KR20080101408A - Composition for aid to stop smoking and its manufacturing method - Google Patents

Abstract

A composition for the smoking cessation assistance and the manufacturing method thereof are provided to remove the temporary nicotine withdrawal symptom by the prohibition of smoking. A composition for the smoking cessation assistance comprises: solvent extract of the mixture of dried bupleuri radix radical 11~14 weight%, dried scutellariae radix radical 8~11 weight%, dried liquorice root 5~8 weight%, dried anemarrhenae rhizoma radical 5~8 weight%, dried liriopis tuber lump root 5~8 weight%, dried gardenia berries 5~8 weight%, dried gentianae scabrae radix radical 5~8 weight%, dried coptidis rhizoma radical 5~8 weight%, dried asparagus cochinchinensis lump root 5~8 weight%, dried ginseng 5~8 weight%, dried acori graminei rhizoma 16~22 weight%, as an active ingredient.

Description

Auxiliary composition for smoking cessation and its manufacturing method

The present invention relates to a non-smoking auxiliary composition and a method for manufacturing the same, and more specifically, 11 specific herbal medicines, which have been used in traditional medicine as a medicinal herb and whose stability has been proven, and extracts suitable for taking the selected herbal medicines. The present invention relates to a non-smoking supplement composition and a method for manufacturing the same, which have almost no side effects or harm caused by taking and can remove the temporary withdrawal phenomenon due to smoking cessation while lowering the taste of tobacco by smoking.

In Korea, cigarettes are a favorite item of male and female adults.

Generally, cigarettes are known to contain various toxic substances such as nicotine, tar and carbon monoxide and about 20 kinds of carcinogens. Among them, carbon monoxide interferes with oxygen transport of blood and impairs metabolism, causing premature aging. Nicotine may also stimulate the peripheral blood vessels to increase blood pressure, which may provide an arousing effect, but may cause ulcers in atherosclerosis and digestive system, especially intoxication, making it difficult to quit smoking, and when tar accumulates into the lungs, It is known to act as a major cause of various lung diseases.

Specifically, the diseases caused by smoking lungs are medically reported as lung cancers, as well as many cancer diseases such as oral cavity, larynx, esophagus, bladder, kidney, stomach, pancreas, and cervix, as well as cardiovascular diseases and chronic obstructive pulmonary diseases. have.

However, in recent years, the age of smoking, including adolescents, gradually decreases and the harmful effects of smoking due to cigarettes are widely known, and the awareness of cigarettes is heightened, resulting in a smoking cessation craze.

However, as described above, smokers who are addicted to tobacco by nicotine are often abandoned due to withdrawal even if they try to quit.

Specifically, the withdrawal phenomenon caused by smoking refers to the mental and physical symptoms that occur when a smoker is addicted to nicotine in a cigarette and then stops smoking. Generally, physical symptoms include sneezing, sputum, itching, headache, Constipation, diarrhea, vomiting and the like, and mental symptoms such as insomnia, pain, anxiety, deprivation, concentration concentration, hallucinations, delusions, smoking desire is known to appear.

Accordingly, the present inventors have attempted to develop a stable smoking cessation composition with little toxicity or side effects while relieving withdrawal and smoking urges and lowering the taste of cigarettes, ultimately making smoking cessation smoothly, when quitting smoking. .

However, ginseng, astronomical dong, rhubarb, gentian, gardenia fruit, macmundong, jimo-geun, licorice, golden, shiho and Seokchangpo mixed extracts have been used to alleviate the withdrawal phenomenon as a composition for aiding smoking. Data have not been disclosed yet.

An object of the present invention is to provide a non-smoking auxiliary composition containing a mixed extract of ginseng, astronomical dong, rhubarb, gentian, gardenia fruit, mackmundong, jimo-geun, licorice, golden, siho and Seokchangpo as an active ingredient.

In addition, another object of the present invention to provide a method for preparing the smoking cessation auxiliary composition.

In order to achieve the above object, the present invention is dried ginseng root 5 ~ 8% by weight, dried astronomical tuberculosis root roots 5 ~ 8% by weight, dried yellow lotus root 5 ~ 8% by weight, dried gentian root 5 ~ 8% by weight, dried 5-8% by weight of Gardenia fruit, 5-8% by weight of dried wormwood roots, 5-8% by weight of dried hair roots, 5-8% by weight of dried licorice root, 8-11% by weight of dried golden root. Provided is a non-smoking auxiliary composition containing as an active ingredient a solvent extract of a mixture of 11-14% by weight of dried Shiho-geun and 16-22% by weight of dried Seokchang-po.

In addition, in order to achieve another object, the present invention is dried dried ginseng root 5 ~ 8% by weight, dried astronomical dong dong root 5 ~ 8% by weight, dried yellow lotus root 5 ~ 8% by weight, dried gentian root 5 ~ 8% by weight, dried 5-8% by weight of Gardenia fruit, 5-8% by weight of dried wormwood roots, 5-8% by weight of dried hair roots, 5-8% by weight of dried licorice root, 8-11% by weight of dried golden root. Provided is a method for producing a non-smoking auxiliary composition, characterized in that the mixture is mixed with 11 ~ 14% by weight of dried shiho root and 16 ~ 22% by weight dried rhizome roots in a solvent of water or alcohol.

Hereinafter, the present invention will be described in detail.

At this time, if there is no other definitions in the technical terms and scientific terms used herein, those having ordinary skill in the art to which this invention belongs have the meaning that is commonly understood.

In addition, repeated description of the same technical configuration and operation as in the prior art will be omitted.

The present invention by selecting 11 specific herbal medicines that have been used in traditional medicine as a herbal medicine has been proven to be stable, and manufactured by extracts suitable for taking the selected herbal medicine, there are almost no side effects or harms caused by the use of smoking It has been developed a composition for smoking cessation aids that can remove the temporary withdrawal caused by smoking cessation while lowering the taste of tobacco.

The composition for smoking cessation aid of the present invention is easy to take, in order to eliminate the rejection, dried ginseng root, dried astronomical dong dong root, dried rhododendron root, dried gentian root, dried gardenia fruit, dried gingko dong tuberculum, dried Jimi root, dried licorice Root, dried golden root. Eleven mixtures consisting of dried Shihogeun and dried Seokchangpo were used as extracts of non-smoking components using an extraction solvent.

At this time, it is preferable to use water or alcohol such as methanol or ethanol as the extraction solvent. This is because by using an extraction solvent that is harmless to the human body or minimizes harm, such as water and alcohol described above, it is possible to eliminate the additional removal of the residual solvent that is stable to the human body and harmful to the human body in the extract.

However, the herbal extracts according to the present invention are not limited to the above-described extraction solvents, and any extraction solvents suitable for the purpose of the present invention may be used.

The water used in the present invention refers to water suitable for drinking standards based on the Ministry of Health, and generally can be purified water filtered through a filter or water purifier, sterilized water, anion water, tap water, bottled water and the like.

The dried herbal medicine in the present invention refers to a herbal medicine dried in a natural state or dried in an artificial dryer, and in particular, it is preferable to use the dried herbal medicine in a state in which the total weight of the medicine does not vary within 6% during the drying period.

In the present invention, the tuber root is also known as goose root (塊根), the root is fat to store nutrients.

In the present invention, the extract may be in the form of a liquid or a solid, and in the case of a solid, it refers to one prepared by hot-air drying, vacuum drying or spray drying of the extract extracted solvent mixture of the mixed medicine according to the present invention. However, the composition of the present invention is preferably taken as an extract in a liquid state in terms of speed of drug efficacy or convenience of taking.

The eleven kinds of herbal medicines used in the present invention are medicines that are generally used in herbal medicine as herbal medicines without toxicities and side effects, and there are no herbal medicines which are contraindicated in the mixed medicines of the 11 medicines. In academic circles, the stability is obvious.

Of these, the dried ginseng root (人蔘 根) in the present invention is scientific name Panax It is schinseng Nees, and it is used in tonic, strong heart (强 心), healthy stomach (健,), correction, soothing, and nourishment. In addition to the effects described above, the smoking cessation composition of the present invention serves to activate energy and stamina due to anxiety and stress caused by smoking cessation, along with herbs such as licorice, yellow lotus and astronomical dong.

Aspargus, scientific name sown in dried astronomical tube lucidus Lindl, used in herbal medicine as antitussive, diuretic, tonic. In the smoking cessation composition of the present invention, gold, gardenia, gentian, and pulmonary pulmonary stimulation with diuresis act as a urine to quickly discharge smoking wastes such as nicotine in the body.

Dried yellow lotus root is known as Jeffersonia dubia (Maxim) benth, et Hook, f. For herbal use, it is used for dryness, soothing and anti-inflammatory. The anti-smoking supplement composition of the present invention serves to relieve indigestion due to smoking and withdrawal symptoms such as mental anxiety, tension due to quitting smoking, as well as enhanced energy and quarries.

Dried gentian root is known as Gentiana It is scabra Beg, and it is used for dry stomach, lowering blood pressure and diuresis in oriental medicine. In the composition for smoking cessation aid of the present invention serves to relieve tension by lowering blood pressure while quickly discharging harmful substances to the body through diuretic action.

Dried gardenia fruit is scientific name Gradenia It is jasminoides Ellis, and it is used to dry ripe fruits. In oriental medicine, it is used for diuresis, heat poisoning , thirst quenching and insomnia. The smoking cessation composition of the present invention serves to remove smoking waste due to diuretic action and to alleviate insomnia withdrawal.

Dried maekmundong (麥門冬) tuberous root is the scientific name Liriope It is platyphylla wang et Tang, and it is used in Korean medicine for nourishment, tonic, diuresis and hypoglycemic. The anti-smoking supplement composition of the present invention serves to relieve tension or stress due to blood sugar drop and quickly discharge harmful substances of nicotine out of the body.

Dried Jimo Geun (知 학 根) Anemarrhena It is a bundle of asphodeloides , and it is used in herbal medicine to quench thirst, cough and sputum. In the anti-smoking supplement composition of the present invention serves to remove sputum caused by smoking and to reduce the psychological anxiety caused by thirst to alleviate the withdrawal phenomenon.

Dried licorice root has the scientific name Glycyrrhiza uralensis Fisch, and oriental medicine such as Dongbobogam controls the heat and fraud of the five intestines, normalizes the physiology of the eyes, nose, mouth, ears and faeces, communicates all blood veins, It is used to strengthen and improve nutrition, to detoxify the toxicity of all medicines, and to show the efficacy of the combined herbs. In the composition for smoking cessation aid of the present invention provides a sweetness (甘味) and serves to make the effect between the other medicines used well while being easy to take.

Dried golden root is known as Scutellaria baicalensis Georgi, and is used in herbal medicine as antipyretic, diuretic, branch, itch and anti-inflammatory. In the composition for assisting smoking cessation of the present invention, nicotine is quickly discharged to the outside by the diuretic effect.

Dried Shiho-geun is known as Bupleurum Komarovianum It is L and is used for antipyretic, analgesic, and tonic in one shot. In the composition for smoking cessation aid of the present invention serves to alleviate the pain caused by withdrawal phenomenon and to smooth the metabolism.

Dried Seokchangpo (石菖蒲) uses roots and stems, scientific name is Acorus gramineus Soland, and in oriental medicine, it is used for soothing, dry stomach, pain relief, diuresis, fever, hot flashes, consciousness dreams, breathing impulse, consciousness disorder. In the smoking cessation composition of the present invention, in particular, serves to relieve lethargy or excessive stress caused by withdrawal phenomenon.

At this time, 5 ~ 8% by weight of ginseng root, 5 ~ 8% by weight of dried Root Root Root, 5-8% by weight of dried Rhododendron, 5-8% by weight of dried gentian root, dried gardenia 5-8% by weight of the berries, 5-8% by weight of dried worms, 5-8% by weight of dried hair roots, 5-8% by weight of dried licorice root, 8-11% by weight of dried golden root. A mixture of 11-14% by weight of dried Siho-geun and 16-22% by weight of dried Seokchang-po is placed in water and extracted with extraction solvent.In case of ginseng, cheonmun-dong, rhubarb, gentian, gardenia fruit, macmundong, jimo, licorice In the same amount, at least 5% by weight of the mixture, gold, 8% by weight, Siho 11% by weight and Seokchangpo should use 16% by weight to fully exhibit the above-mentioned efficacy, ginseng, cheonmundong, hwangyeon, gentian, gardenia fruit, If more than 8% by weight of ganmundong, gimo, licorice, or 11% by weight of gold, 14% by weight of sea tiger and 22% by weight of stone spear is not used enough other medicines.

 In addition, food and pharmaceutically acceptable sweeteners, flavoring agents, excipients and preservatives in order to improve the stability and convenience to take in the anti-smoking supplement composition of the present invention described above. It is preferable to add (iv) and the like further.

Specifically, in the case of the excipient, saline, buffer, dextrose, water, glycerol, Ringer's solution, lactose, sucrose, calcium silicate, methyl cellulose or ethanol using a carrier powder, granules, injection solution, syrup, solution, tablet It may be prepared in a pharmaceutical formulation such as suppositories. In addition, the formulation may further include fillers, anti-coagulants, lubricants, wetting agents, flavors, emulsifiers, preservatives, and the like, and may be formulated to provide rapid, sustained or delayed release of the active ingredient after administration to a mammal.

Hereinafter, a preferred process for producing a composition for smoking cessation aid of the present invention is as follows.

(1) extraction process

Dried Ginseng Root 5-8% by weight, Dried Astronomical Root Root 5-8% by weight, Dried Rhododendron Root 5-8% by weight, Dried Yongdam-Geun 5-8% by weight, Dried Gardenia Fruit 5-8% by weight, Dried Macmundong Tube 5-8% by weight of root, 5-8% by weight of dried hair root, 5-8% by weight of dried licorice root, 8-11% by weight of dried golden root. A mixture of 11-14% by weight of dried Siho root and 16-22% by weight of dried Seokchang-po is placed in an extraction solvent of water or alcohol and extracted by heating.

At this time, in the present invention, it is preferable to put 1 g of the medicinal herb mixture in 20 to 40 ml of the extraction solvent and heat it. This is because if the extraction amount is less than 20 ml, the solvent is reduced while heating, so that it cannot be handled for a sufficiently long time, and if the concentration exceeds 40 ml, the concentration of the active ingredient is lowered. However, the present invention is not limited to the above-mentioned range of use, and the use range of the medicinal mixture and the extraction solvent can be adjusted by adjusting the concentration of the active ingredient according to the taste of the ingestor.

In addition, in the present invention, when the extraction solvent is water, the temperature of the heating means (gas fire, heater, etc.) is soaked by immersing the medicine mixture in water of about 20 to 25 ℃ for 1 to 2 hours, and then heated to boil water It is advisable to lower the temperature and slowly squeeze until the amount of water initially added is reduced by about 40%. Specifically, it is preferable to bridge about 5 hours or more. This is because the loss of the extraction active ingredient, which is susceptible to destruction under continuous high temperature conditions, can be suppressed if possible.

(2) refining process

The liquid extract extracted in the first step removes solids through a strainer or a filter.

In addition, in the present invention, the filtered filtrate may be just taken, but may be dried and taken as a powder.

On the other hand, the anti-smoking supplement composition of the present invention is not limited to the dosage depending on the taste or habit of the user, but usually once, extract adult extract 140 ~ 150ml (about 2/3 cup of the normal cup) on an adult basis It is recommended to take it continuously or intermittently within 2 hours after breakfast and lunch and 30-40 minutes before bedtime.

Hereinafter, the present invention will be described in more detail with reference to specific examples. However, the present invention is not limited to the following examples, and it will be apparent to those skilled in the art that various changes or modifications can be made within the spirit and scope of the present invention.

[ Example ] Preparation of Anti-Smoking Auxiliary Composition of the Invention

Dried Ginseng Root 5-8% by weight, Dried Astronomical Root Root 5-8% by weight, Dried Rhododendron Root 5-8% by weight, Dried Yongdam-Geun 5-8% by weight, Dried Gardenia Fruit 5-8% by weight, Dried Macmundong Tube 5-8% by weight of root, 5-8% by weight of dried hair root, 5-8% by weight of dried licorice root, 8-11% by weight of dried golden root. 100 g of a mixture of 11-14% by weight of dried Siho root and 16-22% by weight of dried Seokgu root was immersed in 3 liters (3,000 ml) of water before and after 22 ° C for 1 hour, heated in a gas cooker and boiled immediately. It was injured for 5 hours with reduced.

1.2 liter of the Darin extract was passed through a strainer to prepare an anti-smoking auxiliary composition (extract filtrate) of the present invention.

[ Comparative example  One]

In this comparative example, K Company's Ssanghwa tea was purchased commercially and used.

[ Experimental Example  1] Preference check

In this Experimental Example, 50, sensory test applicants (28 males, 22 females) were given five points for color, aroma, taste, and overall acceptability in order to measure the dose of the smoking cessation composition prepared according to the present invention. It was measured by the scale method and compared / analyzed (Chang, Kun-Sung, Palatability of Food, Gaemunsa, 1975).

As a result, as shown in Table 1, it was found that the composition for smoking cessation aid of the present invention in a general preference diagram is easy to take as in the comparative example (traditional herbal drink).

[ Experimental Example  2] efficacy test

1. Ease of craving for smoking and withdrawal phenomenon

In the present experimental example, 30 smokers (30 males) who had a history of quitting smoking were allowed to quit smoking, and then 30 minutes before bedtime, 2 hours after breakfast, and 2 hours after lunch, the composition for assisting smoking according to the present invention was prepared. 150 ml each was taken for 1 week.

Then, the feeling of the taking of the withdrawal phenomenon through the questionnaire was measured by the sensory test as in Experimental Example 1.

The questionnaire items were whether there was a desire for smoking and whether there were psychological stresses such as anxiety and tension. At this time, the control group responded to the questionnaire about the experience of quitting smoking before the experiment only for the same person who participated in the experiment.

As a result, as shown in Table 2, it can be seen that the anti-smoking supplement composition of the present invention had a significant effect in alleviating the withdrawal phenomenon such as smoking desire and anxiety or tension than when the previous quit. At this time, Table 2 shows the average value of the sum of the scores of the survey respondents. In addition to the following data, even when taking the composition of the present invention for one day it was possible to obtain the effect of significantly lowering the smoking desire.

5 points: very large, 4 points: large, 3 points: normal, 2 points: small, 1 point: very small

2. tobacco flavor effect

In the present experimental example, 30 smokers (30 males) were allowed to quit smoking, and then 30 minutes before bedtime, 2 hours after breakfast, and 2 hours after lunch, 150 ml of the non-smoking supplement composition according to the present invention. Taken daily.

Then, the same person was allowed to smoke again, and then they were asked to answer the questionnaire compared to their usual taste of cigarettes.

As a result, as shown in Table 3 below, the composition for smoking cessation aid of the present invention was able to prove to significantly lower the taste of tobacco.

From the above results, it is determined that the anti-smoking supplement composition according to the present invention can play a sufficient role as a smoking cessation aid by reducing tobacco taste and alleviating withdrawal phenomenon and smoking desire due to smoking cessation.

As described above, the anti-smoking supplement composition according to the embodiment of the present invention provides an effect of eliminating temporary withdrawal phenomena due to smoking cessation while reducing the taste of tobacco due to no side effects or harm caused by taking.

In addition, the non-smoking auxiliary composition of the present invention is made up of herbal medicines used as conventional medicines to provide health benefits.

However, the above disclosure is capable of a range of modifications, changes and substitutions, and in some cases only some of the features of the invention may be used. Accordingly, the appended claims should be construed broadly in accordance with the spirit and scope of the invention.

Claims (4)

Dried Ginseng Root 5-8% by weight, Dried Astronomical Root Root 5-8% by weight, Dried Rhododendron Root 5-8% by weight, Dried Yongdam-Geun 5-8% by weight, Dried Gardenia Fruit 5-8% by weight, Dried Macmundong Tube 5-8% by weight of root, 5-8% by weight of dried hair root, 5-8% by weight of dried licorice root, 8-11% by weight of dried golden root. A non-smoking auxiliary composition comprising as an active ingredient a solvent extract of a mixture of 11-14% by weight of dried Shiho-geun and 16-22% by weight of dried Seokchang-po. The method of claim 1, The solvent extract is a non-smoking auxiliary composition, characterized in that the extract extracted by mixing 20 ~ 40mL of the solvent on the basis of the mixture 1g. The method according to claim 1 or 2, The solvent is a non-smoking auxiliary composition, characterized in that the water or alcohol. Dried Ginseng Root 5-8% by weight, Dried Astronomical Root Root 5-8% by weight, Dried Rhododendron Root 5-8% by weight, Dried Yongdam-Geun 5-8% by weight, Dried Gardenia Fruit 5-8% by weight, Dried Macmundong Tube 5-8% by weight of root, 5-8% by weight of dried hair root, 5-8% by weight of dried licorice root, 8-11% by weight of dried golden root. A method for producing a composition for assisting smoking cessation comprising extracting by heating a mixture of 11-14% by weight of dried Shiho-geun and 16-22% by weight of dried Sigma root in an extraction solvent of water or alcohol.