KR20070050624A - Healthy and functional food for constipation improvement - Google Patents

Abstract

The present invention relates to a health functional food having an improved constipation improvement function of red ginseng extract, more specifically, containing red ginseng, tangui, white sewage, safflower seed, broiler, astragalus, jujube and licorice extract, in particular to improve chronic constipation It relates to a health functional food having a function.

Constipation, Red ginseng, Angelica, Baekhasuo, Safflower seed, Broiler, Astragalus, Jujube, Licorice

Description

Healthy and functional food for constipation improvement

The present invention relates to a health functional food having an improved function of improved constipation of red ginseng extract, in particular chronic constipation.

In recent years, the rapid increase in dietary standards has led to an increase in the consumption of high-calorie foods such as meats and instant foods containing high fat and high protein, while reducing the intake of foods containing vegetables and fiber, resulting in reduced adult and obese patients. It is a well known fact that the trend is increasing day by day.

In general, the definition of chronic functional constipation is not repeated in the past 12 months, but for at least 12 weeks or more, the following five symptoms are: ⑴ force, ⑵ solid or lumpy stools, ⑶ incomplete discharge sensation, ⑷ defecation sensation, ⑸ 1 It is assumed that two or more bowel movements are complained twice a week.

Constipation is a chronic gastrointestinal disease with a variety of symptoms ranging from relatively mild to moderate social life to severely severe cases that make normal daily life difficult. Recently, the number of patients has increased as well as the number of patients has increased along with the westernization of social and economic conditions.

In addition, the cause of irritable growth syndrome is unknown, but the pathophysiology associated with it is known that the internal organs, sensory, motor abnormalities and social factors work together. It is divided into constipation type and diarrhea type according to the main symptoms, and treatment is also treated according to the main symptoms.

Therefore, there is no significant difference in the treatment between constipation type and functional constipation. The constipation is divided into six subtypes and divided into simple type, hypersensitivity syndrome, delayed intestinal pain, difficulty in defecation, fecal constriction and gastric obstruction.

Common causes of constipation are problems with diet, such as low intake of fiber or low amounts of food, neglected or suppressed bowel movements, and too limited physical exercise. Other causes of secondary constipation are the use of medicinal herbs that reduce bowel movement, various endocrine diseases, neurological diseases and mental problems. Of course, secondary constipation, which may be the cause of constipation, can be removed by finding it, but in most cases, so-called "simple constipation" or "hypersensitivity syndrome" as a form of constipation, so the treatment method is the same can do.

For the treatment of constipation, various constipation treatments are used along with general treatments, such as lifestyle changes, psychological adjuvant therapy, improved diet and increased fluid intake. Types of constipation treatments include fibrin preparations that can be expected after several weeks of treatment, osmotic constipation agents that can be expected after 2-3 days, and irritant agents that can be expected within 1 day.

Ginseng has been well known to have a prophylactic and therapeutic effect against various diseases, and in particular, the effect on the digestive system is well known to promote the improvement of digestive function and colon movement, and is used as a herbal composition for treating constipation. For example, Korean Patent Registration No. 149389 discloses a herbal composition for treating constipation containing ginseng, schisandra chinensis, alum, licorice, apricot seed and goji berry as its main ingredient.

Also, unlike ginseng, that is, ginseng (about 75% moisture) or white ginseng (dry ginseng as it is: about 12% moisture), red ginseng is steamed with steam under certain temperature conditions and dried to make starch of ginseng deluxe. Ginsenoside Re, which contains glycosides but is a saponin component of white ginseng, is a substance different from white ginseng polysaccharides by decomposing glycosyl residues at 20 carbons or isomerization by converting hydroxyl groups into saponins unique to red ginseng. Red ginseng acid polysaccharide is produced, and has an adaptogen effect, which increases the ability to defend against various diseases such as fistula, stress, etc. It contains and is treated as a different material from ginseng.

Red ginseng is also known to be used as a herbal composition for the treatment of constipation, for example, Korean Patent Laid-Open No. 2004-63430, Constipation containing red ginseng, outcrops, hemp and baekchul extracts in aloe and kelp with a constipation improving effect Improvement compositions are known.

Thus, the present inventors found that red ginseng extract is much more effective in intestinal function than ginseng extract while studying the function of red ginseng. With this in mind, we studied a red ginseng-containing herbal composition with more effective constipation improving function.

Meanwhile, many studies have been conducted to solve constipation using herbal medicines.

Korean Patent Registration No. 435825 describes a herbal composition for the treatment of constipation containing Angelica, Jisil, Sewao, Baekchul, Cheongung, Dermis, Ginger, Licorice and Broiler.

Korean Patent Registration No. 506824 describes a herbal composition containing radish, tea, carrot, dermis, green skin, fig, onion, ume and apricot extract as a herbal composition having an effect of improving bowel function and constipation disease.

In addition, Korean Patent Registration No. 376307 discloses a health food composition for treating constipation containing Angelica, Astragalus, Count, Baekchul, Hawthorn, Cinnamon, Wolfberry, Cornus and Licorice.

Korean Patent Registration No. 451665 is based on safflower seed, anchovies, kelp, jujube, ginger, black bean, pine needles, garlic, earth and sand, dew, cucumber skin, tofu, green tea, licorice, Banggi, sewao, Schisandra chinensis, jihwang, jimo, Herbal medicine composition with added white molecule, cheoncho, phalanx, gall bladder, cinnamon, dermis, reed, white extract and creation is known as a health functional food that prevents the occurrence of osteoporosis, constipation, high blood pressure, hair loss and acidification of the human body.

However, even though many studies have been conducted to solve constipation using natural plants as described above, reflective constipation is very difficult and incomplete treatment.

While studying a number of herbal medicines used in the prior art, the inventors noted that Angelica, safflower seed, Baek Ha Shou, broiler and Astragalus as herbal medicines to enhance the constipation improvement function of red ginseng.

Angelica is a medicinal root (초 根草) belonging to the mountain-shaped family, and the root of the true donkey is used as a medicinal herb.

Baek Ha Shou (白 何首烏) is used as a tonic as the root of a large mock ( Cynanchum wilfordii ), and safflower seeds are known to be effective in strengthening bones, attaching broken bones, and treating osteoporosis. It has been used to prevent and treat arteriosclerosis caused by excessive cholesterol, and broilers are frequently used as medicinal sweats, fever, analgesics, and sensitizers. Astragalus membranaceus Bunge ) Is flavonoid with 2 ', 4'-dihydroxy-5'6'-dimethoxyisoflavan, 5,4'-dioxy-3, 7-dimethoxyflavone, molecular formula C ₁₆ H ₁₂ O ₅ at the root , Kumatagenine has been isolated, and roots also contain β-sitosterol, fructose, glucose, mucus and alkaloids, choline, betaine, linoleic acid, linoleic acid and amino acids, leucine (16 mg%), and glycine (24 mg%). ), Serine (28 mg%), Allah (55mg%), glutamic acid (77mg%), arginine (83mg%), and γ-aminobutyric acid (24-66mg%) are contained, sedation, blood pressure lowering, vasodilation, hypertension In addition, it is known to be useful for chronic cardiovascular disorders, acute and chronic heart disease in which blood circulation is destroyed, and in oriental medicine, it was used as a tonic, tonic, and diuretic.

However, although there are examples used in the herbal composition having the function of improving constipation symptoms, Baek Sewao, safflower seeds, broilers and Astragalus have not been reported to have an effect of improving constipation symptoms themselves.

The inventors have improved the constipation symptoms, especially chronic constipation of red ginseng extract, which is a mixed composition of the Angelica, Baek Sewao, safflower seed, broiler, and Astragalus with red ginseng extract, among many herbal medicines that have been used to improve constipation in the past. The present invention has been found to have the capability of being capable of.

It is an object of the present invention to provide a health functional food composition having an improved function of constipation symptoms of red ginseng extract.

It is another object of the present invention to provide a health functional food composition containing red ginseng and having a function of improving chronic constipation.

In order to achieve the above object, the present invention contains a red ginseng, Angelica, baekshou, safflower seed, broiler, Astragalus, jujube and licorice extract and provides a health functional food that can improve the constipation improvement effect, especially chronic constipation symptoms do.

It relates to a health functional food having an improved function of enhanced chronic constipation of red ginseng extract.

In the present invention, the red ginseng extract may be prepared separately or a red ginseng extract prepared by a known method may be used.

The present invention is a mixture of Angelica, White Sewage, Safflower Seed, Broiler, Astragalus, Jujube and Licorice extracts to have an improved chronic constipation of red ginseng extract. Extract with water or alcoholic aqueous solution. However, as is well known, it is preferable not to use an alcoholic aqueous solution which is harmful to human body such as methanol.

The present invention can be extracted by mixing each or mixed with Angelica, Baekshou, safflower seed, broiler, Astragalus, jujube and licorice extract according to the appropriate blending ratio, red ginseng 5-15% by weight, Angelica 10-44.9% by weight, Baekshou 10 ~ 15% by weight, safflower seed 10-15% by weight, broiler 10-15% by weight, Astragalus 10-15% by weight, jujube 10-15% by weight and licorice 0.1-0.5% by weight.

The mixed extracts of Angelica, Baekshou, Safflower, Broiler, Astragalus, Jujube and Licorice according to the present invention are mixed and extracted by hot water extraction at 80-100 ° C. for 1-5 hours to produce an extract under reduced pressure, and extracted with ethanol. Extract 1 to 5 hours at 60 ~ 80 ℃ to concentrate under reduced pressure to prepare an extract.

The mixed extract may be mixed with a red ginseng extract prepared in advance, and then mixed and prepared as a liquid health functional food for a drink. Each extract may be lyophilized or vacuum dried, preferably lyophilized to prepare a powder extract. After the powder can be prepared as a dietary supplement composition of the form.

The present invention may be added to food or beverages for improving constipation symptoms, and may be commercialized in the form of beverages, pills, capsules or tablets in the form of pouches, cheer packs or bottles.

In general, the health functional food according to the present invention may be added at 0.01 to 80% by weight of the total food weight, the health beverage composition may be added in a ratio of 0.02 to 30g, preferably 0.3 to 5g based on 50ml. .

In addition, the present invention may further include oligosaccharides or dietary fiber in the mixed extract or mixed powder extract for improved constipation improving function and sweetening effect.

Oligosaccharides are a type of carbohydrate in which two to eight monosaccharides such as glucose, fructose and galactose are combined. It is also used for intestinal useful bacteria, including bifidus bacteria, which are inhabited by the intestine without being degraded by intestinal digestive enzymes when ingested, and have the function of inhibiting the proliferation of harmful or pathogenic bacteria. Oligosaccharides include soy oligosaccharides, fructooligosaccharides, galactooligosaccharides and isomaltooligosaccharides, all of which have lower sweetness than sugar.

Dietary fiber is a total of indigestible constituents in foods that are not hydrolyzed by human digestive enzymes. Water-soluble dietary fiber belonging to the plant includes pectin, gums, seaweed polysaccharides and polydextrose, and insoluble cellulose, hemicellulose and Lignin and animals include chitin and chitosan. In the present invention, all of these dietary fibers may be used, but it is preferable to use polydextrose listed in the Korean Food Code.

The addition amount of the oligosaccharides and dietary fiber may be easily determined in the art considering the taste of the health functional food according to the present invention. However, in the case of oligosaccharide, it is preferable to add it within the range not exceeding 40% by weight of the total weight of the health functional food, and in the range not exceeding 50% by weight of the dietary fiber, in which case the health with improved constipation improvement function Functional food can be provided.

In addition, the present invention may further include additives such as conventional excipients, fragrances, sweeteners, deodorants, etc. within the range not more than 2% by weight of the whole health functional food.

In the present invention, as a deodorant, a champinion extract is preferred. Recently, champinions are neutralized or odorized by combining components such as amino acids, polyphenols, and flavonoids with odorous components such as ammonia and amines. It is known to deodorize the odor component in the structure, and is known to assist intestinal movement by increasing bifidus in the intestine.

The present invention may be formulated in the form of capsules, tablets or pills according to a conventional method after powdering for convenient taking, or may be formulated in the form of a beverage or the like as a liquid form.

Hereinafter, the present invention will be described in detail with reference to the following Examples and Experimental Examples, but the present invention is not limited thereto.

Example 1 Preparation of Red Ginseng Extract

In this embodiment, according to the method described in Korean Patent Laid-Open Publication No. 1998-19946, 100 g of red ginseng was hot-water extracted at 100 ° C. for 2 hours, and the extract was concentrated under reduced pressure (40% of water) to prepare a red ginseng extract.

Example 2 Preparation of Red Ginseng, Angelica, Baekshou, Safflower Seed, Broiler, Astragalus, Jujube, Licorice Extract

Angelica 3110g, Baek Sewao, Safflower Seed, Broiler, Astragalus, Jujube, 1370g and 40g of Licorice, respectively, were mixed and extracted by hot water at 100 ° C for 2 hours, and the resulting extract was concentrated under reduced pressure (water content of 40%), and the concentrate was prepared in 41g and Example 1. 3 g of the red ginseng extract was mixed to prepare an extract.

Comparative Example 1. Preparation of Ginseng Extract

100 g of ginseng was extracted with hot water at 100 ° C. for 2 hours, and the extract was concentrated under reduced pressure (40% of water) to prepare a ginseng extract.

Experimental Example 1. Effect on activated carbon dietary shift

In order to evaluate the effect of constipation, 10 rats in each group of the control group and the test group were tested using an average animal of 25-28 g of Valb / C male mice (Korean Biolink, DMATD). In the test group, the herbal extracts prepared in Examples 1, 2 and Comparative Example 1 were dissolved in drinking water at a concentration of 3.2 mg / ml, and then administered for 3 days, followed by fasting on the fourth day, and continued during fasting. The control group was administered in the same manner as the test group, but only drinking water was administered. On day 5, 0.2 ml orally of the herbal extracts prepared in Examples 1, 2 and Comparative Example 1 were administered orally to the test group and the control group on day 5, and activated carbon (Sigma, USA) and Arabian gum (Sigma, USA) were 1 hour later. 0.2 ml of the activated carbon diet mixed with 5% and 10% weight ratio was orally administered, and after 30 minutes, the gastrointestinal tract was extracted to investigate the rate of movement of the activated carbon diet in the intestinal distance from the duodenum to the ileum. Indicated.

TABLE 1

Experimental group % Growth Control 100.0 Example 1 139.5 Example 2 167.3 Comparative Example 1 125.2

As can be seen in Table 1, the intestinal transfer effect of the activated carbon diet as a whole was increased in the test groups of Examples 1, 2 and Comparative Example 1 compared to the control group administered only drinking water, compared to the ginseng extract administration group of Comparative Example 1 In the red ginseng extract group of Example 1 it can be seen that the intestinal mobilization effect of the activated carbon diet, it can be seen that the red ginseng extract will be very useful to improve chronic constipation, especially in Example 2 shows an enhanced effect than expected It can be seen that the present invention has an improved function of constipation symptoms of the red ginseng extract more enhanced.

Experimental Example 2. Chronic Constipation Improvement Sensory Evaluation

end. Selection of test group

Chronic constipation applicants with repeated or prolonged constipation symptoms for at least 12 weeks in the past 12 months have a history of organic bowel disease or history, and if there has been a severe drug or alcohol abuse in the past year, If you have a history of severe cardiovascular, respiratory, kidney, liver, gastrointestinal, blood, nervous and mental illness, pregnant and lactating women, and other medicines that affect gastrointestinal motility and intestinal sensation regularly In order to rule out the two-dimensional cause of chronic constipation, the basic blood test (CBC), liver function test (LFT), and urine test (U / A) were performed. The test was divided into three test groups of Examples 1, 2 and Comparative Example 1. The applicants were screened at Chungnam National University Hospital.

I. Evaluation of Chronic Constipation

To examine the improvement of constipation symptoms by comparing the before and after administration of the extract prepared in Examples 1, 2 and Comparative Example 1 twice a day for four weeks to 30 people each of the three selected test groups. Chronic constipation improvement effect was determined according to the criterion of Table 2 (95% confidence interval) and the results are shown in Table 3.

Table 2 Judging Criteria

Rating Evaluation indicator A noticeable effect Constipation is almost completely lost available Mild constipation persists or significantly improves Slightly valid If constipation is improved but insufficient invalidity If no change

[Table 3] Evaluation of Chronic Constipation Improvement

Rating Number of judgments Remarks Example 1 A noticeable effect 4  63.3% Chronic Constipation available 15 Slightly valid 8 invalidity 3 system 30 Example 2 A noticeable effect 20  86.7% Chronic Constipation available 6 Slightly valid 3 invalidity One system 30 Comparative Example 1 A noticeable effect One  26.7% Chronic Constipation available 7 Slightly valid 19 invalidity 3 system 30

As can be seen in Table 3, the test group administered the ginseng extract of Comparative Example 1 in the sensory evaluation for chronic constipation patients showed less than expected results, 70 in the red ginseng extract administration group of Example 1 The constipation of more than% is almost disappeared to confirm the difference between the efficacy of the red ginseng extract and the efficacy of the ginseng extract, in particular, very remarkable in Example 2 of the present invention for the purpose of improving chronic constipation of red ginseng Has been improved.

Therefore, the herbal composition containing red ginseng, Angelica, baekshou, safflower seed, broiler, jujube, jujube and licorice extracts according to the present invention not only have a function of improving constipation symptoms, but also significantly improve chronic constipation symptoms. Could confirm.

All. Evaluation of improvement of constipation symptoms

The five constipation symptoms are as follows.

(1) the number of bowel movements

The results of the examination of the average number of bowel movements per week for the administration groups of Examples 1, 2 and Comparative Example 1 are shown in Table 4 below.

TABLE 4

6 or more times 3 to 5 times 2 times or less Remarks Example 1 Before administration 5 25 After administration 4 15 11 Example 2 Before administration 4 26 After administration 20 6 4 Comparative Example 1 Before administration 3 27 After administration One 7 22

As can be seen in Table 4, the test group administered the ginseng extract of Comparative Example 1 did not change the number of bowel movements significantly, but the red ginseng extract showed a change in the number of bowel movements in the red ginseng extract administration group of Example 1 to improve chronic constipation It can be seen that it can be used as a health functional food material, especially in Example 2 according to the present invention was found to be significantly improved.

Therefore, the herbal composition containing red ginseng, Angelica, baekshou, safflower seed, broiler, jujube, jujube and licorice extracts according to the present invention not only have a function of improving constipation symptoms, but also significantly improve chronic constipation symptoms. It is possible to develop into health functional food.

(2) the appearance of feces

The characteristics of feces for each of the administration groups of Examples 1, 2 and Comparative Example 1 were classified into four and investigated. The results are shown in Table 5 below.

TABLE 5

Solid edge Lump Semisolid edge Yanbian Remarks Example 1 Before administration 25 4 One After administration 3 6 15 4 Example 2 Before administration 26 2 2 After administration One 3 6 20 Comparative Example 1 Before administration 27 One 2 After administration 3 19 7 One

As can be seen in Table 5, the test group to which the ginseng extract of Comparative Example 1 was administered changed the appearance of the stool, but did not meet expectations significantly to improve the symptoms of chronic constipation. However, in the red ginseng extract administration group of Example 1 it can be seen that it can be used as a health functional food material for improving chronic constipation, especially in Example 2 according to the present invention it can be seen that the appearance of bowel movements significantly remarkably.

Therefore, the herbal composition containing red ginseng, Angelica, baekshou, safflower seed, broiler, jujube, jujube and licorice extracts according to the present invention not only have a function of improving constipation symptoms, but also significantly improve chronic constipation symptoms. It can be seen that.

(3) power cycle frequency

Table 6 shows the results of investigating the weekly mean cycle frequency for each of the administration groups of Examples 1, 2 and Comparative Example 1.

TABLE 6

Weekly average power cycle frequency Remarks always 3 to 6 times 2 times or less Example 1 Before administration 30 After administration 9 7 14 Example 2 Before administration 30 After administration One 6 23 Comparative Example 1 Before administration 30 After administration 16 7 7

As can be seen in Table 6, the test group administered the ginseng extract of Comparative Example 1 did not significantly improve the strength symptoms during defecation, which is a characteristic of chronic constipation, the improvement of chronic constipation in the red ginseng extract administration group of Example 1 It can be seen that it can be used as a health functional food material, in particular in Example 2 according to the present invention can be seen that it is significantly improved.

(4) frequency of feeling of obstruction

The frequency of the average closed feeling for the week for each administration group of Examples 1, 2 and Comparative Example 1 was investigated and the results are shown in Table 7.

TABLE 7

Frequency of Weekly Average Closure Remarks always 3 to 6 times 2 times or less Example 1 Before administration 30 After administration 9 10 11 Example 2 Before administration 30 After administration 4 8 18 Comparative Example 1 Before administration 30 After administration 17 7 6

As can be seen in Table 7, Comparative Example 1 was not significantly improved the reduction of the feeling of occlusion after bowel movement, it can be seen that in Example 1, 2 is significantly improved. In particular, it is expected to resolve the habitual obstruction of chronic constipation patients.

(5) residue

Example 1, 2 and Comparative Example 1 evaluated the residual feeling for each of the administration group according to the results are shown in Table 8.

TABLE 8

Have a residual feeling No residual feeling Remarks Example 1 Before administration 30 After administration 19 11 Example 2 Before administration 30 After administration 12 18 Comparative Example 1 Before administration 30 After administration 21 9

As can be seen in Table 8, the residual feeling was improved in Examples 1, 2 and Comparative Example 1, but the ginseng extract in chronic constipation patients was not significantly improved, but the red ginseng extract in Examples 1 and 2 was chronic constipation. It can be seen that it can be used as a health functional food material for improvement, in particular, Example 2 according to the present invention was confirmed that it can be developed as a health functional food for improving the symptoms of chronic constipation.

la. Side Effect

Thirty patients in each of the three selected test groups were examined for side effects compared to before and after dosing.

As described above, the present invention shows the improvement of symptoms in all constipation symptoms, such as an increase in the number of bowel movements, the appearance of feces, the frequency of force cycles, the frequency of obstructive sensation, and residual feeling, the red ginseng according to the present invention is a health for improving the symptoms of chronic constipation It can be confirmed that it can be used as a functional food material, in particular, the herbal composition containing red ginseng, Angelica, Baekshou, safflower seed, broiler, Astragalus, jujube and licorice extract according to the present invention has an improved function of improving constipation symptoms It was evaluated that it could be developed as a dietary supplement.

Preparation Example 1 Preparation of Beverage

44 g of the herbal composition prepared in Example 2, 0.4 g of champinion extract powder, 0.03 g of sucralose and 0.2 g of fruit mix flavor were added to purified water to prepare a total volume of 300 ml. According to the conventional method for preparing a food beverage, the beverage was prepared by stirring and heating at 85 ° C. for about 1 hour.

Preparation Example 2 Preparation of Tablet

The herbal extract prepared in Example 2 was spray-dried to prepare a tablet using a tablet press by mixing 100 g of powder, 20 g of lactose, 150 g of starch, 10 g of crystalline cellulose, 6 g of inositol, 3 g of sodium aluminate, and 2.5 g of food coloring.

Therefore, the present invention can use the red ginseng extract improved constipation improvement function as a material of the health functional food as compared to the ginseng extract, and the present invention is the red ginseng extract, Angelica, Baek seshou, safflower seed, broiler, Astragalus, jujube and licorice extract It is further blended to provide a dietary supplement with improved constipation improvement.

In particular, the present invention can be developed as a dietary supplement for chronic constipation patients.

Claims (7)

Red ginseng 5-15%, Angelica 10-44.9%, White sewage 10-15%, Safflower seed 10-15%, Broiler 10-15%, Astragalus 10-15%, Jujube 10-15%, and A health functional food composition containing 0.1 to 0.5% by weight licorice and improving chronic constipation. A liquid preparation for a dietary supplement containing the herbal composition according to claim 1 and having a chronic constipation improving function. The liquid formulation of the dietary supplement according to claim 2, which is in the form of a beverage in the form of pouches, cheer packs or bottles. A solid preparation for a dietary supplement containing the herbal composition according to claim 1 and having a chronic constipation improving function. The solid preparation for health food with a constipation improving function according to claim 4, wherein the dosage form is a capsule, a pill or a tablet. Food additive containing red ginseng extract with chronic constipation improvement health function. Health functional food containing red ginseng, Angelica, Baek se shou, safflower seed, broiler, Astragalus, jujube and licorice extract.