KR20060038937A - 나노입자를 포함하는 안정화된 입자 분산액 - Google Patents

나노입자를 포함하는 안정화된 입자 분산액 Download PDF

Info

Publication number
KR20060038937A
KR20060038937A KR1020057022748A KR20057022748A KR20060038937A KR 20060038937 A KR20060038937 A KR 20060038937A KR 1020057022748 A KR1020057022748 A KR 1020057022748A KR 20057022748 A KR20057022748 A KR 20057022748A KR 20060038937 A KR20060038937 A KR 20060038937A
Authority
KR
South Korea
Prior art keywords
dispersion
nanoparticles
continuous phase
organic
dispersed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020057022748A
Other languages
English (en)
Korean (ko)
Inventor
지미 알. 쥬니어 베이란
브라이언 제이. 가브리오
제임스 에스. 스테펠리
스테펜 더블유. 스테인
Original Assignee
쓰리엠 이노베이티브 프로퍼티즈 컴파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쓰리엠 이노베이티브 프로퍼티즈 컴파니 filed Critical 쓰리엠 이노베이티브 프로퍼티즈 컴파니
Publication of KR20060038937A publication Critical patent/KR20060038937A/ko
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/773Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/70Nanostructure
    • Y10S977/778Nanostructure within specified host or matrix material, e.g. nanocomposite films
    • Y10S977/786Fluidic host/matrix containing nanomaterials
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00Nanotechnology
    • Y10S977/902Specified use of nanostructure
    • Y10S977/904Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Colloid Chemistry (AREA)
KR1020057022748A 2003-05-30 2004-04-12 나노입자를 포함하는 안정화된 입자 분산액 Ceased KR20060038937A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/449,677 2003-05-30
US10/449,677 US7109247B2 (en) 2003-05-30 2003-05-30 Stabilized particle dispersions containing nanoparticles

Publications (1)

Publication Number Publication Date
KR20060038937A true KR20060038937A (ko) 2006-05-04

Family

ID=33451844

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057022748A Ceased KR20060038937A (ko) 2003-05-30 2004-04-12 나노입자를 포함하는 안정화된 입자 분산액

Country Status (6)

Country Link
US (3) US7109247B2 (enExample)
EP (1) EP1628635A2 (enExample)
JP (1) JP2006526626A (enExample)
KR (1) KR20060038937A (enExample)
CN (1) CN1798543A (enExample)
WO (1) WO2005002544A2 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7459146B2 (en) * 2003-05-30 2008-12-02 3M Innovative Properties Company Stabilized aerosol dispersions
US20040242729A1 (en) * 2003-05-30 2004-12-02 3M Innovative Properties Company Stabilized particle dispersions containing surface-modified inorganic nanoparticles
US7109247B2 (en) * 2003-05-30 2006-09-19 3M Innovative Properties Company Stabilized particle dispersions containing nanoparticles
WO2004112799A1 (en) * 2003-06-13 2004-12-29 Chrysalis Technologies Incorporated Methods and apparatus for producing nanoscale particles
US7470650B2 (en) * 2003-10-15 2008-12-30 Ashland Licensing And Intellectual Property Llc Shock absorber fluid composition containing nanostructures
US7723438B2 (en) * 2005-04-28 2010-05-25 International Business Machines Corporation Surface-decorated polymeric amphiphile porogens for the templation of nanoporous materials
US20070292688A1 (en) * 2005-08-18 2007-12-20 Eastman Kodak Company Silylamine modified nanoparticulate carriers
US20100119697A1 (en) * 2006-05-10 2010-05-13 3M Innovative Properties Company Compositions and coatings containing fluorescent, inorganic nanoparticles
US20070276714A1 (en) * 2006-05-15 2007-11-29 Sap Ag Business process map management
US8527313B2 (en) * 2006-05-15 2013-09-03 Sap Ag Document instantiation triggering a business action
US20080152913A1 (en) * 2006-12-22 2008-06-26 3M Innovative Properties Company Method of making compositions including particles
US20080153963A1 (en) * 2006-12-22 2008-06-26 3M Innovative Properties Company Method for making a dispersion
US20080166558A1 (en) * 2006-12-22 2008-07-10 3M Innovative Properties Company Compositions of particles
US8127237B2 (en) * 2007-09-24 2012-02-28 Sap Ag Active business client
US8250169B2 (en) * 2007-09-24 2012-08-21 Sap Ag Business context data companion tool
US8131668B2 (en) * 2008-05-28 2012-03-06 Sap Ag User-experience-centric architecture for data objects and end user applications
US8741819B2 (en) 2008-12-30 2014-06-03 3M Innovative Properties Company Composite particles and method of forming
CN102272277A (zh) 2008-12-30 2011-12-07 3M创新有限公司 润滑剂组合物及形成方法
US8782530B2 (en) * 2009-03-25 2014-07-15 Sap Ag Method and system for providing a user interface in a computer
US8712953B2 (en) * 2009-03-25 2014-04-29 Sap Ag Data consumption framework for semantic objects
US20110031430A1 (en) * 2009-08-07 2011-02-10 University Of Florida Research Foundation Inc. Synthesis of water-soluble organic nanoparticles as epr standard
BR112012013350A2 (pt) * 2009-12-03 2017-12-12 3M Innovative Properties Co método de deposição eletrostática de partículas, grãos abrasivos e artigos
US8722796B2 (en) * 2010-01-20 2014-05-13 Basf Se Process for preparing an aqueous polymer dispersion
WO2011089078A1 (de) 2010-01-20 2011-07-28 Basf Se Verfahren zur herstellung einer wässrigen polymerisatdispersion
US8211450B2 (en) 2010-05-05 2012-07-03 Senju Usa, Inc. Ophthalmic composition
US8835363B2 (en) 2010-06-16 2014-09-16 Saudi Arabian Oil Company Drilling, drill-in and completion fluids containing nanoparticles for use in oil and gas field applications and methods related thereto
CN102958987A (zh) * 2010-06-24 2013-03-06 3M创新有限公司 不含有机乳化剂的可聚合组合物以及其聚合物和制造方法
CN102416179B (zh) 2010-09-28 2014-05-07 益得生物科技股份有限公司 用于哮喘的吸入性复方组合物
US8951541B2 (en) * 2010-10-04 2015-02-10 3M Innovative Properties Company Method of modifying dissolution rate of particles by addition of hydrophobic nanoparticles
CA2819635A1 (en) 2010-12-01 2012-06-07 Spinal Modulation, Inc. Directed delivery of agents to neural anatomy
CN107699540A (zh) 2011-02-07 2018-02-16 生命技术公司 用于稳定敏感化合物的组合物和方法
US8694911B2 (en) * 2011-11-28 2014-04-08 International Business Machines Corporation Manipulating hidden data entries via representative markers
US20160279055A1 (en) 2013-07-22 2016-09-29 Imprimis Pharmaceuticals, Inc. Pharmaceutical ophthalmic compositions for intraocular administration and methods for fabricating thereof
US20150164882A1 (en) 2013-07-22 2015-06-18 Imprimis Pharmaceuticals, Inc. Pharmaceutical compositions for intraocular administration and methods for fabricating thereof
EP3065717A1 (en) 2013-11-04 2016-09-14 Biopharmx, Inc. Dosage form comprising an active ingredient and a plurality of solid porous microcarriers
KR20180126087A (ko) * 2016-05-06 2018-11-26 임프리미스 파마슈티컬스 인코포레이티드 약학적 안과용 조성물 및 그의 제조 방법
US20180043017A1 (en) * 2016-08-11 2018-02-15 Xtl Biopharmaceuticals Ltd. Pharmaceutical compositions comprising 0.5 mg dose of synthetic human peptides for treating systemic lupus erythematosus
CL2017001945A1 (es) 2017-07-30 2018-10-19 Univ Tecnica Federico Santa Maria Utfsm Método, proceso, composición y kit para medir concentración de moléculas disueltas en la fase continua de un coloide.
CL2018001473A1 (es) * 2018-06-01 2019-10-25 Univ Tecnica Federico Santa Maria Utfsm Kit y métodos para evaluar las propiedades adsorbentes de la superficie de un material
JP7503055B2 (ja) * 2018-10-30 2024-06-19 クローダ,インコーポレイティド 微細粒子を水性又は極性の溶媒中に分散させる方法
CN115227833B (zh) * 2022-07-29 2023-03-21 西安交通大学医学院第一附属医院 一种氟化二氧化硅载药纳米粒及其制备方法、用途
WO2024182731A1 (en) * 2023-03-01 2024-09-06 Nevakar Injectables Inc. Injectable compositions of vitamers of vitamin b12 and uses thereof

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE837243C (de) 1944-09-30 1952-04-21 Bayer Ag Schwebemittel fuer waessrige Suspensionen
US2801185A (en) 1952-05-16 1957-07-30 Du Pont Silica hydrosol powder
DE1467023A1 (de) 1964-02-28 1969-01-23 Degussa Verfahren zur Inkorporierung von Wasser in feinst verteilter Kieselsaeure
US4680173A (en) 1977-04-28 1987-07-14 Norman D. Burger Aerosol dispensing system
US4522958A (en) 1983-09-06 1985-06-11 Ppg Industries, Inc. High-solids coating composition for improved rheology control containing chemically modified inorganic microparticles
DE3333639A1 (de) 1983-09-17 1985-03-28 Dynamit Nobel Ag Zubereitung von nitroestern fuer die koronartherapie
FR2666962B1 (fr) 1990-09-26 1996-06-14 Oreal Composition antifongique sous forme de spray sec.
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
FR2677544B1 (fr) 1991-06-14 1993-09-24 Oreal Composition cosmetique contenant un melange de nanopigments d'oxydes metalliques et de pigments melaniques.
FR2698002B1 (fr) * 1992-11-13 1995-01-13 Oreal Composition cosmétique de maquillage contenant un fullerène ou un mélange de fullerènes comme agent pigmentant.
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5492688A (en) 1993-04-28 1996-02-20 The Center For Innovative Technology Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent
JP3756213B2 (ja) * 1995-02-27 2006-03-15 独立行政法人科学技術振興機構 微粒子膜とその形成方法並びにその装置
IT1275955B1 (it) 1995-03-22 1997-10-24 Dompe Spa Formulazioni farmaceutiche in forma di gel tissotropico
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
FR2746302B1 (fr) * 1996-03-20 1998-12-24 Oreal Compositions cosmetiques comprenant des nanopigments
FR2759582A1 (fr) * 1997-02-14 1998-08-21 Oreal Composition deodorante
GB9711625D0 (en) * 1997-06-06 1997-07-30 Ciba Geigy Ag Pigment compositions
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
DE19811790A1 (de) * 1998-03-18 1999-09-23 Bayer Ag Nanopartikel enthaltende transparente Lackbindemittel mit verbesserter Verkratzungsbeständigkeit, ein Verfahren zur Herstellung sowie deren Verwendung
FR2781373B1 (fr) 1998-07-07 2001-09-21 Pf Medicament Formulations thixotropes pour le remplissage de gelules
CA2338917A1 (en) 1998-07-30 2000-02-10 Minnesota Mining And Manufacturing Company Nanosize metal oxide particles for producing transparent metal oxide colloids and ceramers
US6319513B1 (en) 1998-08-24 2001-11-20 The Procter & Gamble Company Oral liquid mucoadhesive compounds
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
US6258896B1 (en) * 1998-12-18 2001-07-10 3M Innovative Properties Company Dendritic polymer dispersants for hydrophobic particles in water-based systems
US6270806B1 (en) * 1999-03-03 2001-08-07 Elan Pharma International Limited Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions
ES2293913T3 (es) 1999-07-20 2008-04-01 THE PROCTER & GAMBLE COMPANY Particulas de aceite encapsulado mejoradas.
AU776770B2 (en) 1999-12-03 2004-09-23 Kuraray Co., Ltd. Dental or oralogic composition
JP4665322B2 (ja) * 2000-03-16 2011-04-06 東レ株式会社 ポリ(脂環式オレフィン)
FR2808704B1 (fr) * 2000-05-10 2002-08-16 Rhodia Chimie Sa Agents tensioactifs formes par des particules minerales de dimension nanometrique de surface modifiee
CA2382133C (en) 2000-05-10 2010-11-23 Alliance Pharmaceutical Corporation Phospholipid-based powders for drug delivery
HUP0302311A3 (en) 2000-10-09 2006-07-28 3M Innovative Properties Co Medicinal aerosol formulations
US20040081627A1 (en) * 2000-10-09 2004-04-29 Jinks Phillip A Medicinal aerosol formulations
US6586483B2 (en) 2001-01-08 2003-07-01 3M Innovative Properties Company Foam including surface-modified nanoparticles
US6467897B1 (en) 2001-01-08 2002-10-22 3M Innovative Properties Company Energy curable inks and other compositions incorporating surface modified, nanometer-sized particles
WO2002057004A1 (en) * 2001-01-19 2002-07-25 Efka Additives B.V. Dispersing agent
JP4293735B2 (ja) * 2001-01-19 2009-07-08 三栄源エフ・エフ・アイ株式会社 フラーレン誘導体およびそれからなる組成物
WO2003055469A1 (en) * 2001-12-21 2003-07-10 Celator Technologies Inc. Improved polymer-lipid delivery vehicles
FR2830450B1 (fr) 2001-10-09 2004-02-06 Univ Pasteur Utilisation de dendrimeres dans une composition ophtalmique
US7129277B2 (en) * 2002-12-31 2006-10-31 3M Innovative Properties Company Emulsions including surface-modified inorganic nanoparticles
US7001580B2 (en) * 2002-12-31 2006-02-21 3M Innovative Properties Company Emulsions including surface-modified organic molecules
US7141612B2 (en) 2002-12-31 2006-11-28 3M Innovative Properties Company Stabilized foams including surface-modified organic molecules
US7109247B2 (en) 2003-05-30 2006-09-19 3M Innovative Properties Company Stabilized particle dispersions containing nanoparticles
US7459146B2 (en) 2003-05-30 2008-12-02 3M Innovative Properties Company Stabilized aerosol dispersions
US20040242729A1 (en) 2003-05-30 2004-12-02 3M Innovative Properties Company Stabilized particle dispersions containing surface-modified inorganic nanoparticles

Also Published As

Publication number Publication date
US20040242730A1 (en) 2004-12-02
US7109247B2 (en) 2006-09-19
US7425582B2 (en) 2008-09-16
WO2005002544A2 (en) 2005-01-13
JP2006526626A (ja) 2006-11-24
US20070077209A1 (en) 2007-04-05
US7476694B2 (en) 2009-01-13
US20060286175A1 (en) 2006-12-21
CN1798543A (zh) 2006-07-05
WO2005002544A3 (en) 2005-04-21
EP1628635A2 (en) 2006-03-01

Similar Documents

Publication Publication Date Title
KR20060038937A (ko) 나노입자를 포함하는 안정화된 입자 분산액
CN1798549B (zh) 稳定的气雾剂分散体
KR101117846B1 (ko) 표면 개질 무기 나노입자를 포함하는 안정화된 입자 분산액
DE60219677T2 (de) Wasserlösliche polymerkonjugate von retinoesäure
EP0689424B1 (en) Aerosol formulation containing an ester-, amide-, or mercaptoester-derived dispersing aid
US9861580B2 (en) Method of making a dry powder pharmaceutical composition
US9956170B2 (en) Dry powder pharmaceutical compositions for pulmonary administration, and methods of manufacturing thereof
JP2002501885A (ja) 微粒子吸入用製剤
Paul et al. Potentials and challenges of Levodopa particle formulation for treatment of Parkinson’s disease through intranasal and pulmonary delivery
CN100592908C (zh) 包括氢氟烷和酰化环糊精的药用喷雾剂
WO2009059219A2 (en) Method of engineering polar drug particles with surface-trapped hydrofluoroalkane-philes
Kawakami Particle Architectonics for Pulmonary Drug Delivery
Wan Controlled Precipitation and Agglomeration of Itraconazole Nanoparticles for Pulmonary Delivery
Tam Synthesis, stabilization, and controlled assembly of organic and inorganic nanoparticles for therapeutic and imaging applications
Agnihotri et al. Fabrication of Novel Maleyl Functionalized Bovine Serum Albumin for Carrier Application in Dry Powder Inhaler

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20051129

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20090410

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20110330

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20110728

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20110330

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I