KR20070102911A - A cosmetic composition for improving a skin conditon containing chamaecyparis obtusa extracts - Google Patents

Abstract

A cosmetic composition for improving skin condition containing the extract of Chamaecyparis obtusa is provided to improve skin troubles caused by stresses by promoting secretion of alpha wave and beta-endorphin and inhibiting secretion of cortisol, thereby enlarging the sleeping time, improving skin wrinkles and skin elasticity, and increasing skin moisturizing. A cosmetic composition for improving skin condition contains 0.01-10.0 wt.% of the Chamaecyparis obtusa extract which is prepared by extracting Chamaecyparis obtusa with water, C1-C4 anhydrous or hydrous lower alcohol, a mixed solvent thereof, acetone, ethyl acetate, chloroform or 1,3-butyleneglycol, and is formulated as solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation or spray.

Description

A cosmetic composition for improving a skin conditon containing chamaecyparis obtusa extracts}

The present invention utilizes the effect of neuro-relaxation of the extract of chamaecyparis obtusa , an evergreen tree of the Cypressaceae, by adding it to the composition of cosmetics to induce a good night's sleep through emotional stabilization of skin problems of the modern man due to mental and physical stress. The present invention relates to a cosmetic composition capable of improving skin. In addition, the present invention relates to a cosmetic composition characterized by enhancing skin function, preventing skin aging, improving skin wrinkles, improving skin elasticity, and improving skin moisturizing power.

Modern people are living under various stresses. When you're stressed, you're releasing hormones to cope with them, the stress hormone cortisol. The body's endocrine system is connected to the brain and terminal hormonal organs, and hormones from the hypothalamus, pituitary gland, and adrenal gland in the left and right kidneys, which are representative endocrine organs, play a central role. Doing. When the human body is stressed, corticotropin releasing hormone (CRH) is formed in the paraventricular nuclear (PVN) of the hypothalamus, and then secreted into the anterior pituitary, which is secreted by the corticosteroid promotes the synthesis of adrenocorticotropin (ACTH). The adrenal cortical stimulating hormone thus formed is secreted into the adrenal gland in the blood to promote the synthesis and secretion of cortisol, a steroid hormone. The hormone is responsible for blood sugar rise, protein breakdown, lipolysis, and immune suppression. Therefore, cortisol may resist stress in the early stages of stress, but if it is constantly stressed, cortisol is secreted continuously, and the balance of the body is totally collapsed and the activity of skin cells is reduced, thereby decreasing the function of the skin.

If stress continues to accumulate in the human body, the body contracts muscles to protect itself and consumes a lot of energy, resulting in hormonal imbalance and blood circulation disorder. Therefore, the metabolism of the skin is not well balanced, the activity of keratinocytes and fibroblasts is reduced, collagen synthesis ability and elastin synthesis capacity, water retention capacity, transdermal moisture loss Due to the increase in the MMP synthesis, such as sensitive to external stimulation, the elasticity of the skin is reduced, wrinkles are increased and eventually skin aging is promoted.

In general, between 10 pm and 2 am, hormonal secretion is active, resulting in active cell division, and growth hormone secretion, which restores body fatigue, is the highest, and beta-endorphin secretion is increased. It is known. Cortisol increases in the morning, peaking in the day and lowest in the evening. However, constant stress does not reduce the amount of cortisol in the evening, but rather is a major obstacle to getting enough sleep. Growth hormone is secreted during sleep, the most active between three hours immediately after going to sleep, and then slowly decreases. Skin cells also have the most active cellular activity at this time, so to get a deep sleep, you need to relax your mind and soften your nerves before going to bed to get a good night's sleep. In other words, if you can take a good night's sleep at the most active time of cell division, the activity of skin cells is increased to improve skin troubles.

When we close our eyes and relax, our brain wave activity slows down. At this time, our brain produces alpha waves between 8Hz and 12Hz, and our brain is in alpha state. In other words, the alpha wave state is the relaxation state of the brain. Alpha waves, also known as meditation waves, mean a very stable state where the muscles are relaxed and the mind is relaxed. It is important to have peace of mind before getting enough sleep. Recently, many people use forest baths to relieve stress and to have mental stability. Comfort in the woods is due to the effects of phytoncide. Phytoncide is a substance that plants exhale or secrete to resist pathogens, insects, and fungi. When a person inhales it, it activates an alpha wave that affects the brain and stabilizes the mind and body. You get an effect.

Among many trees used for forest bathing, many cypress trees that secrete phytoncide from other trees are frequently used. Therefore, the development of many products using cypress has been made, and the cypress extract is known to have an antimicrobial effect, and is used as an antibacterial fragrance or natural preservative, and it is also used as flooring and furniture by applying the emotional stability effect of the cypress. It has been widely developed in the same place as the forest bath, inducing comfortable sleep.

On the other hand, if you look at the case of the use of the protein in cosmetics, it is known that the use of essential oil (essential oil) on the skin to reduce the itching of the skin and effective for atopic dermatitis (Korean Patent Publication No. 2004-0089942), In addition, there were cases where antibacterial and antifungal effects were added to cosmetics and used as antibacterial or antiseptic (Korean Patent Publication No. 2004-0027274, Korean Patent Publication No. 1999-0083666).

In addition, there is a case applied to the cosmetic composition for skin whitening by inhibiting the production of melanin (Japanese Patent Publication No. 2003-073290, Japanese Patent Publication No. 1999-060467), gloss to dry skin using steam distillate There was an example of granting a patent (Japanese Patent Laid-Open No. 2001-220312).

However, the composition containing the extract of the cypress induces a good night's sleep through emotional stability and enhances the proliferation and activity of skin cells to improve skin condition such as preventing skin aging, improving skin elasticity, improving skin wrinkles and enhancing skin moisturizing. Unknown.

Therefore, the present inventors have conducted research on various uses for improving the skin condition by applying the extract of the protein to the cosmetic composition, and as a method for improving the skin troubles caused by stress, extracts from the protein that is frequently used in forest baths. We studied how to maintain healthy skin. As a result, it was found that the cypress extract has an effect of promoting the secretion of alpha waves, inhibiting the release of cortisol, and promoting the secretion of beta-endodorpin to prolong sleep time. Therefore, when it is contained in the cosmetic composition, it was confirmed that there is an effect of skin improvement by enhancing the function of the skin to increase skin elasticity and moisturizing power and completed the present invention.

Therefore, it is an object of the present invention to provide a cosmetic composition for improving skin condition containing a protein extract as an active ingredient.

The present invention relates to a cosmetic composition for improving skin condition containing a protein extract, characterized in that it contains the protein extract as an active ingredient in an amount of 0.01 to 10.0% by weight based on the total weight of the composition.

The cypress used as an active ingredient in the present invention is an evergreen coniferous tree, which grows to a height of 40m and a diameter of 2m, has horizontal, sunk sag, bark reddish brown, and torn vertically. The leaves are ovate ridges, thick, vaginal, with one line on the green surface, white spots on the back, and the leaves on the side fall only at the ends. Fruits ripen brown in September-October, diameter is 1-1.2cm, flowers bloom in April, and male and female run on different branches with monogamous flowers. Yellow flowers are yellow. It is native to Japan, and in Korea, it has been planted as a planting species on Jeju Island and the south coast. It is known to contain Junicic acid, Sabinic acid, Thujone, etc., and it is also used as a medicinal herb.

An active ingredient contained in the cosmetic composition of the present invention, the extract is characterized by extracting the leaves and branches of the extract using various extraction solvents. That is, the protein is selected from various extraction solvents, such as water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol, etc.), a mixed solvent of the lower alcohol with water, acetone, ethyl acetate, Cycloprotein extract can be obtained using chloroform or 1,3-butylene glycol.

However, it will be apparent to those skilled in the art that the extract of the present invention is not limited to the above-described extraction solvent, but an extract of Soru-Zhich which exhibits substantially the same effect using other extraction solvents can be obtained.

On the other hand, the cypress extract is characterized in that it contains 0.01 to 10.0% by weight based on the total weight of the cosmetic composition. Preferably it is 0.1 to 5.0 weight%. If the content of the protein extract is less than 0.01% by weight, it is difficult to expect the effect, when the content of more than 10.0% by weight does not appear to increase the apparent effect of increasing the content.

The components included in the cosmetic composition of the present invention include components conventionally used in cosmetic compositions in addition to the protein extract as an active ingredient, such as conventional inclusions such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings. General auxiliaries, and carriers.

The cosmetic improvement for improving skin condition of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, interfaces. It may be formulated as an active agent-containing cleansing, etc., but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, the carrier components include animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide and the like. Can be used.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol , Fatty acid esters of 1,3-butyl glycol, oils, glycerol aliphatic esters, polyethylene glycols or sorbitan.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizer or an emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, Fatty acid esters of 1,3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the dosage form of the present invention is a suspension, a liquid diluent such as water, ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester as a carrier component , Microcrystalline cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The cosmetic composition of the present invention has a skin improving effect. It utilizes the nerve stabilizing effect of the protein to reduce the secretion of cortisol and increase the secretion of alpha waves and beta-endorphine to induce a good night's sleep to enhance the proliferation and activity of skin cells, improving skin elasticity, improving skin wrinkles and skin moisture Through to improve the trouble of the skin. On the other hand, the present invention is interpreted to include the use of skin anti-aging through improving the elasticity of the skin, improve the skin wrinkles and improve the skin moisturizing power.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited to these examples in accordance with the gist of the present invention to those skilled in the art. Will be self explanatory.

Preparation Example 1 Preparation of Cypress Extract

Collect 500g of cypress leaves and branches, wash them with water, and dry them in the shade. After crushing the leaves and branches of dried cypresses finely using a crusher, put them in a reflux extractor, and then put purified water of 10 times the weight of the crushed liquor into 100 ℃ for 90 minutes to extract hot water. After filtering the extract, the precipitate was discarded and the filtrate was collected to obtain 30 g of dried cypress extract using a lyophilizer . The dry protein extract was used by dissolving in 70% ethanol.

Experimental Example 1 Effects of Cypress Extracts on the Levels of Cortisol and Beta-Endorphin in Rats

The cypress extract of Preparation Example 1 influenced the secretion of cortisol and beta-endorphin, and it was confirmed that it showed a relieving effect on stress in rats. If a rat is placed in a small box to prevent movement by forcing it to stress, it is known to increase the secretion of the stress hormone cortisol.

After the rats were put in a box for 16 hours to inhibit movement, the oral administration of the protein extract of Preparation Example 1 was orally administered to the rats at 15 mg / kg, and after 1 hour, the stress of cortisol and beta-endorphin with and without stress was given. The amount was measured. The results are shown in Table 1 below.

Effects of Cypress Extracts on Cortisol and Beta-Endorphin Levels in Rat Blood Survey subject Steady state When stress only Administration of Cypress Extracts After Stress Beta-Endorphin (μg / ml) 7.35 2.97 8.01 ㅁ 2.92 Cortisol (μg / ml) 3.02 7.88 W2.58 3.55

As can be seen from the results of Table 1, in the case of stress-only rats, the amount of beta-endorphin was reduced by 40% compared to normal, but when the administration of the protein extract showed a return to the normal level. In the case of cortisol, stress-bearing rats showed a 2.6-fold increase in secretion compared to normal rats. In rats receiving the protein extract, cortisol secretion was reduced by normal levels, and the protein-containing extract was found to be secreted from the cortisol and beta endorphin secretions. It can be seen that it affects.

Experimental Example 2 Sleep Time Extension Effect of Cypress Extract

In the same manner as in Experiment 1, the rats were placed in a box for 16 hours and subjected to forcing stress, followed by injection of the extract of Preparation Example 1, followed by prolonging the sleep time of the mice induced by hexobarbital. Giving effect was measured. Five male rats weighing 17-23 grams per group were injected with 10 mg, 15 mg, and 20 mg of each protein per kilogram of body weight, followed by intraperitoneal injection of 50 mg / kg of hexobarbital. Sleep time extension effect by the extract was carried out. The results are shown in Table 2 below.

Sleep-induced sleep is extended by sleepy extract division Steady state When stress only Administration of Cypress Extracts After Stress Dose 10 mg / kg 15 mg / kg 20 mg / kg Sleep time (minutes) 32.2 ± 3.6 26.8 ± 3.1 35.6 ± 2.8 43.5 ± 3.6 45.4 ± 2.7 effect(%) 0 33.3 60.2 69.4

As can be seen from the above results, when the cypress extract was added to the stressed mice, it showed an effect of prolonging the sleep time. The effect of prolonging sleep time was found to increase concentration-dependently, but the effect of prolonging sleep time was not seen at concentrations above 20 mg / kg.

Preparation Example 2 Examples and Comparative Examples

To the cosmetic composition of Example 1 containing 3% by weight relative to the total weight of the cosmetic composition in the form of a lotion having a composition ratio of Table 3 and Comparative Example 1 containing no extract was prepared.

Cosmetics Containing Cypress Extracts Ingredient (% by weight) Example 1 Comparative Example 1 Cypress Extract 3.0 ?? glycerin 5.1 5.1 Propylene glycol 4.2 4.2 Tocopheryl Acetate 3.0 3.0 Liquid paraffin 4.6 4.6 Triethanolamine 1.0 1.0 Squalane 3.1 3.1 Macadamia Nuts 2.5 2.5 Polysorbate 60 1.6 1.6 Sorbitan sesquirrolate 1.6 1.6 Propylparaben 0.6 0.6 Carboxyl Vinyl Polymer 1.5 1.5 incense a very small amount a very small amount antiseptic a very small amount a very small amount Purified water Remaining amount Remaining amount system 100 100

Experimental Example 3 Survey on Sleep Effects

The cosmetic composition containing the protein extract of the present invention was applied to the human body and the sleep effect was evaluated. Sleeping effect was measured one month after applying each of the cosmetics prepared in Example 1 and Comparative Example 1 to the face once before bedtime divided into two groups for 32 insomnia women in their 30-40s. The experimental results are shown in Table 4.

division Example 1 Comparative Example 1 Very good Great usually Very good Great usually Respondents 5 9 2 0 3 13

It can be seen that the sleep effect is improved when the cosmetic composition containing the protein extract is used as compared to the cosmetics without the protein extract.

Experimental Example 4 Skin Wrinkle Improvement Effect

After applying the cosmetic composition comprising the extract of the present invention to the human body, the skin wrinkle improvement was evaluated. Forty healthy women in their 40s and 40s were divided into two groups of Example 1 containing the protein extract prepared in Preparation Example 2 and Comparative Example 1 containing no protein extract in two groups of 20 people twice daily for two months. After that, the replica was made using silicon, and the wrinkles were analyzed by visiometer (SV600, Courage + Khazaka electronic GmbH, Germany) for image analysis. The results are shown in Tables 5 and 6, Table 5 is a result of analyzing the wrinkle image before use and Table 6 is a result of analyzing the wrinkle image after 2 months. The resulting value is for an average of 20 people.

O day Example 1 Comparative Example 1 HR1 HR2 HR3 HR4 HR5 HR1 HR2 HR3 HR4 HR5 medium 3.042 3.001 1.254 0.223 0.385 3.124 3.224 1.542 0.209 0.352

60 day Example 1 Comparative Example 1 HR1 HR2 HR3 HR4 HR5 HR1 HR2 HR3 HR4 HR5 medium 2.984 2.742 1.120 0.198 0.336 3.120 3.241 1.521 0.202 0.353

As shown in Tables 5 and 6, the lotion containing the Example Cypress extract was found to be excellent in improving skin wrinkles.

Experimental Example 5 Survey on Skin Wrinkle Improvement Effect

In the same manner as in Experiment 4, after applying the cosmetic composition of Example 1 and Comparative Example 1 to the right and left of the face twice daily morning and evening twice each month for 20 healthy women in their 30-40 years, 1 Months later, she surveyed the extent to which she felt skin wrinkles. The results of the survey are shown in Table 7 below.

division Respondents Very good Great usually dissatisfaction Example 1 2 12 6 0 Comparative Example 1 0 5 12 3

In the survey results of Experimental Example 5 it was confirmed that the cosmetic of Example 1 of the present invention has an effect of improving wrinkles.

Experimental Example 6 Skin Elasticity Improvement & Moisturizing Effect

In order to compare the skin elasticity recovery effect of Example 1 and Comparative Example 1 prepared in Preparation Example 2, it was measured by dividing the group into two groups of 15 healthy women in 30 to 40 years of age as one group It was. After applying twice a week for 6 weeks each morning and evening on the right and left sides of the face, skin elasticity and moisturizing power were measured every week. Cutometer (MPA 580, Courage + Khazaka GmbH, Germany) was used for skin elasticity measurement, and coneometer (CM825, Courage + Khazaka GmbH, Germany) was used to measure moisturizing power. The experimental results are shown in Table 8 below.

Experiment period Skin elasticity improvement (%) Moisturizing power improvement (%) Example 1 Comparative Example 1 Example 1 Comparative Example 1 Week 0 1 week 5 One 6 2 2 weeks 10 4 8 3 3 weeks 18 6 19 5 4 Weeks 25 7 28 7 5 Weeks 33 8 30 8 6 Weeks 42 8 33 10

In the survey results of Table 8, it was confirmed that the cosmetic composition of Example 1 of the present invention is effective in improving skin elasticity and improving skin moisturizing power.

Formulation Example 1 Skin Lotion

A skin lotion containing the above-obtained cypress extract was prepared according to a conventional method.

Raw material name Content (% by weight) Cypress Extract 3.0 1,3-butylene glycol 5.2 Oleyl alcohol 1.5 ethanol 3.2 Polysorbate 20 3.2 Benzophenone-9 2.0 Carboxyl Vinyl Polymer 1.0 glycerin 3.5 incense a very small amount antiseptic a very small amount Purified water Remaining amount system 100

[Formulation Example 2] Lotion

A lotion containing a protein extract as shown in Table 10 below was prepared according to a conventional method.

Raw material name Content (% by weight) Cypress Extract 3.0 Cetostearyl alcohol 1.0 Glyceryl Monostearate 0.8 Sorbitan monostearate 0.3 Porofilparaben 0.1 Polysorbate 60 1.0 Mineral oil 5.0 Pyromethicone 3.0 Dimethicone 0.5 Allantoin 0.1 glycerin 5.0 Alcohol 2 Propylene glycol 3.0 incense a very small amount antiseptic a very small amount Purified water Remaining amount system 100

Formulation Example 3 Essence

Essences containing a protein extract as shown in Table 11 below were prepared according to a conventional method.

Raw material name Content (% by weight) Cypress Extract 3.0 1,3-butylene glycol 4.0 glycerin 3.0 Allantoin 0.5 Panthenol 0.1 EDTA-2Na 0.01 ethanol 5.0 Triethanolamine 1.5 Squalane 2.0 Beeswax 2.5 Polysorbate 60 3.5 Carboxyl Vinyl Polymer 1.0 Sorbitan sesquioleate 2.5 incense a very small amount antiseptic a very small amount Purified water Remaining amount system 100

Formulation Example 4 Formulation Example 4 Pack

As shown in Table 12 below, a pack containing a protein extract was prepared according to a conventional method.

Raw material name Content (% by weight) Cypress Extract 3.0 Ethyl alcohol 3.0 EDTA-2Na 0.05 Propylene glycol 5.0 Glyceline 4.5 Cabopol 1.5 Polyoxide 0.2 antiseptic a very small amount incense a very small amount Purified water Remaining amount system 100

Formulation Example 4 Massage Cream

A massage cream containing a cypress extract as shown in Table 13 below was prepared according to a conventional method.

Raw material name Content (% by weight) Cypress Extract 3.0 glycerin 4.0 Vaseline 3.5 Triethanolamine 0.5 Liquid paraffin 24.0 Squalane 3.0 Beeswax 2.1 Tocopheryl Acetate 0.1 Polysorbate 60 2.4 Carboxyl Vinyl Polymer 1.0 Sorbitan sesquioleate 2.3 incense a very small amount antiseptic a very small amount Purified water Remaining amount system 100

As described in detail above, the present invention provides a cosmetic composition containing a protein extract. The protein extract of the present invention has shown an excellent effect of inhibiting the secretion of cortisol, promoting the secretion of beta-endorphin and prolonging sleep time, preventing skin degradation through stress and improving skin wrinkles It is very useful as a cosmetic composition that has a great effect on improving skin elasticity and increasing skin moisturizing effect.

Claims (8)

Cosmetic composition for improving the skin condition, characterized in that containing the extract as an active ingredient. The cosmetic composition for improving skin condition according to claim 1, wherein the extract contains 0.01 to 10.0 wt% based on the total weight of the composition. The extract of claim 1, wherein the extract is extracted by adding water, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, a mixed solvent of lower alcohol and water, acetone, ethyl acetate, chloroform or 1,3-butylene glycol. Cosmetic composition for improving the skin condition, characterized in that. According to claim 1, wherein the composition is a cosmetic composition for improving the skin condition, characterized in that for improving the skin condition caused by mental and physical stress. The cosmetic composition for improving skin condition according to claim 1, wherein the composition is for improving skin wrinkles, improving skin elasticity or improving skin moisturizing ability. The composition of claim 1, wherein the composition is a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray Cosmetic composition for improving the skin condition, characterized in that it has a formulation selected from the group consisting of. A composition characterized by inhibiting cortisol secretion, containing an extract of cyanobacteria as an active ingredient, increasing beta-endorphin production, improving insomnia through stress, emotional stability by alpha waves, or a combination thereof. According to claim 7, wherein the composition is a cosmetic composition, characterized in that for improving the skin condition.