KR20050057415A - 전환성장인자(ｔｇｆ) 억제제로서의 신규한 싸이아졸 및 옥사졸 화합물 - Google Patents

전환성장인자(ｔｇｆ) 억제제로서의 신규한 싸이아졸 및 옥사졸 화합물 Download PDF

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Publication number
KR20050057415A
KR20050057415A KR1020057004611A KR20057004611A KR20050057415A KR 20050057415 A KR20050057415 A KR 20050057415A KR 1020057004611 A KR1020057004611 A KR 1020057004611A KR 20057004611 A KR20057004611 A KR 20057004611A KR 20050057415 A KR20050057415 A KR 20050057415A
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KR
South Korea
Prior art keywords
alkyl
phenyl
methyl
formula
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020057004611A
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English (en)
Korean (ko)
Inventor
라우라 쿡 블룸버그
마이클 존 먼츠호프
Original Assignee
화이자 프로덕츠 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 화이자 프로덕츠 인코포레이티드 filed Critical 화이자 프로덕츠 인코포레이티드
Publication of KR20050057415A publication Critical patent/KR20050057415A/ko
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1020057004611A 2002-09-18 2003-09-08 전환성장인자(ｔｇｆ) 억제제로서의 신규한 싸이아졸 및 옥사졸 화합물 Ceased KR20050057415A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US41212002P 2002-09-18 2002-09-18
US60/412,120 2002-09-18
US47126503P 2003-05-16 2003-05-16
US60/471,265 2003-05-16
US48458103P 2003-07-02 2003-07-02
US60/484,581 2003-07-02

Publications (1)

Publication Number Publication Date
KR20050057415A true KR20050057415A (ko) 2005-06-16

Family

ID=32034216

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057004611A Ceased KR20050057415A (ko) 2002-09-18 2003-09-08 전환성장인자(ｔｇｆ) 억제제로서의 신규한 싸이아졸 및 옥사졸 화합물

Country Status (28)

Country Link
US (1) US7273936B2 (enExample)
EP (1) EP1542994B1 (enExample)
JP (1) JP4518956B2 (enExample)
KR (1) KR20050057415A (enExample)
CN (1) CN1681810A (enExample)
AP (1) AP2005003261A0 (enExample)
AR (1) AR041273A1 (enExample)
AT (1) ATE430147T1 (enExample)
AU (1) AU2003256003A1 (enExample)
BR (1) BR0314383A (enExample)
CA (1) CA2499429C (enExample)
CO (1) CO5550473A2 (enExample)
CR (1) CR7743A (enExample)
DE (1) DE60327443D1 (enExample)
EA (1) EA200500354A1 (enExample)
ES (1) ES2323421T3 (enExample)
HR (1) HRP20050250A2 (enExample)
IS (1) IS7711A (enExample)
MA (1) MA27443A1 (enExample)
MX (1) MXPA05002332A (enExample)
NO (1) NO20051838L (enExample)
OA (1) OA12926A (enExample)
PA (1) PA8582701A1 (enExample)
PE (1) PE20040987A1 (enExample)
PL (1) PL375975A1 (enExample)
TW (1) TW200413362A (enExample)
UY (1) UY27978A1 (enExample)
WO (1) WO2004026863A1 (enExample)

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US20070275968A1 (en) * 2004-09-07 2007-11-29 Hitoshi Kurata Substituted Biphenyl Derivative
CN101084207A (zh) 2004-09-20 2007-12-05 泽农医药公司 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途
US7951805B2 (en) 2004-09-20 2011-05-31 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
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JP5149009B2 (ja) 2004-09-20 2013-02-20 ゼノン・ファーマシューティカルズ・インコーポレイテッド ヒトステアロイル−ＣｏＡデサチュラーゼを阻害するためのピリダジン誘導体
MX2007003321A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos y su uso como agentes terapeuticos.
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US8268874B2 (en) 2008-03-03 2012-09-18 University Of Notre Dame Du Lac Anti-cancer compounds, synthesis thereof, and methods of using same
US8865732B2 (en) 2008-03-21 2014-10-21 Novartis Ag Heterocyclic compounds and uses thereof
AU2012203026B2 (en) * 2008-03-21 2014-06-12 Novartis Ag Novel heterocyclic compounds and uses thereof
US8338604B2 (en) 2008-06-20 2012-12-25 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
CN109045032A (zh) 2014-01-01 2018-12-21 麦迪威森技术有限责任公司 氨基吡啶类化合物和使用方法
UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
CN105585565B (zh) * 2014-10-23 2019-10-01 中国医学科学院药物研究所 含2-苯胺基-4-噻唑基吡啶衍生物及其制法和药物组合物与用途
CN106243012A (zh) * 2016-08-02 2016-12-21 北方民族大学 新型吲哚类衍生物及其制备方法
AU2017329090B9 (en) 2016-09-19 2019-09-05 Novartis Ag Therapeutic combinations comprising a RAF inhibitor and a ERK inhibitor
US11266653B2 (en) 2017-05-02 2022-03-08 Novartis Ag Combination therapy
IL271149B2 (en) * 2017-06-14 2024-05-01 Trevena Inc Compounds for modulating s1p1 activity and methods of using the same
CA3138123A1 (en) 2019-05-13 2020-11-19 Novartis Ag New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2 (trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
CN112694477B (zh) * 2019-10-22 2024-02-06 四川科伦博泰生物医药股份有限公司 吡唑并环类化合物，包含其的药物组合物，其制备方法及其用途
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Also Published As

Publication number Publication date
JP2006502235A (ja) 2006-01-19
UY27978A1 (es) 2004-04-30
EP1542994B1 (en) 2009-04-29
PL375975A1 (en) 2005-12-12
IS7711A (is) 2005-02-24
US7273936B2 (en) 2007-09-25
CO5550473A2 (es) 2005-08-31
CA2499429A1 (en) 2004-04-01
BR0314383A (pt) 2005-07-19
CN1681810A (zh) 2005-10-12
AU2003256003A1 (en) 2004-04-08
PA8582701A1 (es) 2004-04-23
CR7743A (es) 2005-06-15
MA27443A1 (fr) 2005-07-01
AR041273A1 (es) 2005-05-11
DE60327443D1 (de) 2009-06-10
PE20040987A1 (es) 2004-12-27
EP1542994A1 (en) 2005-06-22
ATE430147T1 (de) 2009-05-15
NO20051838L (no) 2005-04-15
OA12926A (en) 2006-10-13
ES2323421T3 (es) 2009-07-15
JP4518956B2 (ja) 2010-08-04
EA200500354A1 (ru) 2005-10-27
TW200413362A (en) 2004-08-01
HRP20050250A2 (en) 2005-10-31
WO2004026863A1 (en) 2004-04-01
MXPA05002332A (es) 2005-06-08
AP2005003261A0 (en) 2005-03-31
US20040110797A1 (en) 2004-06-10
WO2004026863A8 (en) 2005-04-21
CA2499429C (en) 2010-09-21

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