KR20070070338A - Mixed beverage of onion juice and orange juice - Google Patents

Abstract

A mixed beverage containing onion juice and citrus juice is provided, which can be applied to a food composition and pharmaceutical composition for lowering blood pressure. The mixed beverage contains 60 to 80 parts by weight of onion juice and 20 to 40 parts by weight of citrus juice. The onion juice and citrus juice have each a concentrated solid shape or liquid shape. The mixed beverage is used as a pharmaceutical composition containing a pharmaceutically acceptable carrier and an additive selected from a lubricant, wetting agent, sweetener, flavoring agent, emulsifying agent, suspension agent and preservative. The pharmaceutical composition has a daily dose of 0.001 to 150mg/kg body weight.

Description

Mixed Drink of Onion Juice and Citrus Juice

The present invention discloses a mixed drink of onion juice and citrus juice.

Onion is a plant belonging to the family Liliaceae, and it is cultivated mainly in South Korea including Muan-gun, Jeonnam in Korea, and its pharmacological effects have been well known for a long time.

According to the agreement, onion is said to remove the secretary (肝 邪), control the five Jang (通 臟), kill the poison of the white medicine (百 藥) and heal each.

In addition, sulfur compounds, which cause onion's irritating odor in general, are known to promote blood circulation and metabolism, and other components of onions have antioxidant activity, energetic enhancement, and blood clots. It is known to dissolve, lower blood pressure, and hangover.

On the other hand, citrus fruits contain many bioactive substances such as citric acid, vitamins, carotenoids and flavonoids, and are known to be good for skin care and fatigue, help calcium absorption, and prevent arteriosclerosis and hypertension. In particular, the tangerine peel has been used as a medicine for the dermis in one room, and has been used for pandemic flu, gastrointestinal diseases, edema, and shellfish poisoning.

When the present invention produces a beverage by mixing onion juice and citrus juice, the present invention is confirmed by synergistically improving not only its palatability, but also the synergistically improved blood pressure lowering effect of onion and the lowering of blood pressure of citrus fruit. It was completed.

Therefore, an object of the present invention is to provide a mixed drink of onion juice and citrus juice with improved palatability.

Other objects and specific aspects of the present invention will be presented below.

The present invention relates to a mixed drink of onion juice and citrus juice.

The present inventors produce onion juice by compressing and compressing onion, and preparing a mixed drink of onion juice and citrus juice by adding citrus juice prepared by compressing organically grown citrus fruits with a peel to the onion juice. In contrast, the results of sensory evaluation showed that the taste and taste were greatly improved, and the flavor and color were improved.

The present invention is provided based on this sensory evaluation.

Therefore, the mixed drink of onion juice and citrus juice of the present invention is characterized by including onion juice and citrus juice.

In the above, onions that can be used for the production of onion juice are understood to be of any kind as long as they can be classified as onions in plant taxonomics. Therefore, whether the skin is red onion, yellow onion or hin onion, sweet onion or spicy onion, it can be used for the preparation of the onion juice as long as it can be classified as a taxonomy onion as a plant belonging to the family Liliaceae. .

Actually, as shown by the following Reference Examples, Examples and Experimental Examples, whether the onion juice obtained from onions or onion juice obtained from spicy onions when mixed with citrus juice, the sensory evaluation results for taste, flavor, etc. did not differ.

However, the onion juice should be understood to mean onion juice obtained by compressing the increased onion. Onion was not obtained due to its characteristic irritant scent, when the raw onion is compressed to obtain onion juice without obtaining a mixed drink with improved palatability as desired of the present invention.

Therefore, unless specifically mentioned herein, the onion juice should be understood as onion juice obtained by compressing the enhanced onion. The thickening temperature and time here can be any temperature and time as long as it can eliminate the pungent odor of onions.

On the other hand, citrus fruits that can be used in the production of citrus juices above are defined as fruits obtained from fruit trees belonging to the taxonomic citrus fruits of all types (ie, dicotyledonous fennel and fruit citrus fruits). Is defined as a generic term for fruit from various fruits belonging to citrus, golden persimmon and tangerine and fruits derived from these three genera. Therefore, the "citrus fruits" is not only the citrus ( C. natsudaidai Hayata) used in the following reference example citron (citron) grown in southern Europe, lemon (lemon) grown in the United States, California, etc. paragraphs cultivated in the tropics, etc. Paragraph fruit such as grapefruit and grapefruit, grape fruit, cultivated in Floridian, USA, sour orange grown in India, Italy, Tangerine grown in India, China, It is understood that all of the citron (柚子) grown in Korea, the tangerine grown in Jeju Island, etc., the golden persimmon grown in China, and other tangerines are included.

Nevertheless, in the following examples and experimental examples of the present invention, in the sense that the tangerine is preferably citrus, preferably tangerine, particularly organically grown mandarin. In the case of organically grown mandarin, it is possible to edible up to the rind, and when the citrus juice is obtained including the rind, the mixed beverage of the present invention includes various useful substances contained in the rind, so that nutritional or pharmacological This is because it is very preferable.

On the other hand, the mixing ratio of onion juice and citrus juice may be any ratio as long as the onion juice and citrus juice is mixed, but on the basis of the following Examples and Experimental Examples Onion juice when preferably based on the total weight of the mixed beverage 60 parts by weight to 80 parts by weight, citrus juice is preferably included in 20 to 40 parts by weight.

In addition to the onion juice and citrus juice, the mixed beverage of the present invention may be added with glucose, monosaccharides such as fructose, disaccharides such as maltose and sucrose, and / or polysaccharides such as dextrin and cyclodextrin, Alcohols such as xylitol, sorbitol, erythritol and the like may also be added, sweeteners such as taurine, stevia extract and the like may also be added, and other food additives may be added.

The additive may be added in various ranges depending on the purpose to be added to the mixed beverage of the present invention and will usually be added in small amounts.

On the other hand, the mixed beverage of the present invention can be prepared or used diluted to the consumer's preference.

In another aspect, the present invention relates to a blood pressure lowering composition comprising onion juice and citrus juice.

When the present inventors mixed onion juice and citrus juice and administered orally to the experimental animals for a certain period of time, the systolic blood pressure of the experimental animals was lowered when onion juice and citrus juice were administered alone.

The composition for lowering blood pressure of the present invention is based on these experimental results.

The blood pressure lowering composition of the present invention may be regarded as a food composition and a pharmaceutical composition in a specific embodiment. When the pharmaceutical composition is identified, onion juice and citrus juice contained in the pharmaceutical composition of the present invention are concentrated. It would be desirable to be in solid or liquid form.

And onion juice and citrus juice will vary depending on the degree that they are included in the pharmaceutical composition of the present invention, etc., but is usually 1.0% by weight to 25% by weight based on the total weight of the pharmaceutical composition Will be added in the range of.

On the other hand, the pharmaceutical composition of the present invention may include a pharmaceutically acceptable carrier in addition to the onion juice and citrus juice as an active ingredient, such a pharmaceutically acceptable carrier is commonly used in pharmaceutical formulations as , Lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia rubber, calcium phosphate, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, syrup, methylcellulose, methyl Hydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, mineral oil, and the like, but are not limited thereto.

The pharmaceutical compositions of the present invention may also further comprise lubricants, wetting agents, sweeteners, flavoring agents, emulsifiers, suspending agents, preservatives and the like known in the art as additives.

On the other hand, the pharmaceutical composition of the present invention may be administered orally or parenterally, preferably may be administered by oral administration.

The pharmaceutical compositions of the present invention may be prepared in unit dose form by formulating with a pharmaceutically acceptable carrier or may be prepared by incorporation into a multi-dose container. In this case, the formulation may be in the form of a solution, a suspension or an emulsion, or may include elexirs, extracts, powders, granules, tablets, ointments, and the like.

The daily dosage of the pharmaceutical composition of the present invention is usually 0.001 ~ 150 mg / kg body weight range, it can be administered once or divided into several times. However, since the dosage of the pharmaceutical composition of the present invention is determined in view of various related factors such as the route of administration, the age, sex, weight of the patient, the severity of the patient, the duration of use, and the like, the dosage may be determined in any aspect of the present invention. It should not be understood as limiting the scope of.

Hereinafter, the present invention will be described with reference to Examples and Experimental Examples. However, the scope of the present invention is not limited to these examples and experimental examples.

Reference Example Preparation of Onion Juice and Citrus Juice

Reference Example 1 Preparation Example of Onion Juice 1

The hot onion was washed with tap water to remove foreign substances, peeled, and then divided into two to three parts and steamed for about 10 minutes with steam at 90 to 110 ° C. The steamed onion was pressed with a press to obtain onion juice.

Reference Example 2 Preparation Example 2 of Onion Juice

Onion juice was obtained in the same manner as in <Reference Example 1>, but sweet onions were used instead of hot onions.

Reference Example 3 Preparation of Citrus Juices

C. natsudaidai Hayata, which is grown organically and can be eaten to the skin, was washed, and then pressed in a press to obtain citrus juice.

< Example > Preparation of Onion Juice and Citrus Juice Mixture

Example 1 Preparation Example 1 of Mixture

70% by weight of onion juice of <Reference Example 1> and 30% by weight of citrus juice of <Reference Example 3> were mixed to obtain a mixture of onion juice and citrus juice.

Example 2 Preparation Example 2 of Mixture

70% by weight of onion juice of <Reference Example 2> and 30% by weight of citrus juice of <Reference Example 3> were mixed to obtain a mixture of onion juice and citrus juice.

< Experimental Example > Blood pressure drop test and sensory evaluation for palatability

Experimental Example 1 Blood Pressure Drop Experiment Using Experimental Animals

<1> experimental animals

Male white rats (Samdae Science, Daejeon, Korea) of SD (Sprague Dawley) system weighing about 250-300 g are kept in the breeding ground (room temperature 24-26 ℃, humidity 30-50%, contrast cycle 12:12 hr) And feed (pellet, Samyang Yuji Feed, Korea) were used for the experiment after one week of adaptation.

<2> hypertension induced in experimental animals

To induce hypertension, anesthetized with pentobarbital sodium (Entobar, Hallym Pharmaceutical Co., Ltd., 50 mg / kg) intraperitoneally to anesthetized animals, and then excised the abdomen to expose the left renal artery. After clearing them, a 0.2 mm-thick silver clip was inserted into the renal artery and sutured. The blood pressure was measured 30 days after the operation, and a test animal having a systolic blood pressure of 150 mmHg or more was used as a test for hypertension.

<3> Administration of the Mixture of Examples

After restoring the hypertension-induced experimental animals for 30 days as described above, the mixture of each of <Examples> was orally administered at a dose of 3.0ml / 250g. Oral administration was performed five times, once every two days, using an oral zonde needle.

On the other hand, the experimental animal as a control group was administered saline instead of the mixture of <Example>, the experimental animal as a <Comparative Example> was administered onion juice or citrus juice of each of the <Reference Example>.

<4> blood pressure measurement

Observation of blood pressure fluctuations in experimental animals was performed using a rat tail blood pressure system (RTBP2003, WPI, U.S.A.), a non-invasive blood pressure measuring instrument. The rat is placed in an animal warming restrainer, a piezoelectric pulse sensor and an occlusion cuff are placed on the tail of the rat and the magnitude of the pulse signal connected to the computer. Is observed to a moderate degree, the instrument is then operated to observe systolic blood pressure. Blood pressure was measured 1 hour after oral administration.

<5> results

The results are shown in Table 1 below.

The result is the mean value of the measurements for the experimental animals belonging to each experimental group (or control group, comparative example).

Hypotensive effect of the mixture division 0 1 time Episode 2 3rd time 4 times 5 times Control 157.4 157.6 156.4 165.4 161.8 160.6 Reference Example 1 150.3 152.3 145.2 148.4 145.4 142.5 Reference Example 2 165.5 168.5 166.4 157.5 158.0 155.1 Reference Example 3 159.5 158.1 155.2 154.3 148.3 152.4 Example 1 168.9 152.6 155.3 152.5 153.3 148.5 Example 2 163.2 155.3 150.1 152.0 149.6 148.4

As confirmed in Table 1, it can be seen that the onion juice, citrus juice, and the mixture of the <Example> all have blood pressure lowering effects. However, the blood pressure drop effect of the mixture of <Example> was much higher than the blood pressure drop effect than the onion juice or citrus juice of <Reference Example>.

Experimental Example 2 Sensory Evaluation Experiments on Palatability

First, sensory evaluation was performed on the mixtures of the above Examples.

In the sensory evaluation, the agents of male and female 30 were grouped as 1 group, and the members were allowed to sample the mixture of each of the above <Example> and scored according to the following criteria. It is shown in Table 2 below.

5 points | pieces: The taste and aroma are outstanding. 4 points | pieces: Excellent taste and aroma

3 points | pieces: Taste and aroma are common. 2 points | pieces: Bad taste and aroma

1 point | piece: Very bad taste and aroma.

Sensory evaluation result division Taste and Aroma <Example 1> 4.56 <Example 2> 4.67 Reference Example 1 2.34 Reference Example 2 2.42 Reference Example 3 2.64

As shown in Table 2, it can be seen that the mixture of each <Example> is better taste and flavor than the mixture of each <Reference Example>.

As described above, according to the present invention can provide a mixed drink of onion juice and citrus juice with improved palatability.

Furthermore, the mixed beverage of the present invention may be prepared by being applied as a blood pressure lowering food composition or a pharmaceutical composition by synergistically increasing the blood pressure lowering effect of onions and tangerines.

Claims (7)

Including onion juice and citrus juice, wherein the onion juice is a mixed drink of onion juice and citrus juice, characterized in that the onion juice obtained from the enhanced onion. The method of claim 1, The citrus juice is a mixed drink of onion juice and citrus juice, characterized in that the citrus juice is organically grown and obtained from the peeled tangerine peel. The method of claim 1, Onion juice and citrus juice mixing ratio is 60 parts by weight to 80 parts by weight of onion juice, citrus juice is 20 parts by weight to 40 parts by weight based on the total weight of the mixed beverage Onion juice and citrus juice Mixed drink. Blood pressure lowering composition comprising onion juice and citrus juice. The method of claim 4, wherein The onion juice and citrus juice is a composition for lowering blood pressure, characterized in that the onion juice and citrus juice in a concentrated solid or liquid form, respectively. The method of claim 4, wherein The composition is a blood pressure lowering composition, characterized in that the food composition. The method of claim 4, wherein The composition is a blood pressure lowering composition, characterized in that the pharmaceutical composition.