KR20090005937A - Powder having anti-inflammatory and anti-atopic activity, medicine, soap and building materials manufactured by the same - Google Patents
Powder having anti-inflammatory and anti-atopic activity, medicine, soap and building materials manufactured by the same Download PDFInfo
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- KR20090005937A KR20090005937A KR1020070109778A KR20070109778A KR20090005937A KR 20090005937 A KR20090005937 A KR 20090005937A KR 1020070109778 A KR1020070109778 A KR 1020070109778A KR 20070109778 A KR20070109778 A KR 20070109778A KR 20090005937 A KR20090005937 A KR 20090005937A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
Description
본 발명은 항염, 항부종, 항아토피성 및 가려움증 진정성이 우수한 항염 및 항아토피성 분말, 이를 이용하여 제조된 약제, 비누 및 인테리어용 자재에 관한 것으로서, 상세하게는 증자된 닥속대를 건조한 후 분말화된 닥속대 분말을 포함하여 이루어진 것을 특징으로 하는 항염 및 항아토피성 분말, 이를 이용하여 제조된 약제, 비누 및 인테리어용 자재에 관한 것이다.The present invention relates to an anti-inflammatory and anti-atopic powder having excellent anti-inflammatory, anti-edema, anti-atopic and itching sedation, pharmaceuticals, soaps, and interior materials prepared using the same, and in particular, powder after drying the pot It relates to an anti-inflammatory and anti-atopic powder, characterized in that it comprises a shamrock powder, pharmaceuticals, soaps and interior materials prepared using the same.
닥나무는 쌍떡잎식물 쐐기풀목 뽕나무과의 낙엽활엽 관목에 해당하는 다년생식물로서, 한지 등의 종이를 만들기 위하여 예전부터 널리 사용되고 있다.It is a perennial plant that corresponds to the deciduous broad-leaved shrubs of the dicotyledonous nettle mulberry, and has been widely used in the past to make paper such as Hanji.
닥나무를 이용하여 전통 한지를 제조하는 방법은 먼저 줄기를 1~2m로 잘라 밀폐된 솥에 넣고 증기로 찐 다음 꺼내에 닥껍질을 벗겨낸 말린다. 그리고 말린 닥 껍질을 물에 불린 후 표피를 긁어 벗겨 백피를 얻는다. 그리고 백피를 양잿물어 섞어 3시간 이상 삶아 압축기로 물을 짜낸다. 여기에 닥풀뿌리를 으깨어 짜낸 끈적끈적한 물을 넣고 잘 혼합하여 고루 풀리게 한 후 발로 종이물을 걸러서 뜬 후 건조시키면 전통 한지가 제조된다.The traditional method of making traditional Korean paper using paper mulberry is to cut the stem into 1 ~ 2m, put it in a closed pot, steam it with steam, and take out the dried bark. Then, the dried peeled bark is soaked in water, and the cuticle is scraped off to get white skin. Then mix the white skin and boil it for more than 3 hours and squeeze out the water with a compressor. Here, add the sticky water crushed scallop root, mix well, let it loosen, filter the paper with your feet, float it, and dry it.
이와 같이, 닥나무 중 닥나무의 껍질인 닥껍질만 한지 등의 종이를 제조하는데 이용하고, 닥속대는 들판에 버려져 폐기되고 있는 실정이고, 현재 폐기물로서 버려지고 있는 닥속대의 활용방안에 대해 전혀 논의되고 있지 않다.In this way, it is used to manufacture paper such as only the bark of the mulberry among the mulberry, and the mulberry is being discarded and discarded in the field, and there is no discussion on the utilization method of the mulberry that is discarded as waste. .
본 발명자는 현재 폐기물로서 버려지고 있는 닥속대의 활용방안에 대해 여러 방면으로 연구개발한 결과 닥속대에 항염, 항아토피 및 가려움증 진정효과 등이 있음을 발견하였다.The present inventors have researched and developed various applications of Daksak as currently wastes, and found that Daksack has anti-inflammatory, anti-atopic and itching effects.
본 발명은 폐기물인 닥속대를 활용하여 항염, 항부종, 항아토피 및 가려움 진정성이 우수한 항염 및 항아토피성 분말 및 이를 이용하여 제조된 항염 및 항아토피제, 비누 및 인테리어용 자재를 제공함에 그 목적이 있다.An object of the present invention is to provide an anti-inflammatory and anti-atopic powder, excellent anti-inflammatory, anti-edema, anti-atopic and itching sedation by using the sesame, which is a waste material, and an anti-inflammatory and anti-atopic agent, soap and interior materials prepared using the same. There is this.
상기와 같은 목적을 달성하기 위한 본 발명은, 증자된 닥속대를 건조한 후 분말화된 닥속대 분말을 포함하여 이루어진 것을 특징으로 하는 항염 및 항아토피 효능을 갖는 분말을 제공한다..The present invention for achieving the above object, it provides a powder having anti-inflammatory and anti-atopic efficacy, characterized in that comprising dried powdered mulberry powder after drying the steamed mulberry.
그리고 상기 항염 및 항아토피 효능을 갖는 분말이 함유된 것을 특징으로 하는 항염 및 항아토피성 약제를 제공한다.And it provides an anti-inflammatory and anti-atopic drug characterized in that the powder containing the anti-inflammatory and anti-atopic efficacy.
또한 상기 항염 및 항아토피 효능을 갖는 분말이 함유된 것을 특징으로 하는 항염 및 항아토피성 비누를 제공한다.It also provides an anti-inflammatory and anti-atopic soap, characterized in that the powder containing the anti-inflammatory and anti-atopic efficacy.
상기 항염 및 항아토피 효능을 갖는 분말이 함유된 것을 특징으로 하는 항염 및 항아토피성 화장품을 제공한다.It provides an anti-inflammatory and anti-atopic cosmetics, characterized in that the powder containing the anti-inflammatory and anti-atopic efficacy.
아울러 항염 및 항아토피 효능을 갖는 분말이 함유된 것을 특징으로 하는 항염 및 항아토피성 인테리용 자재를 제공한다.In addition, it provides an anti-inflammatory and anti-atopic dermatitis material, characterized in that the powder containing anti-inflammatory and anti-atopic efficacy.
이하, 본 발명의 항염 및 항아토피 효능을 갖는 분말, 이를 함유한 약제, 비누, 화장품 또는 인테리어 자재에 대해 설명한다.Hereinafter, the powder having an anti-inflammatory and anti-atopic effect of the present invention, drugs containing the same, soap, cosmetics or interior materials will be described.
본 발명의 항염 및 항아토피 효능을 갖는 분말은 닥속대를 증자 및 건조시킨 후 분말화한 닥속대 분말을 포함하여 이루어진다.Powder having the anti-inflammatory and anti-atopic efficacy of the present invention comprises powdered mulberry powder powder after drying and drying the mulberry.
닥속대를 증자시키는 방법은 닥나무를 통째로 증자시켜 닥속대를 증자시킬 수 있고, 또한 닥나무의 닥껍질을 벗겨내어 얻어진 닥속대를 증자시킬 수 있는 등 크게 한정되는 것은 아니다.The method of increasing the amount of mulberry is not limited to the fact that the whole mulberry can be increased to increase the mulberry, and also the mulberry obtained by peeling the mulberry of the mulberry can be increased.
그리고 상기 증자된 닥속대를 햇빛 또는 그늘에서 자연건조시키거나, 열풍, 원적외선 등을 이용하여 건조시킨 후 건조된 닥속대를 분쇄기를 이용하여 미분화하여 분말화한다.The dried mulberry is naturally dried in sunlight or shade, or dried using hot air, far-infrared rays, etc., and then the dried mulberry is powdered by micronization using a grinder.
이와 같이 제조된 닥속대 분말은 항염 및 항아토피효능이 우수할 뿐만 종래에 폐기물로 버려진 닥속대를 이용함에 따라 폐기물을 재활용할 수 있는 이점이 있다.Thus prepared mulberry powder is excellent in anti-inflammatory and anti-atopic efficacy, and there is an advantage that can be recycled waste by using a conventional dumpling dumped as waste.
상기 닥속대 분말을 그대로 사용할 수 있을 뿐만 아니라 다른 기능성물질과 혼합하여 사용할 수 도 있다.The mulberry powder may be used as it is, as well as mixed with other functional materials.
이러한 본 발명의 항염 및 항아토피 효능을 갖는 분말을 이용하여 항염 및 항아토피의 효능을 갖는 약제, 비누, 화장품 및 인테리용 자재로서 널리 사용할 수 있다.By using the powder having the anti-inflammatory and anti-atopic efficacy of the present invention, it can be widely used as a material for drugs, soaps, cosmetics and interiors having the anti-inflammatory and anti-atopic efficacy.
상기 비누는 통상의 비누, 샴푸, 린스 등을 포함한다. 그리고 상기 인테리용 자재로서는 벽지, 바닥재, 건축내장재, 몰딩 등 기타 자재로서 사용할 수 있고, 이와 같이 인테리용 자재에 항아토피성이 우수한 분말 및 추출액을 함유됨으로써, 친환경적인 실내분위기를 연출할 수 있는 이점이 있다.The soaps include conventional soaps, shampoos, rinses and the like. In addition, the interior material may be used as wallpaper, flooring, building interior materials, molding, or other materials. As such, the interior material contains powders and extracts having excellent anti-atopic properties, thereby creating an environment-friendly indoor atmosphere. have.
이와 같은 본 발명은 항염, 항부종, 항아토피 및 가려움증 진정효과가 우수할 뿐만 아니라 종래에 폐기물로서 들판에 버려지는 닥속대를 이용하여 제조됨에 따라 폐기물을 재활용할 수 있는 효과가 있다.As described above, the present invention not only has excellent anti-inflammatory, anti-edema, anti-atopic and itching effect, but also has the effect of recycling waste according to the conventional manufacture of the dumplings discarded in the field as waste.
이하, 본 발명을 실시예를 들어 더욱 상세하게 설명하면 다음과 같고, 본 발명의 권리범위는 하기의 실시예에 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to Examples. The scope of the present invention is not limited to the following Examples.
[실시예 1]Example 1
닥나무를 통째로 120℃에서 증자시킨 후 닥껍질을 벗겨내어 증자된 닥속대를 얻었다. 그리고 증자된 닥속대를 12~14 시간 동안 자연건조시킨 후 분쇄기를 이용하여 평균입도 400mesh의 닥속대 분말을 얻었다.The whole mulberry was increased at 120 ° C., and then the bark was peeled off to obtain the dried mulberry. The dried mulberry was dried for 12 to 14 hours and then dried to obtain an average particle size of 400 mesh mulberry powder.
이와 같이 제조된 닥속대 분말을 하기의 방법에 의하여 항염증, 항부종 및 항아토피의 효능을 실험하였다. Solanum powder prepared as described above was tested for the efficacy of anti-inflammatory, anti-edema and anti-atopy by the following method.
[닥속대 분말의 추출물 제조][Preparation of Extract of Radix Powder]
추출기에 닥속대 분말 100g과 증류수 2kg을 투입한 후 100℃에서 6시간동안 가열하여 추출한 후 냉각 및 여과하여 닥속대 분말의 추출물을 제조하였다.100 g of Daksakdae powder and 2 kg of distilled water were added to the extractor, and the extract was heated and extracted at 100 ° C. for 6 hours, and then cooled and filtered to prepare extracts of Daksakdae powder.
[항염증 및 항부종 효능 실험][Anti-inflammatory and anti-edema efficacy test]
대식세포주인 Raw 264.7 세포를 24 well plate에 분주시키고, 분주된 세포들을 CO2 인큐베이터내에서 24시간 배양하였다. PBS로 세척한 후 세포가 부착되어 있는 각 well에 1㎍/㎖의 LPS가 포함된 배지 190㎛씩을 넣고, 닥속대 분말의 추출물 10㎕ 처리하여 18시간 배양하였고, 배양 후 arachidonic acid의 최종농도가 30μM이 되도록 15분간 처리하였다. 상측액을 분리하고 PGE2 생성량을 키트를 이용하여 정량하였으며, PGE2 분비억제율을 하기의 수학식 1의 방법으로 계산하였고, PGE2 분비억제율은 78%로서 뛰어난 항염증효과를 나타내었다.Raw 264.7 cells, a macrophage line, were divided into 24 well plates and the divided cells were incubated for 24 hours in a CO 2 incubator. After washing with PBS, each well to which the cells were attached was added 190 µm of medium containing 1 µg / ml LPS, and 10 µl of extracts of the powders of the mulberry powder were incubated for 18 hours. After the incubation, the final concentration of arachidonic acid was incubated. The treatment was carried out for 15 minutes to 30 μM. The supernatant was separated and PGE 2 production was quantified using the kit. PGE 2 secretion inhibition rate was calculated by the method of Equation 1 below, and PGE 2 secretion inhibition rate was 78%, indicating an excellent anti-inflammatory effect.
수학식Equation 1 One
PGE2 분비억제율(%) = [1-(B/A)]×100PGE 2 secretion inhibition rate (%) = [1- (B / A)] × 100
A: 닥속대 분말의 추출물을 처리하지 않은 대조군의 450nm 흡광도A: 450 nm absorbance of the control group not treated with the extract of the pounding
B: 닥속대 분말의 추출물을 처리한 비교군의 450nm 흡광도B: 450 nm absorbance of the control group treated with the extract of the mulberry powder
[항히스타민 억제효과 실험][Antihistamine Inhibitory Effect Experiment]
비만세포를 24 well plate에 1×106cells/㎖ 농도가 되도록 분주하고, 2시간 이 경과한 후 항-DNP를 DMEM 배지와 1:1,000비율로 1㎖를 첨가하여 37℃ CO2 Incubator에서 24시간동안 배양하였다. 닥속대 분말의 추출물을 50㎕ 처리하여 10분간 배양한 후 DNP BSA를 1㎍/㎖을 첨가하여 37℃에서 30분간 배양하여 히스타민을 유리시켰다. 히스타민 유리억제율은 하기의 수학식 2의 방법으로 계산하였고, 히스타민 유리억제율은 39%로서 우수한 항히스타민 억제효과를 나타냈다.The mast cells in the 24 well plate 1 × 10 6 cells / ㎖ dispensed so that the concentration, and after the second time, wherein the -DNP DMEM medium with 1: 1,000 was added to 1㎖ ratio at 37 ℃ CO 2 Incubator 24 Incubated for hours. 50 µl of the extracts of the mulberry powder were incubated for 10 minutes, and 1 µg / ml of DNP BSA was added thereto, followed by incubation for 30 minutes at 37 ° C to release histamine. The histamine free inhibition was calculated by the method of Equation 2 below, and the histamine free inhibition was 39%, indicating an excellent antihistamine inhibitory effect.
수학식Equation 2 2
히스타민 유리억제율(%) = [1-(B/A)]×100Histamine release ratio (%) = [1- (B / A)] × 100
A: 닥속대 분말의 추출물을 처리하지 않은 대조군의 450nm 흡광도A: 450 nm absorbance of the control group not treated with the extract of the pounding
B: 닥속대 분말의 추출물을 처리한 비교군의 450nm 흡광도B: 450 nm absorbance of the control group treated with the extract of the mulberry powder
위 항염증 및 항부종 효능 실험 및 항히스타민 억제효과 실험 결과에서 확인되는 바와 같이 본 발명의 항염 및 항아토피성 분말은 항염 및 항히스타민 등의 항아토피 효과가 우수하다.As shown in the gastric anti-inflammatory and anti-edema efficacy test and antihistamine inhibitory results, the anti-inflammatory and anti-atopic powder of the present invention is excellent in anti-atopic effects such as anti-inflammatory and anti-histamine.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012002782A2 (en) * | 2010-07-02 | 2012-01-05 | 주식회사 아모레퍼시픽 | Skin-whitening composition for external application on skin containing extracts from paper mulberry flowers and fruits |
| WO2012002784A2 (en) * | 2010-07-02 | 2012-01-05 | (주)아모레퍼시픽 | Composition containing paper mulberry extracts |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR101951156B1 (en) | 2018-09-07 | 2019-02-21 | 고가인 | Method for manufacturing the soap, the soap containing the geumhwagyu, and the geumhwagyu soap manufactured by the method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100361090B1 (en) * | 2000-08-02 | 2002-11-18 | 강삼식 | A novel prenylated flavonoid-type compound showing antiinflammatory activity purified from Broussonetia papyrifera and extracts containing the said compound as a major component, a method for preparing them and pharmaceutical compositions containing them |
| KR100492517B1 (en) * | 2002-03-07 | 2005-06-03 | 장형수 | Manufacturing apparatus for bast fibers paper using bast fibers extracted from paper mulberry tree, manufacturing methode of the same and bast fibers paper thereby |
| KR100530318B1 (en) * | 2003-12-05 | 2005-11-22 | 재단법인서울대학교산학협력재단 | Composition comprising papyriflavonol A for control of microorganism |
| KR100757949B1 (en) * | 2006-07-31 | 2007-09-11 | 안치용 | Method for producing the korean traditional paper tile comprising herbs |
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2007
- 2007-10-30 KR KR1020070109778A patent/KR101049973B1/en active IP Right Grant
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012002782A2 (en) * | 2010-07-02 | 2012-01-05 | 주식회사 아모레퍼시픽 | Skin-whitening composition for external application on skin containing extracts from paper mulberry flowers and fruits |
| WO2012002784A2 (en) * | 2010-07-02 | 2012-01-05 | (주)아모레퍼시픽 | Composition containing paper mulberry extracts |
| WO2012002784A3 (en) * | 2010-07-02 | 2012-05-03 | (주)아모레퍼시픽 | Composition containing paper mulberry extracts |
| WO2012002782A3 (en) * | 2010-07-02 | 2012-05-03 | 주식회사 아모레퍼시픽 | Skin-whitening composition for external application on skin containing extracts from paper mulberry flowers and fruits |
| CN103037880A (en) * | 2010-07-02 | 2013-04-10 | 株式会社爱茉莉太平洋 | Composition containing paper mulberry extracts |
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| Publication number | Publication date |
|---|---|
| KR101049973B1 (en) | 2011-07-15 |
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