KR20050115455A - 효능이 증강된 케모킨 수용체 결합 헤테로사이클 화합물 - Google Patents
효능이 증강된 케모킨 수용체 결합 헤테로사이클 화합물 Download PDFInfo
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- KR20050115455A KR20050115455A KR1020057020099A KR20057020099A KR20050115455A KR 20050115455 A KR20050115455 A KR 20050115455A KR 1020057020099 A KR1020057020099 A KR 1020057020099A KR 20057020099 A KR20057020099 A KR 20057020099A KR 20050115455 A KR20050115455 A KR 20050115455A
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US50523003P | 2003-09-22 | 2003-09-22 | |
| US60/505,230 | 2003-09-22 |
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| KR20050115455A true KR20050115455A (ko) | 2005-12-07 |
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| US7501518B2 (en) * | 2003-04-22 | 2009-03-10 | Genzyme Corporation | Methods of making 2,6-diaryl piperidine derivatives |
| BRPI0514343A (pt) * | 2004-08-13 | 2008-06-10 | Anormed Inc | combinações de quimiocinas para mobilizar células progenitoras/tronco |
| EP1838321A4 (en) | 2005-01-07 | 2009-03-18 | Univ Emory | CXCR4 ANTAGONISTS FOR THE TREATMENT OF HIV INFECTION |
| WO2007025166A2 (en) * | 2005-08-25 | 2007-03-01 | Repair Technologies, Inc. | Devices, compositions and methods for the protection and repair of cells and tissues |
| JP5251127B2 (ja) | 2005-10-28 | 2013-07-31 | 小野薬品工業株式会社 | 塩基性基を含有する化合物およびその用途 |
| PL1961744T3 (pl) | 2005-11-18 | 2013-09-30 | Ono Pharmaceutical Co | Związek zawierający grupę zasadową oraz jego zastosowanie |
| WO2008008854A2 (en) | 2006-07-11 | 2008-01-17 | Emory University | Cxcr4 antagonists including diazine and triazine structures for the treatment of medical disorders |
| MX2009001272A (es) * | 2006-08-02 | 2009-02-11 | Genzyme Corp | Terapia de combinacion. |
| BRPI0715393A2 (pt) * | 2006-08-07 | 2013-06-25 | Genzyme Corp | terapia de combinaÇço |
| CN102015717A (zh) | 2008-03-28 | 2011-04-13 | 奥蒂瑞斯治疗公司 | 趋化因子受体调节剂 |
| CN103275071B (zh) * | 2013-05-17 | 2015-04-15 | 山西大学 | 一种香豆素衍生物及其制备方法和用途 |
| US20170105969A1 (en) * | 2014-06-02 | 2017-04-20 | Tobira Therapeutics, Inc. | Cenicriviroc for the treatment of hiv-2 infection |
| EP3389652B1 (en) | 2015-12-14 | 2022-09-28 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| US10953003B2 (en) | 2015-12-14 | 2021-03-23 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| US11433136B2 (en) | 2015-12-18 | 2022-09-06 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
| ES2935834T3 (es) | 2015-12-22 | 2023-03-10 | X4 Pharmaceuticals Inc | Métodos para tratar enfermedad de inmunodeficiencia |
| CA3019394A1 (en) | 2016-04-08 | 2017-10-12 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| WO2017223243A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| CN109640988A (zh) * | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
| CN109562106B (zh) * | 2016-06-21 | 2023-03-21 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
| WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
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| EP4117662A4 (en) | 2020-03-10 | 2024-04-03 | X4 Pharmaceuticals, Inc. | METHODS OF TREATING NEUTROPENIA |
| WO2025224720A1 (en) | 2024-04-24 | 2025-10-30 | Biolinerx Ltd. | Methods of selecting treatment regimen against solid tumors |
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| US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| US6001826A (en) | 1989-12-21 | 1999-12-14 | Anormed, Inc. | Chemical compounds |
| US5021409A (en) | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
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| US6365583B1 (en) * | 1999-02-02 | 2002-04-02 | Anormed, Inc. | Methods to enhance white blood cell count |
| DE60028354T2 (de) | 1999-03-24 | 2007-02-08 | Anormed Inc., Langley | Chemokine rezeptor bindende heterozyklische verbindungen |
| PT1307455E (pt) * | 1999-10-20 | 2005-06-30 | Tanabe Seiyaku Co | Inibidores de adesao celular mediada por (alfa)l (beta)2 |
| AU5811001A (en) * | 2000-05-09 | 2001-11-20 | Univ British Columbia | Cxcr4 antagonist treatment of hematopoietic cells |
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| BR0113930A (pt) | 2000-09-15 | 2003-06-24 | Anormed Inc | Compostos heterocìclicos de ligação aos receptores de quimiocina |
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| GB0030673D0 (en) * | 2000-12-15 | 2001-01-31 | Unilever Plc | Ligand and complex for catalytically bleaching a substrate |
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| EP1615633B1 (en) * | 2003-04-22 | 2012-08-15 | Genzyme Corporation | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| US7498346B2 (en) | 2003-12-11 | 2009-03-03 | Genzyme Corporation | Chemokine receptor binding compounds |
| US10468384B2 (en) | 2017-09-15 | 2019-11-05 | STATS ChipPAC Pte. Ltd. | Semiconductor device and method of forming embedded die substrate, and system-in-package modules with the same |
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| BRPI0409655B8 (pt) | 2021-05-25 |
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| HK1089930A1 (en) | 2006-12-15 |
| NZ542850A (en) | 2007-12-21 |
| AU2004232361A1 (en) | 2004-11-04 |
| ES2393188T3 (es) | 2012-12-19 |
| EP1615633A4 (en) | 2008-07-09 |
| US20090281308A1 (en) | 2009-11-12 |
| RU2005136224A (ru) | 2006-06-10 |
| WO2004093817A2 (en) | 2004-11-04 |
| JP2006524700A (ja) | 2006-11-02 |
| EP1615633A2 (en) | 2006-01-18 |
| IL170207A (en) | 2011-06-30 |
| WO2004093817A3 (en) | 2005-04-28 |
| NO20054405L (no) | 2006-01-19 |
| EP1615633B1 (en) | 2012-08-15 |
| BRPI0409655A (pt) | 2006-04-18 |
| CA2517077A1 (en) | 2004-11-04 |
| CA2517077C (en) | 2013-03-12 |
| IN266744B (enExample) | 2015-05-29 |
| US7550484B2 (en) | 2009-06-23 |
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