KR20070097647A - Shampoo composition for hair growing - Google Patents

Abstract

A shampoo composition is provided to promote hair growth by applying fine electrical stimulation generated from minerals having electrical properties and medicinal functions of medicinal herbs to the hair root and follicle. A shampoo composition for promoting hair growth comprises 42 wt.% of hair growth-promoting effective ingredients which are prepared by pulverizing tourmaline to have particle size of 3500 mesh, separately heating 12g of Xanthium strumarium L. and 12g of Swertia pseudo-chinensis (Bunge) Hara in 10 liter of water for 30 minutes, and mixing 70 wt.% of tourmaline powder with 15 wt.% of Xanthium strumarium L. extract and 15 wt.% of Swertia pseudo-chinensis (Bunge) Hara extract, 34 wt.% of Micolin ES-430 as a liquid anionic surfactant, 3 wt.% of Micopol as a nonionic surfactant, 5 wt.% of Mitaine CA as a general surfactant, 1 wt.% of Jaquar C-13S as a scalp-protecting agent, 0.5 wt.% of citric acid, 2 wt.% of Flocare C-107 as a sterilizing and conditioning agent, 2 wt.% of glycerin and 0.5 wt.% of Incense as a flavoring agent.

Description

Shampoo composition for hair growing

The present invention relates to a hair regrowth shampoo composition, and more particularly, to clean the hair by preparing a shampoo for washing the hair by mixing a tourmaline powder, which is a kind of mineral and at least one herbal extract as a main ingredient, the shampoo formulation The microscopic electrical stimulation of the hair follicles and hair follicles causes the hydroxyl reaction to open the pores, supplying keratin (protein) nutrition, and pharmacological action of the herbal medicine. It relates to a hair regrowth shampoo composition which facilitates growth.

In general, as the harmfulness of chemical hair cleaners is one of the causes of water pollution, the main components of the cleaners are made of a composition extracted from various kinds of natural plants or herbal medicines, and thus the hair growth is friendly to the environment and the human body. Products with functionalities that can contribute to development have emerged.

The wool composition, which was previously registered in Korean Patent No. 37478, extracts an active ingredient with water or methanol from the roots, stems, and roots of a natural plant, the edible shoot, to prepare an extract extract, and extracts the extract extract to the composition. By adding the composition to be used in the form of a solution, tablets or emulsions, but also to include resorcin, hormones, menthol, other fragrance as an active ingredient, and also to be used as a yogurt, The extracted extract widens the capillaries in the skin to improve blood flow and stimulate hair root activity, thereby facilitating the germination of hair while preventing hair loss and gray hair.

However, the composition for wool has been proved to be safe for the human body in that it uses an extract extracted from natural plants, but the clinical effect of pharmacological action of promoting the capillary blood flow and stimulating the hair root is opaque. There was a problem that the effect is insufficient.

Meanwhile, the hair growth promoting composition of Korean Patent No. 89818 is an active ingredient extracted by selecting at least one selected from wild corn, nasturtium, sweet ginseng, cabbage, earthenware, black bean, mulberry, oil, hyssop and hazelnut which are composed of herbal medicine. It is characterized in that it is used as, but in this case, only the safety of the living body due to the herbal medicine was highlighted, and there was a lack of specific techniques for hair loss prevention and hair growth promotion.

The present invention has been made in view of the problems of the wool composition using the conventional natural plant or herbal extracts as described above, the object is to increase the growth of the hair by applying a fine electrical stimulation to the hair root and hair follicle of the hair with the pharmacological action of the herbal medicine It is to provide a hair growth shampoo composition that can be promoted.

In order to achieve the above object, the present invention provides a hair growth material by mixing 15 wt% of extracts obtained by steaming appropriate amounts of naturally dried Changja and sugars in 70 wt% of tourmaline powder having a particle size of 3500mesh or more, and 34% by weight of Mycoline (Micolin ES-430), 3% by weight of Micopol, 5% by weight of Mitaine CA, 1% by weight of Jaquar C-13S, relative to 42% by weight of hair growth material By preparing a gel shampoo composition by mixing 0.5% by weight of citric acid, 2% by weight of Flocare C-107, 2% by weight of glycerin and 0.5,% by weight of incense In addition, the pharmacological action of the herbal medicine is applied to the hair roots and the surrounding hair roots together with the minute electrical stimulation generated from the tourmaline having electrical properties among the components of the shampoo composition, thereby promoting hair growth.

Hereinafter, described in detail the hair growth shampoo composition of the present invention.

The present invention is pulverized tourmaline of the raw material and processed into a powder with a particle size of 3500mesh or more, and prepared naturally dried Changiza and sugar, poured 10 liters of water in a heating container for 12g each of Changi and sugar in a medium heat After 30 minutes of hot water to obtain the respective herbal extracts, 70% by weight of the tourmaline powder is mixed with 15% by weight of the Changzawa sugar extract each to form a hair growth material.

For example, tourmaline, one of the main components of the present invention, is a borosilicate having hexagonal columnar crystals and is a natural mineral belonging to a hexagonal system, and such tourmaline crystals have electric polarization from the beginning even if an electric field is not applied from the outside. So-called polar crystals are called tourmaline because they have the property of generating electricity.

As a result of studying the ingredients for tourmaline having the above characteristics, it is known to have beneficial effects on the human body such as ionic effect, far infrared ray effect, deodorizing effect, surfactant activity and antibacterial effect, and is widely used as a material for improving the environment and health. .

Therefore, the microscopic electrical stimulation generated from the tourmaline with electrical properties in the composition of the present invention is applied to the hair roots and hair follicles of the scalp to induce a hydroxyl reaction, thereby opening up the pores to supply keratin (protein) nutrition, thereby promoting hair growth To act.

On the other hand, Changiza (aka, Dokomari) is one of the most widely used folk herbs, called seeds, shiisil, Hoshi, Jigyu, seals, and sergeants, and has pharmacological action to secure antimicrobial, leprosy, sinusitis, rhinitis It is used as a medicine for the treatment of arthritis, etc., and the medicinal herb (aka, bitter grass) is a plant growing in the grass of Sanya, and its pharmacological action is anti-inflammatory, antipyretic, dry stomach, digestion, and anti-cancer. It is suitable for the drug.

In order to use the hair growth material obtained by mixing 70% by weight of the tourmaline powder and 15% by weight of the Changzawa saccharide extract, respectively, as a hair cleaner, 42% by weight of the hair growth material, mycoline, a liquid anionic surfactant (Micolin ES- 430) 34% by weight, 3% by weight of nonionic surfactant Micopol, 5% by weight of general surfactant Mitaine CA, 1% by weight of Jaquar C-13S scalp protector, citric acid 0.5% by weight of citric acid, 2% by weight of Flocare C-107, a bactericidal and conditioning agent, 2% by weight of glycerin as a moisturizer, and 0.5% by weight of incense as a fragrance. And the like to obtain a gel shampoo composition.

The hair growth material obtained by mixing 70% by weight of the tourmaline powder of the present invention and 15% by weight of the Changzawa saccharide extract, respectively, when the hair is washed, a microscopic electrical stimulation is applied to the hair root and the hair follicle area by the components of the tourmaline to react the hydroxyl reaction. Since the pores are opened, the pores supply keratin (protein) nutrition to the hair roots and the pharmacological action of the herbal medicines, thereby promoting hair growth and supplying the protein, which is a component of the hair, to promote hair growth. Be vigorous.

In the above, the hair growth material of the present invention has been described as being manufactured as a shampoo for washing hair, but it is also possible to prepare a rinse, soap, etc. using the hair growth material, and such modifications belong to the technical category of the present invention. .

As for the efficacy of the shampoo composition containing the hair growth material of the present invention as described above, the test substance is called tourmaline powder (called 'tormarin'), and the positive control substance is volumin (foreign drug, ingredient: minoxidil 5% and dex) The following is an example of a clinical trial conducted on animals (subject: C57BL / 6 mouse) with panthenol 1.6%).

(Test example)

end. Test Materials and Test Methods

1) Experimental system

(1) Species (system): Specific pathogen free (SPF) C57BL / 6 mouse

(2) Gender and age at acquisition: Male 5 weeks

(3) Reason for selection

The C57BL / 6 mouse to be used in this test is an experimental animal species used in hair growth experiments and has abundant basic data, which can be used for interpretation of test results.

(4) Source: Samtako BIO KOREA (77-1, Seolang-dong, Osan-si, Gyeonggi-do)

(5) Date of acquisition: August 05, 2005

(6) Number of animals obtained: 72 males

(7) Quarantine and Purification Period

After the acquisition, the general symptoms were observed for 7 days, and only healthy animals were used.

(8) Age of administration of test substance: 6 weeks of age

(9) Number of animals: 70 males

(10) military separation

After depilation, the skin was scarlet (pause) and 70 healthy animals were selected for group separation and 15 animals were used per group, and 10 were used as a positive control group.

(11) Identification method

Individual identification is done using the unmarked marking method using the magic pen during the period of acclimatization, the testing period, and the individual identification card notation method for each breeding box. A record of actual use of animals, etc., is attached.

2) Animal Breeding Environment

(1) Room number: Room 1, Animal Breeding Area

(2) Temperature and humidity range: Temperature 23 ± 3 ℃, relative humidity 55 ± 15%

(3) Number of ventilation: 10-20 times / hr. (External Air Conditioning Method)

(4) Contrast cycle: Fluorescent lighting 12 hr. (08:00 Lights ~ 20:00 Lights Off)

(5) Roughness: 150 ~ 300 Lux

(6) Kinds (size) of breeding box

Animals were housed in stainless steel cages (size; 165 W x 240 L x 145 H mm) during the acclimatization, quarantine and observation periods.

(7) Number of animals per breeding box

Five animals were reared during the purifying and quarantine periods, and one was reared individually during the administration period.

3) feed

(1) Type: solid feed for experimental animals sterilized by radiation

(2) Producer: Harlan Co. Ltd. (United States of America)

(3) Source: Polars International

(4) Feeding method: Freely consume the radiation sterilized feed.

(5) Identification of pollutants

References were made to data conducted in accordance with the SOP on periodic examination of feed and water at preclinical research centers.

4) water

(1) Type: drinking groundwater

(2) water supply

The ground water sterilized using microfilter and ultraviolet light was freely ingested using a water bottle.

(3) analysis of pollutants

According to the SOP on the periodic inspection of feed and water, there was no detrimental effect on the test results.

5) Mixture of test substance (or control) with excipient

(1) preparation method

Test substance I (Tormarin) was prepared by mixing with excipients and homogeneously mixed. The low dose group was used by diluting the prepared high dose group. The positive control was used by itself weighing the required amount per day.

(2) Reason for selection of excipients

Sterile injection water was used with reference to test substance information provided by the sponsor.

6) Administration method and period

(1) Route of administration of test substance and control substance: transdermal application

(2) Duration of administration of test substance and control substance: once a day for 3 weeks

(3) Establishment of Dose of Test Substance

Tourmaline was set at 30 and 60 mg / head and administered at 0.1 ml / head / day, and positive control Voldumin was administered at 0.1 ml / head / day.

7) Composition of test group

group gender Number of animals (horses) Animal Number Dosage amount (ml / head / day) Dose (mg / head / day) G1 Male 15 1 to 15 0.1 0 G2 Male 15 16-30 0.1 30 G3 Male 15 31-45 0.1 60 G4 Male 10 61-70 0.1 5 (as Minoxidil)

G1: excipient administration group (negative control group)

G2-G3: Tourmaline administered group (Tourmaline, 30mg / head, 60mg / head)

G4: Volumin-administered group (positive control group)

8) Test Methods and Test Items

(1) General symptoms observation: General symptoms of animals were observed and recorded during the test period.

(2) weight measurement

It was measured once a week at the time of acquisition, group separation, test substance administration and autopsy day.

(3) hair removal and screening of animals

24 hours before application of the test substance, the hair was removed using a clipper, and the hair removal agent (nicklin) was applied to the area to be tested in the animal, and after 15 minutes, the hair was thoroughly removed by rubbing with wet gauze. The day after epilation (start of administration), only animals with scarlet (pause) skin were used for the experiment.

(4) Test substance administration

It was applied to the same site by rubbing 10 times with a finger once a day. The negative control group was applied by rubbing the excipient 10 times in the same manner.

(5) Measuring and photographing the area where hair grows

The area of hair growth (%) was determined by measuring the area of application of the test substance, and it was measured on the 12th and 15th day of administration of the test substance. In addition, photographs were taken twice a week from the initiation date to the autopsy day.

(6) autopsy and weighing of hair

Each animal was euthanized with a cervical dislocation and photographed on the day of necropsy. The whole skin was peeled off and the 4 × 2.5 cm marking area was cut out of the test material application site. After the hair was carefully epilated using a clipper, the hair weight was measured.

(7) histopathological examination

Histopathological examination was performed by fixation and H & E staining of the skin of the application site.

9) Statistical method

One-way ANOVA and Student's t-test were used to compare the negative control and treatment groups. Significance was recognized below p <0.05 and SPSS 10.1, a commercial statistics program, was used in accordance with SOP on the statistical processing of Chem.

I. Test result

1) General symptoms

No general symptoms of test material tourmaline and control were observed.

2) Hair growth area (see Table 1, Figure 1)

In some animals, the skin began to darken from the 8th day of test substance administration, and the area of hair growth at the 12th time was negative control group, tourmarin 30 mg / head / day group, tourmarin 60 mg / head / day group, 4.10%, 5.88% and 4.42%, and the area of test group was not statistically significant compared to the negative control group.

The positive control group showed a statistically significant increase of 16.36% (P <0.01).

The hair grew rapidly between the 12th and 15th day of administration, and the area of hair growth at the 15th time was 72.91%, 77.60% and 75.40% in the same order as above, but there was no statistical significance.

The positive control group had a statistically significant increase of 91.69% (P <0.05).

 Tourmaline Effects on Mouse Hair Growth and Hair Weight GROUPS Number of Animal 12day hair growth (%) 15day hair growth (%) 22day hair weights (g) G1 14 4.10 ± 0.75 72.91 ± 5.56 0.0411 ± 0.0031 G2 15 5.88 ± 0.87 77.60 ± 5.92 0.0481 ± 0.0021 G3 15 4.42 ± 0.71 75.40 ± 4.02 0.0469 ± 0.0017 G4 10 16.36 ± 3.81 ** 91.69 ± 3.74 * 0.0560 ± 0.0036 **

Date are expressed as Mean ± S.E.M. The mice were administered vehicle and test items by pasting on the back skin, respectively.

The results were statistically analyzed by student 's t- test .

*: significantly different from G1 value, P <0.05

**: significantly different from G1 value, P <0.01

G1: excipient administration group (negative control group)

G2: tourmaline administered group (30 mg / head)

G3: tourmaline administered group (60 mg / head)

G4: Volumin-administered group (positive control group)

<Figure 1. Effect of Tourmaline Treatment on Mouse Hair Growth after 2 Weeks (% of Area)>

Data are expressed as Mean ± S.E.M. The mice were administered vehicle and test items by pasting on the back skin, respectively.

The results were statistically analyzed by student's t-test.

*: significantly different from G1 value, P <0.05

G1: excipient administration group (negative control group)

G2: tourmaline administered group (30 mg / head)

G3: Tourmaline administered group (Tourmaline, 60mg / head)

G4: Volumin-administered group (positive control group)

3) Hair weight (see Table 1, Figure 2)

Hair weight on autopsy day increased by 70% (P = 0.07) in the tourmarin 30 mg / head / day group and 14% in the 60 mg / head / day group compared with the negative control group, but there was no statistical significance. The positive control group showed a statistically significant increase of 36% (P <0.01).

<Figure 2. Effect on Tourmaline Hair Weight in Mouse after 3 Weeks>

Data are expressed as Mean ± S.E.M. The mice were administered vehicle and test items by pasting on the back skin, respectively.

The results were statistically analyzed by student 's t- test .

*: significantly different from G1 value, P <0.01

G1: excipient administration group (negative control group)

G2: tourmaline administered group (30 mg / head)

G3: Tourmaline administered group (Tourmaline, 60mg / head)

G4: Volumin-administered group (positive control group)

4) Histopathological examination (see Table 2, Figure 3-1 ~ Figure 3-5)

Based on the number of hair follicles observed in individuals showing typical anagen and telogen in the negative control group (grade 1), all animals were given a grade of 0 to 3 depending on the number, distribution and shape of the hair follicles. Evaluated.

As a result, the grades of resting hair follicles in the order of negative control group, tourmarin 30 mg / head / day administration group, tourmarin 60 mg / head / day administration group showed no significant difference as 1.75, 1.67, 1.73, Growing hair follicles were graded 1.25, 1.00 and 1.53, which were somewhat higher in the tourmarin 60 mg / head / day group than in the negative control group. The positive control group had a very low incidence of growing hair follicles (grade 0.6), and the incidence of resting hair follicles was less than that of the negative control group, but was observed at a relatively high frequency on the superficial dermis (grade 1.40).

Tourmaline Effects on Mouse Hair Follicle Condition GROUPS Number of Slide Frequency of hair follicle in anagen phase (grades) Frequency of hair follicle in telogen phase (grade) G1 14 1.25 ± 0.30 1.75 ± 0.25 G2 15 1.00 ± 0.21 1.67 ± 0.21 G3 15 1.53 ± 0.16 1.73 ± 0.15 G4 10 0.60 ± 0.27 1.40 ± 0.22

Date are expressed as Mean ± S.E.M. The mice were administered test and reference items by pasting on the back skin, respectively.

G1: excipient administration group (negative control group)

G2: tourmaline administered group (30 mg / head)

G3: Tourmaline administered group (Tourmaline, 60mg / head)

G4: Volumin-administered group (positive control group)

Grades (grade)

-: negative (0)

±: slight (1)

+: mild (2)

2+: moderate (3)

3+: marked (4)

When the histopathological examination, the skin tissue was observed by H & E staining and magnified 100 times, as shown in Figures 3-1 to 3-5.

Figure 3-1 is a standard histological observation of hair growth in normal (negative control) mice, and is graded based on this tissue sample (however, it is commonly H & E stained and 100 times magnified. )

Figure 3-2 is a photograph of the hair growth tissue when distilled water was administered to the negative control mice for 3 weeks, and the growth phase of the hair in the control animals is indicated by the arrow.

Figure 3-3 is a photograph of hair growth tissue in mice treated with tourmarin 30mg / head for 3 weeks. Unlike the control animals, no hair growth phase was observed (arrows).

Figure 3-4 shows the hair growth tissue in mice treated with tourmarin 60mg / head for 3 weeks. Hair growth is weak compared to control animals (arrow).

Figure 3-5 shows the hair growth tissues of mice treated with inoxidil 5mg / head for 3 weeks. No growth hair was observed.

All. Discussion and conclusion

This study was conducted to evaluate the effect of transdermal coating of test substance tourmaline on hair growth in C57BL / 6 mice and to investigate the possibility of the test substance as a hair growth agent.

Animal models were C57BL / 6 mice, which are known to enter the telogen of the hair cycle from 6 weeks of age. In this test, 5 week old mice were purchased, and after 1 week of acclimation, the experiments were started with 6 week old mice.

In the resting period, the color of the surface of the body became bright red when the hair was shaved, and as the test proceeded, the color of the body surface began to turn black in some animals from the eighth day of administration of the test substance. This means entering the anagen phase from the resting phase.

After that, the hair began to grow to the extent that can be observed from the 12th day of administration, and the area of hair growth was measured from that time. On the 12th and 15th day of administration, the hair grew rapidly and the area of hair growth on the 15th day was negative control group. Compared with.

Relative comparison of the area of hair growth with the negative control group (100%) on the 12th day of administration resulted in 43.4% and 7.8% increase in the tourmarin 30 and 60 mg / head groups, respectively, and 6.4% and 3.4 on the 15th day of administration, respectively. % Increased. At the time of necropsy, the hair weight increased by 17% and 14% compared to the negative control in the above order.

Histopathological examination showed no significant difference in the frequency of resting hair follicles, but the incidence of growing hair follicles was slightly higher in the tourmarin 60 mg / head / day group than in the negative control group, indicating a tendency to promote hair growth. .

In the positive control group, the hair follicle frequency was very low and the hair follicle frequency was relatively high in the superficial dermis, which caused the hair to grow faster as a result of shorter hair growth cycle than the negative control group. Significant increases in area and weight are considered.

Taken together, the results of this study show that the administration of tourmarin shows a consistent increase in hair growth and hair weight and tends to promote hair regrowth. Judging.

When the hair regrowth shampoo composition of the present invention is used to clean the hair, the hydroxyl reaction occurs in the hair follicle and the hair follicle site by the microelectrical stimulation generated from the mineral having electrical properties, thereby opening the pores, thereby providing keratin (protein) nutrition. In addition to the pharmacological action of the herbal medicine is added to the effect of promoting the growth of the hair, and the supply of protein, which is a component of the hair is made smoothly, there is also an advantage that makes the growth of the hair more vigorous.

Claims (2)

Grind the tourmaline and process it into a powder with a particle size of 3500mesh or more, prepare naturally dried Changiza and medicinal herbs, and add 12 liters of Changiza and medicinal herbs to a heating container and pour 10 liters of water into a heating vessel for 30 minutes. After obtaining the herbal extract of the hair-repellent shampoo composition, characterized in that the hair growth material was prepared by mixing each of the tourmaline powder 70% by weight of Changzawa sugar extract each 15% by weight. The tourmaline is pulverized and processed into a powder having a particle size of 3500 mesh or more, and naturally dried Changiza and Sugar are prepared. For each 12g of Changiza and Sugar, 10 liters of water is poured into a heating vessel and heated in medium heat for about 30 minutes. After obtaining the herbal extracts of the tourmaline powder 70% by weight of each of the extracts of Changzawa sugar extracts by mixing 15% by weight to form a hair growth material, and 42% by weight of the hair growth material mycolin as a liquid anionic surfactant ( Micolin ES-430) 34% by weight, 3% by weight of nonionic surfactant Micopol (Micopol), 5% by weight of general surfactant Mitaine CA, 1% by weight of Jaquar C-13S scalp protection agent %, Citric acid citric acid 0.5% by weight, bactericidal and conditioning agent Flocare C-107 2% by weight, moisturizing glycerin 2% by weight and fragrance incense 0.5, Mix by weight percent etc. into a gel shampoo The hair regrowth shampoo composition characterized in that the composition.