JP2008524161A - ３−ヘテロアリール−８ｈ−アザビシクロ（３．２．１）オクト−２−エンのエナンチオマー及びモノアミン神経伝達物質再取込み阻害剤としてのその使用 - Google Patents

３−ヘテロアリール−８ｈ−アザビシクロ（３．２．１）オクト−２−エンのエナンチオマー及びモノアミン神経伝達物質再取込み阻害剤としてのその使用 Download PDF

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JP2008524161A
JP2008524161A JP2007546061A JP2007546061A JP2008524161A JP 2008524161 A JP2008524161 A JP 2008524161A JP 2007546061 A JP2007546061 A JP 2007546061A JP 2007546061 A JP2007546061 A JP 2007546061A JP 2008524161 A JP2008524161 A JP 2008524161A
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disorder
ene
oct
pain
enantiopure
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JP2008524161A5 (enExample
Inventor
ペータース、ダン
ブラウン、デーヴィッド、トリスタム
タウリエ、シニッカ、マルヤッタ
ダム、エバ
ジョーンズ、デーヴィッド、スペンサー
フローストルプ、ブライアン
ニールセン、エルセベット、オステルガード
オルセン、グンナー、エム．
レッドローブ、ジョン、ポール
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ノイロサーチ アクティーゼルスカブ
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Publication of JP2008524161A publication Critical patent/JP2008524161A/ja
Publication of JP2008524161A5 publication Critical patent/JP2008524161A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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    • A—HUMAN NECESSITIES
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2007546061A 2004-12-17 2005-12-15 ３−ヘテロアリール−８ｈ−アザビシクロ（３．２．１）オクト−２−エンのエナンチオマー及びモノアミン神経伝達物質再取込み阻害剤としてのその使用 Abandoned JP2008524161A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200401950 2004-12-17
US63686904P 2004-12-20 2004-12-20
DKPA200500506 2005-04-08
US66988705P 2005-04-11 2005-04-11
PCT/EP2005/056801 WO2006064031A1 (en) 2004-12-17 2005-12-15 Enantiomers of 3-heteroaryl-8h-8-azabicyclo(3.2.1)oct-2-ene and their use as monoamine neurotransmitter re-uptake inhibitors

Publications (2)

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JP2008524161A true JP2008524161A (ja) 2008-07-10
JP2008524161A5 JP2008524161A5 (enExample) 2009-01-08

Family

ID=35976671

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JP2007546061A Abandoned JP2008524161A (ja) 2004-12-17 2005-12-15 ３−ヘテロアリール−８ｈ−アザビシクロ（３．２．１）オクト−２−エンのエナンチオマー及びモノアミン神経伝達物質再取込み阻害剤としてのその使用

Country Status (11)

Country Link
US (1) US7781456B2 (enExample)
EP (1) EP1828173A1 (enExample)
JP (1) JP2008524161A (enExample)
KR (1) KR20070089170A (enExample)
AU (1) AU2005315623A1 (enExample)
BR (1) BRPI0519921A2 (enExample)
CA (1) CA2591621A1 (enExample)
IL (1) IL182738A0 (enExample)
MX (1) MX2007007261A (enExample)
NO (1) NO20073652L (enExample)
WO (1) WO2006064031A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200800980A (en) 2006-02-17 2008-01-01 Neurosearch As Novel compounds
CA2673315A1 (en) * 2006-12-20 2008-06-26 Neurosearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
AU2007336291A1 (en) * 2006-12-20 2008-06-26 Neurosearch A/S Novel chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
TW200904815A (en) 2007-05-09 2009-02-01 Neurosearch As Novel compounds
CN102216295A (zh) * 2008-11-18 2011-10-12 神经研究公司 8-氮杂双环[3.2.1]辛-2-烯衍生物及其作为单胺神经递质再摄取抑制剂的用途
AU2010247514A1 (en) 2009-05-15 2011-11-17 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011092061A1 (en) 2010-01-29 2011-08-04 Neurosearch A/S Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2025172422A1 (en) * 2024-02-13 2025-08-21 Initiator Pharma A/S Compound for use in the treatment of pain and enantiopure compositions thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4819099A (en) * 1998-06-19 2000-01-05 Eli Lilly And Company Inhibition of serotonin reuptake
AU9543601A (en) 2000-10-13 2002-04-22 Neurosearch As Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance
NZ529880A (en) * 2001-07-06 2005-09-30 Neurosearch As Novel compounds, their preparation and use

Also Published As

Publication number Publication date
US20080214820A1 (en) 2008-09-04
NO20073652L (no) 2007-07-16
EP1828173A1 (en) 2007-09-05
KR20070089170A (ko) 2007-08-30
AU2005315623A1 (en) 2006-06-22
US7781456B2 (en) 2010-08-24
BRPI0519921A2 (pt) 2009-08-11
IL182738A0 (en) 2007-07-24
WO2006064031A1 (en) 2006-06-22
MX2007007261A (es) 2007-08-14
CA2591621A1 (en) 2006-06-22

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