KR20070089170A - 3-헤테로아릴-8ｈ-8-아자비사이클로(3.2.1)옥트-2-엔의에난티오머 및 모노아민 신경전달물질 재흡수 억제제로서의이의 용도 - Google Patents

3-헤테로아릴-8ｈ-8-아자비사이클로(3.2.1)옥트-2-엔의에난티오머 및 모노아민 신경전달물질 재흡수 억제제로서의이의 용도 Download PDF

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Publication number
KR20070089170A
KR20070089170A KR1020077013663A KR20077013663A KR20070089170A KR 20070089170 A KR20070089170 A KR 20070089170A KR 1020077013663 A KR1020077013663 A KR 1020077013663A KR 20077013663 A KR20077013663 A KR 20077013663A KR 20070089170 A KR20070089170 A KR 20070089170A
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South Korea
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oct
ene
disorder
pain
compound
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Korean (ko)
Inventor
단 페터스
데이비드 트리스탐 브라운
시니카 마르야타 타우리오
에바 담
데이비드 스펜서 존스
브리안 프뢰스트룹
엘세베트 외스테르가르드 닐센
군나르 엠. 올센
존 폴 레드로브
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뉴로서치 에이/에스
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/20—Hypnotics; Sedatives
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020077013663A 2004-12-17 2005-12-15 3-헤테로아릴-8ｈ-8-아자비사이클로(3.2.1)옥트-2-엔의에난티오머 및 모노아민 신경전달물질 재흡수 억제제로서의이의 용도 Withdrawn KR20070089170A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
DKPA200401950 2004-12-17
DKPA200401950 2004-12-17
US63686904P 2004-12-20 2004-12-20
US60/636,869 2004-12-20
DKPA200500506 2005-04-08
DKPA200500506 2005-04-08
US66988705P 2005-04-11 2005-04-11
US60/669,887 2005-04-11

Publications (1)

Publication Number Publication Date
KR20070089170A true KR20070089170A (ko) 2007-08-30

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KR1020077013663A Withdrawn KR20070089170A (ko) 2004-12-17 2005-12-15 3-헤테로아릴-8ｈ-8-아자비사이클로(3.2.1)옥트-2-엔의에난티오머 및 모노아민 신경전달물질 재흡수 억제제로서의이의 용도

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Country Link
US (1) US7781456B2 (enExample)
EP (1) EP1828173A1 (enExample)
JP (1) JP2008524161A (enExample)
KR (1) KR20070089170A (enExample)
AU (1) AU2005315623A1 (enExample)
BR (1) BRPI0519921A2 (enExample)
CA (1) CA2591621A1 (enExample)
IL (1) IL182738A0 (enExample)
MX (1) MX2007007261A (enExample)
NO (1) NO20073652L (enExample)
WO (1) WO2006064031A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200800980A (en) 2006-02-17 2008-01-01 Neurosearch As Novel compounds
CA2673315A1 (en) * 2006-12-20 2008-06-26 Neurosearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AU2007336291A1 (en) * 2006-12-20 2008-06-26 Neurosearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
TW200904815A (en) 2007-05-09 2009-02-01 Neurosearch As Novel compounds
CN102216295A (zh) * 2008-11-18 2011-10-12 神经研究公司 8-氮杂双环[3.2.1]辛-2-烯衍生物及其作为单胺神经递质再摄取抑制剂的用途
AU2010247514A1 (en) 2009-05-15 2011-11-17 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011092061A1 (en) 2010-01-29 2011-08-04 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2025172422A1 (en) * 2024-02-13 2025-08-21 Initiator Pharma A/S Compound for use in the treatment of pain and enantiopure compositions thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4819099A (en) * 1998-06-19 2000-01-05 Eli Lilly And Company Inhibition of serotonin reuptake
AU9543601A (en) 2000-10-13 2002-04-22 Neurosearch As Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance
NZ529880A (en) * 2001-07-06 2005-09-30 Neurosearch As Novel compounds, their preparation and use

Also Published As

Publication number Publication date
US20080214820A1 (en) 2008-09-04
NO20073652L (no) 2007-07-16
EP1828173A1 (en) 2007-09-05
AU2005315623A1 (en) 2006-06-22
US7781456B2 (en) 2010-08-24
BRPI0519921A2 (pt) 2009-08-11
IL182738A0 (en) 2007-07-24
JP2008524161A (ja) 2008-07-10
WO2006064031A1 (en) 2006-06-22
MX2007007261A (es) 2007-08-14
CA2591621A1 (en) 2006-06-22

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Patent event date: 20070615

Patent event code: PA01051R01D

Comment text: International Patent Application

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WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid