KR20070068621A - Cosmetic composition for skin whitening comprising extract of cnidium officinale and protease as active ingredients - Google Patents

Abstract

A cosmetic composition for skin whitening comprising the extract of Cnidium officinale and a protease as active ingredients is provided to improve skin whitening effects by inhibiting production of tyrosinase by the Cnidium officinale extract and promoting keratin peeling by the protease, and to reduce skin irritation. The cosmetic composition for skin whitening comprises 0.01-10.0 wt.% of the extract of Cnidium officinale and 0.01-10.0 wt.% of the protease as active ingredients, wherein the Cnidium officinale extract is prepared with a solvent selected from (a) water, (b) C1-4 anhydrous or hydrous lower alcohol including methanol, ethanol, propanol and butanol, (c) a mixed solvent of water and C1-C4 lower alcohol, (d) acetone, (e) ethyl acetate, (f) chloroform, (g) 1,3-butyleneglycol and (h) butylacetate. And the composition is formulated as solution, emulsion, suspension, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing oil, powder foundation, emulsion foundation, wax foundation or spray.

Description

Cosmetic composition for skin whitening containing cheongung extract and protease as an active ingredient {Cosmetic Composition for Skin Whitening Comprising Extract of Cnidium officinale and Protease as Active Ingredients}

The present invention relates to a cosmetic composition for skin whitening, and more particularly, the present invention relates to a cosmetic composition for skin whitening containing cheongung extract and protease as active ingredients.

One of the areas of greatest interest to East Asian women in the field of cosmetics is skin whitening. Skin whitening is a concept that prepares the change of skin color due to excessive production of melanin pigment in the skin by external stimulation.

Generally, the blackening of human skin is caused by the melanin pigment produced in the skin. In normal condition, the excessive production of melanin does not occur, but the skin is mediated by external stimuli such as ultraviolet rays, environmental pollution, stress, hormones, or inflammation. Responding to internal factors, such as factors, causes excessive production of melanin pigment, which causes pigmentation when left in the skin rather than being released out of the skin.

When keratinocytes of the epidermal layer are stimulated by ultraviolet rays, they produce and release mediators that promote melanin biosynthesis in melanocytes. These mediators include endothelin-1 (ET-1) and melanocyte stimulating hormone (MSH). ET-1 or α-MSH activate a series of signal transduction processes that bind to receptors specific for pigmented cells and induce melanin biosynthesis.

Tyrosinase is an enzyme inserted into the membrane located in the melanosome. It has copper ions at the active site and is a major rate limiting enzyme in a series of melanin synthesis. Therefore, conventional melanogenesis inhibitors have been actively developed as whitening agents, inhibitors of tyrosinase activity, the main enzyme of melanogenesis. Examples of such tyrosinase activity inhibitors include kojic acid, arbutin, Hydroquinone, vitamin C and its derivatives, licorice extract, and the like. However, they have problems with skin irritation and stability in the formulation and their use is limited.

Recently, whitening cosmetics have developed and applied a whitening raw material that regulates the signal transduction process affecting the melanin biosynthesis process to improve the above problems, for example, Cnidium officinale containing the active quinolide A as an active ingredient. There is a whitening cosmetic containing the extract (Korean Patent No. 504408).

In healthy skin, the cells in the outermost layer of the stratum corneum are constantly detached and replaced with newly created cells in the basal layer of the epidermis. The time it takes for newly formed cells to migrate from the basal layer to the outermost layer of the stratum corneum is called the epidermal renewal time. As skin homeostasis changes, dead cells accumulate in the outermost layer, slowing the rate of renewal and lengthening the time of renewal. As you age, the time needed to renew your skin increases. For young or middle-aged adults, the renewal time is approximately 20 days, whereas for adults 50 and older, the rate of renewal is slower than 30 days (Aging and the skin, Raven Press, New York, 1989, 193-204).

In general, by removing dead skin cells and increasing the rate of skin renewal, the result can be a brighter and younger skin. In particular, regulating the rate of skin renewal may be used to increase the whitening effect. For this purpose, hydroxy acids having a peeling effect such as glycolic acid and lactic acid are used. However, hydroxy acid has a disadvantage in that the effect is large at low pH (3.5 to 4.5) and has a high irritation there is a need in the art to solve the above problems.

Throughout this specification, numerous papers and patent documents are referenced and their citations are indicated in parentheses. The disclosures of cited papers and patent documents are incorporated herein by reference in their entirety, so that the level of the technical field to which the present invention belongs and the contents of the present invention are more clearly explained.

Therefore, the present inventors have tried to solve the problems such as high skin irritation, formulation stability and incomplete whitening effect shown in conventional tyrosinase inhibitors and keratin exfoliants, inhibiting the production of tyrosinase and skin Tyrosocyanine by minimizing irritation and applying proteases that have excellent keratin exfoliation efficacy with little skin irritation compared to hydroxy acid, which is a conventional keratin exfoliant, with cosmetic products. The present invention was completed by confirming that there is an excellent whitening effect through production inhibition and exfoliation action.

Accordingly, it is an object of the present invention to provide a cosmetic composition for skin whitening comprising cheongung extract and protease as an active ingredient.

Other objects and advantages of the present invention will become apparent from the following detailed description and claims.

According to one aspect of the present invention, the present invention provides a cosmetic composition for skin whitening comprising cheongung extract and protease as active ingredients.

Cnidium officinale ( Cnidium officinale ) used as an active ingredient in the composition of the present invention is a perennial herb, 40-70 cm in height, and has the characteristic of smelling plants. The root of the uterus is an irregular nodular lump, 2-7 cm in diameter, yellowish brown with coarse wrinkles, several parallel raised bumps, and a top of the concave circular stem trace. Its cross section is yellowish white or greyish yellow with scattered yellowish brown oil and the formation layer is wavy yellowish gate. The root of Cheongung is used for various gynecological diseases such as cold syndrome, anemia and dysmenorrhea disorder with the aim of blood, tonic, soothing and pain relief in oriental medicine.

The horoscope extract used in the present invention can be obtained by using various organs, tissues (for example, roots, leaves, flowers, stems, fruits and seeds, etc.) of the horoscope, and most preferably is an extract obtained from the root of the horoscope. .

The cheongung extract of the present invention inhibits the activity of melanocyte stimulating hormone, and this property, as a result, inhibits the production of tyrosinase, inhibits melanin production, thereby preventing pigmentation and exhibits a whitening effect.

In addition, the cheongung extract is a plant extract excellent in inhibiting melanocyte stimulating hormone activity, the whitening effect has been proved in the applicant's patent (Korean Patent Application No. 2002-25213).

Cheongung extract used as an active ingredient in the composition of the present invention can be obtained through a variety of methods known in the art, preferably (a) water, (b) anhydrous or hydrous lower alcohol (methanol) having 1-4 carbon atoms , Ethanol, propanol, butanol, etc.), (c) the mixed solvent of the lower alcohol and water, (d) acetone, (e) ethyl acetate, (f) chloroform, (g) 1,3-butylene glycol, ( h) Butyl acetate can be obtained from Cheongung as the extraction solvent. More preferably, the astronomical extract of the present invention is obtained by using a hydrated lower alcohol, most preferably ethanol. The ethanol is preferably 60 to 80% ethanol, most preferably 70% ethanol. On the other hand, it will be apparent to those skilled in the art that the extract of the present invention can be obtained as well as the above-mentioned extraction solvent, as well as using the other extraction solvent can be obtained cheonmul extract exhibiting substantially the same effect.

The uterine extract of the present invention is prepared by a process comprising the following steps: (a) 5-20 times of water in the uterus, anhydrous or hydrous lower alcohols of 1-4 carbon atoms, acetone, ethyl acetate, butyl acetate and 1 Adding a solvent selected from the group consisting of 3 butylene glycol; (b) extracting and filtering the solvent-added uterus of step (a) at 15-35 ° C. for 1 to 10 days; And (c) aging the filtrate of step (b) at 5-10 ° C. for 7-10 days and drying.

According to one specific embodiment of the present invention, the above-described extraction process is carried out as follows: First, the roots of the raw archery are washed, dried and crushed into small pieces and then 70% ethyl alcohol is added to The mixture was added at a volume ratio of 5 times, extracted at 15-35 ° C. for 5 days, filtered, aged at 5-10 ° C. for 7-10 days, filtered, and dried by a reduced pressure evaporator to obtain an extract of the arch.

In addition, the extract of the present invention includes not only the extract by the above-described extraction solvent, but also the extract that has undergone a conventional purification process. Obtained by various additional purification methods, such as, for example, separation using ultrafiltration membranes having a constant molecular weight cut-off value, separation by various chromatography (manufactured for separation according to size, charge, hydrophobicity or affinity). The active fraction is also included in the extract of the uterus of the present invention. In addition, the range of the extract of the uterus includes “Saengcuoride A” and other celestial artifacts extracted and processed from the uterus.

The celestial extract of the present invention may be prepared in powder form by an additional process such as vacuum distillation and freeze drying or spray drying.

Protease, which is used as an active ingredient in the composition of the present invention, is a proteolytic enzyme produced by the intestinal microorganisms of Korean sugarless spiders, and is characterized by degrading various substrate proteins such as keratin, gelatin, elastin, and molecular weight of 51.5 kilos. Dalton (51.5 kDa) Proteolytic enzymes produced by fermentation of microorganisms are pale yellow powder with a slight specific odor.

The protease used in the present invention exhibits activity in a wide pH range (pH 5.0-8.0) and maintains proteolytic ability, especially at low temperatures and high salt concentrations. In addition, since it has the ability to decompose various protein substrates, it speeds up the renewal time of skin by decomposing keratin, which is a component of skin aging keratin, and desmosome, a protein that binds keratin and keratin. Due to the above properties, the protease appears to have an excellent exfoliation effect on the skin.

The protease included as an active ingredient in the cosmetic composition of the present invention may be separated from the microorganism as described above, but may exhibit the same effect even when using a commercially available product.

In addition, the protease is low irritant to the skin, and may be accompanied by mild erythema when the protease is used in the skin, but (i) a clear but weak erythema, which is a criterion for evaluating the degree of irritation to the skin, (ii) Edema and papules, (iii) pronounced erythema, (iv) papules and vesicles, (v) severe erythema and vesicle formation, and (vi) alveolar vesicle formation. Table 4

The cosmetic composition of the present invention may include other whitening active ingredients in addition to the horoscope extract and protease as active ingredients. However, the cosmetic composition of the present invention exhibits a very good whitening effect even with an active ingredient consisting only of cheongung extract and protease.

According to a preferred embodiment of the present invention, the content of the uterine extract and protease is 0.01-10.0% by weight and 0.01-10.0% by weight relative to the total weight of the cosmetic composition, more preferably 0.1-5.0% by weight and 0.05-5.0, respectively Weight percent.

At this time, when the content of the extract and protease is less than 0.01% by weight, the effect is less likely to appear, when the content of all of the above components is more than 10.0% by weight is likely to cause irritation to the skin, it can also have a significant effect on the stabilization of the formulation have.

Ingredients included in the cosmetic composition of the present invention include ingredients commonly used in cosmetic compositions in addition to the cheongung extract and protease as active ingredients, for example, conventional adjuvants such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings. And carriers.

Cosmetic compositions of the present invention may be prepared in any formulation conventionally prepared in the art and include, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing It may be formulated as, oil, powder foundation, emulsion foundation, wax foundation and spray, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, and especially in the case of spray, additionally chlorofluorohydrocarbon, Propellants such as propane / butane or dimethylether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethyleneglycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The cosmetic composition of the present invention by using the cheongung extract and protease together as an active ingredient, the tyrosinase production inhibitory effect of the cheongung extract and the keratin peeling effect of the protease appeared in combination, more synergistic than when using each of the above components alone A synergic whitening effect can be achieved (see Experimental Example 1). In addition, the use of proteases as keratin exfoliants improved the problem that skin irritation occurred due to the use of conventional hydroxy acids (see Experimental Example 2). This fact is specified in the following examples.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it will be apparent to those of ordinary skill in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. .

Preparation Example 1: Preparation of Cheongung Extract

The cheongung extract, an active ingredient of the cosmetic composition of the present invention, was prepared as follows: First, washed with purified water and dried, and then crushed cheongung root powder into small pieces into 10-fold 70% ethanol, 5 days at 15-35 ℃ After extraction, the resultant was filtered with 300 mesh filter cloth, and then aged for 7-10 days at 5-10 ° C., and filtered with Whatman filter paper. This extract was then dried on a rotary vacuum evaporator at 65 ° C. to obtain a celestial extract powder. The above-mentioned archery extract powder was dissolved in a solution in which water and 1,3-butylene glycol were mixed in the same amount to obtain an archery extract of the present invention.

Preparation Example 2 Preparation of Cosmetic Composition of Cream Form Containing Cheongung Extract and Protease

For the whitening effect and the stimulation test of the composition containing the extract and protease, the cream formulation cosmetic composition (example) containing 4.0% by weight and 0.5% by weight of the protease was used in the composition ratio as shown in Table 1 below. It was prepared by a cosmetic preparation method. Cheongung extract used in the preparation of the composition is the extract prepared in Preparation Example 1, the protease is Arazyme product of Insect Biotech Co., Ltd. (Korea).

division Content (% by weight) ingredient Example Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Celestial extract 4.0 - 4.0 - - - Protease 0.5 - - 0.5 - - Lactic acid - - - - 1.0 - Glycolic acid - - - - - 1.0 Butylene glycol 2.0 2.0 2.0 2.0 2.0 2.0 Propylene glycol 6.0 6.0 6.0 6.0 6.0 6.0 Carboxy Vinyl Polymer 0.5 0.5 0.5 0.5 0.5 0.5 Beeswax 2.0 2.0 2.0 2.0 2.0 2.0 vaseline 7.0 7.0 7.0 7.0 7.0 7.0 Polysorbate 60 2.0 2.0 2.0 2.0 2.0 2.0 Sorbitan sesquioleate 2.5 2.5 2.5 2.5 2.5 2.5 Squalane 3.0 3.0 3.0 3.0 3.0 3.0 Liquid paraffin 10.0 10.0 10.0 10.0 10.0 10.0 Triethanolamine 0.5 0.5 0.5 0.5 0.5 0.5 Tocopheryl Acetate 0.1 0.1 0.1 0.1 0.1 0.1 Spices, preservatives a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Sum 100 100 100 100 100 100

Preparation Example 3: Preparation of a cosmetic composition (Comparative Examples 1 to 5) containing no cheongung extract and protease

A cosmetic composition (Comparative Example 1) was prepared by the composition of Table 1 in the same manner as in Example 1, except that the extract of Archery and Protease was not included. According to the composition of Table 1, in the composition of Comparative Example 1 only 4.0% by weight (comparative example 2), only protease 0.5% by weight (Comparative Example 3), 1.0% by weight of lactic acid as the main component of the existing keratin exfoliant (Comparative Example) 4), 1.0% by weight of glycolic acid (Comparative Example 5) was added to prepare a cosmetic composition of the comparative example.

Experimental Example 1: Measurement of the whitening effect

The whitening effect of each of the cosmetic compositions of Examples and Comparative Examples 1 to 3 prepared in Preparation Examples 2 and 3 was measured for 20 women aged 34 to 45 years. After seven places of the subject's arms were displayed by 1 cm by 1 × width, UV-UV-A was irradiated with a light amount of 15 J / cm 2 to cause blackening, and then each of the cosmetics of Examples and Comparative Examples 1 to 3 was applied for one month. It was applied twice. Skin color (L value) was measured after 1 month using Minolta CR 300, a skin color measuring instrument, and the degree of change in skin color was calculated according to the following formula 1, and the results are shown in Table 2 below.

ΔL value = L value before cosmetic application-L value after 1 month

Whitening clinical trial results division Example Comparative Example 1 Comparative Example 2 Comparative Example 3 ΔL value 4.78 0.41 1.56 1.74

According to the results of Table 2, the formulation of the embodiment containing both the cheongung extract and protease is about 3.06 times compared to the cream containing only the cheongung extract (Comparative Example 2), about compared to the cream containing only the protease (Comparative Example 3) The whitening effect was 2.7 times higher. Therefore, it can be seen that synergistically greatly increasing the whitening effect when the cheongung extract and protease are simultaneously contained as in the composition of the present invention.

Experimental Example 2 skin irritation test

In order to test the skin irritation of each of the cosmetic preparations prepared in Preparation Example 2, a patch test was conducted using a Haye's Test Chamber on 20 healthy men and women. Wipe the test site with 70% ethanol and dry, and then use a chamber (Finn chamber, 100x10, EPITEST, Finland) in which 15 μg or 15 μl of the prepared test substance (cosmetics of Preparation Examples 2 and 3, respectively) was added dropwise. (forearm) A closed patch was applied to the inner part. The patch was applied for 24 hours, the patch was removed, and the test site was marked with a marker pen. 1 hour and 24 hours after each removal (1 hour after removal, 24 hours = 24 hours, 48 hours including patch attachment) using a magnifying glass (8MC-150, DAZOR, United States) to observe the test site for erythema and edema Was observed. Skin response was determined according to the rules of the International Contact Dermatitis Research Group (ICDRG) (Table 3), the average skin reactivity was calculated by the following equation 2 and the results are shown in Table 4.

 Evaluation criteria and score of skin reaction sign score Evaluation standard - 0 No response, normal skin ± 0.5 Faint or light erythema + 1.0 Boundary but weak erythema, edema and papules + 2.0 Pronounced erythema, papules and vesicles +++ 3.0 Severe erythema and vesicle formation ++++ 6.0 Cannon formation

Test substance 24 hours 48 hours Average skin reactivity (n = 20) ± + + + ± + + + Example 2 - - One - - 0.63 Comparative Example 1 One - - One - - 0.42 Comparative Example 2    2 - -    --- 0.42 Comparative Example 3 3-- --- 0.63 Comparative Example 4 4 3- 2 2- 3.33 Comparative Example 5 3 5- 3 1- 3.75

As shown in Table 4, in contrast to the results of high skin irritation in the formulations containing lactic acid or glycolic acid (Comparative Examples 4 and 5), which were previously used as keratin release agents, formulations containing the extract of the uterus (comparatively) Example 2) and the formulation containing the protease (Comparative Example 3) had very low skin reactivity, and the cream formulation containing both the extract and protease used in the present invention also had almost no skin irritation, so the extract and protease were skin irritant. It can be seen that it is a component that rarely causes.

Hereinafter, based on the results of the above test examples, to present a cosmetic composition comprising a cheongung extract and protease as an active ingredient. However, the composition of the present invention is not intended to be limited to the following formulation examples.

Formulation Example 1: Softener (Skin Lotion)

As shown in Table 5 below, the flexible makeup was prepared according to a conventional method.

ingredient Content (% by weight) Celestial extract 4.0 Protease 0.5 1,3-butylene glycol 6.0 glycerin 4.0 Oleyl alcohol 0.1 Polysorbate 20 0.5 ethanol 15.0 Benzophenone-9 0.05 Incense, preservative a very small amount Purified water Remaining amount

Formulation Example 2: Nutrients (Milk Lotion)

As shown in Table 6, nutrient lotion was prepared according to a conventional method.

ingredient Content (% by weight) Celestial extract 4.0 Protease 0.5 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 1.2 Tocopheryl Acetate 3.0 Floating paraffin 5.0 Squalane 3.0 Macadamia Nut Oil 2.0 Polysorbate 60 1.5 Sorbitan sesquioleate 1.0 Carboxyvinyl Polymer 1.0 Incense, preservative a very small amount Purified water Remaining amount

Formulation Example 3: Nutrition Cream

As shown in Table 7, nutrition cream was prepared according to a conventional method.

ingredient Content (% by weight) Celestial extract 4.0 Protease 0.5 vaseline 7.0 Liquid paraffin 10.0 Beeswax 2.0 Polysorbate 60 2.0 Sorbitan sesquioleate 2.5 Squalane 3.0 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Carboxy Vinyl Polymer 0.5 Tocopheryl Acetate 0.1 Incense, preservative a very small amount Purified water Remaining amount

Formulation Example 4: Massage Cream

Massage cream was prepared according to a conventional method as shown in Table 8.

ingredient Content (% by weight) Celestial extract 4.0 Protease 0.5 Propylene glycol 6.0 glycerin 4.0 Triethanolamine 0.5 Beeswax 2.0 Tocopheryl Acetate 0.1 Polysorbate 60 3.0 Sorbitan sesquioleate 2.5 Cetearyl Alcohol 2.0 Liquid paraffin 30.0 Carboxy Vinyl Polymer 0.5 Incense, preservative a very small amount Purified water Remaining amount

Formulation Example 5: Pack

Packs were prepared according to conventional methods as shown in Table 9 below.

ingredient Content (% by weight) Celestial extract 4.0 Protease 0.5 Propylene glycol 2.0 glycerin 4.0 Carboxy Vinyl Polymer 0.3 ethanol 7.0 Fiji-40 Hydrogenated Castor Oil 0.8 Triethanolamine 0.3 Incense, preservative a very small amount Purified water Remaining amount

As described in detail above, the present invention provides a cosmetic composition for skin whitening comprising cheongung extract and protease as an active ingredient. The cosmetic composition of the present invention by using the cheongung extract and protease together as an active ingredient, the melanocyte stimulating hormone inhibitory effect of the cheongung extract and the exfoliation effect of the protease appeared in combination, compared to the case of using each of the active ingredients alone Synergic whitening effect can be achieved, there is little skin irritation can be usefully used as a cosmetic composition for skin whitening excellent safety.

Having described the specific part of the present invention in detail, it is apparent to those skilled in the art that such a specific technology is only a preferred embodiment, and the scope of the present invention is not limited thereto. Therefore, the substantial scope of the present invention will be defined by the appended claims and equivalents thereof.

Claims (7)

Cnidium officinale ) Skin cosmetic whitening composition comprising an extract and a protease as an active ingredient. The cosmetic composition for skin whitening according to claim 1, wherein the content of the cheongung extract is 0.01 to 10.0 wt% based on the total weight of the cosmetic composition. The cosmetic composition for skin whitening according to claim 1, wherein the content of the protease is 0.01 to 10.0 wt% based on the total weight of the cosmetic composition. The cosmetic composition for skin whitening according to claim 1, wherein the cheon-gung extract is a root extract of cheon-gung. The method of claim 1, wherein the extract of the uterus is (a) water, (b) anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms (methanol, ethanol, propanol, butanol, etc.), (c) mixing the lower alcohol with water Extracted using a solvent, an extraction solvent selected from the group consisting of (d) acetone, (e) ethyl acetate, (f) chloroform, (g) 1,3-butylene glycol, (h) butyl acetate Cosmetic composition for skin whitening. The cosmetic composition for skin whitening according to claim 5, wherein the extraction solvent is ethanol. The group of claim 1 wherein the composition consists of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray Cosmetic composition for skin whitening, characterized in that the formulation is selected from.