KR20080082956A - 양쪽성 리포솜의 개선 또는 양쪽성 리포솜에 관련된 개선 - Google Patents

양쪽성 리포솜의 개선 또는 양쪽성 리포솜에 관련된 개선 Download PDF

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Publication number
KR20080082956A
KR20080082956A KR1020087008987A KR20087008987A KR20080082956A KR 20080082956 A KR20080082956 A KR 20080082956A KR 1020087008987 A KR1020087008987 A KR 1020087008987A KR 20087008987 A KR20087008987 A KR 20087008987A KR 20080082956 A KR20080082956 A KR 20080082956A
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South Korea
Prior art keywords
liposome
amphoteric
lipid
liposomes
mixture
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KR1020087008987A
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English (en)
Korean (ko)
Inventor
스테펜 판즈너
이본네 케르위츠
우나 라우츠하우스
실케 루츠
제롤드 엔데르트
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노보솜 아게
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Publication date
Priority claimed from EP05020216A external-priority patent/EP1764089A1/en
Priority claimed from EP05020217A external-priority patent/EP1764090A1/en
Priority claimed from PCT/EP2005/011905 external-priority patent/WO2006048329A1/en
Priority claimed from US11/267,423 external-priority patent/US20060159737A1/en
Application filed by 노보솜 아게 filed Critical 노보솜 아게
Publication of KR20080082956A publication Critical patent/KR20080082956A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A—HUMAN NECESSITIES
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    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Wood Science & Technology (AREA)
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  • Biochemistry (AREA)
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  • Diabetes (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
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  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
KR1020087008987A 2005-09-15 2006-09-15 양쪽성 리포솜의 개선 또는 양쪽성 리포솜에 관련된 개선 Withdrawn KR20080082956A (ko)

Applications Claiming Priority (24)

Application Number Priority Date Filing Date Title
US71729105P 2005-09-15 2005-09-15
US71729305P 2005-09-15 2005-09-15
US71719905P 2005-09-15 2005-09-15
EP05020218.3 2005-09-15
US60/717,291 2005-09-15
EP05020217.5 2005-09-15
EP05020216A EP1764089A1 (en) 2005-09-15 2005-09-15 Serum stable liposomes comprising amphoter II lipid mixtures
EP05020216.7 2005-09-15
EP05020218 2005-09-15
US60/717,199 2005-09-15
EP05020217A EP1764090A1 (en) 2005-09-15 2005-09-15 Amphoteric liposomes for local drug applications
US60/717,293 2005-09-15
WOPCT/EP2005/011908 2005-11-04
WOPCT/EP2005/011905 2005-11-04
PCT/EP2005/011905 WO2006048329A1 (en) 2004-11-05 2005-11-04 Improvements in or relating to pharmaceutical compositions comprising an oligonucleotide as an active agent
US11/267,423 US20060159737A1 (en) 2004-11-19 2005-11-04 Pharmaceutical compositions for local administration
US11/266,999 2005-11-04
US11/266,999 US20060216343A1 (en) 2004-11-05 2005-11-04 Pharmaceutical compositions comprising an oligonucleotide as an active agent
PCT/EP2005/011908 WO2006053646A2 (en) 2004-11-19 2005-11-04 Improvements in or relating to pharmaceutical compositions for local administration
US11/267,423 2005-11-04
EP05090322A EP1658839A1 (en) 2004-11-05 2005-11-21 Oligonucleotide/carrier combinations targeting CD40
EP05090322.8 2005-11-21
EP06113784.0 2006-05-10
EP06113784 2006-05-10

Publications (1)

Publication Number Publication Date
KR20080082956A true KR20080082956A (ko) 2008-09-12

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KR1020087008987A Withdrawn KR20080082956A (ko) 2005-09-15 2006-09-15 양쪽성 리포솜의 개선 또는 양쪽성 리포솜에 관련된 개선

Country Status (7)

Country Link
US (3) US20070104775A1 (enExample)
EP (1) EP1764091B1 (enExample)
JP (1) JP5571308B2 (enExample)
KR (1) KR20080082956A (enExample)
AU (1) AU2006291429B2 (enExample)
CA (2) CA2889540A1 (enExample)
WO (1) WO2007031333A2 (enExample)

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US9066867B2 (en) 2015-06-30
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US9737484B2 (en) 2017-08-22
EP1764091B1 (en) 2017-08-30
CA2889540A1 (en) 2007-03-22
EP1764091A3 (en) 2007-06-13
US20110076322A1 (en) 2011-03-31
US20070104775A1 (en) 2007-05-10
US20150231073A1 (en) 2015-08-20
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CA2622584A1 (en) 2007-03-22
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