KR20090030441A - Food composition for reducing abdominal obesity containing dietary fiber and fructooligosaccharide - Google Patents
Food composition for reducing abdominal obesity containing dietary fiber and fructooligosaccharide Download PDFInfo
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- KR20090030441A KR20090030441A KR1020070095753A KR20070095753A KR20090030441A KR 20090030441 A KR20090030441 A KR 20090030441A KR 1020070095753 A KR1020070095753 A KR 1020070095753A KR 20070095753 A KR20070095753 A KR 20070095753A KR 20090030441 A KR20090030441 A KR 20090030441A
- Authority
- KR
- South Korea
- Prior art keywords
- food composition
- abdominal obesity
- fructooligosaccharide
- satiety
- reducing abdominal
- Prior art date
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Images
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/332—Promoters of weight control and weight loss
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/50—Polysaccharides, gums
- A23V2250/502—Gums
- A23V2250/5058—Glucomannan
Abstract
Description
본 발명은 천연 식이섬유와 프락토올리고당을 함유하여 포만감을 증가 시키면서 배변활동을 촉진함으로써 복부비만 감소를 유도하는 식품 조성물에 관한 것이다. 더욱 상세하게는, 주성분으로 식이섬유인 이눌린과 프락토올리고당을 함유하고, 보조성분으로 글루코만난과 레드와인추출물을 함유함으로써 포만감 증진, 배변활동 촉진 및 복부비만 감소 효과가 우수한 식품 조성물에 관한 것이다.The present invention relates to a food composition containing natural dietary fiber and fructooligosaccharide to induce abdominal obesity by promoting bowel activity while increasing satiety. More specifically, the present invention relates to a food composition having an excellent effect on enhancing satiety, promoting bowel movements, and reducing abdominal obesity by containing inulin and fructooligosaccharides, which are dietary fibers as main ingredients, and glucomannan and red wine extracts as auxiliary ingredients.
복부비만은 잘못된 식생활과 무절제한 생활, 과도한 스트레스, 운동 결핍 따위로 기초대사량이 저하되어 있는 경우 쉽게 나타난다. 임상적으로 비만 정도는 허리와 엉덩이의 비율(Waist/Hip ratio)로 측정한다. 남성의 경우 W/H 비가 0.9 이상일 때는 복부비만으로 분류하고, 살은 쪘지만 1 미만일 때에는 말초성비만으로 분류한다. 여성의 경우는 0.85가 기준이 된다. 남성의 경우는 기본적으로 여자에 비 하여 내장지방이 2~3배 많으며, 대개 음주와 흡연 및 고지방 음식을 섭취하는 경우가 많아 생기기 쉽고, 여성의 경우는 폐경기 이후에 난소폐쇄(follicular atresia)로 인한 난소 기능 부전으로 인해 에스트로겐 합성과 분비가 감소되며, 뇌하수체로부터 분비되는 성선 자극 호르몬 수치의 상승으로 인하여 다양한 질병이 발생할 수 있는 것으로 보고되고 있다(Choi Y,Yoon et al. Korean J.Nutr.34(3):322-329,2001). 특히 폐경 후 여성의 경우 여성 호르몬 부족과 다양한 원인에 의해 복부지방 조직이 증가하게 된다(Turcato E.et al.J Intern Med 241(5):363-372,1997). 폐경 이전에는 여성호르몬의 영향으로 심혈관계 질환의 발생이 남자의 1/4 ~ 1/5에 불과하지만 폐경 이후에는 여성호르몬인 에스트로겐이 부족하게 되어 심혈관계 질환의 발생율이 급격히 증가함으로써 남자와 비슷한 수준까지 이르게 된다. Abdominal obesity easily occurs when the basic metabolic rate is lowered due to poor diet, modest lifestyles, excessive stress, and lack of exercise. Clinically, obesity is measured by the waist / hip ratio. In the case of men, W / H ratio is classified as abdominal obesity when 0.9 or more. For women, 0.85 is the standard. Males are basically 2-3 times more visceral than females, and they are more likely to drink, smoke, and consume high-fat foods, and women are more likely to develop postmenopausal follicular atresia. Estrogen synthesis and secretion are reduced due to ovarian dysfunction, and various diseases can be caused by elevated levels of gonadotropins secreted from the pituitary gland (Choi Y, Yoon et al. Korean J. Nutr. 34 ( 3): 322-329,2001). Especially in postmenopausal women, abdominal adipose tissue increases due to female hormone deficiency and various causes (Turcato E. et al. J Intern Med 241 (5): 363-372,1997). Before menopause, the effects of female hormones on cardiovascular disease occur in only 1/4 to 1/5 of men, but after menopause, estrogen, a female hormone, is shortened, leading to a rapid increase in the incidence of cardiovascular disease. It is until.
지난 40여년 간 식사량 조절을 위하여 가장 효과적인 방법으로 알려진 포만감을 증가시킴으로써 배고픔을 억제하는 메커니즘에 관하여 지속적인 연구가 이루어져 왔다. 상기 연구에 있어서는 불용성 탄수화물 등을 이용한 위 장관 내 팽창 및 음식의 이동 시간 지연에 의한 위 공복감을 연장하는 방법 및 복내측 시상하부(VMH)의 포만중추, 보다 구체적으로 콜레시스토키닌(CCK, Cholecystokinin)의 분비 자극을 통한 식욕 억제의 방법이 가장 널리 알려져 있다. 이와 관련하여 미국특허 제 4,491,578호에서는 콜레시스토키닌의 방출을 자극함으로써 포만감을 증가시키는 트립신 억제제의 경구 투여에 대하여 개시하고 미국특허 제 6,207,638호에서는 CCK의 방출을 자극함으로써 포만 상태를 촉진 및 연장시키기 위한 영양학적 간 섭형 조성물에 대하여 개시하고 있다. 그러나 상기 조성물의 복부비만 감소 메커니즘은 전반적인 영양학적 요건에 대한 고려없이 단순히 포만감만을 부여함으로써 칼로리 섭취를 제한하는 것에 관한 것이다.Over the last 40 years, there has been a continuous study of the mechanisms for suppressing hunger by increasing satiety, which is the most effective way to control diet. In this study, a method of prolonging gastric emptying sensation due to gastric intestinal swelling and delayed food movement time using insoluble carbohydrates, and the satiety center of the hypothalamus (VMH), more specifically the secretion of Cholecystokinin (CCK) The method of suppressing appetite through stimulation is most widely known. In this regard, US Pat. No. 4,491,578 discloses oral administration of trypsin inhibitors that increase satiety by stimulating the release of cholecystokinin and US Pat. No. 6,207,638 nutritionally promotes and prolongs the state of satiety by stimulating the release of CCK. Disclosed is a coherent composition. However, the abdominal obesity reduction mechanism of the composition relates to limiting calorie intake by simply giving satiety without considering overall nutritional requirements.
이에 정상적인 식이를 하면서도 포만감 증진뿐만 아니라 배변활동 촉진을 통한 복부비만 감소를 유도할 수 있고 섭취가 용이하여 복부비만 예방 및 감소에 도움을 줄 수 있으면서 무엇보다도 장기 섭취 시에도 안전한 식품 개발의 필요성이 대두되었다.Therefore, it is possible to induce abdominal obesity through the promotion of bowel movements as well as to improve satiety, and to facilitate the prevention of abdominal obesity, and to help prevent and reduce abdominal obesity. It became.
이에 본 발명자들은 그 안전성과 효과가 인정된 식이섬유와 프락토올리고당을 사용하고 기타 포만감 부여와 배변활동 촉진, 지방 분해에 도움이 되는 성분을 첨가하여 복부비만개선 효과를 증진시킬 수 있는 식품 및 건강기능식품을 개발하고자 노력한 결과, 식이섬유인 이눌린, 프락토올리고당, 글루코만난, 레드와인추출물을 함유한 식품 조성물이 섭취시 포만감을 부여하고 배변활동을 촉진시켜 복부비만 감소 효과가 뛰어나며, 장기 섭취시에도 부작용이 없음을 발견하고 본 발명을 완성하게 되었다. Therefore, the present inventors use a dietary fiber and fructooligosaccharide, which have been recognized for its safety and effectiveness, and add foods for improving satiety, promoting bowel movements, and adding fat-assisted ingredients to improve abdominal obesity improvement effect. As a result of efforts to develop functional foods, food composition containing dietary fiber, inulin, fructooligosaccharide, glucomannan, and red wine extract, gives a feeling of satiety and promotes bowel activity, and is effective in reducing abdominal obesity. The discovery of no side effects has led to the completion of the present invention.
따라서, 본 발명의 목적은 식이섬유와 프락토올리고당을 주성분으로 함유하여 복부비만개선 효과를 증진시키며, 장기 섭취시에도 안전한 식품 조성물을 제공하는 것이다. Therefore, it is an object of the present invention to improve the abdominal obesity improvement effect by containing dietary fiber and fructooligosaccharide as a main component, and to provide a safe food composition even in the long-term intake.
상기의 목적을 달성하기 위하여, 본 발명은 이눌린 및 프락토올리고당을 함유하는 복부비만 감소용 식품 조성물을 제공한다.In order to achieve the above object, the present invention provides a food composition for reducing abdominal obesity containing inulin and fructooligosaccharide.
또한, 상기 식품 조성물은 레드와인추출물 및 글루코만난을 더 함유할 수 있다.In addition, the food composition may further contain red wine extract and glucomannan.
상기 식품 조성물은 포만감을 부여하고, 배변활동을 촉진시켜 복부비만을 감소시킨다.The food composition imparts satiety and promotes bowel movements to reduce abdominal obesity.
본 발명은 식이섬유인 이눌린과 프락토올리고당, 글루코만난 및 레드와인추출물을 함유함으로써 포만감을 부여하면서 배변활동을 촉진시키고 이를 통하여 복부비만 감소를 유도하는데 효과적이며, 부작용없이 장기간 섭취할 수 있다. 또한, 평상시와 동일한 생활을 유지하면서 본 발명의 조성물을 추가적으로 섭취하는 것만으로도 복부비만 감소 효과를 얻을 수 있다.The present invention is effective in inducing bowel activity and inducing abdominal obesity by providing a feeling of satiety by containing inulin, fructooligosaccharide, glucomannan and red wine extracts, which are dietary fibers, and can be consumed for a long time without side effects. In addition, it is possible to obtain an abdominal obesity reduction effect only by additionally ingesting the composition of the present invention while maintaining the same life as usual.
본 발명의 식품 조성물은 주성분으로 이눌린 및 프락토올리고당을 함유하고, 보조성분으로 레드와인추출물 및 글루코만난을 함유한다.The food composition of the present invention contains inulin and fructooligosaccharide as main components, and red wine extract and glucomannan as auxiliary components.
이하 본 발명에 대하여 더욱 상세하게 설명한다.Hereinafter, the present invention will be described in more detail.
본 발명의 조성물 중 하나의 성분은 수용성 식이섬유인 이눌린이다. 이눌린(inulin)이란 다당류의 일종으로 자연계에 널리 분포하고 있으며, 달리아(dahlia), 돼지감자, 목향(elecapane) 등의 국화과 식물의 덩이줄기나 치커리(chicory)의 뿌리 등에 콜로이드 상으로 존재하는 물질이다. 그 성질은 전분과는 달리 온수에 용해되며, 그 구조는 수크로오스(sucrose)의 프락토오스(fructose)측에 D-프락토오스가 β-(2→1) 결합에 의해 탈수중합하여 형성된 구조로 이루어져 있다. 식물유래의 이눌린은 다소 차이가 있지만 평균분자량이 2282~17000이다. 이눌린은 난소화성식이섬유일 뿐만 아니라 장내 유익균인 비피더스균의 증식효과에 의한 장내 환경 개선 및 장에서 분비되는 만복호르몬이라고 불리는 GLP-1(Glucagon-Like Peptide-1)의 분비 촉진에도 관여하기 때문에 식이섭취에도 영향을 주는 것으로 알려져 있다. One component of the composition of the present invention is inulin, which is a water soluble fiber. Inulin is a polysaccharide that is widely distributed in the natural world and is present in the form of a colloid in chunks of chrysanthemum plants such as dahlia, pork potato, elecapane, and roots of chicory. . Unlike starch, it dissolves in hot water, and its structure consists of a structure formed by dehydration of D-fractose by the β- (2 → 1) bond on the fructose side of sucrose. . Plant-derived inulin is somewhat different, but has an average molecular weight of 2282-17000. Inulin is not only an indigestible dietary fiber but is also involved in improving the intestinal environment due to the proliferative effect of the intestinal beneficial bacterium, Bifidus, and in promoting the secretion of GLP-1 (Glucagon-Like Peptide-1), which is released from the intestine. It is also known to affect intake.
상기 이눌린의 함유량은 단회 섭취 용량을 기준으로 하여 건조 중량으로 3 내지 25중량g이 바람직하며, 건강기능식품으로 고려하였을 때 3 내지 15중량g을 포함하는 것이 더욱 바람직하다. 3중량g 미만인 경우에는 상기와 같은 효과를 발휘할 수 없으며 25중량g 초과일 경우에는 함유량 증가에 따른 효과 증진을 기대할 수 없기 때문이다.The content of the inulin is preferably 3 to 25 wt.g in dry weight based on a single intake dose, and more preferably 3 to 15 wt.g in consideration of health functional food. If it is less than 3g by weight can not exhibit the same effect as above, if it is more than 25g by weight can not be expected to increase the effect of increasing the content.
본 발명의 조성물 중 다른 성분은 프락토올리고당이다. 프락토올리고당은 수크로오스(sucrose)에 프락토오스(fructose) 1 내지 3분자가 β-(2,1) 결합하여, 1-케토오스(1-ketose GF2), 니스토스(Nystose GF3) 및 프락토실 니스토스(Fructosyl nystose GF4)로 이루어진 올리고당으로서 아스파라거스, 양파, 돼지감자, 치커리 등에 널리 분포되어 있다. 프락토올리고당은 저칼로리면서 유산균과 비피더스균의 증식인자, 장내 세균총의 개선, 유해균 성장 억제, 배변성질 개선, 면역력 강화 등의 기능성이 밝혀져 있으며 일부 프락토올리고당의 경우 칼슘흡수 증진 효과를 증가시키기도 한다. 미국 특허 제 5,827,526호에 따르면 하루 0.5 내지 5g의 프락토올리고당을 섭취하면 설사를 억제하는 효과가 있다고 개시하고 있으며 대한민국 특허공개 제 2000-57520호는 프락토올리고당과 갈락토올리고당을 혼합한 물질로 섭취 시켰을 때, 장내 흐름을 향호한 상태로 개선하여 정장효과가 발현되고, 배변활동에도 긍정적인 결과가 도출되었음을 개시하고 있다.Another component in the composition of the present invention is fructooligosaccharide. Fructooligosaccharide is β- (2,1) -binding of 1 to 3 molecules of fructose (sucrose) to sucrose, 1-ketose (1-ketose GF2), Nystose GF3 and fructosyl Oligosaccharide consisting of nythose (Fructosyl nystose GF4) is widely distributed in asparagus, onion, pork potato, chicory. Fructooligosaccharides are low-calorie and have been shown to have functional properties such as growth factors of lactic acid bacteria and bifidus bacteria, improvement of intestinal flora, inhibition of harmful bacteria growth, improvement of bowel quality, and immunity enhancement. Some fructooligosaccharides increase calcium absorption enhancement effects. According to U.S. Patent No. 5,827,526, ingestion of 0.5-5 g of fructooligosaccharides per day has the effect of inhibiting diarrhea, and Korean Patent Publication No. 2000-57520 discloses a mixture of fructooligosaccharides and galactooligosaccharides. In this case, the intestinal flow is improved to a favorable state, and a formal effect is expressed, and positive results have been obtained for bowel movements.
상기 프락토올리고당의 함유량은 단회 섭취 용량을 기준으로 하여 건조중량으로 0.5 내지 10 중량g이 바람직하다. 상기 주성분 조성물인 이눌린과 동시에 섭취할 경우 더욱 바람직하게는 0.5 내지 5중량g 미만이 가장 바람직하다. 0.5중량g 미만일 경우에는 상기와 같은 효과를 발휘할 수 없고, 10중량g 초과일 때는 설사 유발 및 속이 더부룩함과 같은 특이적인 부작용을 초래할 수 있기 때문이다.The content of fructooligosaccharide is preferably 0.5 to 10 g by weight in dry weight based on a single intake dose. When ingested at the same time as the main ingredient composition inulin, more preferably less than 0.5 to 5g by weight is most preferred. If the amount is less than 0.5g, the above effects may not be exhibited. If the amount is less than 10g, it may cause specific side effects such as diarrhea and bloat.
본 발명의 조성물 중 다른 성분은 레드와인추출물이다. 레드와인추출물은 레드와인을 구성하고 있는 85%의 수분을 제거한 물질로 알코올, 비타민, 당분, 유기산, 각종 미네랄 및 폴리페놀을 함유하고 있다. 특히 와인에 함유되어 있는 폴리페놀은 활성산소를 제거하는 항산화제 역할을 하고 콜레스테롤 산화도 억제하며, 케르세틴으로 알려진 강한 항암 물질뿐만 아니라 박테리아를 제거하고 해독 역할을 하는 PST-P라는 효소도 가지고 있다. 또한 레드와인에 함유된 젖산균과 글리세린은 소화불량과 변비에 좋으며, 포도당과 과당은 장의 소화흡수 촉진에 도움을 준다. Another component of the composition of the present invention is a red wine extract. Red wine extract removes 85% of the water that constitutes red wine and contains alcohol, vitamins, sugars, organic acids, various minerals and polyphenols. In particular, the polyphenols contained in wine act as antioxidants to remove free radicals, inhibit cholesterol oxidation, and have a strong anti-cancer substance known as quercetin, as well as an enzyme called PST-P that removes bacteria and plays a role in detoxification. In addition, lactic acid bacteria and glycerin contained in red wine are good for indigestion and constipation, and glucose and fructose help promote digestive absorption of the intestine.
상기 레드와인추출물의 함량은 단회 섭취용량을 기준으로 하여 건조중량으로 0.01 내지 2 중량g이 바람직하며, 더욱 바람직하게는 0.01 내지 0.5 중량g이 바람직하다. 이는 0.01중량g 미만일 경우에는 상기와 같은 효과를 발휘할 수 없고, 2중량g를 초과하여 함유될 시에는 레드와인의 맛과 향이 관능적인 부분에서 크게 작용할 수 있기 때문이다.The red wine extract is preferably 0.01 to 2 g by weight, more preferably 0.01 to 0.5 g by weight based on a single intake dose. This is because when less than 0.01% by weight can not exhibit the same effect, when contained in more than 2% by weight because the taste and aroma of the red wine can act largely in the sensual part.
본 발명의 조성물 중 다른 성분은 글루만난(일명, 곤약만난)이며, 이는 후기 포만감에 직접적인 영향을 미치는 성분이다. 글루코만난은 곤약을 정제하여 얻어진 저장성 다당류로서, 1분자의 글루코오스와 2분자의 만노오스로 이루어져 있어 글루 코오스와 만노오스가 1:2의 비율로 함유되어 있는 당 이분자가 결합된 소화성 다당체이다. 이것은 분자량이 약 100만인 고분자 화합물로 물에 녹아 점성질을 띤 풀 형태가 되고, 알칼리에 의해 물에 녹지 않는 곤약이 되며 사람의 소화액으로는 잘 소화되지 않는 특성을 가지고 있다. 글루코만난은 1단계로 위에서 수분을 흡수하여 부풀어지고, 2단계로 십이지장에서 콜로이드 상태로 지방분을 포섭하여 교질화가 시작되며, 3단계로 소장에서 수분을 흡수, 숙변과 혼합한다. 이 단계에서는 아직 반유동체이다. 4단계로 대장에서 수분이 흡수되어 교질화가 진행되고, 5단계로 결장에서 교질화하여 변의 형태를 갖추어 마지막으로 숙변과 함께 지방분, 유해균 등을 끌어안고 배설된다. 또한 글루코만난의 경우 수분에 의하여 섭취 후 5분 후부터 팽창하기 시작하여 6시간 후에는 초기 섭취량 대비 200배 이상 팽창하는 성질이 있으므로 후기 포만감 증가에 탁월한 효과를 가진다.Another component in the composition of the present invention is glutmannan (aka konjac mannan), which is a component that directly affects the feeling of late satiety. Glucomannan is a hypotonic polysaccharide obtained by purifying konjac. It is a digestive polysaccharide in which sugar disaccharide is combined, consisting of 1 molecule of glucose and 2 molecules of mannose and containing 1: 2 of glucose and mannose. It is a polymer compound with a molecular weight of about 1 million, and becomes a viscous grass form by dissolving in water. Glucomannan swells by absorbing water from the stomach in the first step, and gelatinization begins by enclosing fat in the colloidal state in the duodenum in the second step, and absorbs water from the small intestine and mixes it with stool in the third step. It is still semi-fluid at this stage. In 4 stages, water is absorbed from the large intestine and gelatinization proceeds. In 5 stages, colonization is performed in the colon to form a stool form. In addition, glucomannan starts to swell 5 minutes after ingestion by water, and after 6 hours, the swelling property is 200 times larger than the initial intake.
상기 글루코만난의 함유량은 단회 섭취 용량을 기준으로 하여 건조중량으로 0.1 내지 5중량g로 할 경우 가장 효과적인 결과를 얻을 수 있다. 이는 0.1 중량g 미만일 경우에는 상기와 같은 효과를 발휘할 수 없고, 5중량g 초과일 때는 함유량 증가에 따른 효과 증진을 기대할 수 없기 때문이다.The content of the glucomannan is most effective when the amount is 0.1 to 5 g by dry weight based on a single intake dose. This is because when it is less than 0.1 wt g, the above effects cannot be exhibited, and when it is more than 5 wt g, it is not possible to expect the effect of increasing the content.
따라서, 본 발명에서는 상기 이눌린, 프락토올리고당, 레드와인추출물 및 글루코만난을 함유함으로써 초기 및 후기 포만감을 증진함과 동시에 배변활동을 촉진함으로써 복부비만 감소에 효과적인 용도로 사용될 수 있다.Therefore, in the present invention, by containing the inulin, fructooligosaccharide, red wine extract and glucomannan can be used for effective use in reducing abdominal obesity by promoting bowel activity while promoting early and late satiety.
본 발명의 조성물은 선택적으로 기타 부형제를 사용하고 적절하게 배합하여 건조분말, 과립제, 캡슐제, 정제, 환제, 음료, 유상액 형태, 다이어트바, 쵸콜렛, 캬라멜 제형, 시리얼 또는 과자류 등으로 제형화하여 건강기능식품 및 일반식품 등으로 사용할 수 있다.The compositions of the present invention may optionally be formulated into dry powders, granules, capsules, tablets, pills, beverages, emulsion forms, diet bars, chocolates, caramel formulations, cereals or confectionary, etc., using other excipients and blending as appropriate. It can be used as health functional food and general food.
이하, 실시예 및 실험예에 의해서 본 발명을 더욱 상세히 설명한다. 하기 실시예 및 실험예는 본 발명을 예시하는 것일 뿐, 본 발명의 내용이 이에 한정되는 것은 아니다. 하기에서 배합량은 중량%로 나타낸다.Hereinafter, the present invention will be described in more detail with reference to Examples and Experimental Examples. The following examples and experimental examples are merely illustrative of the present invention, but the content of the present invention is not limited thereto. In the following, the compounding amount is expressed in weight%.
하기 실험예 1 내지 5에서는 25세 이상 여성 18명을 대상으로 실험을 실시하였으며, 피험자 여성의 평균 연령은 35.8세, 체중 58.3kg, BMI=25.7였다. In Experimental Examples 1 to 5 below, experiments were conducted on 18 women over 25 years old, and the average age of the test subjects was 35.8 years, weight 58.3 kg, and BMI = 25.7.
[참고예][Reference Example]
하기에 나타낸 표 1의 처방대로 원료의 무게를 칭량하고 혼합하여 실시예 1~5 및 비교예의 분말상 조제물을 제조하였다.The powdery preparations of Examples 1 to 5 and Comparative Examples were prepared by weighing and mixing the raw materials as prescribed in Table 1 below.
[실험예 1] 이눌린, 프락토올리고당, 글루코만난 및 레드와인추출물의 포만감 평가 Experimental Example 1 Satiety Evaluation of Inulin, Fructooligosaccharide, Glucomannan and Red Wine Extract
이눌린과 프락토올리고당, 글루코만난 및 레드와인추출물이 포만감에 미치는 영향을 측정하기 위하여 피험자들은 수면 이후 음식물 섭취를 제한하여 공복의 상태에서 섭취 전 포만감을 0으로 산정하고 조식 대용으로 섭취한 후 매 30분 간격으로 느껴지는 포만감을 총 20단계인 0 ± 10으로 나뉘어진 설문지에 기록하였다. 상기 표 1의 함량% 비를 7 중량g 단위로 환산하여 제조한 조성물을 미온수 120㎖에 혼합하여 5분 안에 섭취하도록 하였으며, 비교예로는 전분을 활용하여 비교 평가하였다. 결과는 하기 표 2 및 도 1에 나타내었다.In order to measure the effects of inulin, fructooligosaccharide, glucomannan and red wine on satiety, the subjects limit their food intake after sleep to calculate satiety to zero before intake on an empty stomach, and consume it every 30 minutes after breakfast. The feeling of satiety at intervals was recorded in a questionnaire divided by 0 ± 10, which is a total of 20 levels. The composition prepared by converting the content% ratio of Table 1 in 7 wt g units was mixed with 120 ml of lukewarm water to be consumed within 5 minutes, and compared with the starch as a comparative example. The results are shown in Table 2 and FIG. 1.
상기 표 2 및 도 1의 결과를 보면, 이눌린과 프락토올리고당의 경우 섭취 후 2시간 이전으로 정의할 수 있는 초기 포만감에 영향을 주는 것으로 나타났으며, 글루코만난의 경우 후기 포만감에 보다 큰 효능을 발휘하는 것으로 나타났다. 따라서, 포만감과 관련해서는 이눌린, 프락토올리고당 그리고 글루코만난이 크게 작용함을 알 수 있으며, 레드와인추출물의 경우는 포만감에는 직접적인 영향을 나타내지는 못하는 것을 알 수 있었다. In the results of Table 2 and Figure 1, inulin and fructooligosaccharides were found to affect the initial satiety can be defined as 2 hours before ingestion, Glucomannan exhibited greater efficacy on late satiety Appeared to be. Therefore, it can be seen that inulin, fructooligosaccharide and glucomannan have a great effect on satiety, and red wine extract has no direct effect on satiety.
[실험예 2] 배변활동과 관련된 변화요소 평가Experimental Example 2 Evaluation of Change Factors Associated with Bowel Activity
상기 실시예 5의 조성물을 활용하여 섭취 후 배변횟수와 배변량에 조성물이 미치는 영향을 평가하기 위하여 사전조사로 실험에 참여한 지원자들에게 평상시와 동일하게 생활하면서 3일간의 배변상태를 기록하도록 하였다. 그 후 7일간 실시예 5의 조성물을 섭취할 때 및 섭취 종료 이후 3일간의 배변상태를 기록하도록 하였으며, 결과는 하기 표 3과 같다. In order to evaluate the effect of the composition on the number of bowel movements and bowel movements after ingestion by using the composition of Example 5, the volunteers who participated in the experiment by preliminary investigation were to record the bowel state for 3 days while living as usual. Thereafter, when the intake of the composition of Example 5 for 7 days and 3 days after the end of ingestion was recorded, the results were as shown in Table 3.
* 1회 대변양은 적음, 약간 적음, 보통, 약간 많음, 많음으로 구분.* One large defecation is divided into small, slightly less, normal, slightly more, and more.
** 변의 형태는 단단함, 약간 단단함, 보통, 약간 부드러움, 부드러움으로 구분.** The shape of the side is divided into hard, slightly hard, normal, slightly soft and soft.
상기 표 3의 결과를 보면, 1일 배변횟수는 섭취 전에는 1일 평균 0.76회임에 반하여 섭취 중에는 1.04회로 배변횟수가 36.8% 증가하였으며, 섭취 종료 이후 3일간 측정한 결과에서도 0.94회로 섭취 이전보다 23.7% 증가된 결과를 얻었음을 알 수 있다.In the results of Table 3, the number of bowel movements per day was 0.76 times a day before ingestion, whereas the number of bowel movements increased by 36.8% from 1.04 times during ingestion, and 23.7% compared to 0.94 times before ingestion even after 3 days of intake. It can be seen that an increased result was obtained.
대변을 보고 싶은 반응인 변의에서는 섭취 전에는 70.5%의 지원자만이 변의를 느꼈지만, 섭취 중에는 92.8%로 22.3% 증가하였으며, 섭취 종료 이후에도 83.4%로 13.4% 증가된 결과가 나타났다.In the testimonial, the response to wanting to have a bowel movement, only 70.5% of volunteers felt the variance before ingestion, but during the intake, it increased by 22.8% to 92.8% and increased by 13.4% to 83.4% after the intake.
1회 대변양은 섭취 전에는 보통 이상이라고 느낀 지원자가 46.4%로 다소 적은 편이었으나 섭취 중에는 95.2%, 섭취 후에는 78.5%로 각각 48.8%, 32.1% 증가된 결과를 얻었다. In the case of single stool, 46.4% of volunteers felt more than normal before ingestion, but it was increased by 48.8% and 32.1% to 95.2% during ingestion and 78.5% after ingestion, respectively.
변의 형태는 약간 부드러움 이상이라고 답변한 지원자가 섭취 전에는 42.9%인 반면, 섭취 중에는 112.6%로 2.5배 이상 증가하였으며, 섭취 후에도 90.2%로 2배 이상의 증가 결과가 나타났다.42.9% of volunteers answered that the stool was slightly softer than before, while the intake increased by 112.6% to 2.5 times and 90.2% after the intake.
[실험예 3] 체중 및 체지방, 복부 비만 감소에 관한 평가Experimental Example 3 Evaluation on Weight, Body Fat and Abdominal Obesity Reduction
상기 실시예 5의 조성물을 활용하여 8주간 섭취 후 포만감과 배변활동 촉진이 체중 및 체지방, BMI, 체지방율(%), WHR, 내장지방면적 변화에 미치는 영향을 평가하기 위하여 섭취 시작 전과 섭취 시작 후 4주±5일, 섭취 시작 후 8주±7일 총 3회에 걸쳐 InBody 4.0(바이오스페이스사, 전기임피던스 활용 측정기)으로 측정한 결과는 하기 표 4와 같다. 측정 시에는 옷에 의한 편차를 줄이기 위하여 측정 당일에는 동일한 복장을 입도록 하였으며 기계적 측정 오차를 최소화하기 위하여 착용하고 있는 금속성분은 모두 탈의 후 측정에 임하도록 하였다. Before and after the start of intake to evaluate the effects of satiety and bowel movement promotion on weight and body fat, BMI, body fat percentage (%), WHR, visceral fat area change after 8 weeks of ingestion using the composition of Example 5 Three days a week ± 5 days, 8 weeks ± 7 days after the start of intake measured by InBody 4.0 (Biospace, electric impedance utilization meter) is shown in Table 4 below. During the measurement, the same clothing should be worn on the day of measurement to reduce the deviation caused by clothing. To minimize the mechanical measurement error, all worn metals were measured after undressing.
수치는 평균치±표준편차를 나타낸다.The numerical values represent mean ± standard deviation.
* 는 t-test 결과 섭취 전에 비해 섭취 후 유의한 차이가 있음을 의미한다(p < 0.05)* Indicates a significant difference after ingestion compared to before ingestion of t-test results (p <0.05)
BMI(체질량지수) = Body Mass Index = Body weight(kg) / height(㎡)BMI (Body Mass Index) = Body Mass Index = Body weight (kg) / height (㎡)
WHR : Waist-Hip RatioWHR: Waist-Hip Ratio
내장지방(Visceral Fat Area, ㎠)Visceral Fat Area (㎠)
통계는 통계프로그램인 미니탭을 이용하여 처리하였으며, 실험에 참여한 지원자 중 80% 미만의 제품 섭취 순응도를 가진 인원 2명은 통계처리에서 제외하였다.Statistics were processed using Minitab, a statistical program, and 2 persons with less than 80% compliance with product intake were excluded from the statistical process.
상기 표 4의 결과와 같이 체중에서는 4주 섭취 후 감소하는 경향은 있었지만 유의적인 차이는 나타나지 않았으며, 8주 섭취 후에는 초기 체중 대비하여 유의적인 차이(P<0.05)가 나타났다. 체지방율(%)도 4주 섭취 후에 유의적인 차이를 나타냈으며, 복부지방 감소량을 판단하는 지표인 WHR과 내장지방에서도 유의적인 결과를 나타내는 것을 통하여 포만감을 부여하면서 배변활동을 원활하게 하는데 도움을 주는 것이 체중 및 복부비만을 감소하는데 직접적인 효과를 발현하는 것을 알 수 있었다.As shown in the results of Table 4, the weight tended to decrease after 4 weeks of ingestion, but no significant difference appeared. The percentage of body fat (%) also showed a significant difference after 4 weeks of ingestion, and WHR and visceral fat, which are indicators of abdominal fat loss, also showed significant results to help improve bowel movements while giving satiety. It was found to express a direct effect on reducing body weight and abdominal obesity.
도 1은 실시예 1~5 및 비교예의 포만감을 평가한 그래프이다.1 is a graph evaluating satiety of Examples 1 to 5 and Comparative Examples.
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Cited By (4)
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WO2010140182A1 (en) * | 2009-06-05 | 2010-12-09 | Lorenzo Caramelli | Food compositions comprising flour, glucomannan and a mixture of soluble prebiotic fibres and process for the preparation thereof |
WO2014020344A1 (en) * | 2012-07-31 | 2014-02-06 | Imperial Innovations Limited | Compounds and their effects on appetite control and insulin sensitivity |
CN104095180A (en) * | 2013-04-12 | 2014-10-15 | 中国科学院烟台海岸带研究所 | Probiotics inulin sheet and preparation method thereof |
CN104939082A (en) * | 2015-06-02 | 2015-09-30 | 西安膳方医药科技有限公司 | Composite prebiotic and preparation method thereof |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2010140182A1 (en) * | 2009-06-05 | 2010-12-09 | Lorenzo Caramelli | Food compositions comprising flour, glucomannan and a mixture of soluble prebiotic fibres and process for the preparation thereof |
WO2014020344A1 (en) * | 2012-07-31 | 2014-02-06 | Imperial Innovations Limited | Compounds and their effects on appetite control and insulin sensitivity |
US9642875B2 (en) | 2012-07-31 | 2017-05-09 | The University Court Of The University Of Glasgow | Compounds and their effects on appetite control and insulin sensitivity |
CN104095180A (en) * | 2013-04-12 | 2014-10-15 | 中国科学院烟台海岸带研究所 | Probiotics inulin sheet and preparation method thereof |
CN104939082A (en) * | 2015-06-02 | 2015-09-30 | 西安膳方医药科技有限公司 | Composite prebiotic and preparation method thereof |
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