Natural Extract)

Natural Antibacterial Antioxidant effect (min) Tocopherol 2.0% Ascorbic Acid 3%  60 Complex natural extract exclusion 25 Natural extract 0.5% 39 Natural Extract 1.0% 45 Natural extract 1.5% 53 Natural Extract 2.0% 58 Natural extract 2.5% 60 Natural Extract 3.0% 65

Antioxidant Effect: Time (min) for photohemolysis of 50% of red blood cells

As shown in Table 5, it can be seen that at the concentration of more than 1.5% of the complex natural extract, the antioxidant activity is similar to that of the positive control of tocopherol and ascorbic acid. This fact can be judged to suggest the link between the mechanism of action of antimicrobial activity and antioxidant activity of natural extracts.

As can be seen from the above experimental examples, the natural extract as a complex extract prepared from the present invention, despite being made from natural products, exhibits a broad spectrum of high antibacterial activity against resistant bacteria and fungi without causing resistance and exhibits a broad spectrum of appropriate antioxidants. You can see that it has a function. Therefore, it is expected that a wide range of applications will be possible as a multifunctional preservative in food, medicine, cosmetics, etc. and as a multifunctional antimicrobial agent in mammals including humans.

(Effects of the Invention)

Multifunctional natural antimicrobial agent according to the present invention as a new material has antiseptic and antioxidant functions in food, pharmaceuticals, cosmetics, fiber, etc. to increase the safety and stability of the quality, and safe and resistant in mammals, including humans, without proper antioxidation function It has the effect of treating and preventing infectious diseases.

Multifunctional natural preservative of the present invention is preferably used as a natural extract 0.01% ~ 10%, and more preferably used in a concentration range of 0.1% ~ 5%.

Claims (4)

Natural preservative containing one or more extracts selected from the group consisting of 0.01 to 1.0% by weight of golden extract, 0.05 to 1.0% by weight of Echo herb extract, 0.01 to 1.0% by weight of mugwort extract, and 0.05 to 2.0% by weight of citron extract A cosmetic composition comprising a natural preservative comprising the complex natural extract of claim 1 as an active ingredient The method of claim 2, Formulation of the cosmetic composition is a flexible lotion, gel, water-soluble liquid, milk lotion, nourishing cream, massage cream, essence, emulsion, oil dispersion, ionic or nonionic lipid vesicles, ointments, cleansing foam and water, packs, etc. Cosmetic composition having antimicrobial and antiseptic activity, characterized in that it is selected from cosmetics and makeup base, makeup base, foundation, face powder, two-way cake, skin cover, eye care, mascara, etc. The method of claim 2, The cosmetic composition is a cosmetic composition having antibacterial and antiseptic activity, characterized in that it is a face wash and bath composition.