KR20080018176A - 다가 바이러스 유사 입자 생산 방법 - Google Patents

다가 바이러스 유사 입자 생산 방법 Download PDF

Info

Publication number
KR20080018176A
KR20080018176A KR1020077028015A KR20077028015A KR20080018176A KR 20080018176 A KR20080018176 A KR 20080018176A KR 1020077028015 A KR1020077028015 A KR 1020077028015A KR 20077028015 A KR20077028015 A KR 20077028015A KR 20080018176 A KR20080018176 A KR 20080018176A
Authority
KR
South Korea
Prior art keywords
virus
peptide
capsid fusion
fusion peptide
viral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020077028015A
Other languages
English (en)
Korean (ko)
Inventor
라다 라소코바
필립 푸옥 다오
제임 펠프스
Original Assignee
다우 글로벌 테크놀로지스 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 다우 글로벌 테크놀로지스 인크. filed Critical 다우 글로벌 테크놀로지스 인크.
Publication of KR20080018176A publication Critical patent/KR20080018176A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/14011Bromoviridae
    • C12N2770/14022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/14011Bromoviridae
    • C12N2770/14023Virus like particles [VLP]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020077028015A 2005-06-01 2006-06-01 다가 바이러스 유사 입자 생산 방법 Withdrawn KR20080018176A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68654105P 2005-06-01 2005-06-01
US60/686,541 2005-06-01

Publications (1)

Publication Number Publication Date
KR20080018176A true KR20080018176A (ko) 2008-02-27

Family

ID=38006346

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077028015A Withdrawn KR20080018176A (ko) 2005-06-01 2006-06-01 다가 바이러스 유사 입자 생산 방법

Country Status (9)

Country Link
US (1) US20070041999A1 (https=)
EP (1) EP1885394A4 (https=)
JP (1) JP2009501001A (https=)
KR (1) KR20080018176A (https=)
CN (1) CN101287489A (https=)
AU (1) AU2006309286A1 (https=)
BR (1) BRPI0611336A2 (https=)
CA (1) CA2608515A1 (https=)
WO (1) WO2007053188A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130083426A (ko) * 2009-06-19 2013-07-22 아이진 주식회사 자궁경부암 백신

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100021391A1 (en) * 2006-07-14 2010-01-28 Montana State University Novel nanoparticles for biofilm targeting
SG10202012986SA (en) 2006-09-29 2021-01-28 Ligocyte Pharmaceuticals Inc Norovirus vaccine formulations
WO2009033004A1 (en) * 2007-09-07 2009-03-12 Montana State University Protein cages and their uses
JP2010539192A (ja) 2007-09-18 2010-12-16 リゴサイト ファーマスーティカルズ,インコーポレイテッド ノロウイルスに対して防御免疫応答を付与する方法
US20100266636A1 (en) 2007-09-18 2010-10-21 Ligocyte Pharmaceuticals, Inc. Method of conferring a protective immune response to norovirus
AU2011276328C1 (en) 2010-07-06 2016-01-21 Novartis Ag Norovirus derived immunogenic compositions and methods
CA2841356C (en) 2011-07-11 2022-03-01 Takeda Vaccines, Inc. Parenteral norovirus vaccine formulations
CA2872803C (en) * 2012-05-11 2016-10-11 Medicago Inc. Rotavirus-like particle production in plants
EP2870238A4 (en) 2012-07-05 2016-03-09 Ohio State Innovation Foundation COMPOSITIONS AND METHODS RELATED TO VIRAL VACCINES
US10086062B2 (en) 2012-07-05 2018-10-02 Ohio State Innovation Foundation Infectious pancreatic necrosis virus (IPNV) vaccine compositions
WO2015101666A1 (en) * 2014-01-03 2015-07-09 Fundación Biofísica Bizkaia VLPs, METHODS FOR THEIR OBTENTION AND APPLICATIONS THEREOF
WO2015191546A2 (en) * 2014-06-10 2015-12-17 The Board Of Regents Of The University Of Texas System Adp-ribose detection reagents
CN105018463A (zh) * 2015-06-05 2015-11-04 北京百迈客生物科技有限公司 一种用于次生代谢物含量高的植物组织的dna提取方法
KR101830792B1 (ko) * 2016-01-27 2018-02-21 건국대학교 산학협력단 항균 펩타이드를 포함하는 불용성 융합단백질 및 이를 이용한 항균 펩타이드의 제조 방법
CN108558990A (zh) * 2018-01-05 2018-09-21 山东省科学院生态研究所 肿瘤靶向肽f3修饰的豇豆褪绿斑驳病毒样颗粒的构建、表达及其应用
US20230038487A1 (en) * 2019-11-25 2023-02-09 The Regents Of The University Of California Modified viral therapeutics and uses thereof
US12440553B2 (en) 2020-11-11 2025-10-14 California Institute Of Technology Multivalent carriers and related vaccine compositions
CN115747170B (zh) * 2022-08-29 2023-08-04 四川大学 一种豇豆褪绿斑驳病毒-多肽复合物及其在骨质疏松治疗中的应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511503A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
GB9108386D0 (en) 1991-04-19 1991-06-05 Agricultural Genetics Co Modified plant viruses as vectors
GB9414118D0 (en) * 1994-07-13 1994-08-31 Axis Genetics Ltd Modified plant viruses as vectors of heterologous peptides
US6042832A (en) * 1996-08-28 2000-03-28 Thomas Jefferson University Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins
ES2572628T3 (es) * 1997-09-05 2016-06-01 Medimmune, Inc. Método in vitro para desmontaje/remontaje de partículas análogas al virus del papiloma humano (VLP)
US6171591B1 (en) 1997-12-08 2001-01-09 Pentamer Pharmaceuticals, Inc. Recombinant nodavirus compositions and methods
KR100312456B1 (ko) * 1999-03-13 2001-11-03 윤덕용 슈도모나스 플루오레슨스 유래의 외래단백질 분비촉진유전자
US6514948B1 (en) * 1999-07-02 2003-02-04 The Regents Of The University Of California Method for enhancing an immune response
GB9924352D0 (en) * 1999-10-14 1999-12-15 Hellendoorn Koen Methods,compositions and applications relating to the generation of novel plant viral particles
US7135282B1 (en) * 1999-10-14 2006-11-14 The Dow Chemical Company Viral particles with exogenous internal epitopes
EP1253947A4 (en) * 2000-01-31 2005-01-05 Univ California IMMUNOMODULATORY POLYNUCLEOTIDES FOR THE TREATMENT OF INFECTION BY AN INTRACELLULAR PATHOGEN
US20030050268A1 (en) * 2001-03-29 2003-03-13 Krieg Arthur M. Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases
WO2003068163A2 (en) * 2002-02-14 2003-08-21 Novavax, Inc. Optimization of gene sequences of chimeric virus-like particles for expression in insect cells
US20030235818A1 (en) * 2002-04-08 2003-12-25 Vsevolod Katritch Immunogenic peptides, and method of identifying same
WO2003103605A2 (en) * 2002-06-07 2003-12-18 Large Scale Biology Corporation Flexible vaccine assembly and vaccine delivery platform
JP4953570B2 (ja) * 2002-07-05 2012-06-13 フォリア バイオテック インコーポレイテッド アジュバントウィルス粒子
WO2005005614A2 (en) 2003-07-03 2005-01-20 Pecos Labs, Inc. Combined b-cell and t-cell epitopes on vlp for improved vaccines
EP1644034B1 (en) * 2003-07-10 2011-01-12 Cytos Biotechnology AG Composition for enhancing an immune response comprising packaged virus-like particles
EP1758925A4 (en) * 2003-12-01 2009-04-08 Dow Global Technologies Inc PRODUCTION OF A RECOMBINANT ICOSAHEDRIC VIRUS LIKE PARTICLE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130083426A (ko) * 2009-06-19 2013-07-22 아이진 주식회사 자궁경부암 백신

Also Published As

Publication number Publication date
BRPI0611336A2 (pt) 2010-08-31
WO2007053188A2 (en) 2007-05-10
AU2006309286A1 (en) 2007-05-10
EP1885394A2 (en) 2008-02-13
WO2007053188A3 (en) 2007-12-06
US20070041999A1 (en) 2007-02-22
CA2608515A1 (en) 2007-05-10
CN101287489A (zh) 2008-10-15
JP2009501001A (ja) 2009-01-15
EP1885394A4 (en) 2009-10-21

Similar Documents

Publication Publication Date Title
KR20080018176A (ko) 다가 바이러스 유사 입자 생산 방법
AU2004313458B2 (en) Recombinant icosahedral virus like particle production in pseudomonads
McCormick et al. Genetically engineered Tobacco mosaic virus as nanoparticle vaccines
US20130236491A1 (en) Spherical nano and microparticles derived from plant viruses for the display of foreign proteins or epitopes
US20070128213A1 (en) Novel plant virus particles and methods of inactivation thereof
CA3030447A1 (en) Compositions and methods for flavivirus vaccination
CA2557668A1 (en) High efficiency peptide production in plant cells
US6730306B1 (en) Parvovirus vaccine as viral coat protein fusions
US20090093019A1 (en) Production and in vivo assembly of soluble recombinant icosahedral virus-like particles
TW201831689A (zh) 一種用於展示目的多肽的多肽載體及其用途
Walker et al. Internal core protein cleavage leaves the hepatitis B virus capsid intact and enhances its capacity for surface display of heterologous whole chain proteins
JP2007518415A (ja) 伝染性ファブリキウス嚢病ウイルス(ibdv)のキメラエンプティーキャプシド、取得方法および用途
US20070207167A1 (en) Immunologically enhanced recombinant vaccines
CN114276969A (zh) 一种SARS-CoV-2细菌样颗粒及其在疫苗中的应用
Manuel-Cabrera et al. Immune response to a potyvirus with exposed amino groups available for chemical conjugation
EP3665186B1 (en) Recombinant protein vp60 and procedure for its production and purification
CN110917343A (zh) 一种新城疫与传染性法氏囊病二联亚单位疫苗
CN116376948A (zh) 一种质粒载体及展示外源蛋白的ms2噬菌体类似颗粒的制备方法
HU210606A9 (hu) Aggregált formájú, celluláris, amfipatikus proteinek, valamint eljárás azok előállítására, továbbá tisztítására Az átmeneti oltalom az 1-9. és 12. igénypontra vonatkozik.
LV14084B (lv) Paņēmiens izvēlētā bioloģiskā materiāla iepakošanai hepatīta B vīrusa Core pilna garuma proteīna kapsīdās

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20071130

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid