KR20080097685A - Cosmetic composition for atopy or burned skin - Google Patents

Abstract

A cosmetic composition for the skin damaged fire or for an atopic skin is provided to prevent moisture of the skin from falling down, to relieve pruritus of skin, to cure damage of the skin and to have no side effect by natural matters. A cosmetic composition for an atopic skin comprises (A) 65 - 93 weight of vaseline, (B) 5 - 20 weight of oriental herbs distillate obtained from purslane, scutellariae Radix, phellodendri Cortex and rosin, (C) 1 - 10 weight of Purslane condensed products and (D) 1 - 5 weight of alum. The cosmetic composition is a cosmetic water composition.

Description

Cosmetic composition for skin damaged by atopic dermatitis or burn {COSMETIC COMPOSITION FOR ATOPY OR BURNED SKIN}

The present invention relates to a cosmetic composition for skin damaged by atopic dermatitis or burns, and more specifically, (A) 65 to 93% by weight of petrolatum, (B) purslane, gold, yellowish white, rosin and yellow alga By containing 5 to 20% by weight of herbal plant distillate, 1 to 10% by weight of (C) purslane concentrate, and 1 to 5% by weight of (D) alveolar, it can prevent the moisturizing of the skin from falling and it is excellent for alleviating skin itch. It relates to a cosmetic composition that is effective in the treatment or alleviation of atopic dermatitis, as well as effective in skin damage such as burns.

The skin is a tissue surrounding the human body, and functions to protect the body, regulate body temperature, excrete sweat, and waste products, and breathe the skin. However, when the skin of the human body is damaged by atopic dermatitis or burns, it may not function properly, and itching, erythema of the wound area, blisters, and the like are often accompanied by great discomfort.

Atopy was named in 1925 for human innate hypersensitivity to certain kinds of substances unique to A. Coca in the United States. Atopy is known to have asthma, inflammation, and many other allergens (eg, egg white, dandruff, pollen, dust). Have a high positive rate of intradermal reaction, the presence of antibodies in the serum (atopic allergen), or an abnormal response to various stresses (temperature, humidity, trauma, mental strain, infection, etc.) many.

Atopic dermatitis has been known to occur mainly in infancy and is known as febrile fever. In particular, atopic dermatitis has a poor function of retaining moisture in the stratum corneum, making the skin dry and flaking easily, and as a function of the protective barrier of the skin, irritant substances invade the stratum corneum and cause irritation. As allergens, which are difficult to invade, invade skin allergies and the like, and are generally unbearable pruritus symptoms.

Severe scratching of these atopy skin is accompanied by eczema, keloids and severe keratinization. This atopic skin has been found to be caused by the following four causes so far. First, due to the genetic causes, the skin protective film is in a state of lacking gamma-linoleic acid, an essential fatty acid constituting the intercellular lipid, which is a binding material between the phospholipids and keratinocytes of the cell membrane, which is a skin protective layer that acts as a skin protective function. Second, atopy is caused by environmental factors. As a result of changing the residential environment of modern people to dry environment such as apartments, atopic skin is increasing in the world, which reduces water retention. And skin protection is lost and allergic reactions are sensitive to even small stimuli. Third, active oxygen is used to generate lipid peroxide by free radicals, which in turn causes atopy skin. Fourth, it is caused by infection with microorganisms such as bacteria, viruses, and fungi. In recent years, it is common to think that atopic symptoms occur due to a combination of the above-mentioned causes.

In order to improve such atopic skin, conventionally, clean the skin to remove substances that can act as antigens, strengthen the skin barrier function to supply ceramide, an intercellular lipid component necessary to protect the skin from drying, so as not to irritate the stratum corneum. I have used the method. So, to improve atopic skin, known ingredients such as ceramides, linoleic acid, vegetable oils and mineral oils, steroid preparations such as hydrocortisone, or certain plant extracts are included in the formulation of common emulsified products or lecithin, which is a phospholipid component. It is used in the form of liposomes to supply to the stratum corneum of the skin to create an oil film to prevent the moisturizing effect and water loss, and to prevent the bacterial contamination, etc. Skin external preparations or cosmetics have been mainly used to strengthen the antibacterial and anti-inflammatory functions.

These methods have some results in the prevention and treatment of atopic skin, but there are some problems in terms of effectiveness and skin safety. For example, the use of steroids such as hydrocortisone has been reported to cause side effects such as growth inhibition or side effects of the epidermis, and urea peroxide is irritating to the skin and may cause other contact dermatitis. there is a problem. In addition, antibiotics such as antihistamines are known to be resistant to bacteria, and the known antibiotics, haphwanpi, changja, malt, wormwood, etc. have some effect but allergic hypersensitivity reactions on sensitive atopic skin in some cases There was a problem that can be limited to the use range.

In addition, burns are generally damages to the skin of the body caused by contact with heat, chemicals, electricity, or radiation, and are medically called thermal burns. Burns caused by the heating or boiling water vapor are also called steam burns. do. Such burns are classified into first-degree burns, second-degree burns, and third-degree burns according to their area and extent of skin damage. In case of first-degree burns, only the epidermal layer is damaged. Systemic symptoms are very mild, accompanied by a slight headache and swelling, and the epidermis peels off naturally within 5 to 10 days after the injury, leaving no scars. 2 In case of burns, most of the epidermis and most of the dermis are damaged and blisters are formed. When the subcutaneous tissue is accompanied by edema and the blisters are removed, a glossy surface of pink to red color appears and there is a tendency for the exudation of tissue fluid. In addition, third degree burns are epidermis. Tissue necrosis of the wound area is severe with damage spread to the entire layer of the dermis and subcutaneous fat layer, swelling is severe compared to the first degree burn, and the skin is formed by necrotic skin tissue, and after 2 to 3 weeks, the necrotic skin tissue is fused. To be eliminated.

In particular, the wider the range of burns, the more necrotic and ulcerous tissues will develop, and even after scars, scars, jails, and keloids will occur. In addition to fever and difficulty breathing, the body loses water and protein, causing dehydration, shock and kidney failure, and accompanying wound infection. In adults, burns of more than one-third of the body's total area are life-threatening.

The present inventors have studied and tried on these skin damage symptoms, petroleum jelly; Herbal plant distillates obtained by sequentially distilling purslane, golden, yellowish white, rosin and yellow almond; Purslane concentrate; And by producing a cosmetic composition comprising a high whitening can prevent the fall of the skin's moisturizing power and excellent in relieving skin itching to be effective in the treatment or alleviation of atopic dermatitis, as well as excellent effect on skin damage such as burns The present invention has been completed.

Thus, the present invention relates to petrolatum; Herbal plant distillates obtained by sequentially distilling purslane, golden, yellowish white, rosin and yellow almond; Purslane concentrate; And it is an object to provide a cosmetic composition for atopic dermatitis comprising a specific ratio of high alum.

In addition, the present invention is petrolatum; Herbal plant distillates obtained by sequentially distilling purslane, golden, yellowish white, rosin and yellow almond; Purslane concentrate; And it is another object to provide a cosmetic composition for burn skin comprising a specific ratio of vitiligo.

In addition, the present invention has another object to provide a method for producing a cosmetic composition for atopic dermatitis or burn skin.

The present invention is (A) 65 to 93% by weight of petrolatum, (B) 5 to 20% by weight of herbal plant distillate obtained by distilling purslane, golden, yellowish white, rosin and yellow almond, (C) purslane concentrate 1 to 10 It is characterized by the cosmetic composition for atopy skin containing 1 weight% and (B) 1-5 weight% of high alums.

The present invention will be described in more detail as follows.

The present invention is (A) 65 to 93% by weight of petrolatum, (B) 5 to 20% by weight of herbal plant distillate obtained by distilling purslane, golden, yellowish white, rosin and yellow almond, (C) purslane concentrate 1 to 10 By including 1% by weight and (D) 1-5% by weight of high-density skin, it is possible to prevent the moisturizing power of the skin from falling off, and it is excellent for relieving itching of the skin, and it is not only effective for treating or alleviating atopic dermatitis, but also for skin damage such as burn It relates to an effective cosmetic composition.

When explaining the (A) petrolatum, (B) herbal plant distillate, (C) purslane concentrate and (D) goblet which are essential components of the cosmetic composition for atopic dermatitis or burn skin of this invention are as follows.

(A) Vaseline

The petrolatum of the present invention can be used that is commonly used in cosmetics or medicines and is not limited to a specific kind. Vaseline is made by bleaching oil residue and is often used as a therapeutic ointment for wounds.

The cosmetic composition for atopic dermatitis or burn skin of the present invention contains 65 to 93% by weight of petrolatum based on the total composition. When the amount of petrolatum is less than 65% by weight of the total may be a slight effect of improving the cracking of the skin, when the content of more than 93% by weight of the other essential components may not be properly contained, the atopic improvement may be inferior.

(B) herbal plant distillate

Herbal plant distillate of the present invention, after putting boiled purslane in sesame oil or the like and then boiled down when the purslane is hardened, put it out here, put it in gold and boil it again for a suitable time, then take it out, put it in again and boil it and discard it, again It means distillate obtained by boiling rosin and yellow dumpling.

The purslane ( Portulaca oleracea L.) is a yearly plant, also called pentaceum, jangmyeongchae, machichae and the like. It grows naturally on roadsides and gardens. The stem is about 15-30 cm high and has no hairs. The stem has a diameter of 2-3 mm, reddish brown, and many branches are divided and grow obliquely on the ground. Purslane has been mixed with spices and used as a medicinal herb. In the past, folk remedies of ancestors were used as antidote such as detoxification and poisoning. It has also been used in the Arabian Peninsula as an antiseptic, anti-neuropathy, antispasmodic, diuretic, antiparasitic and skin soothing agent. In addition, studies on muscle relaxation activity and anticancer effects have been reported. In addition, purslane is known to have the effect of reducing inflammation, and also apply juice to boil or inflammation raw. Purslane chemicals are known as L-noradrenaline, dopamine, dopa and potassium, various organic acids, glutamic acid, aspartic acid, alanine and portuloside A, a monoterpene glycoside.

The golden ( Scutellaria baicalensis ) grows in the grass of the mountain, 20 to 60 cm in height, several generations come out and grow in fur, hairs and branches. The leaves are opposite each other, lanceolate, and the edges are flat. The flowers bloom in July-August, turn purple, and run toward the side with gunshot flowers. In oriental medicine, the roots have been used as antipyretic, diuretic, branch, edam and anti-inflammatory agents and are grown as medicinal plants. Gold Silver Bicalin (C21H18O11), Bicalane (C15H10O5), Wigonin (C16HsO5), Wagonoside (C22H20O11 · 4H2O), 7-Methoxy-Bicalane (C22H20O11), Neo-Bikalane (C19H18O8), 7-Meth It contains flavonoids such as oxynorwegonin (C16H12O5), oroxylin A (C16H12O5), school capflavone I (C17H14O6), and school capflavone II (C19H18O8), and other pyrocateline tannins, beta (β)- It contains a testosterol resin essential oil. The flavonoids are put in water, boiled to raise the temperature, and then extracted from boiling water. The various flavonoids have excellent anti-inflammatory, antibacterial and antioxidant effects. While it inhibits anaphylaxis, Baikallein inhibits both histamine skin reactions and anaphylaxis.

The yellow and white is a rutaceae (芸香 科; Rutaceae) plants, the nature is cold, bitter and poisonous. It mainly eliminates the heat, jaundice, and devices gathered in the intestine and intestine. It is known to relieve diarrhea, dysentery, baekbyeongdae, to heal the food window, to kill worms, to get rid of scabies and ringworms, fever and soreness due to heat in the eyes, and to relieve osteoporosis fever. . In addition, it contains flavonoids and alkaloids, so it is excellent in UV protection and antibacterial, anti-inflammatory and antiviral effects on the skin. The active ingredient in the antibacterial activity of yellow and white is berberin, and in Vitro's experiment, it has excellent effects on staphylococcus aureus, Escherichia coli, Typhoid, cholera, and Gram (+) and Gram (-). It has antibacterial and anti-inflammatory effects such as eczema, adenopathy and chronic dermatitis. In addition, the yellow berberine sterilization action, such as rhinitis, mouth mucositis, burns and sterilization.

The rosin is also called rosin (松脂), refers to the secretion secreted when the pine tree is damaged. The components are 70 to 75% of resin (rosin), 18 to 22% of essential oil (terebin oil), 5 to 7% of water and other impurities, among which 60% to 65% of rosinic acid is levopimaric acid. It consists of neoabietin acid etc. The turpentine oil is mainly an ointment, a paint solvent, a refining agent, or a shoe polish. Used in solvents of rubber and waterproofing agents, rosin is mainly used in medicines such as soaps, paint desiccants, insecticides, printing inks, paper additives and adhesive plasters. Refers to the essence of pine. Clean is a colorless transparent liquid with a whitish and sticky nature over time, mainly used in ointments, paint solvents, reinforcements, shoe polish, rubber or waterproofing solvents. Rosin is mainly used for soaps, paint desiccants, insecticides, printing inks and paper making. It is used in medicines such as additives and plasters.

The yellow dandelion (黃丹) is poisonous in cold energy, spicy and salty taste. Heart, rain (간), liver (肝) three 경 (들어가) to enter the pharmacological action. It is tribium tetraoxide (Pb3O4) produced by smelting lead. Podium (丹), Gwangmyeongdan (光 明丹), also called red yeon (??) ?? The recipe is pure lead (鉛) in a crucible, heated to 290 to 320 degrees Celsius, melted and cooled to harden. This may be deflected with bovine powder, placed in a crucible again, heated, melted at 390 to 420 degrees Celsius, cooled, cooled, and dried again with boiled powder. The superior product as a medicinal herb contains 23 to 25% of PbO2, and may be used as a basic rust preventive pigment for steel or as a pigment for priming.

The cosmetic composition for atopic dermatitis or burn skin of the present invention contains 5 to 20% by weight of herbal plant distillate based on the total composition. If the content of herbal plant distillate is less than 5% by weight, the therapeutic effect of atopic skin or burned skin is remarkably decreased. If the content of the herbal plant distillate is greater than 20% by weight, other essential ingredients are not adequately contained to improve atopic or burned skin. Can fall.

(C) purslane concentrate

Purslane concentrate of the present invention is put in a solvent such as water and put the purslane described in (B) herbal plant distillate to boil for a suitable time to take out the contents and boil again continuously (for example, until it is about 100 ml) Means the concentrated concentrate of purslane.

The cosmetic composition for atopic dermatitis or burn skin of the present invention comprises 1 to 10% by weight of purslane concentrate, based on the total composition. When the content of purslane concentrate is less than 1% by weight of the whole, the therapeutic effect of atopic skin or burned skin is remarkably decreased, and when it exceeds 10% by weight, the essential ingredients are not properly contained so that atopic or burned skin is improved. Can fall.

(D) Confession

Confessions detoxify all poisons. Burnt alum refers to dehydrated alum, ie potassium alum KAl (SO4) 2 · 12H2O.Like alum, it is used for medicines such as hemostatic agents and astringents. It is said to be more effective than alum because of its properties, and it is known to be used for the clarification of colored liquids, including alcoholic beverages.

The cosmetic composition for atopic dermatitis or burn skin of the present invention contains 1 to 5% by weight of high whitening based on the total composition. If the content of the high alum is less than 1% by weight of the whole, the effect of adding the high alum may be insignificant. If the content of the high alum is more than 5% by weight, it is difficult to expect an increase in the effect on the content increase.

In addition, the cosmetic composition according to the present invention may contain, in addition to the above essential ingredients, an adjuvant commonly used in the cosmetic field within a range that does not impair the main effect of the present invention. Such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, fragrances, fillers, blockers, pigment odorants and dyes. The amounts of these various adjuvants are amounts commonly used in the art, such as from 0.01% to 20% by volume relative to the total weight of the composition. Depending on their nature, such adjuvants may be incorporated into the fatty phase, aqueous phase, lipid vesicles and / or nanoparticles. In any case, the adjuvant and its proportions will be chosen so as not to adversely affect the desirable properties of the cosmetic composition according to the invention.

The compositions of the present invention may be in the form of an aqueous, aqueous-alcoholic or oily solution, oil-in-water or oily water or multiple emulsions, aqueous or oily gels, liquid, pasty or solid anhydrous products, oil dispersions in aqueous phase using globules. Can be.

The composition may be somewhat fluid and may have the appearance of a white or colored cream, ointment, milk lotion, serum, essence, paste or mousse. It may optionally be applied to the skin in the form of an aerosol or may be in the form of a solid, such as a stick. It may be used as a skin care product and / or makeup product.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to Examples.

Example 1: Preparation of Cosmetic Composition 1

In order to prepare the cosmetic composition of the present invention, (B) herbal plant distillate was first prepared by the following method. 200 g of purslane in 1 liter of sesame oil, boiled for about 10 minutes, and then removed when the purslane was hardened. After that, add 100 g of golden, boil again for 10 minutes, take it out, put it again, add 100 g of yellow-white and boil it for 10 minutes, then take out the contents, put 30 g of rosin and 10 g of yellow altar again and boil until it becomes 200 ml.

Then, 2 liters of water was poured into 1 kg of purslane and boiled for about 2 hours, and then the contents were taken out, boiled again to 100 ml, and concentrated to a concentration. (C) Purslane concentrate was prepared.

200 ml of the herbal plant distillate (B) and 100 ml of (C) purslane concentrate prepared as described above are poured into 1.8 kg of (A) petrolatum and 60 g of (D) goblet and stir well to prepare the cosmetic composition of the present application in a conventional manner. Prepared.

Example 2: Preparation of Cosmetic Composition 2

After (B) herbal plant distillate and (C) purslane concentrate were prepared in the same manner as in Example 1, (B) 150 ml of herbal plant distillate and (C) 80 ml of purslane concentrate (A) 1.7 kg of vaseline And (D) was poured into 70 g of baekban and stirred well to prepare a cosmetic composition of the present application in a conventional manner.

Example 3: Preparation of Cosmetic Composition 3

In the same manner as in Example 1, (B) herbal plant distillate and (C) purslane concentrate were prepared, followed by (B) 200 ml of herbal plant distillate and (C) 90 ml of purslane concentrate (A) 1.65 kg of petrolatum And (D) was poured into 60 g of baekban and stirred well to prepare a cosmetic composition of the present application in a conventional manner.

Experimental Example 1: Confirmation of the effect of the composition of Examples 1 to 3 for atopic dermatitis

The skin lotion of the examples was correctly applied to 30 patients (male to female ratio 1: 1) of 10 patients each with atopic dermatitis for 30 days, and the results as shown in Table 1 were obtained.

TABLE 1

As can be seen from the table above, in the case of the cosmetic composition of Example 1, two patients were healed as the wounds disappeared, four patients had fewer or improved lesions, and four patients had no effect but the skin Itching has resolved. And in the case of the cosmetic lotion composition of Example 2 and Example 3, it was confirmed that the wound of the atopy, the symptom is improved or the itching is resolved as in the case of Example 1.

Experimental Example 2: Confirmation of the effect on the burn of the composition of Examples 1 to 3

When the composition of the above examples were used as an external preparation for five patients with second degree burns, there was a marked improvement in effect, and when applied for about 10 days, it was confirmed that there was a significant effect on burns.

As described above, the cosmetic composition for skin damaged by atopic dermatitis or burn of the present invention is (A) 65 to 93% by weight of petrolatum, (B) herbal plant distillation obtained by distilling purslane, golden, yellowish white, rosin and yellow altar in order By containing 5 to 20% by weight of water, 1 to 10% by weight of (C) purslane concentrate, and 1 to 5% by weight of (D) plaque, it can prevent the skin's moisturizing ability from falling and it is excellent for relieving itching of the skin and is atopic. It is effective not only for the treatment or alleviation of dermatitis, but also for skin damage such as burns.

In addition, by using a large amount of natural raw materials, there are no side effects as in the case of using conventional chemicals, and the effect is excellent for skin damage caused by atopic dermatitis and burns.

Claims (5)

(A) 65 to 93% by weight of petrolatum, (B) 5 to 20% by weight of herbal plant distillate obtained by distilling purslane, golden, yellowish white, rosin and yellow almond, (C) 1 to 10% by weight of purslane concentrate, And (D) 1 to 5% by weight of albino skin cosmetic composition. (A) 65 to 93% by weight of petrolatum, (B) 5 to 20% by weight of herbal plant distillate obtained by distilling purslane, golden, yellowish white, rosin and yellow almond, (C) 1 to 10% by weight of purslane concentrate, And (D) 1 to 5 wt% of high white spots. The herbal plant distillate according to claim 1 or 2, wherein the herbal plant distillate is put into the sesame oil and boiled and then boiled out after the purslane is hardened, put it in the gold and boil it again, then take it out, and put it back and boil it again. After discarding it, the composition is characterized in that the distillate obtained by boiling again by putting rosin and yellow. The composition of claim 1 or 2, wherein the purslane concentrate is concentrated by pouring water into the purslane and boiling, then taking out the contents and boiling again. The composition of claim 1 or 2, wherein the cosmetic composition is a lotion composition.