KR20070079367A - Wrinkle treatment cosmetic composition with fructose 1,6-diphosphate trisodium salt - Google Patents

Abstract

Provided is a cosmetic composition comprising fructose 1,6-diphosphate trisodium salt in which the fructose 1,6-diphosphate trisodium salt is capsulated by physicochemically binding it to a polymer chain using a cationic polymer and an anionic polymer, thereby showing the skin wrinkle improving effect. The cosmetic composition for improving wrinkle comprises 5.0-20.0 wt.% of fructose 1,6-diphosphate trisodium salt capsule base which includes 1.0-5.0 wt.% of fructose 1,6-diphosphate trisodium salt, 0.01-5.0 wt.% of a cationic polymer such as chitosan, lysine, arginine, cystine, polyethylene imine and polyvinylpyrrolidone, 0.01-5.0 wt.% of an anionic polymer such as gelatin, hyaluronic acid, alginic acid, sodium alginate, starch, starch oxide, and carboxymethylcellulose and the remaining amount of water.

Description

Cosmetic composition for improving skin wrinkles containing fructose 1,6-diphosphate trisodium salt {Wrinkle treatment cosmetic composition with fructose 1,6-diphosphate trisodium salt}

The present invention relates to a cosmetic composition for improving wrinkles containing fructose 1,6-diphosphate trisodium salt (Fructose 1,6-Diphos-phate Trisodium Salt). More specifically, the cosmetic composition for improving skin wrinkles according to the present invention contains fructose 1,6-diphosphate trisodium salt stabilized by encapsulating cationic and anionic polymers to improve skin wrinkles and also moisturize naturally. It contains more ingredients and shows the effect of further reducing skin wrinkles.

Skin is not only occupying the largest area of our body tissue, but it is always exposed to harmful environmental conditions. Acting as the body's primary barrier, skin is always at risk of oxidative damage. It is generally well known that if this is not effectively defended, skin aging such as wrinkles is accelerated. Fructose 1,6-diphosphate trisodium salt has been used to protect tissues from oxidative damage such as ischemia, reperfusion, or to prevent damage caused by ATP depletion of isolated organs. Whether fructose 1,6-diphosphate trisodium salt can protect skin cells in an environment that causes oxidative damage, such as UV, as well as protect tissues such as the heart in rapid conditions such as surgery. Fructose 1,6-diphosphate trisodium salt has been tested by UV on skin as well as animals and humans to see if the effect can directly alleviate or delay skin aging. In addition to inhibiting cell damage, the results have been shown to significantly suppress or improve skin aging.

However, fructose 1,6-diphosphate trisodium salt is very unstable and has a problem of being easily decomposed by being sensitive to external environment such as air, especially oxygen, heat, and light.

On the other hand, recently, a method of adding an antioxidant as a method for inhibiting the oxidation of fructose 1,6-diphosphate trisodium salt, in terms of formulation, to suppress the oxidation of fructose 1,6-diphosphate trisodium salt A method of stabilizing in an emulsion, a method of stabilizing in an oil-in-water type emulsion, and a method of inhibiting oxidation of fructose 1,6-diphosphate trisodium salt by using zinc sulfate and L-tyrosine together have been proposed.

However, all of the above-described methods have the following problems. That is, when using phenol derivatives such as tocopherol, which is widely used as a natural antioxidant among the methods of using antioxidants, it is known that there is some antioxidant effect, but when oxidized, the color is changed from yellow to purple generally. There is a drawback, and the effect is relatively insignificant compared to the antioxidant power of fructose 1,6-diphosphate trisodium salt, it is not recognized as an effective antioxidant method of fructose 1,6-diphosphate trisodium salt. On the other hand, the method of using a thiosulfate analogue as an inorganic salt antioxidant is a pH of about 2 to 4 when the fructose 1,6-diphosphate trisodium salt is dissolved, in the pH range The unpleasant odor derived from the liberated sulfur dioxide gas by the equilibrium of thiosulfate and sulfur dioxide gas has the disadvantage that the value as a product is greatly reduced. There are other ways to add chemically synthesized antioxidants, but they are not compatible with the natural concept of using fructose 1,6-diphosphate trisodium salt and are not suitable for practical applications. There was a problem. In addition, in the case of stabilizing fructose 1,6-diphosphate trisodium salt in multiple emulsions, even if the fructose 1,6-diphosphate trisodium salt stabilizes in the multiple emulsion itself, most of the multiple emulsions are stable over time. There is a problem that the poor inevitably decreases the potency over time. On the other hand, efforts have been made to stabilize the oil phase, but it is difficult to add it to the award-winning product, so there is a problem in that the award-winning product such as medicine or cosmetics is not easy to use.

Therefore, the present inventors have conducted a number of studies to solve the above-mentioned conventional problems, by physically bonding the fructose 1,6-diphosphate trisodium salt to the polymer chain using a cationic polymer and an anionic polymer When encapsulated and stabilized fructose 1,6-diphosphate trisodium salt was found to exhibit the effect of improving the skin wrinkles to complete the present invention.

Accordingly, an object of the present invention is to provide a cosmetic composition for improving skin wrinkles containing fructose 1,6-diphosphate trisodium salt.

In order to achieve the above object, the cosmetic composition for improving skin wrinkles according to the present invention is (A) fructose 1,6-diphosphate trisodium salt capsule base (5.0 ~ 20.0) weight%; (B) 20-40 wt% of natural moisturizing ingredients; And (c) a residual amount of water.

Wherein the fructose 1,6-diphosphate trisodium salt capsule base is based on the total weight of the capsule base, (A) fructose 1,6-diphosphate trisodium salt 0.1 to 5.0% by weight; (B) 0.01 to 5.0% by weight of cationic polymer; (C) 0.01 to 5.0% by weight of anionic polymer; And (d) residual water.

Hereinafter, the present invention will be described in more detail.

The composition according to the present invention is based on the fact that fructose 1,6-diphosphate trisodium salt is dissolved and becomes anionic, and cationic polymer such as fructose 1,6-diphosphate trisodium salt and chitosan, amino acid, etc. in the composition After forming a stable acid-base complex, fructose 1,6-diphosphate trisodium salt was first stabilized, and then the complex was encapsulated secondarily by an anionic polymer such as gelatin to form fructose 1,6-di The phosphate trisodium salt is more stabilized. At this time, the fructose 1,6-diphosphate trisodium salt is contained 0.1 to 5.0% by weight relative to the total weight of the fructose 1,6-diphosphate trisodium salt capsule base composition. This is because when it is too small, there is no significant difference in efficacy, whereas when too much it involves problems such as stimulation.

Since fructose 1,6-diphosphate trisodium salt may be decomposed by water in the composition before stabilization, it may be contained in a form dissolved in a polyhydric alcohol. In this case, as the polyhydric alcohol used, at least one selected from the group consisting of propylene glycol, glycerin, 1,3-butanediol and sorbitol is preferable, and the amount used is generally fructose 1,6-diphosphate trisodium salt capsule base total weight. It is preferred to use in an amount of 10.0 to 30.0% by weight, but this is not limitative in the present invention.

In addition, although the kind of cationic polymer contained in the composition of this invention is not limited, The molecule | numerator which is harmless to a human body, having two or more amine groups in a molecule | numerator is preferable.

Specific examples thereof include chitosan, lysine, arginine, cystine, polyethyleneimine, and polyvinylpyrrolidone. If too little is used, the complexing effect on fructose 1,6-diphosphate trisodium salt does not appear, and if the amount is high, fructose 1,6-diphosphate hemp may occur due to solubility. It is preferable to contain in the amount of 0.01-5.0 weight% with respect to the total weight of a sodium salt capsule base.

In addition, the composition of the present invention further contains an anionic polymer in order to completely encapsulate the fructose 1,6-diphosphate trisodium salt complexed with the cationic polymer. The anionic polymer surrounds the fructose 1,6-diphosphate trisodium salt, which forms a complex with the cationic polymer, in a three-dimensional manner to completely separate it from water. Furthermore, in the case of the anionic polymer, since the ultraviolet ray penetrates, the ability to absorb ultraviolet rays can protect the fructose 1,6-diphosphate trisodium salt.

Although the kind of anionic polymer contained in the composition of this invention is not limited, Gelatin, hyaluronic acid, alginic acid, sodium alginate, starch, starch oxide, carboxymethylcellulose, etc. are preferable. In particular, gelatin or hyaluronic acid is preferred, but gelatin or hyaluronic acid improves the strength of the capsule membrane when the molecular weight is large, but the solubility is limited and the viscosity of the composition may be too high, which may cause problems in ease of use. One having a molecular weight of several hundred thousand to several million is used, and in the case of hyaluronic acid, one having a molecular weight of two million to eight million is used.

The amount of the anionic polymer used is preferably the same amount as the cationic polymer in order to stabilize the capsule membrane.

The composition of the present invention may further contain an antioxidant tyrosine, tryptophan and the like to further increase the stabilizing effect of fructose 1,6-diphosphate trisodium salt. However, antioxidants have both amine groups and carboxylic acids in their structure, and because they are acidic, they increase the acidity of the solution when the amount is high and cationic to form a complex with fructose 1,6-diphosphate trisodium salt. Since it is possible to reduce the stabilizing effect of fructose 1,6-diphosphate trisodium salt by blocking the amine group of the polymer, it is preferable to contain in an amount of 1% by weight or less based on the total weight of the composition.

In addition, in order to minimize the effect of acidity as described above, it may further contain basic compounds such as sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, aluminum hydroxide. It is used within the range of adjusting the pH of the composition according to the present invention to 6 or less.

Method for producing a fructose 1,6-diphosphate trisodium salt capsule base in the composition of the present invention is as follows.

Method for stabilizing fructose 1,6-diphosphate trisodium salt in the water phase according to the present invention comprises the steps of dissolving fructose 1,6-diphosphate trisodium salt in water; Adding a cationic polymer to the aqueous solution of fructose 1,6-diphosphate trisodium salt; And adding an anionic polymer to the fructose 1,6-diphosphate trisodium salt and a cationic polymer solution.

Since fructose 1,6-diphosphate trisodium salt is simply dissolved in water in the manufacturing process of the present invention, fructose 1,6-diphosphate trisodium salt may be decomposed by water before stabilization of fructose 1,6-diphosphate trisodium salt. Preferably, it may be dissolved in a polyhydric alcohol first and then introduced into water. This is not limitative in the present invention. In this case, as the polyhydric alcohol used, at least one selected from the group consisting of propylene glycol, glycerin, 1,3-butanediol and sorbitol is preferable, and the amount used is generally fructose 1,6-diphosphate trisodium salt capsule base total weight. It is preferred to use in an amount of 10 to 30% by weight with respect to, but this is not limiting in the present invention.

Next, the natural moisturizing ingredient used in the present invention is characterized in that it contains at least one type of skirt mushroom polysaccharide, hyaluronic acid, niacinamide, honey extract, and keeps the skin always moist by absorbing and maintaining the necessary moisture for the skin. Do it. Therefore, it inhibits the aging process due to skin drying and makes the skin elastic.

In the cosmetic composition of the present invention using the fructose 1,6-diphosphate trisodium salt capsule base to 5.0 ~ 20.0% to achieve the maximum efficacy. At this time, when using too much amount, various problems appear in the irritation and usability and too little amount does not show the beneficial skin effect on the human body.

In addition, the natural moisturizing component is used to contribute to maintaining the homeostasis of the skin by using as little as 20% to as much as 40%. In other words, by using a large amount of natural moisturizing ingredients that are harmless to the human body to continuously moisturize the skin to prevent aging due to moisture depletion and to improve the absorption of potent substances.

Hereinafter, the present invention will be described in more detail with reference to Examples, Comparative Examples, and Test Examples, but the present invention is not limited thereto.

<Examples 1-5 and Comparative Examples 1-2>

Preparation of fructose 1,6-diphosphate trisodium salt capsule base (unit: wt%) Furtherance Fructose 1,6-diphosphate trisodium-salt capsule base Reference Example 1 Reference Example 2 Reference Example 3 (1) water To 100 To 100 To 100 (2) glycerin - - 20 (3) cationic polymer Arginine 0.1 - - Cystine - 0.1 - Chitosan 0.75 0.75 0.1 (4) anionic polymer gelatin 0.75 0.75 0.75 Hyaluronic acid - - 0.75 (5) tryptophan 0.1 0.5 0.1 (6) Fructose 1,6-diphosphate trisodium salt 5 5 5 (7) sodium hydroxide (0.5N) - 5 10

 <Manufacturing method-Fructose 1,6-diphosphate trisodium salt capsule base>

1) First, component (2) or a mixture of (1) and (2) was placed in a beaker or flask, and component (6) was dissolved.

2) Component (3) was dissolved in the solution of 1) at room temperature.

3) Component (4) was dissolved in the solution of 2) above, and Component (5) and Component (7) were added to encapsulate the fructose 1,6-diphosphate trisodium salt.

Example, Comparative Example Preparation (Unit: wt%) Furtherance Example Comparative example One 2 3 4 5 One 2  (1) glycerin - - 20 30 30 - 10  (2) Skirt Mushroom Polysaccharides 20.0 15.0 10.0 10.0 15.0 15.0 20.0  (3) Niacinamide 4.0 4.0 4.0 - 4.0 4.0 4.0  (4) hyaluronic acid 10.0 - 20.0 10.0 15.0 20.0 10.0  (5) Honey Extract - - - 10.0 - - -  (6) Fructose 1,6-diphosphate trisodium salt capsule base-Reference Example 1 10.0 - - 10.0 - - -  (7) Fructose 1,6-diphosphate trisodium salt capsule base-Reference Example 2 - 10.0 - - 10.0 - -  (8) Fructose 1,6-diphosphate trisodium salt capsule base-Reference Example 3 - - 10.0 - - - -  (9) Fructose 1,6-diphosphate trisodium salt - - - - - 0.5 0.5  10 water to 100 to 100 to 100 to 100 To 100 to 100 to 100

<Manufacturing Method-Example, Comparative Example>

1) First, a mixture of components (1) to (5) was placed in a beaker or flask, and components (6) to (9) were dissolved, respectively.

2) Component (10) was added to the solution of 1) at room temperature.

Experimental Example 1 Wrinkle Improvement Test on Human Skin

In Examples 1 to 2 and Comparative Example 1 of Table 2, the wrinkle improvement effect was confirmed and evaluated as follows.

Sixty women in their thirties were divided into three groups of 20 people in Example 1,2 and Comparative Example 1, and applied once a day for 8 weeks, and then, using a silicone, a replica was used to measure the state of wrinkles using a visometer (SV600, Courage + Khazaka electronic GmbH, Germany) was used to measure the depth and area of wrinkles and to evaluate the extent of wrinkle improvement. The results in Table 3 show the average of each parameter value after 8 weeks of application minus the parameter value before application.

Clinical results after 8 weeks of use R1 R2 R3 R4 R5 Example 1 -0.25 -0.24 -0.20 -0.06 -0.04 Example 2 -0.29 -0.28 -0.23 -0.04 -0.04 Comparative Example 1 -0.21 -0.20 -0.14 -0.04 -0.04

 R1: Difference between the highest and lowest of the wrinkle contour

R2: Divide the wrinkle contours by 5 spaces, and then average the R1 values

R3: Highest value of R1 divided by 5

R4: The mean value of the baseline of the fold contour minus the top and valley values of each angle

R5: difference between the baseline of the wrinkle contours minus each wrinkle contour

Through Table 3, it was found that the cosmetic composition containing the encapsulated fructose 1,6-diphosphate trisodium salt of Examples 1 and 2 has a very good skin wrinkle improvement effect.

Test Example 2 Wrinkle Improvement Panel Test for Human Skin

Seventy healthy women aged 30 or older were divided into seven groups of 10 people each, and the cosmetics of Examples 1 to 5 and Comparative Examples 1 and 2 were applied to the face twice a day for 12 weeks. The efficacy evaluation was carried out. The results are shown in Table 4 below.

Applicator Responders (People) Very good Good usually Inadequate Example 1 4 6 0 0 Example 2 5 5 0 0 Example 3 3 7 0 0 Example 4 4 5 One 0 Example 5 5 4 One 0 Comparative Example 1 0 0 5 5 Comparative Example 2 0 One 3 6

As can be seen in Table 4, it was confirmed that the skin wrinkle improvement effect was remarkable in Examples 1 to 5.

As described above, the cosmetic composition for improving skin wrinkles according to the present invention encapsulates fructose 1,6-diphosphate trisodium salt in the formulation or further contains a natural moisturizing ingredient to make skin wrinkles more prominent. Can be reduced.

Claims (4)

Fructose 1,6-diphosphate trisodium salt 0.1 to 5.0% by weight relative to the total weight of the capsule base; 0.01 to 5.0% by weight of cationic polymer; 0.01 to 5.0% by weight of anionic polymer; And 5.0-20.0% by weight of fructose 1,6-diphosphate trisodium salt capsule base containing a residual amount of water. According to claim 1, wherein the cationic polymer is chitosan, lysine, arginine, cystine, polyethyleneimine and polyvinylpyrrolidone cosmetic composition for improving skin wrinkles, characterized in that selected from the group consisting of. The cosmetic composition for improving skin wrinkles according to claim 1, wherein the anionic polymer is selected from the group consisting of gelatin, hyaluronic acid, alginic acid, sodium alginate, starch, starch oxide, and carboxymethyl cellulose. The cosmetic composition for improving skin wrinkles according to any one of claims 1 to 3, wherein the composition further contains at least one selected from the group consisting of a dentifrice polysaccharide, hyaluronic acid, niacinamide and honey extract. Composition.