KR100588464B1 - Composition for stabilizing Vitamin C and its derivatives in water phase and method for stabilizing Vitamin C and its derivatives using thereof - Google Patents

Abstract

The present invention is vitamin C (Ascorbic acid) or derivatives thereof 5.0 to 25.0% by weight, cationic polymer 0.1 to 5.0% by weight, anionic polymer 0.01 to 1.2% by weight and vitamin C in the water phase characterized in that it comprises water And a composition for stabilizing its derivatives and a method for stabilizing vitamin C and its derivatives using the same. According to the present invention, vitamin C and its derivatives are stabilized using a cationic polymer and an anionic polymer. The derivatives can be effectively prevented from being decomposed not only by water but also by an external environment such as temperature and light.

Vitamin C Derivatives, Ascorbic Acid Derivatives, Ionic Polymers, Complexes, Capsules

Description

Composition for stabilizing vitamin C and its derivatives in water, and method for stabilizing vitamin C and its derivatives in water phase {Composition for stabilizing Vitamin C and its derivatives in water phase and method for stabilizing Vitamin C and its derivatives using}

The present invention relates to a composition for stabilizing vitamin C and its derivatives in an aqueous phase, and a method for stabilizing vitamin C and its derivatives using the same, more particularly cationic that can interact with vitamin C and its derivatives in an aqueous phase. A composition which can effectively prevent the decomposition of vitamin C and its derivatives by external environment such as temperature, light, as well as water by stabilizing vitamin C and its derivatives using polymers and anionic polymers, and vitamin C and the same A method for stabilizing derivatives.

Vitamin C (ascorbic acid) and its derivatives enhance the body's immune function, and when applied to the skin, promotes the production of collagen, a component of cartilage, capillaries, and muscles. Not only plays a role in destroying chemicals to prevent skin damage, but also prevents wrinkles, keeps skin healthy, helps heal wounded skin tissue, forms histamines known to cause allergic reactions, and It is known to play an anti-aging role that prevents the formation of melamine, which discolors the skin during the aging process, it is expected to be able to exhibit an excellent function when applied to not only cosmetic compositions, but also pharmaceutical compositions, household goods.

However, vitamin C and its derivatives are unstable as _Y -lactones and have a problem of being easily decomposed by oxidation because they are sensitive to air, particularly oxygen, heat, light, and the like. Oxidation of vitamin C and its derivatives is usually a continuous two electron transfer process, resulting in the dehydroascorbate radical, an intermediate of vitamin C, due to the dissociation of hydrogen ions. It is known to produce abundant reactivity and react with two molecules to produce one molecule of vitamin C or a derivative thereof and dihydroascorbic acid. Such vitamin C and its derivatives are advantageously dissolved in very small amounts in non-aqueous solutions, whereas large amounts are dissolved in aqueous solutions. It has been reported that only a small amount of vitamin C can be used as an active ingredient in food and cosmetics.

As a method for supplementing the vitamin C inherent problems and improving the stability, recently, a method of adding an antioxidant that inhibits the antioxidant of pure vitamin C to US Patent No. 4,938,969 and European Patent Publication No. 533,667 B1. In terms of formulation, a method of stabilizing among multiple emulsions that inhibit the oxidation of vitamin C, a method of stabilizing in an emulsion of water type, and a method of inhibiting the oxidation of vitamin C using zinc sulfate and L-tyrosine together have been proposed. However, there are disadvantages in terms of efficiency and inferiority to the melt of the aqueous phase when the skin is applied.

In addition to the above methods for improving the stability of vitamin C itself, a lot of research has recently been conducted to improve the oxidation resistance to water, light, air by changing the structure of vitamin C. Representative structures thereof include sodium ascorbylphosphate, magnesium ascorbyl phosphate, calcium ascorbylphosphate, ascorbic acid polypeptide, and ethyl ascorbyl ether. (Ethyl ascorbyl ether), ascorbyl dipalmitate, ascorbyl palmitate, ascorbyl glucoside, ascorbyl glucoside, ascorbyl ethylsilanol pectinate, etc. Although they are stabilized in chemical structure, they have been reported to destroy stability when exposed to water, light and air for a long time.

Therefore, there has been a demand for stabilizing pure vitamin C in water as well as derivatives thereof.

In accordance with this request, the present inventor has filed a patent application regarding the technology for stabilizing pure vitamin C through Korean Patent Application No. 2003-15017 as of March 11, 2003, and stabilized not only pure vitamin C but also vitamin C derivatives. More research has been made on technical problems.

Therefore, the present inventors have conducted research to solve such a conventional problem for stabilizing vitamin C and its derivatives, when the vitamin C and its derivatives are encapsulated by physicochemical bonding to the polymer chain that can interact, The present invention has been accomplished by discovering that vitamin C and its derivatives can effectively prevent degradation in response to external environments such as water, oxygen, heat, air, light, and the like.

It is an object of the present invention to provide a composition which can effectively stabilize vitamin C and its derivatives in an aqueous phase.

It is another object of the present invention to provide a method of stabilizing vitamin C and derivatives thereof using the composition described above.

In order to achieve this object, the composition for stabilizing vitamin C and its derivatives in the water phase according to the present invention is 5.0 to 25.0% by weight of vitamin C or derivatives thereof; 0.1 to 5.0% by weight of cationic polymer; 0.01 to 1.2% by weight of anionic polymer; And water as the residual amount.

Method for stabilizing vitamin C and its derivatives in an aqueous phase according to the present invention comprises the steps of dissolving vitamin C or its derivatives in water or a mixture of water and polyhydric alcohol; Adding a cationic polymer to the aqueous solution at room temperature to mix; And adding an anionic polymer to the cationic polymer mixture, wherein the vitamin C or derivative thereof is 5.0 to 25.0 wt%, the cationic polymer is 0.1 to 5.0 wt%, the anionic polymer 0.01 to 1.2 wt%, Water or a mixture of water and polyhydric alcohols is characterized as being added as the balance.

Hereinafter, first, the composition for stabilizing vitamin C and its derivatives in the water phase of the present invention will be described in detail.

The composition for stabilizing vitamin C and its derivatives in the water phase according to the invention is characterized in that it comprises vitamin C or its derivatives, cationic polymer, anionic polymer and water as essential components.

The vitamin C derivatives may be used without particular limitation, in particular, sodium ascorbylphosphate (SAP), magnesium ascorbylphosphate (MAP), calcium ascorbylphosphate (Calsium ascorbylphosphate) Ascorbic acid poly peptide, Ascorbyl ether, Ethyl ascorbyl ether, Ascorbyl dipalmitate, Ascorbyl palmitate, Ascorbyl stearate ), Ascorbyl glucoside or ascorbyl ethylsilanol pectinate is preferred.

Of these, vitamin C or derivatives thereof are dissolved in water to become anions and react with cationic polymers to form stable acid-base complexes, whereby vitamin C and its derivatives are primarily stabilized, and then the complexes are anionic polymers. It is encapsulated secondary by to further stabilize the vitamin C and its derivatives. At this time, the vitamin C or derivatives thereof is preferably contained in an amount of 5.0 to 25.0% by weight based on the total weight of the composition. If vitamin C or derivatives thereof are contained in an amount of less than 5.0% by weight, there may be a problem in that the positive and anionic polymer remaining unreacted reacts with other ingredients added together when applied to cosmetics or medicines, When C or derivatives thereof are contained in an amount of more than 25.0% by weight, there may be a problem that excess vitamin C or derivatives thereof remaining without forming a complex with the cationic polymer.

Therefore, the cationic polymer and the anionic polymer may be used as the polymer that can interact with the vitamin C or derivatives thereof, and the cationic polymer may form a stable acid-base complex with the vitamin C and the derivative thereof in the composition. Although the kind is not limited if it can be used, It is more preferable if it is a molecule which has two or more amine groups in a molecule, and is harmless to a human body. Specific examples thereof include chitosan, polyethyleneimine, cationic copolymers of polyvinylpyrrolidone, polymethylmethacrylate copolymers including quaternary ammonium, styrene copolymers containing quaternary ammonium salts, and the like. However, when they are used in a small amount, the complex effect on vitamin C and its derivatives does not appear, and when the amount is high, the solubility is limited so that precipitates are generated to separate them. Therefore, the cationic polymer is preferably contained in an amount of 0.1 to 5.0% by weight based on the total weight of the composition.

On the other hand, the anionic polymer is used to completely encapsulate vitamin C and its derivatives complexed with the cationic polymer, and surrounds the vitamin C and its derivatives complexed with the cationic polymer in three dimensions. If it is cheap to completely isolate vitamin C and its derivatives from water, the type is not limited. Since the anionic polymer has the ability to absorb ultraviolet rays, it is possible to protect vitamin C and its derivatives even when ultraviolet rays penetrate. Specific examples thereof include monosaccharides, polysaccharides, cellulose, gelatin, hyaluronic acid, alginic acid, sodium alginate, starch, starch oxide, carboxymethyl cellulose and the like. In particular, gelatin or hyaluronic acid is preferable, but gelatin or hyaluronic acid improves the strength of the capsule membrane when the molecular weight is large, but the solubility is limited and the viscosity of the composition is too high, which may cause problems in ease of use. It is better to use one having a molecular weight of several hundred thousand to several million, and in the case of hyaluronic acid, one having a molecular weight of two million to eight million. However, if they are used in a small amount, there is no sequestration effect on vitamin C or derivatives thereof, and when the amount is high, solubility is limited, so that precipitates are generated to separate them. Therefore, the anionic polymer is preferably contained in an amount of 0.01 to 1.2% by weight based on the total weight of the composition. In order to stabilize the capsule membrane, the anionic polymer has an excellent effect when used in the same amount as the cationic polymer within the weight range.

In addition to the above essential components, polyhydric alcohols, antioxidants, basic additives and the like may be further added.

The polyhydric alcohol is used to prevent the problem that vitamin C and its derivatives can be decomposed by water in the composition before the vitamin C and its derivatives are stabilized, and used as a solvent of the vitamin C and its derivatives together with water. Can be. The polyhydric alcohol used at this time can be used without any limitation, specific examples, ethylene glycol, propylene glycol, diethylene glycol, dipropylene glycol, dibutylene glycol, glycerin, 1,3-butanediol, sorbitol And the like can be used. The polyhydric alcohol is most preferably added in an amount of 10 to 30% by weight based on the total weight of the composition, but this is not limitative in the present invention.

On the other hand, antioxidants are used to further increase the stabilizing effect of some unstabilized vitamin C and its derivatives, such as tyrosine, tryptophan, alpha lipoic acid, vitamin E and its derivatives, vitamin A and its derivatives, sodium sulfite, sodium Disulfite and the like are preferred. However, when an antioxidant is included in excess, vitamin C and its derivatives may have an effect of blocking the interaction of the polymer, and thus may have a problem of destroying stability or showing no increase in stability. There may be a problem that the stabilization effect is insufficient. Accordingly, the antioxidant is preferably contained in an amount of 10% by weight or less based on the total weight of the composition. More preferably, it is contained in the amount of 5 weight% or less.

In addition, basic additives are added to neutralize the hydrogen ions generated during ionization of vitamin C and its derivatives, thereby strengthening the bond between the vitamin C and its derivatives and the cationic polymer, thereby further enhancing the stabilizing effect of the vitamin C and its derivatives. It may contain. Although the kind of basic additive will not be specifically limited if it exhibits the above-mentioned effect, Sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, aluminum hydroxide, etc. are preferable. The amount of use is appropriately selected within a range such that the pH of the composition is 6 or less. If the pH is 6 or more, there is a problem that can cause skin irritation.

Hereinafter, a method of stabilizing vitamin C and its derivatives in an aqueous phase according to the composition of the composition described above will be described in detail.

The method for stabilizing vitamin C and its derivatives in an aqueous phase according to the invention comprises dissolving vitamin C or its derivatives in water or a mixture of water and polyhydric alcohol; Adding a cationic polymer to the aqueous solution at room temperature to mix; And adding an anionic polymer to the cationic polymer mixture.

In the step of dissolving the vitamin C or its derivatives, simply dissolving the vitamin C or its derivatives in water may be decomposed by water before the vitamin C or its derivatives are stabilized. Dissolution in is most preferred because it can minimize decomposition in the preparation.

Additional antioxidant and basic additives may be added in the anionic polymer addition step.

The vitamin C and its derivative-containing compositions stabilized by this method are based on the fact that vitamin C and its derivatives are dissolved and become anions, and the acid in which the cationic polymer such as vitamin C and its derivatives and chitosan in the composition is stabilized. -Stabilizing vitamin C and its derivatives primarily by forming a base complex, and further stabilizing by encapsulating the vitamin C and its derivatives, which are complexed with cationic molecules and encapsulating them secondaryly, by anionic polymers. By doing so, it is possible to effectively prevent the decomposition of vitamin C and its derivatives by water, light and the like even in the water phase.

Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples, but the present invention is not limited thereto.

<Examples 1-5 and Comparative Examples 1-2>

Furtherance Example Comparative example One 2 3 4 5 One 2 Polyhydric alcohol glycerin 20.0 30.0 30.0 10.0 Cationic polymer Lysine 0.25 0.25 0.2 Arginine 0.1 0.1 Cystine 0.1 Chitosan 0.75 0.75 0.75 0.75 0.75 0.5 Anionic polymer gelatin 0.75 0.75 1.0 0.75 0.75 Hyaluronic acid 0.1 0.25 0.25 Antioxidant Tryptophan 0.1 0.5 0.4 0.4 0.1 Vitamin C derivatives Ascorbic Acid Polypeptides 15.0 15.0 20.0 20.0 20.0 15.0 5.0 Basic additives Sodium Hydroxide (0.5N) 5.0 10.0 15.0 15.0       water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount

-Manufacturing Method-

1) First, water (or a mixture of water and a polyalcohol) was placed in a beaker or flask, and the vitamin C derivative was added and dissolved at room temperature according to the composition of Table 1 above.

2) The cationic polymer was added and dissolved in the solution of 1) at room temperature according to the composition of Table 1 above.

3) Anionic polymer was added and dissolved in the solution of 2) according to the composition of Table 1, followed by addition of antioxidant and basic additive to encapsulate the vitamin C derivative.

Experimental Example 1 Assay of Vitamin C Derivatives-Ascorbic Acid Polypeptide

The initial titer of the ascorbic acid polypeptide as the vitamin C derivative encapsulated in Examples 1 to 5 and Comparative Examples 1 and 2 was set to 100, and the titer of the vitamin C derivative after 1 month was measured at room temperature, 37 ° C. and 45 ° C., The results are shown in Table 2. The measurement was first quantified using the HPLC of Waters company. The conditions of the HPLC operating to determine the residual amount were measured at a flow rate of 0.8 ml / min using a Luna C18 column of Phenomenex, having a wavelength of 254 nm of the detector. After drawing the standard calibration graph using the measured residual amount and the peak height appearing at 266 nm of the ultraviolet spectrometer, the amount of vitamin C was relatively determined using the ultraviolet spectroscope. The ultraviolet spectrometer used Heλios β type from Spectronic Unicam.

Example Comparative example One 2 3 4 5 One 2 Room temperature 93 94 97 99 99 90 92 37 ℃ 90 92 95 98 98 87 89 45 ℃ 88 90 94 97 97 85 88

As can be seen from Table 2, the titers of the compositions of Comparative Example 1 without the addition of the cationic polymer and the anionic polymer and Comparative Example 2 without the addition of the anionic polymer were compared with those of the compositions of Examples 1-5. It was slightly lower at room temperature and higher temperature. Therefore, it can be seen that the compositions of Examples 1 to 5 are superior to the compositions of Comparative Examples 1 and 2 to stabilize the vitamin C derivatives against the external environment. In particular, it can be seen that the higher titers of Examples 3 to 5, in which polyhydric alcohol and an antioxidant were added, may provide a more stabilized vitamin C derivative.

<Examples 6 to 10 and Comparative Examples 3 to 4>

Furtherance Example Comparative example 6 7 8 9 10 3 4 Polyhydric alcohol glycerin 20.0 30.0 30.0 10.0 Cationic polymer Lysine 0.25 0.25 0.2 Arginine 0.1 0.1 Cystine 0.1 Chitosan 0.75 0.75 0.75 0.75 0.75 0.5 Anionic polymer gelatin 0.75 0.75 1.0 0.75 0.75 Hyaluronic acid 0.1 0.25 0.25 Antioxidant Tryptophan 0.1 0.5 0.4 0.4 0.1 Vitamin C derivatives Ascorbyl Glucoside 15.0 15.0 20.0 20.0 20.0 15.0 5.0 Basic additives Sodium Hydroxide (0.5N) 5.0 10.0 15.0 15.0       water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount

Vitamin C derivatives were encapsulated according to the same method as the preparation method of Examples 1 to 5 and Comparative Examples 1 to 2.

Experimental Example 2 Assay of Vitamin C Derivatives-Ascorbyl Glucoside

Except for using only ascorbyl glucoside, a vitamin C derivative encapsulated in Examples 6 to 10 and Comparative Examples 3 to 4, the titer was measured according to the same method as in Experimental Example 1, and the results are shown in Table 4. Indicated.

Example Comparative example 6 7 8 9 10 3 4 Room temperature 93 94 97 99 99 90 92 37 ℃ 90 92 95 98 98 87 89 45 ℃ 88 90 94 97 97 85 88

As can be seen from the titer values in Table 4, it can be seen that the compositions of Examples 6 to 10 are superior to the compositions of Comparative Examples 3 and 4 in stabilizing vitamin C derivatives to the external environment. In particular, it can be confirmed that higher titers of Examples 8 to 10 to which polyhydric alcohols and antioxidants are added may provide a more stabilized vitamin C derivative.

<Examples 11-15 and Comparative Examples 5-6>

Furtherance Example Comparative example 11 12 13 14 15 5 6 Polyhydric alcohol glycerin 20.0 30.0 30.0 10.0 Cationic polymer Lysine 0.25 0.25 0.2 Arginine 0.1 0.1 Cystine 0.1 Chitosan 0.75 0.75 0.75 0.75 0.75 0.5 Anionic polymer gelatin 0.75 0.75 1.0 0.75 0.75 Hyaluronic acid 0.1 0.25 0.25 Antioxidant Tryptophan 0.1 0.5 0.4 0.4 0.1 Vitamin C derivatives Sodium Ascorbyl Phosphate 15.0 15.0 20.0 20.0 20.0 15.0 5.0 Basic additives Sodium Hydroxide (0.5N) 5.0 10.0 15.0 15.0       water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount

Vitamin C derivatives were encapsulated according to the same method as the preparation method of Examples 1 to 5 and Comparative Examples 1 to 2.

Experimental Example 3 Measurement of Titer of Vitamin C Derivative-Sodium Ascorbyl Phosphate

Except for using only sodium ascorbyl phosphate which is a vitamin C derivative encapsulated in Examples 11 to 15 and Comparative Examples 5 to 6 and measuring the titer according to the same method as in Experimental Example 1 Table 6 Shown in

Example Comparative example 11 12 13 14 15 5 6 Room temperature 94 94 97 98 99 92 93 37 ℃ 91 92 95 97 98 90 91 45 ℃ 88 90 94 95 97 87 89

As can be seen from the titer values of Table 6, it can be seen that the compositions of Examples 11 to 15 are superior to the compositions of Comparative Examples 5 and 6 in stabilizing vitamin C derivatives to the external environment. In particular, it can be seen that the higher titers of Examples 13 to 15 to which a polyhydric alcohol and an antioxidant were added may provide a more stabilized vitamin C derivative.

<Examples 16-20 and Comparative Examples 7-8>

Furtherance Example Comparative example 16 17 18 19 20 7 8 Polyhydric alcohol glycerin 20.0 30.0 30.0 10.0 Cationic polymer Lysine 0.25 0.25 0.2 Arginine 0.1 0.1 Cystine 0.1 Chitosan 0.75 0.75 0.75 0.75 0.75 0.5 Anionic polymer gelatin 0.75 0.75 1.0 0.75 0.75 Hyaluronic acid 0.1 0.25 0.25 Antioxidant Tryptophan 0.1 0.5 0.4 0.4 0.1 Vitamin C derivatives Ethyl ascorbyl ether 15.0 15.0 20.0 20.0 20.0 15.0 5.0 Basic additives Sodium Hydroxide (0.5N) 5.0 10.0 15.0 15.0       water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount

Vitamin C derivatives were encapsulated according to the same method as the preparation method of Examples 1 to 5 and Comparative Examples 1 to 2.

Experimental Example 4 Measurement of Titer of Vitamin C Derivative-Ethyl Ascorbyl Ether

Except for the use of ethyl ascorbyl ether, a vitamin C derivative encapsulated in Examples 16 to 20 and Comparative Examples 7 to 8, the titer was measured according to the same method as in Experimental Example 1, and the results are shown in Table 8 below. Shown in

Example Comparative example 16 17 18 19 20 7 8 Room temperature 95 96 98 99 99 95 96 37 ℃ 93 94 96 98 98 93 94 45 ℃ 91 92 95 97 98 90 92

As can be seen from the titer values in Table 8, it can be seen that the compositions of Examples 16 to 20 are superior to the compositions of Comparative Examples 7 and 8 to stabilize the vitamin C derivatives against the external environment. In particular, it can be seen that the higher titers of Examples 18 to 20 to which polyhydric alcohol and an antioxidant were added may provide a more stabilized vitamin C derivative.

The stabilized vitamin C or derivatives thereof may be contained in an amount of 1.0 × 10 ⁻⁴ to 1.0 × 10 ¹ wt% of the total composition as an active ingredient in a conventional cosmetic composition to prepare a cosmetic composition comprising the same. In addition, stabilized vitamin C or derivatives thereof may be contained in the pharmaceutical composition, such as dressing gauze or mask pack, in the above composition range.

As described above, the composition for stabilizing vitamin C and its derivatives in the aqueous phase according to the present invention is to improve the stability by encapsulating the vitamin C and its derivatives with a positive and anionic polymer, as well as water, temperature, light, etc. Since it effectively inhibits the decomposition by the external environment of the improved stability, it can be usefully used as a cosmetic composition, pharmaceutical composition, household goods, etc., because it is an aqueous phase, it can be said to be a molecular assembly excellent in usability.

Claims (15)

5.0-25.0% by weight of vitamin C or its derivatives; 0.1 to 5.0% by weight of cationic polymer; 0.01 to 1.2% by weight of anionic polymer; And Water as residual quantity Composition for stabilizing vitamin C and derivatives thereof in an aqueous phase comprising a. The method of claim 1, wherein the vitamin C derivative is sodium ascorbylphosphate (SAP), magnesium ascorbyl phosphate (MAP), calcium ascorbylphosphate (Calsium ascorbylphosphate), ascorbic acid polypeptide (Ascorbic acid polypeptide ), Ethyl ascorbyl ether, ascorbyl dipalmitate, ascorbyl palmitate, ascorbylstearate, ascorbylstearate, ascorbyl glucoside or Stabilizing composition characterized in that the ascorbyl ethyl silanol pectinate (Ascorbylethylsilanolpectinate). The method of claim 1 or claim 2, wherein the cationic polymer is a cationic copolymer of chitosan, polyethyleneimine, polyvinylpyrrolidone, polymethyl methacrylate copolymer including quaternary ammonium, styrene air containing a quaternary ammonium salt Stabilizing composition, characterized in that one or more mixtures selected from the group consisting of coalescence. The method of claim 1 or 2, wherein the anionic polymer is one or a mixture of one or more selected from the group consisting of monosaccharides, polysaccharides, cellulose, gelatin, hyaluronic acid, alginic acid, sodium alginate, starch, starch oxide and carboxymethylcellulose. Stabilizing composition characterized in that. The stabilizing composition according to claim 1 or 2, wherein the composition further contains an antioxidant in an amount of 5% by weight or less based on the total weight of the composition. According to claim 5, wherein the antioxidant is tyrosine, tryptophan, alpha lipoic acid, vitamin E and its derivatives, vitamin A and its derivatives, sodium sulfite and sodium disulfite selected from the group consisting of one or more characterized in that Stabilizing composition. The method of claim 1 or 2, wherein the composition further contains a basic additive to adjust the pH of the composition to 6 or less, wherein the basic additive is sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide or aluminum hydroxide stabilization, characterized in that Composition. The method according to claim 1 or 2, wherein the composition further contains polyhydric alcohol in an amount of 10 to 30% by weight based on the total weight of the composition, wherein the polyhydric alcohol is ethylene glycol, propylene glycol, diethylene glycol, dipropylene glycol, Stabilizing composition, characterized in that one or more mixtures selected from the group consisting of dibutylene glycol, glycerin, 1,3-butanediol and sorbitol. Dissolving vitamin C or a derivative thereof in water or a mixture of water and polyhydric alcohol; Adding a cationic polymer to the aqueous solution at room temperature to mix; And Comprising the step of adding an anionic polymer to the cationic polymer mixture, In the aqueous phase characterized in that the vitamin C or derivatives thereof is 5.0 to 25.0% by weight, cationic polymer is 0.1 to 5.0% by weight, anionic polymer 0.01 to 1.2% by weight, water or a mixture of water and polyhydric alcohol is added as a residual amount Method of stabilizing vitamin C and its derivatives. The method of claim 9, wherein the vitamin C derivative is sodium ascorbyl phosphate, magnesium ascorbyl phosphate, calcium ascorbyl phosphate, ascorbic acid polypeptide, ethyl ascorbyl ether, ascorbyl dipalmitate, ascorbyl palmitate, Stabilization method characterized in that it is ascorbyl stearate, ascorbyl glucoside or ascorbyl ethyl silanol pectinate. 10. The method of claim 9, wherein dissolving the vitamin C or derivatives thereof in a mixture of water and polyhydric alcohol, dissolves the vitamin C or derivatives thereof in polyhydric alcohol, and then dissolves in water, wherein the polyhydric alcohol is 10 to 30 weight Stabilization method characterized in that the addition in the amount of%. 10. The method of claim 9, wherein the cationic polymer comprises chitosan, polyethyleneimine, polyvinylpyrrolidone cationic copolymer, polymethyl methacrylate copolymer including quaternary ammonium, and styrene copolymer including quaternary ammonium salts. The anionic polymer is one or one selected from the group consisting of monosaccharides, polysaccharides, cellulose, gelatin, hyaluronic acid, alginic acid, sodium alginate, starch, starch oxide and carboxymethyl cellulose. The polyhydric alcohol is one or more mixtures selected from the group consisting of ethylene glycol, propylene glycol, diethylene glycol, dipropylene glycol, dibutylene glycol, glycerin, 1,3-butanediol and sorbitol. Stabilization method. A cosmetic composition comprising the vitamin C of claim 1 and a derivative stabilizing composition thereof as an active ingredient. A pharmaceutical composition comprising the vitamin C of claim 1 and a derivative stabilizing composition thereof as an active ingredient. Food containing the vitamin C and derivative derivative stabilizing composition of claim 1 as an active ingredient.