KR20080056370A - Cosmetic compositions containing ginseng and siberian ginseng extracts and deep sea water - Google Patents

Abstract

A cosmetic composition is provided to show excellent skin aging and itch alleviating effects, provide satisfactory skin diseases improving, moisturizing and whitening effect, and have excellent appearance aging stability. A cosmetic composition comprises 0.0001-75 wt.% of an extract of red ginseng or ginseng, 0.01-0.3 wt.% of an extract of Acanthopanax senticosus and 0.01-25 wt.% of deep sea water. The composition further comprises 0.1-3 wt.% of an extract of Foeniculum vulgare. Further, the extract of red ginseng or ginseng is extracted by water, ethanol or a mixed solution thereof.

Description

Cosmetic composition comprising ginseng and thorny ginseng extract and deep sea water {Cosmetic Compositions containing ginseng and siberian ginseng extracts and deep sea water}

The present invention relates to a cosmetic composition for exfoliation, skin moisturizing, whitening, skin elasticity enhancement and alleviation of atopic dermatitis, more specifically, 0.001 to 75% by weight of red ginseng or ginseng extract, 0.01 to 0.3% by weight of ginseng extract and Deep seawater 0.01 to 25% by weight, and when added, it comprises 0.1 to 3% by weight of fennel extract as an optional ingredient, and by their synergism, exfoliation, itching, skin disease improvement and skin softening, moisturizing and whitening The present invention relates to a cosmetic composition exhibiting an excellent effect.

The desire to have a beautiful, shiny and elastic skin is the constant desire of all women, but as the skin ages, the skin loses its elasticity and shine, and it goes through a series of processes where keratinization progresses and becomes rough.

The skin of the human body functions as a primary barrier to protect the human body from external environmental stimuli such as ultraviolet rays, various pollutants and pollutants, or changes in temperature and humidity. The skin is divided into three layers: epidermis, dermis, and subcutaneous tissue. The epidermis is further divided into stratum corneum, granule layer, pore layer and basal layer. The stratum corneum is the outermost layer that is apparently exposed and shows physicochemical resistance to harmful external environment. It is very important cosmetically.

Epidermal cells undergo a differentiation process called keratinization, and the cells are repeatedly eliminated as keratinocytes constituting the outermost layer through the base layer, the pole layer, the granule layer, and the stratum corneum in order. The keratin layer functions as an outer barrier, and dead keratinocytes are removed from the skin and replaced with new keratinocytes. The flat keratinocytes are connected to each other and remain strong and show flexibility. The keratinocytes are successively generated, and the outermost layer of the oldest keratinocytes is continuously dropped, so that the epidermis always maintains a constant thickness. These turnover cycles vary depending on the part of the body, age, sex, and health, but the cycle of epidermis replacement in normal skin is about four weeks. However, if the keratinization process is not normal, the keratinocytes are excessively produced, leading to a thickening of the stratum corneum on the surface of the skin, or to rough skin, and to a dull appearance of the skin, resulting in poor makeup or overall appearance.

The stratum corneum is divided into keratinocyte and keratinocyte lipids, and the structure of brick and mortar model, which is analogous to brick and cement, is established as the keratin layer model theory. In general, the main functions of the stratum corneum are roughly divided into a defense function that provides a barrier function from the external environment, that is, a protection function and a moisturizing function to keep moisture on the skin. It is known that lipid components between keratinocytes play an important role in the protection and moisturizing function of the stratum corneum, that is, the skin barrier function (Elias PM, Lipid and the epidermal permeability barrier, Arch dermatol Res 1981; 27: 95-). 117). Important substances of these keratinocyte lipid components are ceramides, cholesterol and derivatives thereof, and fatty acids.

In general, abnormality of skin barrier function is closely related to abnormality of lipid structure among keratinocytes. It is reported that various skin diseases such as atopic dermatitis occur when the skin barrier function is weakened (Ogawa H and Yoshiike). T, A speculative viex lf atopic dermatitis: barrier dysfunction in pathogenesis.J Dermatol Sci 1993; 5: 197-204).

On the other hand, fine skin is closely related to moisture retention, and in general, the moisture content of the dermis is about 70%, but decreases toward the epidermis, about 10-30% in the outermost layer, and the moisture supplied from the dermis is mainly due to passive diffusion. It diffuses to the top of the stratum corneum and disappears to the outside. Therefore, cosmetically, the moisture retention ability of the stratum corneum is known to be very important in maintaining smooth, supple and fine skin. Involvement in the water retention capacity of the stratum corneum is called Natural Moisurizing Factor (NMF), and the flexibility of the stratum corneum is due to the action of NMF. Such NMF is known to have a hydrophilic water retention material such as various amino acids, inorganic salts, pyrrolidone carboxylic acid, lactic acid, and the like, and an oily component such as an intracellular lipid component such as ceramide or sebum.

However, despite the retention of the above natural moisturizing factors, the skin's secretion of various hormones that regulate metabolism and decrease of immune cell function and activity of the immune cells are required for living body. Their biosynthesis decreases, and free radicals and harmful environmental factors such as wind, cold or dry weather, increased UV radiation due to ozone depletion, excessive soap or detergent use, shaving, etc. The generation of harmful factors such as active harmful oxygen is increased, and the skin is deteriorated due to excessive physical and chemical external stimuli and internal stimuli due to stress, so that the skin becomes rough and aging is accelerated, and the degree of damage Becomes worse.

Therefore, to prevent and alleviate this phenomenon, in order to maintain healthier and more beautiful skin, cosmetics contain a variety of highly bioactive substances derived from natural products, plants, and microorganisms, which are conventionally obtained from various animals, plants, and microorganisms, to maintain the unique function of the skin. And various attempts have been made to effectively inhibit or alleviate skin aging by enhancing and activating skin cells.

In addition, melanocytes among the cells constituting human skin are known as important cells for synthesizing and releasing melanin to determine the color of the skin. Melanosite is known to synthesize melanin by ultraviolet rays, free radicals and other factors, making the skin black. In particular, the long wavelength band (UV-A 320-400 nm) of ultraviolet rays is reported to be directly related to the melanin synthesis of the skin. The process of synthesizing melanin is produced by tyrosinase as a substrate, and dopaquinone is produced by tyrosinase, and melanin is produced through spontaneous and enzymatic reaction from dopaquinone. Therefore, the whitening cosmetics have the function of inhibiting the activity of tyrosinase during the melanin biosynthesis process for the purpose of inhibiting melanin biosynthesis, and it is currently reported to have excellent whitening function ascorbic acid, kojic acid, arbutin, hydroquinone and epidermis Extracts, upper lichen extracts, licorice extracts, and extracts of the mulberry. Natural extract-derived materials are somewhat inferior to composites in terms of effects, but are superior in terms of safety, and are therefore actively searching for safe natural products with whitening, wrinkle, and anti-aging functions.

As part of such efforts, a cosmetic composition containing ginseng or red ginseng extract as an active ingredient has been proposed, and as related related art, for example, Korean Patent Publication No. 2002-0040707 (cosmetic composition containing ginseng extract polysaccharide Jinsan) , Korean Patent Publication No. 1996-0020985 (cosmetic composition for hair), Japanese Patent Publication No. 62-93217 (hair tonic using ginseng extract), US Patent No. 5,182,373 (Ginseng saponin reacted with tetravalent ammonium epoxide Hair and skin care products), Japanese Patent Application Laid-Open No. 4-342519 (a composition having a whitening, anti-aging, and skin improvement effect), Korean Patent Registration No. 100334944 (a composition for treating alopecia of herbal ingredients), Korean Patent Publication 2004-0051255 (Cosmetic composition), Korean Patent Publication No. 2005-0087672 (antimicrobial composition), etc. are disclosed, but these are all due to ginseng or red ginseng components Despite its superiority, starch and protein components in ginseng or red ginseng extracts are relatively inferior in stability over time due to relatively inferior stability, leading to phase separation and precipitation during long-term storage. There was a problem that it is difficult to completely exclude.

On the other hand, as another part of the above-mentioned efforts, a cosmetic composition containing deep seawater, which has recently been spotlighted as an active ingredient, has been proposed. As a related related art, for example, Korean Patent Publication No. 2004-0028253 (deep water concentrate) Cosmetics), Korean Patent Publication No. 2005-0064758 (Ocher powder skin cosmetic composition using deep water), Korean Patent Publication No. 2006-0031329 (composition for skin elasticity containing beta 1,3-glucan and deep sea water) ), Korean Patent Publication No. 2004-0025267 (Cosmetic Composition for Exfoliation), Korean Patent Publication No. 2005-0081543 (Moisturizing Cosmetic Composition), Japanese Patent Publication No. Hei 9-110702 (Marine Deep Water-containing Gel Formulation), etc. These are produced by filtration or electrolysis by deep seawater, their dilution or concentrate, or reverse osmosis membranes, permeable membranes or cations and / or anion exchange resins. And using the number of desalination. However, since they mainly use the effects of relatively rich minerals and organics in the deep water, there is a certain limit to the implementation of the effects.

However, as far as the present inventors understand, the synergistic effect is utilized by harmonizing stabilizing the active ingredient in ginseng or red ginseng extract and the thorny opi extract and the rich minerals and organics in the deep seawater by the inert salt effect. Therefore, there is no attempt to develop a cosmetic having excellent anti-aging and itching effect, skin disease improvement effect, skin softening, skin moisturizing, and whitening effect, and excellent cyanogenic stability.

Accordingly, an object of the present invention is to provide a cosmetic composition that is excellent in preventing skin aging and removing itch, and satisfactorily satisfying skin disease improvement, skin softening, and skin moisturizing and whitening effects, and also excellent aging stability.

According to a preferred aspect of the present invention for achieving the above object of the present invention, 0.001 to 75% by weight of red ginseng or ginseng extract, 0.01 to 0.3% by weight of barberry extract and 0.01 to 25% by weight of deep seawater, If desired, a cosmetic composition is provided comprising 0.1 to 3% by weight of fennel extract as an optional ingredient.

According to another preferred aspect of the present invention for achieving the above object of the present invention, the red ginseng or ginseng and thorny opi, and the fennel extract is an extract by ethanol, water, or a mixed solvent thereof, the deep sea water Has a hardness of 6720 to 6620, generally 6760 to 6800, evaporation residues 32000 to 38000 mg / l, generally 34000 to 36000 mg / l, and a pH of 7.8 to 7.9 Turbidity of 0.2 NTU or less, preferably 0.15 NTU or less, with a salinity of 34 to 34.2 ‰, zinc content of 0.001 to 0.818 µg / l, generally 0.100 to 0.625 µg / l, iron content of 0.004 to 0.217 µg / l, Generally, it is 0.005 to 0.455 µg / l, manganese content of 0.005 to 0.265 µg / l, generally 0.005 to 0.455 µg / l, potassium content of 390 to 420 mg / l, and generally 402 to 452 mg / l. , Calcium content 400-465 mg / l, generally 410 There is provided a cosmetic composition having a content of -480 mg / l, a magnesium content of 1320-1390 mg / l, generally 1330-1470 mg / ml, and a molybdenum content of 0.015-0.005 mg / l.

According to another preferred aspect of the present invention for achieving the above object of the present invention, the red ginseng or ginseng extract is 1.5 to 80 ° brix, specifically the red ginseng or ginseng extract is 1.5 to 3.5 ° brix, When added with an extract, a cosmetic composition is provided wherein the fennel extract is 1.5-3.5 ° brix.

According to still another preferred aspect of the present invention for achieving the above object of the present invention, the red ginseng or ginseng extract, thorny opi extract, and fennel extract are passed through a membrane having an average pore size of 3 to 5㎛ Cosmetic compositions are provided.

According to still another preferred aspect of the present invention for achieving the above object of the present invention, there is provided a cosmetic composition wherein the salt concentration of the above-mentioned deep water is desalted in the range of 0.85 to 0.90%, or less.

As a source of the active ingredient used in the preparation of the cosmetic composition of the present invention, ginseng or red ginseng, thorny red ginseng and deep sea water, and fennel as an optional ingredient.

In the present specification, when the ginseng or red ginseng is not specifically described, the term 'ginseng' is defined as a higher conceptual meaning including all of ginseng, white ginseng, and red ginseng.

The cosmetic composition according to the present invention contains phytochemical maltol, β-pinene, dl-mentone and d-limonene and various saponin components derived from ginseng or red ginseng extract, and is rich in minerals derived from deep seawater. And various organic matters matured in the seabed over thousands of years, and the rich mineral ingredient makes various active ingredients derived from red ginseng extract in the form of salts, stabilized by uncorrelated salt effect in cosmetics, and absorbed to skin It is believed that these ingredients have a markedly enhanced anti-aging and itching effect, a skin disease improvement effect, a skin softening effect, a skin moisturizing effect, and a whitening effect. Satisfied enough

The ginseng or red ginseng extract added in the cosmetic composition of the present invention may be an extract extracted at atmospheric pressure or reduced pressure using ethanol, water, or any mixed solvent thereof, or a concentrated extract thereof, but it is prepared from 4-6 year old ginseng. Commercially available red ginseng concentrates can be used, for example Red Ginseng Extract from Korea Ginseng Corporation.

Ginseng (Panax ginseng CA Meyer) or red ginseng contains glycosides, polyacetylene compounds, nitrogen-containing compounds, flavonoids, vitamins (group B), trace elements, enzymes, antioxidants, organic acids and amino acids. In particular, the main component of the non-saponin substance is known to promote physiological activity because it contains the phenol component and the polyacetylene component which is an antioxidant activity and cancer cell proliferation inhibitory active ingredient. Red ginseng has sedative and excitatory effects on the central nervous system. It also acts on the circulatory system to prevent hypertension and arteriosclerosis, while lowering hematopoietic and blood sugar levels, protecting the liver, and acting on the endocrine system. Indirectly effective on the reproductive effect, has an anti-inflammatory and anti-tumor effect, is known to act as a protective effect against radiation, in particular to protect and soften the skin.

Especially, red ginseng contains cancer cell proliferation inhibitor, anti-tumor ingredient (ginsenoside RH2) and cancer cell metastasis inhibiting ingredient (20, s, Ginsenoside RG3) .In addition, red ginseng contains 60 ~ 70% of carbohydrates such as starch. Although not found in other plants, ginseng saponin (ginsenoside), polyacetylene (polyacetylene), antioxidant phenolic compounds, gomisin-N (-A), hepatoprotective acid, insulin-like acid It is known that peptides and the like are contained.

Maltol, one of its active ingredients, is an antioxidant that contains a lot of red ginseng. It is known to increase liver function, renal function, heart function, inhibit the accumulation of aging substances and restore fatigue, thus showing great efficacy in preventing aging. Biochem.Molec.Bio, Vol. 39, No. 2, Mar. 2006, 145-149; J. Agri. Food Chem. 2006, 54, 2558-2562; Biol. Pharm. Bull. 29 (4) 750- 754 (2006).

One of the other active ingredients, β-pinene, is known to have an excellent biochemical action in antibacterial, anti-swelling, anti-inflammatory, and blood circulation (Phytother. Res. 17, 1-18 (2003); J. Der. Sci. (2006) 41, 137-142), dl-mentone has been reported for analgesic, anti-allergic, anti-toxic, antibacterial, insecticidal, anti-cancer activity (Int. J. Pharm. 229 (2001) 37-44; Int. J. Pharm. 219 (2001) 177-181) and d-limonene have been reported to have analgesic effects, antidepressants, anti-tumor, and blood circulation lowering by enhancing blood circulation (Int. Immunopharmacology 5 (2005) 829). -838; Drug Des Deliv. 1990 Sep; 6 (3): 229-38; Vitam Horm. 2005; 72: 505-35).

In addition, the other effective plant extract component in the cosmetic composition of the present invention is an extract of Eleutherococcus senticosus or Acanthopanax nticosus, which is aliased as Siberian ginseng (siberian sinseng), the active ingredient of which is particularly contained in the dermis. (Eleutheroside E) and Acanthocide D and the like.

Prickly Ogapi is a low-temperature and grotesque plant that lives in Siberia, northeastern China, Manchuria, high altitudes over 600m above sea level, and Hokkaido.It is a variety of species including thorny oopi, mingashiopi, wangagaipi, jirisanopi, seoulopi, island ogapi According to the recent research results, it is reported that Korean prickly pears have 4 and 6 times higher content of eleuteroside E and acantoside D than Siberian prickly pears or Chinese prickly pears, respectively.

The thorny ogapi used in the present invention is not particularly limited even if any one of thorny ogapi, mingashiogai, jirisan ogapi, island ogapi, white hair ogapi and the like is used herein. It means, but it is preferably thorny ogapi, folk house ogapi, white hairy ogapi.

Prickly tortoise has a tonic effect and an unspecific adaptogen effect, and its extract prevents disease, and it is effective against adrenal weight increase and spleen contraction caused by stress in restraint stress experiment using rats In addition, it has been reported that there is a slight effect on reducing the content of ascorbic acid in the adrenal glands and also does not excite humans, so there is no side effect such as insomnia unlike ginseng (Lloydia, Vol. 32, No. 1, 1969). In addition, labor force improvement and gonadotropin have been reported.

In the cosmetic composition of the present invention, the above-mentioned prickly pear extract (1.5-30 ° brix) is used at about 0.01 to 0.3% by weight, and if it is less than 0.01% by weight, the expected effect may not be sufficient, whereas 0.3% by weight is used. If it exceeds, since it may cause skin irritation, it is not preferable.

In addition, in the cosmetic composition of the present invention, the fennel (Foeniculum vulgare Mill) as an optional plant, the extract of which may be used as one of the active ingredients, is widely known as fennel, and has been used as a breast milk promoting agent and for treating a stomachache. Its main components are volatile oils (anethole, fenchone), flavonoids, sterols, vitamins and minerals, and antiseptic and anti-inflammatory and antibacterial effects (Int J Antimicrob Agents 1997 Jan; 9 (3): 195-9. 1996; 10: 33-6.Plan Med 2000; 66: 687-93).

The mixed extract of the above-mentioned plants added as an active ingredient in the cosmetic composition of the present invention may be extracted from the roots, leaves, stems, fruits, or a mixture thereof of these plants, but preferably in the case of ginseng or red ginseng, the roots, In the case of prickly pear, the extract is derived from the root bark, and in the case of fennel.

Meanwhile, deep seawater added as an active ingredient to the cosmetic composition of the present invention is a seawater at a depth of 200 m or more in which solar light does not reach the continental shelf from the continental shelf, and forms a deep flow that circulates the earth every 1500 to 2000 years. It is known.

Deep water is formed (aged) over a long period of time under high water pressure under low temperature (low temperature stability) with a constant annual water temperature, and is rich in 60 kinds of minerals, as well as enriching nutrients up to tens of times of surface water. Eutrophic) and is less than one-hundredth the number of microorganisms (clean) compared to surface water.

More specifically, ocean surface water consumes nitrogen, phosphorus, and nitric acid in water by photosynthesis, whereas phytoplankton consuming nutrients do not exist because deep sunlight below 200 m does not reach sunlight. As a result, photosynthesis hardly occurs, and thus, deep water contains inorganic nutrients such as nitrogen, phosphorus, and nitric acid, which are consumed by photosynthesis, and contains many minerals and essential trace elements necessary for the human body. In addition, since it exists in the depth of water, there is no fear of contamination by E. coli or general bacteria, and the possibility of contamination by chemicals from land or the air is low, thus maintaining cleanliness. In addition, it has a low water temperature, stable and low temperature change all year round, and since it is a seawater formed over thousands of years, its properties are stable, and it has ripening due to the action of various enzymes. In addition, it contains the essential trace elements and various mineral components in a balanced manner and has the excellent scavenging effect on free radicals by the action of dissolved metal ions, and exfoliates and whitens the skin, and activates moisturizing and water retention functions. It is known that there is.

Deep water is attracting attention as a regenerative circulation natural resource, and recently, medicines for the treatment of marine temperature difference, salt production, marine therapy, and atopic dermatitis (Jadowa News, Vol. 5, No. 1, 2001), skin care cosmetics, aquaculture industry Research is being actively conducted for a wide variety of applications, including the production of various food products, including cultivation, fishery, and beverages.

The above-mentioned deep water is raw water taken from the sea area 660m in the sea area of 4.2km in front of Goseong-gun, Gangwon-do and Hyunpo-ri, Buk-myeon, Ulleung-gun, Gyeongsangbuk-do, or Oki, Suruga Bay, Toyama, Suruga Bay, Kochi, Okinawa, and Kona, Hawaii Raw water taken from the water may be used, and in the case of a lotion, desalted water may be used. For example, Iromsa of Korea, Deep Water Co., Ltd., New Jena of Japan, Ito Chuo Fisheries of Japan, and Enzamin of USA Various deep water products are commercially available from Coyosa, Deep Sea Health, Cyanotech, and others.

If necessary, the above-described deep salt water may be desalted and adjusted to a concentration of 0.85 to 0.9% of the physiological salt concentration of the body by membrane filtration, ion exchange resin passage, electrolysis dialysis, or the like.

According to the analysis results of the various deep waters by the inventors, these deep waters have a hardness in the range of 6720 to 6620, generally 6760 to 6800, and an evaporation residue content in the range of 32000 to 38000 mg / L, in general. It is in the range of 34000 to 36000 mg / l, pH is in the range of 7.8 to 7.9, turbidity is 0.2 NTU or less, preferably 0.15 NTU or less, salinity is in the range of 34 to 34.2 ‰, zinc content 0.001 to 0.818 Μg / L, generally 0.100 to 0.625 μg / L, iron content 0.004 to 0.217 μg / L, generally 0.005 to 0.455 μg / L, manganese content 0.005 to 0.265 μg / L, generally 0.005 to 0.455 G / l, potassium content 390-420 mg / l, generally 402-452 mg / l, calcium content 400-465 mg / l, generally 410-480 mg / l, magnesium content 1320-1390 Mg / L, generally 1330-1470 mg / ml, and the molybdenum content is in the range of 0.015-0.005 mg / L.

In the cosmetic composition according to the present invention, the mixed extract added as an active ingredient may include ginseng or red ginseng extract and barberry extract, and may further include a fennel extract.

In the cosmetic composition according to the present invention, the composition ratio of the above-mentioned mixed extract is 0.001% to 75.0% of ginseng or red ginseng extract, 0.01% to 0.3%, and fennel extract of 0.1% to 3.0% based on the weight of the composition before cosmetics. However, the ratio is not absolute and optional in the present invention because it may be changed by various parameters such as the formulation of the cosmetic composition, the age group or skin tendency to be applied, the kind of the surfactant added, and the like.

Next, the manufacturing process of the above-mentioned mixed extract contained in the cosmetic composition of the present invention as an active ingredient will be described.

The ginseng or red ginseng used in the extraction of the present invention is roots, roots and thorns of at least 3 years from which the brains are removed, and stems and leaves and roots (preferably root) and fennel are preferably used in dry places. There is no particular limitation, but water, ethyl ether, ethanol, methanol, 1-butanol, isopropanol, chloroform, benzene may be used, but preferably water, ethanol, or any mixture thereof, but also commonly used in the art. Conventional extractive organic solvents or mixed solvents thereof may also be used.

Ginseng or red ginseng, thorny ginseng, and fennel extract, which are the active ingredients in the cosmetic composition according to the present invention, are prepared using the specific solvent described above for 8 to 24 hours under moderate stirring at 100 to 150 rpm at a temperature of 60 to 100 ° C. Extract to atmospheric pressure or reduced pressure, and then filtered to remove solids, if necessary using a rotary evaporator under reduced pressure concentrator of 1.5 to 80 brix, particularly 1.5 to 3.5 brix, in some cases using a freeze dryer. It may be used in a powdered state. In addition, depending on the formulation, it may be used after making it clear through a membrane having an average pore size of 3 to 5 µm.

In the present invention, in order to effectively extract the above-mentioned effective ingredient, it is necessary to select a target extraction component and a solvent capable of obtaining an optimum extraction amount (yield), and to consider the ease of removal of the solvent and the residual allowable amount.

The cosmetic composition according to the present invention also comprises conventional at least one or more anionic surfactants, nonionic surfactants, amphoteric surfactants, cationic surfactants and mixtures thereof conventionally used in the preparation of conventional cosmetic compositions. And their content is generally from 2 to 40% by weight, preferably from about 2 to 25% by weight, based on the total weight of the composition. In addition, in addition to the above surfactants, the usual ingredients specified in the cosmetic regulations such as viscosity regulators, pH regulators, fragrances, colorants, antioxidants can be used.

In addition, if necessary, the structure of sesquiterpene-based panacene, panaxinol, etc., having a relatively low boiling point between 0.92 and 0.93 and boiling point of 60-110 ° C. contained about 0.05% of the root, is uncertain. As a yellow oily substance mixed with unknown components, the aromatic component of ginseng, which is known to have excellent pharmacological effects such as anticancer, neurostable, and vascular movement promotion, may be separately included. These fragrance components are mostly lost with water vapor due to high temperature boiling water during 2-3 hours of steaming hot ginseng for 2-3 years in the case of white ginseng or red ginseng. Such fragrance components may be added to essences or foundation lotions to contribute to the improvement of the sensory properties according to the unique ginseng flavor.

In the cosmetic composition according to the present invention, if the amount of the active ingredient is less than the above-mentioned range, the addition effect may be weak. Conversely, if it exceeds the above-mentioned range, it is not economically desirable or formulated. There is a fear that it may be difficult to use, in particular, the use of deep water source water content of 25% by weight or more may be undesirable because there is a fear of increasing skin irritation.

The cosmetic composition according to the present invention may be formulated in various forms such as packs, nutrient creams, massage creams, body cleansers, nourishing lotions, flexible lotions, essences, body lotions, hair lotions, etc., in particular, exfoliating packs, moisturizers, It is expected to be of great applicability as an adjuvant for the prevention of skin diseases such as whitening agent and atopic dermatitis.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples and Test Examples, which are intended to illustrate the present invention but are not intended to limit the present invention.

Extraction Example 1:

Chop 100 g of Korean ginseng and 0.2 g of ginseng seedlings for 6 years from Korea Ginseng Corporation and extract it for 24hr at a stirring speed of 150rpm at a temperature of 70 ℃ using a mixed solvent of 300g of water: ethanol = 70: 30 in volume ratio and extract the extract solution by vacuum evaporator. Concentrated under reduced pressure with Briggs 3 using.

Extraction Example 2:

Chop 100 g of Korean ginseng, 0.3 g of thorny red ginseng, and 1.5 g of fennel for 6 years from Korea Ginseng Corporation, extract the extract for 24hr at a stirring speed of 150 rpm at a temperature of 70 ° C. using 300 g of a mixed solvent of water: ethanol = 70: 30 in volume ratio. Was concentrated under reduced pressure to Briggs 2.5 using a vacuum evaporator.

Extraction Example 3:

10 g of barbed oak skin was cut and extracted with a volume ratio of 300 g of water: ethanol = 70: 30 at 300 ° C. at a temperature of 70 ° C. for 24hr at 150 rpm, and 0.2 ml of barbed oak extract concentrate concentrated with brix 3 and red ginseng extract (72 ° C) brix) 100 ml were mixed.

Analysis example:

Deep water taken from 660m of the seabed in 4.2km in front of Buk-myeon, Ulleung-gun, Gyeongsangbuk-do and its major elements, nutrients, trace elements, viable counts, and general water quality were analyzed and the results are shown in Table 1 below.

Item Deep ocean water Surface waters General item Water temperature (℃) 10.8 to 12.3 16.5-24.0 pH 7.98 8.15 DO (mg / L) 7.80 8.91 TOC (mg / L) 0.962 1.780 Soluble Evaporation Residue 40750 37590 M alkaline 114.7 110.5 Major element Cl (%) 2.237 2.192 Na (%) 1.080 1.030 mg (%) 0.130 0.131 Ca (mg / L) 456 441 K (mg / L) 414 399 Br (mg / L) 68.8 68.1 Sr (mg / L) 7.77 7.61 B (mg / L) 4.44 4.48 Ba (mg / L) 0.044 0.025 F- (mg / L) 0.53 0.56 SO42 (mg / L) 2833 2627 Nutrients NH4-N (mg / L) 0.05 0.03 NO3-N (mg / L) 1.158 0.081 PO4- (mg / L) 0.177 0.028 Si (mg / L) 1.89 0.32 Trace elements Pb (ug / L) 0.102 0.087 Cd (ug / L) 0.028 0.008 Cu (ug / L) 0.153 0.272 Fe (ug / L) 0.217 0.355 Mn (ug / L) 0.265 0.313 Ni (ug / L) 0.387 0.496 Zn (ug / L) 0.624 0.452 As (ug / L) 1.051 0.440 Mo (ug / L) 5.095 5.555 Bacteria Viable count (dog / mL) 10 ^ 2 10 ^ 3 to 10 ^ 4

Example 1 and Comparative Examples 1,2:

A peel off pack having the compositional components and the composition ratios as shown in Table 2 below was formulated in a conventional manner.

Peel-off pack weight% ingredient Example 1 Comparative Example 1 Comparative Example 2 Dipropylene glycol 2.0 2.0 2.0 Polyvinyl alcohol 1.0 1.0 1.0 Carboxymethyl Cellulose 7.0 7.0 7.0 glycerin 1.5 1.5 1.5 Cyclomethicone 2.5 2.5 2.5 Cetyloctanoate 3.5 3.5 3.5 Sorbitan stearate 1.5 1.5 1.5 Mixed solution of extraction example 3 50.0 50.0 - Depth ^{* 1} 15.0 - 15.0 ethanol 10.0 10.0 10.0 Spices Quantity Quantity Quantity Purified water Remaining amount Sum 100.0

* 1: Head of Korea Deep Water Co., Ltd.

Examples 2,3 and Comparative Examples 3,4

Nutrient cream having the composition and the ratio of the composition as shown in Table 3 below was formulated in a conventional manner.

Nutrient Cream weight% ingredient Example 2 Example 3 Comparative Example 3 Comparative Example 4 Liquid paraffin 6.0 6.0 6.0 6.0 Squalane 4.0 4.0 4.0 4.0 Sorbitan sesquioleate 0.5 0.5 0.5 0.5 Polysorbate 60 1.5 1.5 1.5 1.5 beeswax 10.0 10.0 10.0 10.0 glycerin 6.0 6.0 6.0 6.0 Caprylic Triglycerides 5.0 5.0 5.0 5.0 Propylene glycol 3.0 3.0 3.0 3.0 Butylene glycol 2.0 2.0 2.0 2.0 Triethanolamine 0.2 0.2 0.2 0.2 Extract of Extraction Example 2 3.0 3.0 3.0 - Deep water 15.0 ^{* 1} 15.0 ^{* 2} - 15.0 ^{* 2} Spices 0.3 0.3 0.3 - Purified water Remaining amount Sum 100.0

* 1: Head of deep water of Korea

* 2: Desalination deep water (US salt concentration 0.9%)

Example 4 and Comparative Examples 5,6

Massage creams having the composition and the composition ratio as shown in Table 4 below were formulated in a conventional manner.

Massage cream weight% ingredient Example 4 Comparative Example 5 Comparative Example 6 Liquid paraffin 30.0 30.0 30.0 Squalane 5.0 5.0 5.0 Sorbitan sesquioleate 0.9 0.9 0.9 Polysorbate 60 1.5 1.5 1.5 beeswax 10.0 10.0 10.0 Caprylic Triglycerides 3.0 3.0 3.0 glycerin 6.0 6.0 6.0 Propylene glycol 2.0 2.0 2.0 Butylene glycol 4.0 4.0 4.0 Extract of Extraction Example 1 15.0 15.0 - Depth ^{* 1} 15.0 - 15.0 Spices Quantity Quantity Quantity Purified water Remaining amount Sum 100.0

* 1: Head of deep water of Korea

Example 5 and Comparative Example 7.8

A nutritional lotion having a composition and a composition ratio as shown in Table 5 below was formulated in a conventional manner.

Nutrition lotion weight% ingredient Example 5 Comparative Example 7 Comparative Example 8 Cetanol 1.0 1.0 1.0 Stearyl alcohol 1.0 1.0 1.0 Glycerin Monostearate 3.0 3.0 3.0 Sorbitan monostearate 1.0 1.0 1.0 POE sorbitan monostearate 2.0 2.0 2.0 vaseline 2.0 2.0 2.0 Liquid paraffin 6.0 6.0 6.0 Squalane 5.0 5.0 5.0 Octyldodecyl Myristate 5.0 5.0 5.0 glycerin 5.0 5.0 5.0 1,3-butylene glycol 5.0 5.0 5.0 Carboxy Vinyl Polymer 0.2 0.2 0.2 Triethanolamine 0.2 0.2 0.2 Extract of Extraction Example 2 1.5 1.5 - Depth ^{* 1} 15.0 - 15.0 Spices Quantity Quantity Quantity Purified water Remaining amount Sum 100.0

* 1: Japan's Itozu-Suisan Kabushiki Kaisha Desalting Deep Water (salt concentration 0.9%)

Example 6 and Comparative Examples 9,10

A flexible lotion having a composition component and a composition ratio as shown in Table 6 below was formulated in a conventional manner.

Flexible lotion weight% ingredient Example 6 Comparative Example 9 Comparative Example 10 glycerin 2.0 2.0 2.0 Propylene glycol 3.0 3.0 3.0 1,3-butylene glycol 2.0 2.0 2.0 Carboxy Vinyl Polymer 0.1 0.1 0.1 Triethanolamine 0.1 0.1 0.1 Extract of Extraction Example 2 ^{* 1} 15.0 15.0 - Deep Water ^{* 2} 10.0 - 10.0 Spices Quantity Quantity Quantity Purified water Remaining amount Sum 100.0

* 1: average pore size of the extract of Extraction Example 2 3 μm membrane clear liquid

* 2: Desalted deep water of Japan Itozuosuisan Co., Ltd. (salt concentration 0.9%)

Example 7 and Comparative Examples 11,12

Essences having the composition components and composition ratios as shown in Table 7 below were formulated in a conventional manner.

essence weight% ingredient Example 7 Comparative Example 11 Comparative Example 12 glycerin 10.0 10.0 10.0 Propylene glycol 5.0 5.0 5.0 1,3-butylene glycol 10.0 10.0 10.0 Carboxy Vinyl Polymer 0.5 0.5 0.5 Polyethylene Glycol 1500 5.0 5.0 5.0 Hydroxyethyl cellulose 0.5 0.5 0.5 Carboxy Vinyl Polymer 0.5 0.5 0.5 Polyoxyethylene nonylphenyl ether 0.8 0.8 0.8 Triethanolamine 0.5 0.5 0.5 Extract of Extraction Example 1 ^{* 1} 15.0 15.0 - Deep Water ^{* 2} 12.0 - 12.0 Spices Quantity Quantity Quantity Purified water Remaining amount Sum 100.0

* 1: Average pore size of the extract of Extraction Example 1 3 μm membrane clear liquid

* 2: Desalted deep water of Japan Itozuosuisan Co., Ltd. (salt concentration 0.9%)

Example 8 and Comparative Examples 13 and 14

A body cleanser having a compositional component and a composition ratio as shown in Table 8 below was formulated in a conventional manner.

Body cleanser weight% ingredient Example 8 Example 13 Comparative Example 14 Ammonium Laureth Sulfate 16.0 16.0 16.0 Ammonium Lauryl Sulfate 6.0 6.0 6.0 Cocamidopropyl Betaine 5.0 5.0 5.0 Alkylpolyglycosides 2.0 2.0 2.0 PEG-7 glyceryl cocoate 0.5 0.5 0.5 glycerin 1.5 1.5 1.5 Extract of Extraction Example 3 25.0 25.0 - Depth ^{* 1} 8.0 - 8.0 Spices 0.4 0.4 0.4 Purified water Remaining amount Sum 100.0

* 1: Head of deep water of Korea

Test Example 1:

The tyrosinase inhibitory effect was measured for the extract obtained in Extraction Example 3, the raw water of Daehan Deep Water Co., Ltd., and a mixed solution of 4: 1 in a weight ratio thereof.

85 μl of tyrosinase (125 unit / ml, manufactured by Sigma) was added to a 96-well plate, and 85 μl of the extract was added thereto, and allowed to stand at 37 ° C. for 10 minutes, and then 85 μl of tyrosine (0.1 mg.ml) was added thereto. After reacting at 37 ° C. for 30 minutes, the absorbance at 475 nm was measured by spectrophotometer. As a control, purified water was used.

Tyrosinase activity inhibitory effect was calculated | required with the following formula about ten samples, respectively, and the average value is shown in Table 9 below.

% Inhibition = (absorbance of control-absorbance of extract) / absorbance of control] X 100

IC ₅₀ (μg / ml) Extract Liquid of Extraction Example 3 74.1 Commercial Deep Water 8.4 Mixed solution 91.1

The above results indicate that the mixed solution of the extract of the extraction example 3 and the raw water of the deep water has surprisingly higher tyrosinase activity effect than expected, which indicates that the mineral rich in the deep water of the extract of extract example 3 It is believed that this is due to the synergistic interaction with some active ingredients.

Test Example 2:

After applying the pack prepared according to Example 1 and Comparative Examples 2, 3, the melanin index was measured by using a melanin-erythema index meter (Table 10).

Melanin index Before use after use Example 1 104.61 ± 32.14 95.87 ± 29.61 Comparative Example 1 105.42 ± 28.72 99.53 ± 27.92 Comparative Example 2 107.53 ± 31.87 104.84 ± 31.57

From the above results, the experimental group using the cosmetic according to Example 1 was able to confirm that the melanin index was much reduced compared to the case of using the extract and the deep water of the extraction example 3 in Comparative Examples 1 and 2. From this, the whitening effect on the cosmetic composition of Example 1 according to the present invention was confirmed.

Test Example 3:

In order to examine the skin irritation properties of formulations prepared according to the conventional methods in Examples 2 and 3 and Comparative Examples 3 and 4, an appropriate amount (2.0 g) of each sample was applied to the lower arm and hip for 30 healthy adult men and women. Buried in the hazel chamber for 48 hours, the hazel chamber was removed, and after 30 minutes to 1 hour, the skin condition change was visually determined and determined first, and then removed and read again after 48 hours. The results are shown in Table 11 below.

Test embroidery - ± + ++ Primary Secondary Primary Secondary Primary Secondary Primary Secondary Stimulus Example 2 30 29 30 One 0 0 0 0 0 0.27 Example 3 30 30 29 0 0 0 0 0 0 0.27 Comparative Example 3 30 30 29 0 0 0 0 0 0 0.27 Comparative Example 4 30 29 28 One 2 0 0 0 0 0.83

* Judgment

-: No reaction (Irritation degree: 0)

± suspected positive reaction. Slight erythema reaction. (Irritation degree: 0.5)

+: Slight positive reaction. Erythema, papules, positive pullback reaction (irritation degree: 1.0)

++: Severe positive reaction. Vesicular reactions: erythema, papules, infiltrating lesions, vesicles (irritation degree: 2.0)

+++: Extremely positive

* Stimulus = {(ㅁ Respondents x 0.5) + (+ Responders x1) + (++ Responders x2) / Total Responders x Maximum Response (3)} x 100 x1 / 2

The skin irritation test results showed a lower irritation degree in Examples 2 and 3 than in Comparative Example 4 using the deep water alone, which was found to have an alleviating effect by the extract of Extraction Example 3.

Test Example 4:

The irritation and the exfoliation effect of the packs prepared according to Example 1 and Comparative Examples 2 and 3 were evaluated as follows.

Twenty female subjects who suffered from keratin were assessed on a 5-point scale based on the five-point scale.

In the evaluation, 5 points were given when the satisfaction was high because of the excellent exfoliation effect but no irritation, and 1 point was given when the satisfaction was low due to the lack of the exfoliation effect and the strong irritation.

Exfoliation effect pepper Example 1 4.2 4.0 Comparative Example 1 2.7 4.3 Comparative Example 2 3.5 3.2

Compared to the case of using only the deep water, the exfoliation effect is increased while the irritation is reversed, compared to the case of using only the deep water.

Test Example 5:

For Example 8 and Comparative Examples 13 and 14, 20 female professional evaluation groups were evaluated after actually using the cosmetic composition according to the following items and criteria, and the results are shown in Table 13 below.

항목 Evaluation item: Skin disease (erythema, papule) improvement, skin softening and moisturizing effect

기준 Evaluation criteria

Five points: Good / Four points: Somewhat good / Three points: There is no difference / Two points: Somewhat poor / 1 point: Poor

* Evaluation results of body cleanser

Evaluation item Comparative example Example 13 14 8 Skin disease (erythema, papule) improvement 4.2 3.8 4.7 Skin softening 4.4 4.1 4.5 Moisturizing effect 4.0 3.4 4.1

As a result of evaluation, the body cleanser as a cosmetic composition according to the present invention showed a significant result when compared with the comparative example in improving skin diseases (erythema, papule), skin softening and moisturizing effect.

Test Example 6:

Twenty women aged 20 to 30 years were observed for skin condition before and after the test and the amount of stratum corneum was measured. During the test period, skin irritation, red spots and rashes were examined. Transdermal moisture loss (TEWL) was measured using Dermalab® (Cortex Technology, Hadsund, Denmark). 20 female professional evaluation groups were evaluated after using the cosmetic compositions of Example 7 and Comparative Examples 11 and 12 for 6 weeks based on the evaluation items and criteria shown in Table 14 below, and the results are shown in Table 15 below.

Evaluation item Evaluation item evaluation score   Skin condition Clear skin condition 5 Clear skin condition 4 Skin condition 3 Partial stratum corneum detachment 2 Extensive exfoliation of the stratum corneum One   Skin familiarity Good 5 Somewhat good 4 usually 3 Multiple failures 2 Bad One   Skin irritation No irritation 5 Fine irritation 4 Slight irritation 3 Feel clearly 2 Feeling strongly One   Skin abnormalities Not checked 5 Fine over 4 Slight abnormalities 3 Some abnormalities 2 Serious abnormalities One

Evaluation results Item Example Comparative example 7 11 12 Skin condition improvement 4.4 4.1 3.7 Skin familiarity 4.0 3.9 3.9 Skin irritation 4.8 4.8 4.1 Skin abnormalities 4.9 4.6 4.3

Test Example 7:

Stability for the cosmetic composition according to the present invention was measured by the following method. The cosmetic composition of Examples 1 to 8 was stored in an opaque glass container in a constant temperature bath at 25 ° C. and 45 ° C. and stored for 12 weeks. Stability was measured and evaluated by visual observation of occurrence of precipitation and phase separation.

As a result, good results were obtained in all of Examples 1 to 8.

The results are shown in Table 16 below.

Item Example 1 Example 2 Example 4 Example 5 Example 6 Example 7 Example 8  stability 25 ℃ ◎ ◎ ◎ ◎ ◎ ◎ ◎ 45 ℃ ◎ ◎ ○ ◎ ◎ ◎ ○ -20 ~ 25 ℃ ○ ◎ ◎ ◎ ◎ ◎ ◎  * Very stable: ◎, stable: ○, unstable: ×

As described above, the cosmetic composition according to the present invention is a synergistic (synergy) action of ginseng or red ginseng extract components and thorny opi extract components, and deep sea water components, exfoliation, itching, skin diseases such as atopic dermatitis improvement and skin softening And excellent effects on moisturizing and whitening, low irritation, and good stability over time.

Claims (9)

A cosmetic composition comprising 0.001 to 75% by weight of red ginseng or ginseng extract, 0.01 to 0.3% by weight of barberry extract and 0.01 to 25% by weight of deep sea water. The cosmetic composition according to claim 1, further comprising 0.1 to 3% by weight of fennel extract. The cosmetic composition according to claim 1 or 2, wherein the red ginseng or ginseng extract is 1.5 to 80 ° brix as an extract by water or ethanol, or a mixed solvent thereof. The cosmetic composition according to claim 1 or 2, wherein the prickly pear extract is 1.5 to 3 ° brix as an extract by water or ethanol, or a mixed solvent thereof. The cosmetic composition according to claim 2, wherein the fennel extract is 1.5 to 3 ° brix as an extract by water or ethanol, or a mixed solvent thereof. 3. The method according to claim 1 or 2, wherein the above-mentioned deep seawater has a hardness of 6720 to 6620, the evaporation residue content is 32000 to 38000 mg / l, and the pH is 7.8 to 7.9 , Turbidity of 0.2 NTU or less, salinity of 34 to 34.2 ‰, zinc content of 0.001 to 0.818 µg / l, iron content of 0.004 to 0.217 µg / l, manganese content of 0.005 to 0.265 µg / l, potassium A cosmetic composition having a content of 390 to 420 mg / l, a calcium content of 400 to 465 mg / l, a magnesium content of 1320 to 1390 mg / l, and a molybdenum content of 0.015 to 0.005 mg / l. The cosmetic composition according to claim 2, wherein the red ginseng or ginseng, thorny scabies, and fennel extracts are clarified by passing through a membrane having an average pore size of 3 to 5 µm. The cosmetic composition according to claim 6, wherein the deep water is desalted at a salt concentration of 0.85 to 0.90%. The cosmetic composition according to claim 3, wherein the red ginseng extract comprises a ginseng-derived aromatic component having a specific gravity of 0.92 to 0.93 and a boiling point of 60 to 110 ° C collected by reflux cooling.